Eleonora Bonacci

Summary

Publications

  1. ncbi request reprint Autoantibody production in patients treated with anti-TNF-alpha
    Fabiola Atzeni
    Rheumatology Unit, University Hospital L Sacco, Via GB Grassi, 74, 20157 Milano, Italy
    Expert Rev Clin Immunol 4:275-80. 2008
  2. ncbi request reprint Anti-cytokine antibodies for rheumatic diseases
    Fabiola Atzeni
    L Sacco University Hospital, Rheumatology Unit, Via GB Grassi 74, 20127, Milan, Italy
    Curr Opin Investig Drugs 10:1204-11. 2009
  3. doi request reprint Predictors of response to anti-TNF therapy in RA patients with moderate or high DAS28 scores
    Fabiola Atzeni
    Rheumatology Unit, L Sacco University Hospital of Milan, Milan, Italy Electronic address
    Joint Bone Spine 81:37-40. 2014
  4. doi request reprint Lung involvement and drug-induced lung disease in patients with rheumatoid arthritis
    Fabiola Atzeni
    Rheumatology Unit, L Sacco University Hospital, Milan, Italy
    Expert Rev Clin Immunol 9:649-57. 2013
  5. pmc Morphological distribution of μ chains and cd15 receptors in colorectal polyp and adenocarcinoma specimens
    Caterina Defendenti
    Laboratory Unit and Divisions of Fatebenefratelli Hospital, Milan, Italy
    BMC Clin Pathol 13:8. 2013
  6. doi request reprint Immunogenicity and autoimmunity during anti-TNF therapy
    F Atzeni
    Rheumatology Unit, L Sacco University Hospital, Milan, Italy
    Autoimmun Rev 12:703-8. 2013
  7. doi request reprint Different effects of biological drugs in rheumatoid arthritis
    Fabiola Atzeni
    Rheumatology Unit, L Sacco University Hospital, Milan, Italy
    Autoimmun Rev 12:575-9. 2013
  8. doi request reprint Long-term anti-TNF therapy and the risk of serious infections in a cohort of patients with rheumatoid arthritis: comparison of adalimumab, etanercept and infliximab in the GISEA registry
    Fabiola Atzeni
    Rheumatology Unit, L Sacco University Hospital, Milan, Italy
    Autoimmun Rev 12:225-9. 2012
  9. doi request reprint Chronic widespread pain in the spectrum of rheumatological diseases
    Fabiola Atzeni
    Rheumatology Unit, L Sacco University Hospital, Milan, Italy
    Best Pract Res Clin Rheumatol 25:165-71. 2011
  10. pmc Central motor control failure in fibromyalgia: a surface electromyography study
    Roberto Casale
    Department of Clinical Neurophysiology and Pain Rehabilitation Unit, Salvatore Maugeri Foundation, IRCCS, Scientific Institute of Montescano, Montescano PV, Italy
    BMC Musculoskelet Disord 10:78. 2009

Detail Information

Publications89

  1. ncbi request reprint Autoantibody production in patients treated with anti-TNF-alpha
    Fabiola Atzeni
    Rheumatology Unit, University Hospital L Sacco, Via GB Grassi, 74, 20157 Milano, Italy
    Expert Rev Clin Immunol 4:275-80. 2008
    ..This has led some authors to conclude that it is necessary to add methotrexate to infliximab in order to reduce the risk of the appearance of anti-idiotype autoantibodies...
  2. ncbi request reprint Anti-cytokine antibodies for rheumatic diseases
    Fabiola Atzeni
    L Sacco University Hospital, Rheumatology Unit, Via GB Grassi 74, 20127, Milan, Italy
    Curr Opin Investig Drugs 10:1204-11. 2009
    ..This review describes the efficacy and adverse events associated with anti-cytokine treatments for autoimmune rheumatic diseases...
  3. doi request reprint Predictors of response to anti-TNF therapy in RA patients with moderate or high DAS28 scores
    Fabiola Atzeni
    Rheumatology Unit, L Sacco University Hospital of Milan, Milan, Italy Electronic address
    Joint Bone Spine 81:37-40. 2014
    ..2-5.1 [MDA] and high>5.1 [HDA])...
  4. doi request reprint Lung involvement and drug-induced lung disease in patients with rheumatoid arthritis
    Fabiola Atzeni
    Rheumatology Unit, L Sacco University Hospital, Milan, Italy
    Expert Rev Clin Immunol 9:649-57. 2013
    ..The development of treatment-related ILD is a paradoxical adverse event, and patients should be warned about this rare but serious complication of biological or disease-modifying antirheumatic drug therapy. ..
