David Borsook

Summary

Publications

  1. ncbi request reprint Pain: the past, present and future
    David Borsook
    Descartes Therapeutics, Inc, 790 Memorial Drive, Suite 104, Cambridge, MA, USA
    Adv Drug Deliv Rev 55:931-4. 2003
  2. ncbi request reprint Pain imaging: future applications to integrative clinical and basic neurobiology
    David Borsook
    Descartes Therapeutics, Inc, 790 Memorial Drive, Suite 104, Cambridge, MA, USA
    Adv Drug Deliv Rev 55:967-86. 2003
  3. ncbi request reprint Specific and somatotopic functional magnetic resonance imaging activation in the trigeminal ganglion by brush and noxious heat
    David Borsook
    Center for Pain Functional Neuroimaging and Therapy Research, Athinoula Martinos NMR Center, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    J Neurosci 23:7897-903. 2003
  4. ncbi request reprint Antineuropathic effects of the antibiotic derivative spicamycin KRN5500
    David Borsook
    Center for Functional Pain Neuroimaging and Therapy Research, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Pain Med 5:104-8. 2004
  5. doi request reprint Parallel buprenorphine phMRI responses in conscious rodents and healthy human subjects
    Lino Becerra
    Imaging Consortium for Drug Development, P A I N Group, Harvard Medical School, Children s Hospital of Boston, Waltham, Massachusetts 02453, USA
    J Pharmacol Exp Ther 345:41-51. 2013
  6. pmc BOLD responses in somatosensory cortices better reflect heat sensation than pain
    Eric A Moulton
    Center for Pain and the Brain, Department of Psychiatry, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Neurosci 32:6024-31. 2012
  7. doi request reprint A statistical framework for optimal design matrix generation with application to fMRI
    Gautam V Pendse
    Imaging and Analysis Group IMAG, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    IEEE Trans Med Imaging 29:1573-611. 2010
  8. pmc Interictal dysfunction of a brainstem descending modulatory center in migraine patients
    Eric A Moulton
    PAIN Group, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, United States of America
    PLoS ONE 3:e3799. 2008
  9. ncbi request reprint The effect of antinociceptive drugs tested at different times after nerve injury in rats
    Aldric T Hama
    Descartes Therapeutics, Inc, Waltham, Massachusetts, USA
    Anesth Analg 101:175-9, table of contents. 2005
  10. pmc Transient and persistent pain induced connectivity alterations in pediatric complex regional pain syndrome
    Clas Linnman
    Pain and Analgesia Imaging Neuroscience P A I N Group, Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 8:e57205. 2013

Detail Information

Publications65

  1. ncbi request reprint Pain: the past, present and future
    David Borsook
    Descartes Therapeutics, Inc, 790 Memorial Drive, Suite 104, Cambridge, MA, USA
    Adv Drug Deliv Rev 55:931-4. 2003
  2. ncbi request reprint Pain imaging: future applications to integrative clinical and basic neurobiology
    David Borsook
    Descartes Therapeutics, Inc, 790 Memorial Drive, Suite 104, Cambridge, MA, USA
    Adv Drug Deliv Rev 55:967-86. 2003
    ..In the future, correlations with such states and behavioral, genetic, epigenetic or other chemical markers may help define specific diagnostic tools and novel approaches to drug discovery...
  3. ncbi request reprint Specific and somatotopic functional magnetic resonance imaging activation in the trigeminal ganglion by brush and noxious heat
    David Borsook
    Center for Pain Functional Neuroimaging and Therapy Research, Athinoula Martinos NMR Center, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    J Neurosci 23:7897-903. 2003
    ....
  4. ncbi request reprint Antineuropathic effects of the antibiotic derivative spicamycin KRN5500
    David Borsook
    Center for Functional Pain Neuroimaging and Therapy Research, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Pain Med 5:104-8. 2004
    ..This finding led to animal studies that have provided support for the possible use of KRN5500 in the treatment of neuropathic pain in humans as well as some insight into the possible mechanism(s) of action of this drug...
