Michael Bordonaro

Summary

Publications

  1. ncbi request reprint Cell type- and promoter-dependent modulation of the Wnt signaling pathway by sodium butyrate
    Michael Bordonaro
    Department of Pharmacology and Developmental Therapeutics Section, Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Int J Cancer 97:42-51. 2002
  2. pmc Pharmacological and genetic modulation of Wnt-targeted Cre-Lox-mediated gene expression in colorectal cancer cells
    Michael Bordonaro
    Department of Pharmacology and Developmental Therapeutics Section, Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Nucleic Acids Res 32:2660-74. 2004
  3. ncbi request reprint Modulation of Wnt-specific colon cancer cell kill by butyrate and lithium
    Michael Bordonaro
    Department of Pharmacology and Developmental Therapeutics Section, Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Oncol Res 14:427-38. 2004
  4. ncbi request reprint Linear relationship between Wnt activity levels and apoptosis in colorectal carcinoma cells exposed to butyrate
    Darina L Lazarova
    Department of Pharmacology and Developmental Therapeutics Program, Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Int J Cancer 110:523-31. 2004
  5. ncbi request reprint Hyperinduction of Wnt activity: a new paradigm for the treatment of colorectal cancer?
    Michael Bordonaro
    Department of Pharmacology and Developmental Therapeutics Program, Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Oncol Res 17:1-9. 2008
  6. pmc The activation of beta-catenin by Wnt signaling mediates the effects of histone deacetylase inhibitors
    Michael Bordonaro
    Department of Pharmacology and Developmental Therapeutics Program, Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Exp Cell Res 313:1652-66. 2007
  7. ncbi request reprint Butyrate and Wnt signaling: a possible solution to the puzzle of dietary fiber and colon cancer risk?
    Michael Bordonaro
    Department of Pharmacology and Developmental Therapeutics Program, Cancer Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Cell Cycle 7:1178-83. 2008
  8. ncbi request reprint [Fiber, cancer stem cells, and the Wnt signaling continuum: possibilities for colorectal cancer prevention and therapeutics]
    Michael Bordonaro
    Department of Pharmacology and Developmental Therapeutics Program, Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Ai Zheng 27:766-70. 2008

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Cell type- and promoter-dependent modulation of the Wnt signaling pathway by sodium butyrate
    Michael Bordonaro
    Department of Pharmacology and Developmental Therapeutics Section, Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Int J Cancer 97:42-51. 2002
    ....
  2. pmc Pharmacological and genetic modulation of Wnt-targeted Cre-Lox-mediated gene expression in colorectal cancer cells
    Michael Bordonaro
    Department of Pharmacology and Developmental Therapeutics Section, Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Nucleic Acids Res 32:2660-74. 2004
    ..These findings demonstrated that the Cre-Lox system, in combination with pharmacological and genetic modulators, represents effective methodology for enhancing Wnt-targeted gene therapy...
  3. ncbi request reprint Modulation of Wnt-specific colon cancer cell kill by butyrate and lithium
    Michael Bordonaro
    Department of Pharmacology and Developmental Therapeutics Section, Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Oncol Res 14:427-38. 2004
    ..The findings suggest that effective CRC cell kill can be achieved by gene therapy through modulation of Wnt signaling by butyrate and/or lithium...
  4. ncbi request reprint Linear relationship between Wnt activity levels and apoptosis in colorectal carcinoma cells exposed to butyrate
    Darina L Lazarova
    Department of Pharmacology and Developmental Therapeutics Program, Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Int J Cancer 110:523-31. 2004
    ....
  5. ncbi request reprint Hyperinduction of Wnt activity: a new paradigm for the treatment of colorectal cancer?
    Michael Bordonaro
    Department of Pharmacology and Developmental Therapeutics Program, Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Oncol Res 17:1-9. 2008
    ....
  6. pmc The activation of beta-catenin by Wnt signaling mediates the effects of histone deacetylase inhibitors
    Michael Bordonaro
    Department of Pharmacology and Developmental Therapeutics Program, Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Exp Cell Res 313:1652-66. 2007
    ..Results from comparative studies between HDACi-resistant and HDACi-sensitive cells suggest that non-histone targets of HDACis mediate the effects on Wnt signaling and apoptosis...
  7. ncbi request reprint Butyrate and Wnt signaling: a possible solution to the puzzle of dietary fiber and colon cancer risk?
    Michael Bordonaro
    Department of Pharmacology and Developmental Therapeutics Program, Cancer Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Cell Cycle 7:1178-83. 2008
    ..We discuss the evidence by which these factors influence the effects of fiber on colonic tumorigenesis and outline experimental approaches for testing these hypotheses...
  8. ncbi request reprint [Fiber, cancer stem cells, and the Wnt signaling continuum: possibilities for colorectal cancer prevention and therapeutics]
    Michael Bordonaro
    Department of Pharmacology and Developmental Therapeutics Program, Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Ai Zheng 27:766-70. 2008
    ..Finally, we considered possible gene therapy approaches that target Wnt-positive CRC stem cells...