  5. pmc Morphological distribution of μ chains and cd15 receptors in colorectal polyp and adenocarcinoma specimens
    Caterina Defendenti
    Laboratory Unit and Divisions of Fatebenefratelli Hospital, Milan, Italy
    BMC Clin Pathol 13:8. 2013
    ..The aim of the study was to analyse variations in IPCs and CD15+ cell morphology or distribution in bowel biopsy specimens taken from patients with pre-malignant polyps or adenocarcinomas...
  6. doi request reprint Immunogenicity and autoimmunity during anti-TNF therapy
    F Atzeni
    Rheumatology Unit, L Sacco University Hospital, Milan, Italy
    Autoimmun Rev 12:703-8. 2013
    ..The addition of an immunosuppressive drug can reduce the induction of anti-TNF antibodies...
  7. doi request reprint Different effects of biological drugs in rheumatoid arthritis
    Fabiola Atzeni
    Rheumatology Unit, L Sacco University Hospital, Milan, Italy
    Autoimmun Rev 12:575-9. 2013
    ..Finally, although these drugs improve the quality of life of RA patients, they considerably increase direct medical costs...
  8. doi request reprint Long-term anti-TNF therapy and the risk of serious infections in a cohort of patients with rheumatoid arthritis: comparison of adalimumab, etanercept and infliximab in the GISEA registry
    Fabiola Atzeni
    Rheumatology Unit, L Sacco University Hospital, Milan, Italy
    Autoimmun Rev 12:225-9. 2012
    ..To evaluate the risk of serious infections (SIs) in RA patients receiving anti-TNF therapy on the basis of the data included in the GISEA register...
  9. doi request reprint Chronic widespread pain in the spectrum of rheumatological diseases
    Fabiola Atzeni
    Rheumatology Unit, L Sacco University Hospital, Milan, Italy
    Best Pract Res Clin Rheumatol 25:165-71. 2011
    ..A misdiagnosis harms the patients and the community. Rheumatologists should be able to recognise and distinguish primary and secondary FM, and need new guidelines and instruments to avoid making mistakes...
  10. pmc Central motor control failure in fibromyalgia: a surface electromyography study
    Roberto Casale
    Department of Clinical Neurophysiology and Pain Rehabilitation Unit, Salvatore Maugeri Foundation, IRCCS, Scientific Institute of Montescano, Montescano PV, Italy
    BMC Musculoskelet Disord 10:78. 2009
    ..The aim of this study was to assess whether the myoelectrical manifestations of fatigue in patients affected by FM are central or peripheral in origin...
  11. pmc B lymphocyte intestinal homing in inflammatory bowel disease
    Caterina Defendenti
    Laboratory Unit, Fatebenefratelli Hospital, Milan, Italy
    BMC Immunol 12:71. 2011
    ..The objective is to investigate the localisation of immunoglobulin-producing cells (IPCs) in samples of inflamed intestinal tissue taken from patients with IBD, and their possible relationship with clinical features...
  12. pmc Effect of adalimumab on neutrophil function in patients with rheumatoid arthritis
    Franco Capsoni
    Department of Internal Medicine, Ospedale Maggiore Policlinico, IRCCS, University of Milan, Milan, Italy
    Arthritis Res Ther 7:R250-5. 2005
    ....
  13. pmc Development and validation of the self-administered Fibromyalgia Assessment Status: a disease-specific composite measure for evaluating treatment effect
    Fausto Salaffi
    Department of Rheumatology, Polytechnic University of the Marche Medical School, Via dei Colli 52, Jesi, Ancona, Italy
    Arthritis Res Ther 11:R125. 2009
    ....
  14. doi request reprint Coronary flow reserve and asymmetric dimethylarginine levels: new measurements for identifying subclinical atherosclerosis in patients with psoriatic arthritis
    Fabiola Atzeni
    Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, UK
    J Rheumatol 38:1661-4. 2011
    ....
  15. ncbi request reprint What is the role of rituximab in the treatment of rheumatoid arthritis?
    Fabiola Atzeni
    Rheumatology Unit, L Sacco University Hospital, Via GB Grassi 74, 20157 Milan, Italy
    Autoimmun Rev 6:553-8. 2007
    ....
