Willi K Born

Summary

Publications

  1. doi Diversity of γδ T-cell antigens
    Willi K Born
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    Cell Mol Immunol 10:13-20. 2013
  2. doi γδ T cells develop, respond and survive - with a little help from CD27
    Willi K Born
    Integrated Department of Immunology, National Jewish Health and University of Colorado Health Sciences Center, Denver, CO 80206, USA
    Eur J Immunol 41:26-8. 2011
  3. doi Peptide antigens for gamma/delta T cells
    Willi K Born
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    Cell Mol Life Sci 68:2335-43. 2011
  4. ncbi Analysis of gamma delta T cell functions in the mouse
    Willi K Born
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    J Immunol 184:4055-61. 2010
  5. doi Balanced approach of gammadelta T cells to type 2 immunity
    Willi K Born
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    Immunol Cell Biol 88:269-74. 2010
  6. ncbi Different potentials of gamma delta T cell subsets in regulating airway responsiveness: V gamma 1+ cells, but not V gamma 4+ cells, promote airway hyperreactivity, Th2 cytokines, and airway inflammation
    Youn Soo Hahn
    Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 172:2894-902. 2004
  7. ncbi Mismatched antigen prepares gamma delta T cells for suppression of airway hyperresponsiveness
    Niyun Jin
    Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 174:2671-9. 2005
  8. ncbi Aerosolized anti-T-cell-receptor antibodies are effective against airway inflammation and hyperreactivity
    Michael Lahn
    Department of Immunology, National Jewish Medical and Research Center, Denver, Colo, USA
    Int Arch Allergy Immunol 134:49-55. 2004
  9. pmc The influence of IgE-enhancing and IgE-suppressive gammadelta T cells changes with exposure to inhaled ovalbumin
    Yafei Huang
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    J Immunol 183:849-55. 2009
  10. ncbi V gamma 4+ gamma delta T cells regulate airway hyperreactivity to methacholine in ovalbumin-sensitized and challenged mice
    Youn Soo Hahn
    Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 171:3170-8. 2003

