Per Borghammer

Summary

Publications

  1. Knudsen K, Borghammer P. Imaging the Autonomic Nervous System in Parkinson's Disease. Curr Neurol Neurosci Rep. 2018;18:79 pubmed publisher
    ..In vivo imaging techniques provide powerful and noninvasive tools to quantify the degree and extent of this degeneration and its functional consequences. ..
  2. Gjerløff T, Jakobsen S, Nahimi A, Munk O, Bender D, Alstrup A, et al. In vivo imaging of human acetylcholinesterase density in peripheral organs using 11C-donepezil: dosimetry, biodistribution, and kinetic analyses. J Nucl Med. 2014;55:1818-24 pubmed publisher
    ..We propose that (11)C-donepezil PET imaging may be able to quantify the parasympathetic innervation of organs but also detect nonneuronal cholinergic activity in infections. ..
  3. Gjerløff T, Fedorova T, Knudsen K, Munk O, Nahimi A, Jacobsen S, et al. Imaging acetylcholinesterase density in peripheral organs in Parkinson's disease with 11C-donepezil PET. Brain. 2015;138:653-63 pubmed publisher
    ..Decreases in (11)C-donepezil binding may, therefore, represent a marker of parasympathetic denervation of internal organs, but further validation studies are needed. ..
  4. Knudsen K, Fedorova T, Hansen A, Sommerauer M, Otto M, Svendsen K, et al. In-vivo staging of pathology in REM sleep behaviour disorder: a multimodality imaging case-control study. Lancet Neurol. 2018;17:618-628 pubmed publisher
    ..Lundbeck Foundation, Jascha Foundation, and the Swiss National Foundation. ..
  5. Borghammer P, Knudsen K, Brooks D. Imaging Systemic Dysfunction in Parkinson's Disease. Curr Neurol Neurosci Rep. 2016;16:51 pubmed publisher
    ..In this review, we summarize current knowledge about peripheral imaging in Parkinson's disease. ..
  6. Hansen A, Knudsen K, Lillethorup T, Landau A, Parbo P, Fedorova T, et al. In vivo imaging of neuromelanin in Parkinson's disease using 18F-AV-1451 PET. Brain. 2016;139:2039-49 pubmed publisher
    ..These findings suggest a more severe loss of striatal nerve terminal function compared with neuronal cell bodies, in accordance with the post-mortem literature. ..
  7. Jørgensen N, Alstrup A, Mortensen F, Knudsen K, Jakobsen S, Madsen L, et al. Cholinergic PET imaging in infections and inflammation using 11C-donepezil and 18F-FEOBV. Eur J Nucl Med Mol Imaging. 2017;44:449-458 pubmed publisher