  16. ncbi request reprint PLA1/A2 polymorphism of the platelet glycoprotein receptors IIIA in Behçet's disease
    Fabiola Atzeni
    Rheumatology Unit, Ospedale L Sacco, Milan, Italy
    Clin Exp Rheumatol 29:S38-43. 2011
    ..To investigate potential associations between the PlA1/A2 polymorphism of the platelet glycoprotein receptor IIIA (GpIIIa) gene and venous thrombosis and other clinical manifestations in Italian patients with Behçet's disease (BD)...
  17. pmc Combined therapeutic approach: inflammatory bowel diseases and peripheral or axial arthritis
    Fabiola Atzeni
    Rheumatology Unit, L Sacco University Hospital, Milano, Italy
    World J Gastroenterol 15:2469-71. 2009
    ....
  18. ncbi request reprint [Early rheumatoid arthritis]
    F Atzeni
    Unita di Reumatologia, Azienda Ospedaliera Polo Universitario L Sacco, Milano, Italia
    Reumatismo 59:100-17. 2007
    ..Because the tumor necrosis factor (TNF)-alpha inhibitors have proved to stop joint damage progression in severe progressive RA, the achievement of these agents in early RA are currently of great interest...
  19. ncbi request reprint Preclinical impairment of coronary flow reserve in patients with rheumatoid arthritis
    Fabiola Atzeni
    Rheumatology Unit, L Sacco Hospital, University of Milan, Milan, Italy
    Ann N Y Acad Sci 1108:392-7. 2007
    ..CFR is early reduced in RA patients without clinical evidence of heart disease as a result of impaired microcirculation. CFR seems a useful technique able to follow-up and to assess effects of new drugs on RA patients...
  20. ncbi request reprint [Drug-induced lupus erythematosus]
    F Atzeni
    Unità Operativa di Reumatologia, Università Ospedale L Sacco, Milano, Italia
    Reumatismo 55:147-54. 2003
    ..Recognition of DILE is important because it usually reverts within a few weeks after stopping the drug...
  21. doi request reprint Predicting response to anti-TNF treatment in rheumatoid arthritis patients
    Fabiola Atzeni
    Rheumatology Unit, L Sacco University Hospital, Milan, Italy
    Autoimmun Rev 8:431-7. 2009
    ..To identify the clinical factors predicting failure or a good clinical response in the cohort of RA patients entered in the Lombardy Rheumatology Network (LORHEN) registry after 3 years of treatment with anti-TNF agents...
  22. pmc Adalimumab clinical efficacy is associated with rheumatoid factor and anti-cyclic citrullinated peptide antibody titer reduction: a one-year prospective study
    Fabiola Atzeni
    Rheumatology Unit, Department of Medicine, L Sacco University Hospital, 74 Via GB Grassi, 20157 Milano, Italy
    Arthritis Res Ther 8:R3. 2006
    ..Antinuclear and anti-dsDNA autoantibodies, but not anti-phospholipid autoantibodies, can be induced by adalimumab but to a lower extent than in studies with other anti-TNF blocking agents...
  23. ncbi request reprint The evaluation of the fibromyalgia patients
    F Atzeni
    Rheumatology Unit, L Sacco University Hospital, Milan, Italy
    Reumatismo 60:36-49. 2008
    ..To address the identification of core outcome domains, the Initiative on IMMPACT and OMERACT workshop convened a meeting to develop consensus recommendations for chronic pain clinical trials...
  24. ncbi request reprint Successful treatment of pure red cell aplasia in systemic lupus erythematosus with cyclosporin A
    F Atzeni
    Department of Rheumatology, L Sacco University Hospital, Milan, Italy
    Clin Exp Rheumatol 21:759-62. 2003
    ..The patient was successfully treated with cyclosporin A with no recurrence of the disease in the last 2 years...
  25. doi request reprint Effects of long-term disease-modifying antirheumatic drugs on endothelial function in patients with early rheumatoid arthritis
    M Turiel
    Cardiology Unit, Department of Health Technologies, IRCCS Galeazzi Orthopedic Institute, Universita di Milano, Milan, Italy
    Cardiovasc Ther 28:e53-64. 2010
    ..Treatment strategies in ERA patients with high inflammatory activity must be monitored to identify beneficial effects on preclinical markers of vascular function...
