Gregory H Borschel

Summary

Publications

  1. doi request reprint The motor nerve to the masseter muscle: an anatomic and histomorphometric study to facilitate its use in facial reanimation
    Gregory H Borschel
    The Hospital for Sick Children, Division of Plastic and Reconstructive Surgery, University of Toronto, Department of Surgery, Toronto, Ontario, Canada
    J Plast Reconstr Aesthet Surg 65:363-6. 2012
  2. doi request reprint Functional recovery following peripheral nerve injury in the transgenic Thy1-GFP rat
    Stephen W P Kemp
    Department of Surgery, Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada The Hospital for Sick Children Research Institute Program in Neuroscience and Mental Health, Toronto, Ontario, Canada
    J Peripher Nerv Syst 18:220-31. 2013
  3. doi request reprint Fibrin gels containing GDNF microspheres increase axonal regeneration after delayed peripheral nerve repair
    Matthew D Wood
    Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, Toronto, ON, Canada
    Regen Med 8:27-37. 2013
  4. doi request reprint Functional motor recovery is improved due to local placement of GDNF microspheres after delayed nerve repair
    Matthew D Wood
    Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8
    Biotechnol Bioeng 110:1272-81. 2013
  5. doi request reprint GDNF released from microspheres enhances nerve regeneration after delayed repair
    Matthew D Wood
    Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada, M5G 1X8
    Muscle Nerve 46:122-4. 2012
  6. doi request reprint Outcome measures of peripheral nerve regeneration
    Matthew D Wood
    Department of Surgery, Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada
    Ann Anat 193:321-33. 2011
  7. doi request reprint Experimental and clinical evidence for use of decellularized nerve allografts in peripheral nerve gap reconstruction
    Mark Szynkaruk
    Division of Plastic and Reconstructive Surgery, Department of Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada
    Tissue Eng Part B Rev 19:83-96. 2013
  8. doi request reprint Rat-derived processed nerve allografts support more axon regeneration in rat than human-derived processed nerve xenografts
    Matthew D Wood
    Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, 555 University Ave, Toronto, ON, Canada M5G 1X8 Program in Physiology and Experimental Medicine, The Hospital for Sick Children Research Institute, Elizabeth McMaster Building, Toronto, ON, Canada M5G 1X8
    J Biomed Mater Res A 102:1085-91. 2014
  9. doi request reprint Characterization of neuronal death and functional deficits following nerve injury during the early postnatal developmental period in rats
    Stephen W P Kemp
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Hospital for Sick Children, Toronto, Ont, Canada
    Dev Neurosci 37:66-77. 2015
  10. doi request reprint A transgenic rat expressing green fluorescent protein (GFP) in peripheral nerves provides a new hindlimb model for the study of nerve injury and regeneration
    Amy M Moore
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Neurosci Methods 204:19-27. 2012

