Knudsen K, Borghammer P. Imaging the Autonomic Nervous System in Parkinson's Disease. Curr Neurol Neurosci Rep. 2018;18:79 pubmed publisher
..In vivo imaging techniques provide powerful and noninvasive tools to quantify the degree and extent of this degeneration and its functional consequences. ..
GjerlÃ¸ff T, Jakobsen S, Nahimi A, Munk O, Bender D, Alstrup A, et al
. In vivo imaging of human acetylcholinesterase density in peripheral organs using 11C-donepezil: dosimetry, biodistribution, and kinetic analyses. J Nucl Med. 2014;55:1818-24 pubmed publisher
..We propose that (11)C-donepezil PET imaging may be able to quantify the parasympathetic innervation of organs but also detect nonneuronal cholinergic activity in infections. ..
GjerlÃ¸ff T, Fedorova T, Knudsen K, Munk O, Nahimi A, Jacobsen S, et al
. Imaging acetylcholinesterase density in peripheral organs in Parkinson's disease with 11C-donepezil PET. Brain. 2015;138:653-63 pubmed publisher
..Decreases in (11)C-donepezil binding may, therefore, represent a marker of parasympathetic denervation of internal organs, but further validation studies are needed. ..
Knudsen K, Fedorova T, Hansen A, Sommerauer M, Otto M, Svendsen K, et al
. In-vivo staging of pathology in REM sleep behaviour disorder: a multimodality imaging case-control study. Lancet Neurol. 2018;17:618-628 pubmed publisher
..Lundbeck Foundation, Jascha Foundation, and the Swiss National Foundation. ..
Borghammer P, Knudsen K, Brooks D. Imaging Systemic Dysfunction in Parkinson's Disease. Curr Neurol Neurosci Rep. 2016;16:51 pubmed publisher
..In this review, we summarize current knowledge about peripheral imaging in Parkinson's disease. ..
Hansen A, Knudsen K, Lillethorup T, Landau A, Parbo P, Fedorova T, et al
. In vivo imaging of neuromelanin in Parkinson's disease using 18F-AV-1451 PET. Brain. 2016;139:2039-49 pubmed publisher
..These findings suggest a more severe loss of striatal nerve terminal function compared with neuronal cell bodies, in accordance with the post-mortem literature. ..
Jørgensen N, Alstrup A, Mortensen F, Knudsen K, Jakobsen S, Madsen L, et al
. Cholinergic PET imaging in infections and inflammation using 11C-donepezil and 18F-FEOBV. Eur J Nucl Med Mol Imaging. 2017;44:449-458 pubmed publisher