  26. ncbi request reprint Toll-like receptor 4 (TLR4) gene polymorphisms in Italian patients with Behçet's disease
    L Boiardi
    Unita di Reumatologia, Arcispedale S Maria Nuova, Reggio Emilia, Italy
    Clin Exp Rheumatol 27:S43-7. 2009
    ..To investigate potential associations between toll-like receptor 4 (TLR4) gene polymorphisms and susceptibility to, clinical features, and severity of Behçet's disease (BD)...
  27. ncbi request reprint Protein Z G79A and A-13G gene polymorphisms in Italian patients with Behçet's disease
    A Ghinoi
    Unita di Reumatologia, Arcispedale S Maria Nuova, Reggio Emilia, Italy
    Clin Exp Rheumatol 27:S23-8. 2009
    ..To investigate potential associations between A-13G and G79A polymorphisms of the protein Z gene and venous thrombosis and other clinical manifestations in Italian patients with Behçet's disease (BD)...
  28. ncbi request reprint Efficacy and safety of anti-TNF agents in the Lombardy rheumatoid arthritis network (LORHEN)
    P Sarzi-Puttini
    Rheumatology Unit, L Sacco University Hospital, Milan, Italy
    Reumatismo 60:290-5. 2008
    ....
  29. ncbi request reprint Fibromyalgia syndrome: the pharmacological treatment options
    P Sarzi-Puttini
    Rheumatology Unit, L Sacco University Hospital, Milan, Italy
    Reumatismo 60:50-8. 2008
    ..The nature of FM suggests that an individualized, multimodal approach that includes both pharmacologic and nonpharmacologic therapies seems to be the most appropriate treatment strategy to date...
  30. ncbi request reprint Autoantibody profile during short-term infliximab treatment for Crohn's disease: a prospective cohort study
    F Atzeni
    Rheumatology Unit, L Sacco University Hospital, Milan, Italy
    Aliment Pharmacol Ther 22:453-61. 2005
    ..The potential clinical implications of autoimmunity during treatment with infliximab are unclear...
  31. ncbi request reprint The Italian version of the Fibrofatigue Scale, a reliable tool for the evaluation of fibromyalgia symptoms
    P Sarzi-Puttini
    Department of Rheumatology, University Hospital L Sacco, Via GB Grassi, 20157 Milan, Italy
    J Psychosom Res 56:213-6. 2004
    ..To validate a translated Italian version of the Fibrofatigue Scale (FFS)...
  32. ncbi request reprint Tumor necrosis factor-alpha, biologic agents and cardiovascular risk
    P Sarzi-Puttini
    Rheumatology Unit, L Sacco University Hospital, Milan, Italy
    Lupus 14:780-4. 2005
    ..Due to the lack of evidence of a beneficial effect of anti-TNF-alpha agents in treatment of CHF, they should not be used to treat patients with New York Heart Association (NYHA) class III or IV heart failure...
  33. ncbi request reprint Health-related quality of life in fibromyalgia patients: a comparison with rheumatoid arthritis patients and the general population using the SF-36 health survey
    F Salaffi
    Department of Rheumatology, Polytechnic University of Marche, Ancona, Italy
    Clin Exp Rheumatol 27:S67-74. 2009
    ..To compare health-related quality of life (HRQL) in fibromyalgia (FM) patients with that of patients with rheumatoid arthritis (RA) and the general population, and investigate if the factors are associated with the greater impact of FM...
  34. pmc Anti-cyclic citrullinated peptide antibodies in primary Sjögren syndrome may be associated with non-erosive synovitis
    Fabiola Atzeni
    Rheumatology Unit, L, Sacco Hospital, University of Milan, Via G, B, Grassi 74, 20127 Milan, Italy
    Arthritis Res Ther 10:R51. 2008
    ..The purpose of this study was to investigate the prevalence of cyclic citrullinated peptide antibodies (anti-CCP) in patients with primary Sjögren syndrome (pSS) and its correlation with clinical and laboratory data...
  35. ncbi request reprint Lack of association of the -463 G/A myeloperoxidase promoter polymorphism with Behcet's disease in Italian patients
    F Atzeni
    Unita di Reumatologia, Ospedale L Sacco, Milano, Italy
    Rheumatology (Oxford) 46:1547-50. 2007
    ..To investigate potential associations between the -463 G/A myeloperoxidase (MPO) promoter polymorphism and susceptibility to, and clinical expression of, Behçet's disease (BD)...
  36. doi request reprint Cardiovascular involvement in psoriatic arthritis
    F Atzeni
    Rheumatology Unit, L Sacco University Hospital, Milan, Italy
    Reumatismo 63:148-54. 2011
    ..Active PsA is a risk factor for CVD, and so PsA patients should be screened for subclinical forms of the disease and its risk factors, and an early treatment approach should be adopted...