Collaborators

Detail Information

Publications26

  1. doi request reprint The motor nerve to the masseter muscle: an anatomic and histomorphometric study to facilitate its use in facial reanimation
    Gregory H Borschel
    The Hospital for Sick Children, Division of Plastic and Reconstructive Surgery, University of Toronto, Department of Surgery, Toronto, Ontario, Canada
    J Plast Reconstr Aesthet Surg 65:363-6. 2012
    ..In this study we conducted a detailed assessment of its gross and microscopic anatomy and develop a simple, reliable method for locating this nerve...
  2. doi request reprint Functional recovery following peripheral nerve injury in the transgenic Thy1-GFP rat
    Stephen W P Kemp
    Department of Surgery, Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada The Hospital for Sick Children Research Institute Program in Neuroscience and Mental Health, Toronto, Ontario, Canada
    J Peripher Nerv Syst 18:220-31. 2013
    ..Overall, these data support the use of the transgenic Thy1-GFP rat in experiments assessing functional and behavioral recovery following nerve injury and repair. ..
  3. doi request reprint Fibrin gels containing GDNF microspheres increase axonal regeneration after delayed peripheral nerve repair
    Matthew D Wood
    Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, Toronto, ON, Canada
    Regen Med 8:27-37. 2013
    ..Recovery following nerve transection declines when target reconnection is delayed for prolonged periods. GDNF has previously been shown to promote motor axon regeneration following delayed nerve repair...
  4. doi request reprint Functional motor recovery is improved due to local placement of GDNF microspheres after delayed nerve repair
    Matthew D Wood
    Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8
    Biotechnol Bioeng 110:1272-81. 2013
    ..GDNF microspheres partially reversed the deleterious effects of chronic nerve injury, and recovery was slightly favored with the 2 weeks formulation compared to the 4 weeks formulation...
  5. doi request reprint GDNF released from microspheres enhances nerve regeneration after delayed repair
    Matthew D Wood
    Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada, M5G 1X8
    Muscle Nerve 46:122-4. 2012
    ..Regeneration can be improved with delivery of exogenous growth factor. We developed a delivery system that could be applied at the nerve repair site to deliver growth factors locally to regenerating nerve...
  6. doi request reprint Outcome measures of peripheral nerve regeneration
    Matthew D Wood
    Department of Surgery, Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada
    Ann Anat 193:321-33. 2011
    ..Examples of erroneous conclusions are given to illustrate the need for researchers to ensure that the appropriate outcome measures are used in the evaluation of the success of peripheral nerve regeneration...
  7. doi request reprint Experimental and clinical evidence for use of decellularized nerve allografts in peripheral nerve gap reconstruction
    Mark Szynkaruk
    Division of Plastic and Reconstructive Surgery, Department of Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada
    Tissue Eng Part B Rev 19:83-96. 2013
    ..Finally, all clinical studies in which decellularized nerve allografts have been used to bridge nerve gaps in patients are reviewed...
  8. doi request reprint Rat-derived processed nerve allografts support more axon regeneration in rat than human-derived processed nerve xenografts
    Matthew D Wood
    Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, 555 University Ave, Toronto, ON, Canada M5G 1X8 Program in Physiology and Experimental Medicine, The Hospital for Sick Children Research Institute, Elizabeth McMaster Building, Toronto, ON, Canada M5G 1X8
    J Biomed Mater Res A 102:1085-91. 2014
    ..Processed xenografts showed significantly reduced regeneration compared with autografts or processed allografts indicating that cross-species immunological reactions are important considerations in this rat model...
  9. doi request reprint Characterization of neuronal death and functional deficits following nerve injury during the early postnatal developmental period in rats
    Stephen W P Kemp
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Hospital for Sick Children, Toronto, Ont, Canada
    Dev Neurosci 37:66-77. 2015
    ..These findings have important implications concerning the timing of neonatal nerve injury in rats...
  10. doi request reprint A transgenic rat expressing green fluorescent protein (GFP) in peripheral nerves provides a new hindlimb model for the study of nerve injury and regeneration
    Amy M Moore
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Neurosci Methods 204:19-27. 2012
    ..In order to evaluate nerve regeneration in clinically relevant hindlimb surgical paradigms not feasible in fluorescent mice models, we developed a rat that expresses green fluorescent protein (GFP) in neural tissue...
  11. doi request reprint Facial palsy and reconstruction
    Adel Fattah
    Division of Plastic Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada
    Plast Reconstr Surg 129:340e-352e. 2012
    ..This article outlines a thorough approach to facial nerve palsy and reconstruction...
  12. doi request reprint The use of Integra® bilaminar dermal regeneration template in apert syndactyly reconstruction: a novel alternative to simplify care and improve outcomes
    James J Jung
    Division of Plastic and Reconstructive Surgery, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    J Plast Reconstr Aesthet Surg 65:118-21. 2012
    ..We report that both left and right hands achieved similar outcomes, but the hand reconstructed with groin flaps required debulking, whilst the hand reconstructed with Integra was easier to care for...
  13. doi request reprint Controlled delivery of glial cell line-derived neurotrophic factor enhances motor nerve regeneration
    Amy M Moore
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    J Hand Surg Am 35:2008-17. 2010
    ..To determine the effect of a motor-specific neurotrophic factor, glial-derived neurotrophic factor (GDNF) on motor nerve regeneration...
  14. doi request reprint Long-term outcomes following lower extremity sarcoma resection and reconstruction with vascularized fibula flaps in children
    David C G Sainsbury
    Toronto, Ontario, Canada From the Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, and the University of Toronto