Collaborators

Detail Information

Publications38

  1. doi Diversity of γδ T-cell antigens
    Willi K Born
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    Cell Mol Immunol 10:13-20. 2013
    ..While posing a unique challenge in the maintenance of self-tolerance, this broad reactivity pattern might enable multiple overlapping uses of γδ T-cell populations, and thus generate a more efficient immune response...
  2. doi γδ T cells develop, respond and survive - with a little help from CD27
    Willi K Born
    Integrated Department of Immunology, National Jewish Health and University of Colorado Health Sciences Center, Denver, CO 80206, USA
    Eur J Immunol 41:26-8. 2011
    ..This new information underscores the significance of CD27 in γδ T-cell functional differentiation, and is likely to facilitate the development of γδ T-cell-based clinical immunotherapy...
  3. doi Peptide antigens for gamma/delta T cells
    Willi K Born
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    Cell Mol Life Sci 68:2335-43. 2011
    ..To settle the questions of whether peptides can be ligands for the γδ TCRs, and whether responses to small peptides might occur normally, peptide binding will have to be demonstrated, and natural peptide ligands identified...
  4. ncbi Analysis of gamma delta T cell functions in the mouse
    Willi K Born
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    J Immunol 184:4055-61. 2010
    ..They also are revealed as a potentially useful target for immune intervention...
  5. doi Balanced approach of gammadelta T cells to type 2 immunity
    Willi K Born
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    Immunol Cell Biol 88:269-74. 2010
    ..However, after airway allergen exposure, suppressive gammadelta T cells become dominant. The underlying mechanisms are discussed...
  6. ncbi Different potentials of gamma delta T cell subsets in regulating airway responsiveness: V gamma 1+ cells, but not V gamma 4+ cells, promote airway hyperreactivity, Th2 cytokines, and airway inflammation
    Youn Soo Hahn
    Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 172:2894-902. 2004
    ..These findings show how gammadelta T cells can be both inhibitors and enhancers of AHR and airway inflammation, and they provide further support for the hypothesis that TCR expression and function cosegregate in gammadelta T cells...
  7. ncbi Mismatched antigen prepares gamma delta T cells for suppression of airway hyperresponsiveness
    Niyun Jin
    Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 174:2671-9. 2005
    ..We conclude that AHR-suppressive Vgamma4(+) gammadelta T cells require induction. They are induced by allergen stimulation, but AHR suppression by these cells does not require their restimulation with the same allergen...
  8. ncbi Aerosolized anti-T-cell-receptor antibodies are effective against airway inflammation and hyperreactivity
    Michael Lahn
    Department of Immunology, National Jewish Medical and Research Center, Denver, Colo, USA
    Int Arch Allergy Immunol 134:49-55. 2004
    ..The use of aerosolized anti-TCR mAbs may offer an effective approach for the treatment of airway inflammation and AHR...
  9. pmc The influence of IgE-enhancing and IgE-suppressive gammadelta T cells changes with exposure to inhaled ovalbumin
    Yafei Huang
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    J Immunol 183:849-55. 2009
    ..Thus, airway allergen challenge differentially affects two distinct subsets of gammadelta T cells with nonoverlapping functional potentials, and the outcome is IgE suppression...
  10. ncbi V gamma 4+ gamma delta T cells regulate airway hyperreactivity to methacholine in ovalbumin-sensitized and challenged mice
    Youn Soo Hahn
    Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 171:3170-8. 2003
    ..These findings establish Vgamma4(+) gammadelta T cells as negative regulators of AHR and show that their regulatory effect bypasses much of the allergic inflammatory response coincident with AHR...
  11. pmc Allergic airway hyperresponsiveness-enhancing gammadelta T cells develop in normal untreated mice and fail to produce IL-4/13, unlike Th2 and NKT cells
    Niyun Jin
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    J Immunol 182:2002-10. 2009
    ..We conclude that both the development and the cytokine potential of the AHR-enhancing gammadelta T cells differs critically from that of Th2 cells and NKT cells, despite similar influences of these cell populations on AHR...
  12. pmc Th17-polarized immune response in a murine model of hypersensitivity pneumonitis and lung fibrosis
    Philip L Simonian
    Department of Medicine, University of Colorado Denver, Denver, CO 80262, USA
    J Immunol 182:657-65. 2009
    ..These data are the first to demonstrate an important role for Th17-polarized CD4(+) T lymphocytes in the immune response directed against S. rectivirgula in this murine model of hypersensitivity pneumonitis and pulmonary fibrosis...
  13. pmc Evidence that CD8+ dendritic cells enable the development of gammadelta T cells that modulate airway hyperresponsiveness
    Laura Cook
    Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 181:309-19. 2008
    ..Our findings suggest that CD8+ DCs in the lymphoid tissues enable an early step in the development of gammadelta T cells through direct cell contact. DC-expressed CD8 might take part in this interaction...
  14. pmc Vgamma1+ T cells and tumor necrosis factor-alpha in ozone-induced airway hyperresponsiveness
    Shigeki Matsubara
    Division of Cell Biology, Department of Pediatrics, National Jewish Health and the University of Colorado Health Sciences Center, Denver, Colorado, USA
    Am J Respir Cell Mol Biol 40:454-63. 2009
    ..These results demonstrate that TNF-alpha and activation of Vgamma1+ gammadelta T cells are required for the development of AHR after O3 exposure...
  15. pmc Protective role of gammadelta T cells in spontaneous ocular inflammation
    REBECCA L O'BRIEN
    Integrated Department of Immunology, National Jewish Health, Denver, Colorado 80206, USA
    Invest Ophthalmol Vis Sci 50:3266-74. 2009
    ..That certain mice lacking gammadelta T cells often spontaneously develop keratitis, characterized by a progressive and destructive inflammation of the cornea is reported here...
  16. pmc Antigen-specific regulation of IgE antibodies by non-antigen-specific γδ T cells
    Yafei Huang
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    J Immunol 190:913-21. 2013
    ..Together, our data suggest that Ag itself, when acquired by γδ T cells, directs the specificity of their IgE suppression...
  17. pmc Macrophages express multiple ligands for gammadelta TCRs
    M Kemal Aydintug
    Integrated Department of Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, United States
    Mol Immunol 45:3253-63. 2008
    ....
  18. ncbi Regulatory role of gammadelta T cells in the recruitment of CD4+ and CD8+ T cells to lung and subsequent pulmonary fibrosis
    Philip L Simonian
    Department of Medicine, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Immunol 177:4436-43. 2006
