Marco Bortolato

Summary

Publications

  1. ncbi request reprint Steroid 5α-reductase as a novel therapeutic target for schizophrenia and other neuropsychiatric disorders
    Silvia Paba
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Ave PSC 527 Los Angeles, CA 90089, USA
    Curr Pharm Des 17:151-67. 2011
  2. pmc NMDARs mediate the role of monoamine oxidase A in pathological aggression
    Marco Bortolato
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90089, USA
    J Neurosci 32:8574-82. 2012
  3. pmc Social deficits and perseverative behaviors, but not overt aggression, in MAO-A hypomorphic mice
    Marco Bortolato
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Neuropsychopharmacology 36:2674-88. 2011
  4. pmc Sociocommunicative and Sensorimotor Impairments in Male P2X4-Deficient Mice
    Letisha R Wyatt
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, USA
    Neuropsychopharmacology 38:1993-2002. 2013
  5. pmc Cognitive abnormalities and hippocampal alterations in monoamine oxidase A and B knockout mice
    Chanpreet Singh
    Neuroscience Program, and Molecular and Computational Biology Program, University of Southern California, Los Angeles, CA 90089
    Proc Natl Acad Sci U S A 110:12816-21. 2013
  6. pmc Behavioral outcomes of monoamine oxidase deficiency: preclinical and clinical evidence
    Marco Bortolato
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, USA
    Int Rev Neurobiol 100:13-42. 2011
  7. pmc Monoamine oxidase A and A/B knockout mice display autistic-like features
    Marco Bortolato
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Int J Neuropsychopharmacol 16:869-88. 2013
  8. pmc Maladaptive defensive behaviours in monoamine oxidase A-deficient mice
    Sean C Godar
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Int J Neuropsychopharmacol 14:1195-207. 2011
  9. pmc Pharmacological insights into the role of P2X4 receptors in behavioural regulation: lessons from ivermectin
    Marco Bortolato
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, USA
    Int J Neuropsychopharmacol 16:1059-70. 2013
  10. doi request reprint Isolation rearing-induced reduction of brain 5α-reductase expression: relevance to dopaminergic impairments
    Marco Bortolato
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90031, USA
    Neuropharmacology 60:1301-8. 2011

Collaborators

  • Richard F Thompson
  • Sean C Godar
  • Chanpreet Singh
  • Letisha R Wyatt
  • Kevin Chen
  • Jean C Shih
  • Silvia Paba
  • Roberto Frau
  • Michael W Jakowec
  • Namrata Bali
  • Ronald L Alkana
  • Sheraz Khoja
  • Anna L Scott
  • Daryl L Davies
  • Mona Dousti
  • Francesco Marrosu
  • Paola Devoto

Detail Information

Publications10

  1. ncbi request reprint Steroid 5α-reductase as a novel therapeutic target for schizophrenia and other neuropsychiatric disorders
    Silvia Paba
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Ave PSC 527 Los Angeles, CA 90089, USA
    Curr Pharm Des 17:151-67. 2011
    ..In the present article, we review emerging preclinical and clinical evidence related to these effects, and discuss some of the potential mechanisms underlying the role of S5α R in the pathophysiology of mental disorders...
  2. pmc NMDARs mediate the role of monoamine oxidase A in pathological aggression
    Marco Bortolato
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90089, USA
    J Neurosci 32:8574-82. 2012
    ....
  3. pmc Social deficits and perseverative behaviors, but not overt aggression, in MAO-A hypomorphic mice
    Marco Bortolato
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Neuropsychopharmacology 36:2674-88. 2011
    ..Taken together, our findings indicate that MAO A hypomorphism results in behavioral and morphological alterations distinct from those featured by MAO-A KO mice...
  4. pmc Sociocommunicative and Sensorimotor Impairments in Male P2X4-Deficient Mice
    Letisha R Wyatt
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, USA
    Neuropsychopharmacology 38:1993-2002. 2013
    ....
  5. pmc Cognitive abnormalities and hippocampal alterations in monoamine oxidase A and B knockout mice
    Chanpreet Singh
    Neuroscience Program, and Molecular and Computational Biology Program, University of Southern California, Los Angeles, CA 90089
    Proc Natl Acad Sci U S A 110:12816-21. 2013
    ..The characteristics exhibited by MAO A/B KO mice highlight the potential of these animals as a useful tool to provide further insight into the molecular bases of disorders associated with abnormal monoaminergic profiles. ..
  6. pmc Behavioral outcomes of monoamine oxidase deficiency: preclinical and clinical evidence
    Marco Bortolato
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, USA
    Int Rev Neurobiol 100:13-42. 2011
    ....
  7. pmc Monoamine oxidase A and A/B knockout mice display autistic-like features
    Marco Bortolato
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Int J Neuropsychopharmacol 16:869-88. 2013
    ..Thus, MAOA and A/B KO mice may afford valuable models to help elucidate the neurobiological bases of these disorders and related neurodevelopmental problems...
  8. pmc Maladaptive defensive behaviours in monoamine oxidase A-deficient mice
    Sean C Godar
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Int J Neuropsychopharmacol 14:1195-207. 2011
    ..Collectively, these results suggest that MAOA deficiency leads to a general inability to appropriately assess contextual risk and attune defensive and emotional responses to environmental cues...
  9. pmc Pharmacological insights into the role of P2X4 receptors in behavioural regulation: lessons from ivermectin
    Marco Bortolato
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, USA
    Int J Neuropsychopharmacol 16:1059-70. 2013
    ..Taken together, these results suggest that P2X4 receptors may play a role in the regulation of sensorimotor gating...
  10. doi request reprint Isolation rearing-induced reduction of brain 5α-reductase expression: relevance to dopaminergic impairments
    Marco Bortolato
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90031, USA
    Neuropharmacology 60:1301-8. 2011
    ..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'...