  5. doi request reprint Parallel buprenorphine phMRI responses in conscious rodents and healthy human subjects
    Lino Becerra
    Imaging Consortium for Drug Development, P A I N Group, Harvard Medical School, Children s Hospital of Boston, Waltham, Massachusetts 02453, USA
    J Pharmacol Exp Ther 345:41-51. 2013
    ..This investigation further demonstrates the usefulness of phMRI as a translational tool in neuroscience research that can provide mechanistic insight and guide dose selection in drug development...
  6. pmc BOLD responses in somatosensory cortices better reflect heat sensation than pain
    Eric A Moulton
    Center for Pain and the Brain, Department of Psychiatry, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Neurosci 32:6024-31. 2012
    ..These results indicate that heat intensity is encoded by the somatosensory cortices, and that pain evaluation may either arise from multimodal evaluative processes, or is a distributed process...
  7. doi request reprint A statistical framework for optimal design matrix generation with application to fMRI
    Gautam V Pendse
    Imaging and Analysis Group IMAG, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    IEEE Trans Med Imaging 29:1573-611. 2010
    ..Although developed with motivation from fMRI, our framework is quite general and has potentially wide applicability to a variety of disciplines...
  8. pmc Interictal dysfunction of a brainstem descending modulatory center in migraine patients
    Eric A Moulton
    PAIN Group, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, United States of America
    PLoS ONE 3:e3799. 2008
    ..To determine whether a brainstem dysfunction could play a role in facilitating migraine attacks, we measured brainstem function in migraineurs when they were not having an attack (i.e. the interictal phase)...
  9. ncbi request reprint The effect of antinociceptive drugs tested at different times after nerve injury in rats
    Aldric T Hama
    Descartes Therapeutics, Inc, Waltham, Massachusetts, USA
    Anesth Analg 101:175-9, table of contents. 2005
    ....
  10. pmc Transient and persistent pain induced connectivity alterations in pediatric complex regional pain syndrome
    Clas Linnman
    Pain and Analgesia Imaging Neuroscience P A I N Group, Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 8:e57205. 2013
    ..The results add emphasis to the importance of early recognition and management in improving outcome of pediatric CRPS...
  11. pmc Her versus his migraine: multiple sex differences in brain function and structure
    Nasim Maleki
    Department of Anaesthesia, Centre for Pain and the Brain, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Brain 135:2546-59. 2012
    ....
  12. pmc Concurrent functional and structural cortical alterations in migraine
    Nasim Maleki
    Department of Radiology, Children s Hospital Boston, Harvard Medical School, USA
    Cephalalgia 32:607-20. 2012
    ..Defining concurrent cortical alterations may provide specific insights into the unfolding adaptive or maladaptive changes taking place in cortex in migraine...
  13. pmc An approach to localizing corneal pain representation in human primary somatosensory cortex
    Eric A Moulton
    P A I N Group, Center for Pain and the Brain, Children s Hospital Boston, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 7:e44643. 2012
    ..This finding opens future avenues of research to evaluate the relationship between corneal pain and central brain mechanisms relating to the development of chronic pain conditions, such as dry eye-like symptoms...
  14. pmc Thalamic sensitization transforms localized pain into widespread allodynia
    Rami Burstein
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA
    Ann Neurol 68:81-91. 2010
    ....
  15. pmc Imaging drugs with and without clinical analgesic efficacy
    Jaymin Upadhyay
    Imaging Consortium for Drug Development, Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Neuropsychopharmacology 36:2659-73. 2011
    ..This investigation demonstrates how CNS-acting drugs can be compared, and how the phMRI/fMRI methodology may be used with conventional measures to better evaluate candidate analgesics in small subject cohorts...
  16. pmc CNS animal fMRI in pain and analgesia
    David Borsook
    P A I N Group, Department of Radiology, Athinoula A Center for Biomedical Imaging, Massachusetts General Hospital, 115 Mill Street, Belmont, MA 02478, United States
    Neurosci Biobehav Rev 35:1125-43. 2011
    ..In this review we evaluate the role of functional and anatomical imaging in furthering our understanding in pain and analgesia...
  17. pmc Cortical projections of functionally identified thalamic trigeminovascular neurons: implications for migraine headache and its associated symptoms
    Rodrigo Noseda
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neurosci 31:14204-17. 2011
    ....
