Rodolfo Bongiovanni

Summary

Publications

  1. ncbi request reprint A simplified method to quantify dysregulated tyrosine transport in schizophrenia
    Rodolfo Bongiovanni
    Psychiatry Service, Louis Stokes Cleveland DVAMC, Cleveland, OH 44106, United States Electronic address
    Schizophr Res 150:386-91. 2013
  2. doi request reprint Tyrosine depletion lowers in vivo DOPA synthesis in ventral hippocampus
    Rodolfo Bongiovanni
    Psychiatry Service, Louis Stokes Cleveland VA Medical Center, 10701 East Blvd, Cleveland, Ohio 44106, USA
    Eur J Pharmacol 696:70-6. 2012
  3. doi request reprint Tyrosine availability modulates potassium-induced striatal catecholamine efflux in vivo
    George E Jaskiw
    Psychiatry Service, Louis Stokes Cleveland Veterans Affairs Medical Center, USA
    Brain Res 1209:74-84. 2008
  4. ncbi request reprint Increased striatal dopamine synthesis is associated with decreased tissue levels of tyrosine
    Rodolfo Bongiovanni
    Psychiatry Service, Louis Stokes Department of Veterans Affairs Medical Center, Cleveland, OH 44141, USA
    Brain Res 1115:26-36. 2006
  5. ncbi request reprint In rats chronically treated with clozapine, tyrosine depletion attenuates the clozapine-induced in vivo increase in prefrontal cortex dopamine and norepinephrine levels
    George E Jaskiw
    Louis Stokes Department of Veterans Affairs Medical Center, Cleveland, OH, USA
    Psychopharmacology (Berl) 185:416-22. 2006
  6. ncbi request reprint Clozapine-induced dopamine release in the medial prefrontal cortex is augmented by a moderate concentration of locally administered tyrosine but attenuated by high tyrosine concentrations or by tyrosine depletion
    George E Jaskiw
    Psychiatry Service, Louis Stokes Cleveland Veterans Administration Medical Center, Cleveland, Ohio, USA
    Psychopharmacology (Berl) 179:713-24. 2005
  7. ncbi request reprint Tyrosine depletion lowers dopamine synthesis and desipramine-induced prefrontal cortex catecholamine levels
    Rodolfo Bongiovanni
    Psychiatry Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Brecksville, OH 44141, USA
    Brain Res 1190:39-48. 2008
  8. doi request reprint Gamma-butyrolactone-induced dopamine accumulation in prefrontal cortex is affected by tyrosine availability
    George E Jaskiw
    Psychiatry Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44141, USA
    Eur J Pharmacol 589:106-9. 2008
  9. doi request reprint Relationships between large neutral amino acid levels in plasma, cerebrospinal fluid, brain microdialysate and brain tissue in the rat
    Rodolfo Bongiovanni
    Psychiatry Service, Louis Stokes Cleveland Veterans Affairs Medical Center, USA
    Brain Res 1334:45-57. 2010
  10. doi request reprint Increased tyrosine availability increases brain regional DOPA levels in vivo
    Zachary Brodnik
    Research Service, Louis Stokes Cleveland VAMC, Cleveland, OH 44106, USA
    Neurochem Int 61:1001-6. 2012

