Marco Bortolato

Summary

Publications

  1. ncbi Steroid 5α-reductase as a novel therapeutic target for schizophrenia and other neuropsychiatric disorders
    Silvia Paba
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Ave PSC 527 Los Angeles, CA 90089, USA
    Curr Pharm Des 17:151-67. 2011
  2. pmc NMDARs mediate the role of monoamine oxidase A in pathological aggression
    Marco Bortolato
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90089, USA
    J Neurosci 32:8574-82. 2012
  3. pmc Sociocommunicative and sensorimotor impairments in male P2X4-deficient mice
    Letisha R Wyatt
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, USA
    Neuropsychopharmacology 38:1993-2002. 2013
  4. pmc Cognitive abnormalities and hippocampal alterations in monoamine oxidase A and B knockout mice
    Chanpreet Singh
    Neuroscience Program, University of Southern California, Los Angeles, CA 90089, USA
    Proc Natl Acad Sci U S A 110:12816-21. 2013
  5. pmc Monoamine oxidase A and A/B knockout mice display autistic-like features
    Marco Bortolato
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Int J Neuropsychopharmacol 16:869-88. 2013
  6. pmc Social deficits and perseverative behaviors, but not overt aggression, in MAO-A hypomorphic mice
    Marco Bortolato
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Neuropsychopharmacology 36:2674-88. 2011
  7. ncbi The aggression and behavioral abnormalities associated with monoamine oxidase A deficiency are rescued by acute inhibition of serotonin reuptake
    Sean C Godar
    Dept of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS, USA Dept of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, USA
    J Psychiatr Res 56:1-9. 2014
  8. pmc Behavioral outcomes of monoamine oxidase deficiency: preclinical and clinical evidence
    Marco Bortolato
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, USA
    Int Rev Neurobiol 100:13-42. 2011
  9. pmc Pharmacological insights into the role of P2X4 receptors in behavioural regulation: lessons from ivermectin
    Marco Bortolato
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, USA
    Int J Neuropsychopharmacol 16:1059-70. 2013
  10. pmc Maladaptive defensive behaviours in monoamine oxidase A-deficient mice
    Sean C Godar
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Int J Neuropsychopharmacol 14:1195-207. 2011

Collaborators

  • Richard F Thompson
  • Sean C Godar
  • Kevin Chen
  • Jean C Shih
  • Chanpreet Singh
  • Letisha R Wyatt
  • Silvia Paba
  • Roberto Frau
  • Alberto Casti
  • M Grazia Ennas
  • M Paola Castelli
  • Simone Tambaro
  • Angelo Casu
  • Michael W Jakowec
  • Namrata Bali
  • Ronald L Alkana
  • Sheraz Khoja
  • Anna L Scott
  • Daryl L Davies
  • Mona Dousti
  • Francesco Marrosu
  • Paola Devoto

Detail Information

Publications11

  1. ncbi Steroid 5α-reductase as a novel therapeutic target for schizophrenia and other neuropsychiatric disorders
    Silvia Paba
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Ave PSC 527 Los Angeles, CA 90089, USA
    Curr Pharm Des 17:151-67. 2011
    ..In the present article, we review emerging preclinical and clinical evidence related to these effects, and discuss some of the potential mechanisms underlying the role of S5α R in the pathophysiology of mental disorders...
  2. pmc NMDARs mediate the role of monoamine oxidase A in pathological aggression
    Marco Bortolato
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90089, USA
    J Neurosci 32:8574-82. 2012
    ....
  3. pmc Sociocommunicative and sensorimotor impairments in male P2X4-deficient mice
    Letisha R Wyatt
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, USA
    Neuropsychopharmacology 38:1993-2002. 2013
    ....
  4. pmc Cognitive abnormalities and hippocampal alterations in monoamine oxidase A and B knockout mice
    Chanpreet Singh
    Neuroscience Program, University of Southern California, Los Angeles, CA 90089, USA
    Proc Natl Acad Sci U S A 110:12816-21. 2013
    ..The characteristics exhibited by MAO A/B KO mice highlight the potential of these animals as a useful tool to provide further insight into the molecular bases of disorders associated with abnormal monoaminergic profiles. ..
  5. pmc Monoamine oxidase A and A/B knockout mice display autistic-like features
    Marco Bortolato
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Int J Neuropsychopharmacol 16:869-88. 2013
    ..Thus, MAOA and A/B KO mice may afford valuable models to help elucidate the neurobiological bases of these disorders and related neurodevelopmental problems...
  6. pmc Social deficits and perseverative behaviors, but not overt aggression, in MAO-A hypomorphic mice
    Marco Bortolato
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Neuropsychopharmacology 36:2674-88. 2011
    ..Taken together, our findings indicate that MAO A hypomorphism results in behavioral and morphological alterations distinct from those featured by MAO-A KO mice...
  7. ncbi The aggression and behavioral abnormalities associated with monoamine oxidase A deficiency are rescued by acute inhibition of serotonin reuptake
    Sean C Godar
    Dept of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS, USA Dept of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, USA
    J Psychiatr Res 56:1-9. 2014
    ..Furthermore, the translational implications of our results highlight 5-HT reuptake inhibition as an interesting approach for the control of aggressive outbursts in MAO-A deficient individuals. ..
  8. pmc Behavioral outcomes of monoamine oxidase deficiency: preclinical and clinical evidence
    Marco Bortolato
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, USA
    Int Rev Neurobiol 100:13-42. 2011
    ....
  9. pmc Pharmacological insights into the role of P2X4 receptors in behavioural regulation: lessons from ivermectin
    Marco Bortolato
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, USA
    Int J Neuropsychopharmacol 16:1059-70. 2013
    ..Taken together, these results suggest that P2X(4) receptors may play a role in the regulation of sensorimotor gating...
  10. pmc Maladaptive defensive behaviours in monoamine oxidase A-deficient mice
    Sean C Godar
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Int J Neuropsychopharmacol 14:1195-207. 2011
    ..Collectively, these results suggest that MAOA deficiency leads to a general inability to appropriately assess contextual risk and attune defensive and emotional responses to environmental cues...
  11. doi Isolation rearing-induced reduction of brain 5α-reductase expression: relevance to dopaminergic impairments
    Marco Bortolato
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90031, USA
    Neuropharmacology 60:1301-8. 2011
    ..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'...