  18. doi request reprint Robust, unbiased general linear model estimation of phMRI signal amplitude in the presence of variation in the temporal response profile
    Gautam V Pendse
    P A I N Group, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Magn Reson Imaging 31:1445-57. 2010
    ..If not properly accounted for, this variation can result in inaccurate and unevenly biased signal amplitude estimates when modeled within a general linear model (GLM) framework...
  19. pmc Aversion-related circuitry in the cerebellum: responses to noxious heat and unpleasant images
    Eric A Moulton
    Pain Analgesia Imaging Neuroscience Group and Clinical Psychopathology Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Neurosci 31:3795-804. 2011
    ..The separate cortical networks suggest that noxious heat-evoked responses in the cerebellum can be divided into sensorimotor and emotional networks...
  20. pmc Pain response measured with arterial spin labeling
    Nasim Maleki
    P A I N Group, Department of Anesthesia, Boston Children s Hospital and Harvard Medical School, Boston, MA, USA
    NMR Biomed 26:664-73. 2013
    ..We suggest that pCASL is a reliable alternative for functional MRI pain studies in conditions in which blood flow, volume or oxygen extraction are altered or compromised...
  21. pmc Pain and analgesia: the value of salience circuits
    David Borsook
    Center for Pain and the Brain, Harvard Medical School, Boston, MA 02115, United States
    Prog Neurobiol 104:93-105. 2013
    ....
  22. pmc Yohimbine-induced amygdala activation in pathological gamblers: a pilot study
    Igor Elman
    Bedford Veterans Administration Medical Center and Department of Psychiatry, Cambridge Health Alliance, Harvard Medical School, Somerville, Massachusetts, United States of America
    PLoS ONE 7:e31118. 2012
    ..In this pilot functional magnetic resonance imaging (fMRI) study we assessed whether a prototype behavioral addiction, pathological gambling (PG), is likewise associated with an enhanced response to stress...
  23. ncbi request reprint Biomarkers for chronic pain and analgesia. Part 2: how, where, and what to look for using functional imaging
    David Borsook
    P A I N Group, Massachusetts General Hospital, McLean Hospital, and Children s Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Discov Med 11:209-19. 2011
    ..An important area for future research is to image clinical ongoing pain to further our knowledge of brain function in different pain states and the effects of treatment...
  24. pmc Colocalized structural and functional changes in the cortex of patients with trigeminal neuropathic pain
    Alexandre F DaSilva
    PAIN Group, Brain Imaging Center, McLean Hospital, Harvard Medical School, Boston, MA, USA
    PLoS ONE 3:e3396. 2008
    ..The model has a number of advantages including the evaluation of specific changes that can be mapped to known somatotopic anatomy...
  25. pmc Common hippocampal structural and functional changes in migraine
    Nasim Maleki
    Department of Anesthesia and Radiology, Center for Pain and the Brain, MCL, MGH and CHB, Children s Hospital Boston and Harvard Medical School, Boston, MA, USA
    Brain Struct Funct 218:903-12. 2013
    ..The results implicate involvement of hippocampus in the pathophysiology of the migraine...
  26. pmc Direct optic nerve pulvinar connections defined by diffusion MR tractography in humans: implications for photophobia
    Nasim Maleki
    PAIN Group, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Hum Brain Mapp 33:75-88. 2012
    ..Consistent with physiological and anatomical studies in rats, the data provide an anatomical substrate for exacerbation of migraine headache by light in the human...
  27. pmc Migraine attacks the Basal Ganglia
    Nasim Maleki
    Department of Radiology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Mol Pain 7:71. 2011
    ....
  28. pmc Alterations in brain structure and functional connectivity in prescription opioid-dependent patients
    Jaymin Upadhyay
    P A I N Group, Harvard Medical School, c o Brain Imaging Centre, McLean Hospital, Department of Psychiatry, 115 Mill Street, Belmont, MA 02478 9106, USA
    Brain 133:2098-114. 2010
    ..These results may have important clinical implications for uncovering the effects of long-term prescription opioid use on brain structure and function...
  29. ncbi request reprint Biomarkers for chronic pain and analgesia. Part 1: the need, reality, challenges, and solutions
    David Borsook
    P A I N Group, Massachusetts General Hospital, McLean Hospital, and Children s Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Discov Med 11:197-207. 2011
    ..The fit-for-purpose, scientific validation, and clinical qualification of novel CNS biomarkers for chronic pain could dramatically change the current outlook for treatment of chronic pain and research into its etiology...