Detail Information

Publications11

  1. ncbi request reprint A simplified method to quantify dysregulated tyrosine transport in schizophrenia
    Rodolfo Bongiovanni
    Psychiatry Service, Louis Stokes Cleveland DVAMC, Cleveland, OH 44106, United States Electronic address
    Schizophr Res 150:386-91. 2013
    ..Our primary goal was to determine whether tyrosine uptake could be characterized using unlabeled tyrosine. A secondary goal was to assess the effect of antipsychotic drugs added during the incubation...
  2. doi request reprint Tyrosine depletion lowers in vivo DOPA synthesis in ventral hippocampus
    Rodolfo Bongiovanni
    Psychiatry Service, Louis Stokes Cleveland VA Medical Center, 10701 East Blvd, Cleveland, Ohio 44106, USA
    Eur J Pharmacol 696:70-6. 2012
    ..We conclude that while catecholamine synthesis in the ventral hippocampus declines when tyrosine availability is lowered, under basal conditions, compensatory mechanisms are able to maintain stable extracellular catecholamine levels...
  3. doi request reprint Tyrosine availability modulates potassium-induced striatal catecholamine efflux in vivo
    George E Jaskiw
    Psychiatry Service, Louis Stokes Cleveland Veterans Affairs Medical Center, USA
    Brain Res 1209:74-84. 2008
    ..Analyses of LNAA levels suggest that availability of tyrosine for tyrosine hydroxylation may be modulated by competition between LNAAs within brain extracellular fluid...
  4. ncbi request reprint Increased striatal dopamine synthesis is associated with decreased tissue levels of tyrosine
    Rodolfo Bongiovanni
    Psychiatry Service, Louis Stokes Department of Veterans Affairs Medical Center, Cleveland, OH 44141, USA
    Brain Res 1115:26-36. 2006
    ..Under such conditions, near normal extracellular tyrosine levels are maintained despite lower tissue levels. The data are consistent with a net transfer of tyrosine from non-DAergic cells to DA terminals in support of DA synthesis...
  5. ncbi request reprint In rats chronically treated with clozapine, tyrosine depletion attenuates the clozapine-induced in vivo increase in prefrontal cortex dopamine and norepinephrine levels
    George E Jaskiw
    Louis Stokes Department of Veterans Affairs Medical Center, Cleveland, OH, USA
    Psychopharmacology (Berl) 185:416-22. 2006
    ..Judicious manipulation of brain tyrosine levels may provide a useful probe as well as a mechanism for enhancing psychotropic drug actions...
  6. ncbi request reprint Clozapine-induced dopamine release in the medial prefrontal cortex is augmented by a moderate concentration of locally administered tyrosine but attenuated by high tyrosine concentrations or by tyrosine depletion
    George E Jaskiw
    Psychiatry Service, Louis Stokes Cleveland Veterans Administration Medical Center, Cleveland, Ohio, USA
    Psychopharmacology (Berl) 179:713-24. 2005
    ..There are, however, inconsistencies between studies. One possibility is that the relationship between tyrosine availability and DA release is non-linear...
  7. ncbi request reprint Tyrosine depletion lowers dopamine synthesis and desipramine-induced prefrontal cortex catecholamine levels
    Rodolfo Bongiovanni
    Psychiatry Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Brecksville, OH 44141, USA
    Brain Res 1190:39-48. 2008
    ..During other than baseline conditions, however, tyrosine depletion can lower ECF DA and NE levels in MPFC. These data offer a potential mechanism linking dysregulation of tyrosine transport and cognitive deficits in schizophrenia...
  8. doi request reprint Gamma-butyrolactone-induced dopamine accumulation in prefrontal cortex is affected by tyrosine availability
    George E Jaskiw
    Psychiatry Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44141, USA
    Eur J Pharmacol 589:106-9. 2008
    ..GBL-induced striatal dopamine levels were not affected. Hence, increased dopamine synthesis may not be necessary in order for tyrosine availability to affect pharmacologically elevated prefrontal cortex dopamine levels...
  9. doi request reprint Relationships between large neutral amino acid levels in plasma, cerebrospinal fluid, brain microdialysate and brain tissue in the rat
    Rodolfo Bongiovanni
    Psychiatry Service, Louis Stokes Cleveland Veterans Affairs Medical Center, USA
    Brain Res 1334:45-57. 2010
    ....
  10. doi request reprint Increased tyrosine availability increases brain regional DOPA levels in vivo
    Zachary Brodnik
    Research Service, Louis Stokes Cleveland VAMC, Cleveland, OH 44106, USA
    Neurochem Int 61:1001-6. 2012
    ..This would have implications for the pathophysiology and treatment of neuropsychiatric conditions in which dysregulation of DA transmission and l-tyrosine transport have been implicated...
  11. ncbi request reprint Pharmacokinetics of systemically administered tyrosine: a comparison of serum, brain tissue and in vivo microdialysate levels in the rat
    Rodolfo Bongiovanni
    Mental Health Care Line, Louis Stokes Veterans Affairs Medical Center, Cleveland, Ohio 44141, USA
    J Neurochem 87:310-7. 2003
    ....