    ..These findings indicate that chronic inhalation of B. subtilis can result in T cell accumulation in the lung and fibrosis, constituting a new model of immune-mediated pulmonary fibrosis...
  19. pmc αβ TCR⁺ T cells, but not B cells, promote autoimmune keratitis in b10 mice lacking γδ T cells
    REBECCA L O'BRIEN
    Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    Invest Ophthalmol Vis Sci 53:301-8. 2012
    ..To investigate additional factors in the spontaneous development of keratitis previously reported in B10.TCRδ⁻/⁻ female mice...
  20. ncbi Airway hyperresponsiveness through synergy of gammadelta} T cells and NKT cells
    Niyun Jin
    Integrated Department of Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Immunol 179:2961-8. 2007
    ..The data suggest that lymphocytic synergism, which is key to the Ag-specific adaptive immune response, is also intrinsic to T cell-dependent innate responses...
  21. ncbi Subset-specific, uniform activation among V gamma 6/V delta 1+ gamma delta T cells elicited by inflammation
    Christina L Roark
    Integrated Department of Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Leukoc Biol 75:68-75. 2004
    ....
  22. ncbi Distribution and leukocyte contacts of gammadelta T cells in the lung
    J M Wands
    Departments of Immunology, National Jewish Medical and Research Center, Denver, Colorado, USA
    J Leukoc Biol 78:1086-96. 2005
    ..The continuous interaction of gammadelta T cells with these sentinels likely is related to their protective role...
  23. pmc IL-17-producing gammadelta T cells
    REBECCA L O'BRIEN
    Integrated Department of Immunology, National Jewish Health, University of Colorado Denver, Denver, CO 80206, USA
    Eur J Immunol 39:662-6. 2009
    ..Surprisingly, gammadelta T cells are responsible for much of the IL-17 produced in several disease models, particularly early on...
  24. pmc {gamma}{delta} T cell homeostasis is established in competition with {alpha}{beta} T cells and NK cells
    Jena D French
    Integrated Department of Immunology, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, 1400 Jackson Street, Denver, CO 80206, USA
    Proc Natl Acad Sci U S A 102:14741-6. 2005
    ..Our results suggest that CD8(+) alphabeta T cells are the most potent inhibitors of gammadelta T cell homeostasis and exert their effect by competing for IL-15...
  25. pmc Gammadelta T lymphocyte homeostasis is negatively regulated by beta2-microglobulin
    Jena D French
    National Jewish Health, Integrated Department of Immunology, Denver, CO 80206, USA
    J Immunol 182:1892-900. 2009
    ....
  26. ncbi gammadelta T-cell receptors: functional correlations
    REBECCA L O'BRIEN
    Integrated Deaprtment of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Immunol Rev 215:77-88. 2007
    ..The use of recombinant soluble versions of gammadeltaTCRs appears to be a promising approach to finding new ligands, and recent results using this method are reviewed...
  27. ncbi gammadelta T lymphocytes-selectable cells within the innate system?
    Willi K Born
    Department of Immunology at National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206, USA
    J Clin Immunol 27:133-44. 2007
    ....
  28. ncbi Detection of cell surface ligands for the gamma delta TCR using soluble TCRs
    M Kemal Aydintug
    Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 172:4167-75. 2004
    ..This study suggests that soluble versions of gammadelta TCRs can be as tools to identify and characterize the natural ligands of gammadelta T cells...
  29. pmc gammadelta T cells: an important source of IL-17
    Christina L Roark
    Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Curr Opin Immunol 20:353-7. 2008
    ..Interestingly, some gammadelta T cells produce IL-17 in response to IL-23 alone, even in naïve animals, suggesting they are already differentiated and may develop differently than CD4(+) alphabeta Th17 cells...
  30. ncbi Reversal of allergic airway hyperreactivity after long-term allergen challenge depends on gammadelta T cells
    Zhi Hua Cui
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Crit Care Med 168:1324-32. 2003
    ..One of these, focused on airway responsiveness, involves active suppression and requires gammadelta T cells...
  31. ncbi Effect of microbial heat shock proteins on airway inflammation and hyperresponsiveness
    Yeong Ho Rha
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 169:5300-7. 2002
    ..These results indicate selective and distinctive properties among the hsp, and that M. leprae hsp may have a potential therapeutic role in the treatment of allergic airway inflammation and altered airway function...
  32. pmc Exacerbation of collagen-induced arthritis by oligoclonal, IL-17-producing gamma delta T cells
    Christina L Roark
    Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 179:5576-83. 2007
    ..A decrease in total IgG and IgG2a anti-collagen Abs was also seen. These results suggest that Vgamma4/Vdelta4(+) gammadelta T cells exacerbate CIA through their production of IL-17...
  33. pmc γδ T cells recognize the insulin B:9-23 peptide antigen when it is dimerized through thiol oxidation
    M Kemal Aydintug
    Integrated Department of Immunology, National Jewish Health and University of Colorado Denver, 1400 Jackson Street, Denver, CO 80206, USA
    Mol Immunol 60:116-28. 2014
    ..This observation is consistent with the notion that γδ T cell recognition depends on the secondary structure of the dimerized insulin B:9-23 antigen. ..
  34. pmc gammadelta T cell subsets: a link between TCR and function?
    REBECCA L O'BRIEN
    Integrated Dept of Immunology, National Jewish Health, 1400 Jackson St, Denver, CO 80206, United States Univ of Colorado Denver, Aurora, CO 80045, USA
    Semin Immunol 22:193-8. 2010
    ..Here, we describe functionally distinct, TCR-defined gammadelta T cell subsets, and evidence that their functions are predetermined in the thymus...
  35. doi Antigen-restricted gammadelta T-cell receptors?
    Willi K Born
    Integrated Department of Immunology, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA
    Arch Immunol Ther Exp (Warsz) 57:129-35. 2009
    ..Here we outline this hypothetical mechanism and discuss its possible implications for thymic selection and potential for complementing known innate and adaptive mechanisms of immune defense...
  36. ncbi The function of gammadelta T cells in innate immunity
    Willi K Born
    Department of Immunology, at National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Curr Opin Immunol 18:31-8. 2006
    ..Thus, at present, much evidence suggests that gammadelta T cells function in an innate manner, although they are arguably the most complex and advanced cellular representatives of the innate immune system...
  37. pmc MHC class I-dependent Vgamma4+ pulmonary T cells regulate alpha beta T cell-independent airway responsiveness
    Michael Lahn
    Department of Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Proc Natl Acad Sci U S A 99:8850-5. 2002
    ..Moreover, their effect can be demonstrated in the absence of alphabeta T cells. This novel type of negative regulation seems to precede the development of the adaptive, antigen-specific allergic response...