  30. pmc The pain imaging revolution: advancing pain into the 21st century
    David Borsook
    Department of Radiology, Children s Hospital Boston, Waltham, MA 02453, USA
    Neuroscientist 16:171-85. 2010
    ..They also discuss the possible applications of brain imaging to developing a "pain phenotype" that could aid in diagnostic and treatment choices of chronic pain conditions...
  31. doi request reprint Anesthesia and perioperative stress: consequences on neural networks and postoperative behaviors
    David Borsook
    Department of Radiology and Psychiatry, Children s Hospital Boston, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Prog Neurobiol 92:601-12. 2010
    ..We discuss the role of current (and developing) measures of brain function and their potential for monitoring perioperative stress, with an emphasis on functional neuroimaging...
  32. pmc A simple and objective method for reproducible resting state network (RSN) detection in fMRI
    Gautam V Pendse
    PAIN Group, Imaging and Analysis Group, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, United States of America
    PLoS ONE 6:e27594. 2011
    ..org). Our reproducibility analyses indicated that many of the published RSNs in rsfMRI literature are highly reproducible. However, we found several other RSNs that are highly reproducible but not frequently listed in the literature...
  33. pmc Robust reproducible resting state networks in the awake rodent brain
    Lino Becerra
    Pain and Analgesia Imaging Neuroscience Group, A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 6:e25701. 2011
    ..This analysis indicates that 7 networks are robust and reproducible in the rat and their putative role is discussed...
  34. ncbi request reprint Somatotopic activation in the human trigeminal pain pathway
    Alex F M DaSilva
    Center for Pain Functional Neuroimaging and Therapy Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    J Neurosci 22:8183-92. 2002
    ..This approach will be useful for exploring central correlates of plasticity in models of experimental and clinical pain...
  35. pmc A key role of the basal ganglia in pain and analgesia--insights gained through human functional imaging
    David Borsook
    PAIN Group, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Mol Pain 6:27. 2010
    ..These include the integration of motor, emotional, autonomic and cognitive responses to pain...
  36. pmc Challenges of functional imaging research of pain in children
    Simona Sava
    P A I N Group, Department of Radiology, Children s Hospital Boston, Massachuesetts, USA
    Mol Pain 5:30. 2009
    ..In this review we summarize this potential and discuss specific concerns related to the imaging of pain in children...
  37. doi request reprint The human amygdala and pain: Evidence from neuroimaging
    Laura E Simons
    P A I N Group, Boston Children s Hospital, Center for Pain and the Brain, Harvard Medical School, Boston, Massachusetts Division of Pain Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children s Hospital, Boston, Massachusetts Department of Psychiatry, Harvard Medical School, Boston, Massachusetts
    Hum Brain Mapp 35:527-38. 2014
    ..Taken together, these findings suggest several important directions for further research exploring the amygdala's role in pain processing. Hum Brain Mapp 35:527-538, 2014. © 2012 Wiley Periodicals, Inc. ..
  38. doi request reprint Brain imaging in migraine research
    David Borsook
    From P a i n Group, Massachusetts General Hospital, Boston, MA, USA
    Headache 50:1523-7. 2010
    ....
  39. pmc Surgically induced neuropathic pain: understanding the perioperative process
    David Borsook
    Department of Anesthesia and Perioperative and Pain Medicine, Boston Childrens Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Surg 257:403-12. 2013
    ....
  40. ncbi request reprint Functional imaging of pain and analgesia--a valid diagnostic tool?
    David Borsook
    Brain Imaging Centre, Department of Psychiatry, P A I N Group, McLean Hospital, Belmont, MA, USA
    Pain 117:247-50. 2005
  41. pmc Comparison of evoked vs. spontaneous tics in a patient with trigeminal neuralgia (tic doloureux)
    David Borsook
    Pain Analgesia Imaging Neuroscience P A I N Group, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478 1064, USA
    Mol Pain 3:34. 2007
    ..Spontaneous tics showed increased activation in classic aversion circuitry that may contribute to increased levels of anxiety. We believe that this is the first report of functional imaging of brain changes in tic-doloureaux...