    Plast Reconstr Surg 134:808-20. 2014
    ..This study aimed to evaluate functional outcomes, donor-site morbidity, and complications in lower limb bony oncologic defects reconstructed with vascularized fibula flaps in children...
  15. doi request reprint The ErbB2 inhibitor Herceptin (Trastuzumab) promotes axonal outgrowth four weeks after acute nerve transection and repair
    Eva Placheta
    Division of Plastic and Reconstructive Surgery, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Neurosci Lett 582:81-6. 2014
    ..Enhanced axon outgrowth in the presence of this ErbB2 inhibitor indicates that ErbB2 signaling may limit the numbers of axons that are emitted from each regenerating neuron. ..
  16. doi request reprint Corneal neurotization from the supratrochlear nerve with sural nerve grafts: a minimally invasive approach
    Robert D Bains
    Toronto, Ontario, Canada From The Hospital for Sick Children
    Plast Reconstr Surg 135:397e-400e. 2015
    ..This article and accompanying video describes the relevant anatomy and demonstrates the technique in detail...
  17. doi request reprint A prospective study of pediatric hand fractures and review of the literature
    Edward H Liu
    From the Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, Toronto, Ontario Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Toronto, Toronto, Ontario College of Medicine, King Saud University, Riyadh, Saudi Arabia Department of Pediatrics, University of Manitoba, Winnipeg, MB Department of Occupational Science and Occupational Therapy and Institutes of Biomaterials and Biomedical Engineering and Medical Sciences, University of Toronto, Toronto, Ontario and Program in Physiology and Experimental Medicine, The Hospital for Sick Children Research Institute, Toronto, Ontario
    Pediatr Emerg Care 30:299-304. 2014
    ..We examine the demographics, etiology, anatomic location, mechanism, and management of pediatric hand fractures in our center's hand unit...
  18. pmc Limitations of conduits in peripheral nerve repairs
    Amy M Moore
    Division of Plastic and Reconstructive Surgery, Department of Surgery, School of Medicine, Washington University, Campus Box 8238, 660 South Euclid Avenue, St Louis, MO, 63110, USA
    Hand (N Y) 4:180-6. 2009
    ..The reported cases demonstrate the importance of evaluating the length, diameter, and function of nerves undergoing conduit repair. In large-diameter nerves, the use of conduits should be carefully considered...
  19. doi request reprint Reconstruction of facial nerve injuries in children
    Adel Fattah
    Department of Plastic and Reconstructive Surgery, Hospital for Sick Children, Toronto, Ontario, Canada
    J Craniofac Surg 22:782-8. 2011
    ..We review our strategies for addressing facial nerve injuries in children...
  20. doi request reprint The degree of facial movement following microvascular muscle transfer in pediatric facial reanimation depends on donor motor nerve axonal density
    Alison K Snyder-Warwick
    St Louis, Mo Liverpool, United Kingdom and Toronto, Ontario, Canada From the Facial Nerve Institute, Department of Surgery, Division of Plastic and Reconstructive Surgery, Washington University School of Medicine the Facial Nerve Program, Regional Pediatric Burns and Plastic Surgery Service, Alder Hey Children s NHS Foundation Trust the Department of Surgery, Division of Plastic Surgery, and the Department of Pediatric Laboratory Medicine, Division of Pathology, The Hospital for Sick Children and the Division of Plastic and Reconstructive Surgery, University of Toronto
    Plast Reconstr Surg 135:370e-81e. 2015
    ..In this study, the authors compared donor nerve histomorphometry and clinical outcomes in a single patient population undergoing free muscle transfer to the face...
  21. doi request reprint Restoration of corneal sensation with regional nerve transfers and nerve grafts: a new approach to a difficult problem
    Uri Elbaz
    Department of Ophthalmology and Vision Sciences, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    JAMA Ophthalmol 132:1289-95. 2014
    ..Corneal anesthesia is recalcitrant to conventional treatment and can lead to permanent visual loss...
  22. doi request reprint Socioeconomic status and wait times for pediatric surgery in Canada
    Mark Szynkaruk
    Division of Plastic and Reconstructive Surgery, Department of Surgery, and
    Pediatrics 134:e504-11. 2014
    ..The purpose of this study was to determine whether SES was related to meeting surgical wait time access targets for children. We also assessed the effects of gender, age, and distance to hospital on meeting access targets...
  23. doi request reprint Restoration of Trigeminal Cutaneous Sensation with Cross-Face Sural Nerve Grafts: A Novel Approach to Facial Sensory Rehabilitation
    Joseph Catapano
    Toronto, Ontario, Canada From the Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children and the Department of Surgery, University of Toronto
    Plast Reconstr Surg 136:568-71. 2015
    ..Cross-face nerve grafts result in minimal donor-site morbidity and are promising as a surgical strategy to address sensory deficits of the face...
  24. doi request reprint Vascularized composite allotransplantation: an update on medical and surgical progress and remaining challenges
    Blake D Murphy
    University of Toronto, Division of Plastic and Reconstructive Surgery, Toronto, Canada
    J Plast Reconstr Aesthet Surg 66:1449-55. 2013
    ..This technique has been performed for upper extremity, face, and abdominal wall transplants, among many others...
  25. doi request reprint Use of adjunctive palmaris longus abductorplasty (Camitz) tendon transfer in pediatric median nerve injury
    Narges Baluch
    Department of Surgery, Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, Toronto, ON, Canada
    J Plast Reconstr Aesthet Surg 66:726-8. 2013
    ..Transfer of the palmaris longus tendon reliably restores palmar abduction, with minimal to no additional morbidity, in carefully selected pediatric patients with median nerve injury undergoing release of the carpal tunnel...
  26. ncbi request reprint Use of motor nerve material in peripheral nerve repair with conduits
    Brendan M Lloyd
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Microsurgery 27:138-45. 2007
    ..These findings suggest that intact nerve architecture, regardless of neurotrophic or biochemical factors, is a prerequisite for the beneficial effect of motor nerve grafting...