  42. pmc Breaking down the barriers: fMRI applications in pain, analgesia and analgesics
    David Borsook
    P A I N Group, Brain Imaging Center, Department of Psychiatry, McLean Hospital, Belmont, MA, USA
    Mol Pain 2:30. 2006
    ..fMRI has already provided novel insights into the neurobiology of pain. These insights should significantly advance therapeutic approaches to chronic pain...
  43. ncbi request reprint Behavioral and pharmacological characterization of a distal peripheral nerve injury in the rat
    Aldric T Hama
    Descartes Therapeutics, Inc, Waltham, MA 02453, USA
    Pharmacol Biochem Behav 81:170-81. 2005
    ..The pharmacological data suggest that the underlying basis of neuropathic pain may be similar irrespective of the site of nerve injury...
  44. pmc Evaluation of novel drugs using fMRI in early-phase clinical trials: safety monitoring
    Edward George
    Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Drug Discov Today 15:684-9. 2010
    ..This could lead to the adoption of standards. Some of these issues are unique to the application of the technology in early-phase trials...
  45. pmc The missing p in psychiatric training: why it is important to teach pain to psychiatrists
    Igor Elman
    McLean Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Arch Gen Psychiatry 68:12-20. 2011
    ..Nonetheless, remarkably few pain-related themes are currently included in psychiatric residency training...
  46. pmc Migraine: maladaptive brain responses to stress
    Nasim Maleki
    Center for Pain and the Brain, Harvard Medical School, Boston, MA 02453, USA
    Headache 52:102-6. 2012
    ..The cascade of these effects can lead to further deterioration of adaptation and thus lead to transformation or chronification of the disease...
  47. doi request reprint Chronic (neuropathic) corneal pain and blepharospasm: five case reports
    David Borsook
    Center for Pain and the Brain, McLean Hospital, Harvard Medical School, Boston, MA, USA
    Pain 152:2427-31. 2011
    ..A putative relationship between pain and blepharospasm suggests potential involvement of the basal ganglia in both these conditions...
  48. doi request reprint How close are we in utilizing functional neuroimaging in routine clinical diagnosis of neuropathic pain?
    David Borsook
    Center for Pain and the Brain, c o Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Curr Pain Headache Rep 15:223-9. 2011
    ..The routine application of brain imaging as a clinical marker of disease state or therapeutic (drug) efficacy would significantly enhance the clinical process by providing objective measures for clinicians and patients...
  49. doi request reprint Understanding migraine through the lens of maladaptive stress responses: a model disease of allostatic load
    David Borsook
    Center for Pain and the Brain, McLean, Massachusetts General, and Children s Hospitals, Harvard Medical School, Boston, MA 02115, USA
    Neuron 73:219-34. 2012
    ....
  50. pmc Retrospective accounts of initial subjective effects of opioids in patients treated for pain who do or do not develop opioid addiction: a pilot case-control study
    Corey M Bieber
    Inflexxion, Inc, Newton, MA, USA
    Exp Clin Psychopharmacol 16:429-34. 2008
    ....
  51. pmc Enhanced false discovery rate using Gaussian mixture models for thresholding fMRI statistical maps
    Gautam Pendse
    Pain and Analgesia Imaging and Neuroscience Group, McLean Hospital, Belmont, MA, USA
    Neuroimage 47:231-61. 2009
    ..Real fMRI data was also used to confirm GFDR capabilities. Our results indicate that it is very important to account for the form and fraction of the "null" hypothesis adaptively from the data in order to obtain valid inference...
  52. ncbi request reprint Utilizing brain imaging for analgesic drug development
    David Borsook
    Center for Functional Pain Neuroimaging and Therapy Research, NMR Center, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, MA 02129, USA
    Curr Opin Investig Drugs 3:1342-7. 2002
    ..These approaches hold great promise for revolutionizing drug development at preclinical and clinical stages...
  53. pmc Using NMR approaches to drive the search for new CNS therapeutics
    David Borsook
    Pain and Analgesia Imaging Neuroscience PAIN Group, Massachusetts General Hospital, Athinoula Martinos Center for Biomedical Imaging, Department of Radiology and Psychiatry, Charlestown, MA 02129, USA
    Curr Opin Investig Drugs 11:771-8. 2010
    ..However, validation, the implementation of good clinical practices and regulatory acceptance are hurdles that remain to be overcome...
  54. doi request reprint Losses and gains: chronic pain and altered brain morphology
    David Borsook
    Center for Pain and the Brain, P A I N Group, Boston Children s Hospital, Harvard Medical School, c o 9 Hope Avenue, Waltham, MA, USA
    Expert Rev Neurother 13:1221-34. 2013
    ....
  55. doi request reprint Pain: Do ACE inhibitors exacerbate complex regional pain syndrome?
    David Borsook
    P A I N Group, Department of Psychiatry, McLean Hospital, Belmont, MA, USA
    Nat Rev Neurol 5:306-8. 2009
    ..Use of angiotensin-converting-enzyme inhibitors has been associated with an increased risk of developing the chronic pain condition, which suggests possible roles for substance P and bradykinin in the underlying pathogenic process...
  56. doi request reprint Adriamycin injection into the medial cord of the brachial plexus: computed tomography-guided targeted pain therapy
    P Ellen Grant
    Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Pain Med 9:83-7. 2008
    ..5 mg of adriamycin. The patient reported complete pain relief within 12 h of the injection...
  57. ncbi request reprint Trigeminal neuropathic pain alters responses in CNS circuits to mechanical (brush) and thermal (cold and heat) stimuli
    Lino Becerra
    Pain and Analgesia Imaging and Neuroscience Group, Department of Psychiatry, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 26:10646-57. 2006
    ..Thus, sensory processing in patients with trigeminal neuropathic pain is associated with distinct activation patterns consistent with sensitization within and outside of the primary sensory pathway...
  58. ncbi request reprint Phenotyping central nervous system circuitry in chronic pain using functional MRI: considerations and potential implications in the clinic
    David Borsook
    P A I N Group, Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Curr Pain Headache Rep 11:201-7. 2007
    ..It is possible that fMRI may become clinically useful...
  59. ncbi request reprint Functional imaging of the human trigeminal system: opportunities for new insights into pain processing in health and disease
    David Borsook
    P A I N Group, Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, Massachusetts 02478 9106, USA
    J Neurobiol 61:107-25. 2004
    ..These advances are likely to contribute greatly to the diagnosis and treatment of clinical pain conditions affecting the trigeminal system (e.g., neuropathic pain, migraine)...
  60. pmc Signal valence in the nucleus accumbens to pain onset and offset
    Lino Becerra
    P A I N Group, Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont MA, United States
    Eur J Pain 12:866-9. 2008
    ..The study supports the idea that the NAc fMRI signal may provide a useful marker for the effects of pain and analgesia in healthy volunteers...
  61. pmc Neuroimaging revolutionizes therapeutic approaches to chronic pain
    David Borsook
    PAIN Group, Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Mol Pain 3:25. 2007
    ....
  62. ncbi request reprint Cluster headache: a review of neuroimaging findings
    Alexandre F M DaSilva
    PAIN Group, Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Curr Pain Headache Rep 11:131-6. 2007
    ..This article summarizes neuroimaging findings in cluster headache patients, describing neuronal changes that occur during attacks and remission, as well as during hypothalamic stimulation...
  63. ncbi request reprint Functional magnetic resonance imaging measures of the effects of morphine on central nervous system circuitry in opioid-naive healthy volunteers
    Lino Becerra
    P A I N Group, Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, Massachusetts 02478, USA
    Anesth Analg 103:208-16, table of contents. 2006
    ..Activation patterns were opposite to those previously observed for the mu antagonist, naloxone...
  64. ncbi request reprint Functional imaging of the trigeminal system: applications to migraine pathophysiology
    David Borsook
    P A I N Group, Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478 9106, USA
    Headache 46:S32-8. 2006
    ....
  65. pmc Capsaicin-induced thermal hyperalgesia and sensitization in the human trigeminal nociceptive pathway: an fMRI study
    Eric A Moulton
    P A I N Group, Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Neuroimage 35:1586-600. 2007
    ..The involvement of these emotion-related regions suggests that they may be highly sensitive to context, such as prior experience (application of capsaicin) and the specific pain mechanism (hyperalgesic vs. normal skin)...