  37. ncbi request reprint [Pharmacological treatment of fibromyalgia]
    M Cazzola
    U O Reumatologia, Azienda Ospedaliera L Sacco, 20157 Milano, Italia
    Reumatismo 59:280-91. 2007
    ..The results of clinical trials of anti-inflammatory medications have been generally disappointing, but three RCTs have found that tramadol (with or without acetaminophen) is effective in FM...
  38. ncbi request reprint Autoimmunity and anti-TNF-alpha agents
    Fabiola Atzeni
    Rheumatology Unit, Department of Rheumatology, University Hospital L Sacco, Via GB Grassi 74, 20157 Milan, Italy
    Ann N Y Acad Sci 1051:559-69. 2005
    ..3% and in 12.9% of adalimumab-treated RA patients. Only limited data on the induction of aPL antibodies during TNF-alpha blocking treatment are available...
  39. doi request reprint From endothelial dysfunction to atherosclerosis
    S Sitia
    IRCCS Galeazzi Orthopedic Institute, Department of Health Technologies, Universita di Milano, Milan, Italy
    Autoimmun Rev 9:830-4. 2010
    ....
  40. ncbi request reprint Infections and treatment of patients with rheumatic diseases
    F Atzeni
    Rheumatology Unit, L Sacco Hospital, Milan, Italy
    Clin Exp Rheumatol 26:S67-73. 2008
    ..These vaccinations are generally immunogenic (i.e., capable of inducing a protective level of specific antibodies) but may not induce an adequate response in a substantial proportion of patients...
  41. ncbi request reprint Infliximab-induced lupus in Crohn's disease: a case report
    P Sarzi-Puttini
    Rheumatology Unit, L Sacco University Hospital, Milan, Italy
    Dig Liver Dis 35:814-7. 2003
    ..This is the first case, to our knowledge, of onset of prolonged infliximab-induced lupus...
  42. ncbi request reprint Validation of an Italian version of the Fibromyalgia Impact Questionnaire (FIQ-I)
    P Sarzi-Puttini
    Department of Rheumatology and Internal Medicine, University Hospital L Sacco, Milan, Italy
    Clin Exp Rheumatol 21:459-64. 2003
    ..To validate a translated Italian version of the Fibromyalgia Impact Questionnaire (FIQ)...
  43. ncbi request reprint Cardiac imaging techniques in systemic autoimmune diseases
    M Turiel
    Department of Cardiology, Istituto Ortopedico Galeazzi, University of Milan, Milan, Italy
    Lupus 14:727-31. 2005
    ..More recently, other imaging modalities including magnetic resonance and computerized tomography angiography have been developed to allow imaging of the coronary arteries...
  44. ncbi request reprint TNF-alpha, rheumatoid arthritis, and heart failure: a rheumatological dilemma
    Piercarlo Sarzi-Puttini
    Rheumatology Unit, University Hospital L Sacco, Via GB Grassi 74, 20157 Milan, Italy
    Autoimmun Rev 4:153-61. 2005
    ....
  45. doi request reprint Serious infections during anti-TNFalpha treatment in rheumatoid arthritis patients
    Ennio Giulio Favalli
    UOC Day Hospital of Rheumatology, G Pini Orthopedic Institute, University of Milan, Milan, Italy
    Autoimmun Rev 8:266-73. 2009
    ..014), and the concomitant use of corticosteroids (p=0.029) as significant predictors of infections. There was no statistically significant difference in risk between the anti-TNFalpha agents...
  46. ncbi request reprint An open, randomized comparison study of cyclosporine A, cyclosporine A + methotrexate and cyclosporine A + hydroxychloroquine in the treatment of early severe rheumatoid arthritis
    Piercarlo Sarzi-Puttini
    Unità Operativa di Reumatologia, University Hospital L Sacco, Via G B Grassi 74, 20157 Milan, Italy
    Rheumatol Int 25:15-22. 2005
    ....
  47. doi request reprint TNF-alpha antagonist survival rate in a cohort of rheumatoid arthritis patients observed under conditions of standard clinical practice
    Antonio Marchesoni
    Day Hospital of Rheumatology, G Pini Orthopaedic Institute, Milan, Italy
    Ann N Y Acad Sci 1173:837-46. 2009
    ..Comorbidities, increasing DAS28 values and co-therapy with methotrexate were associated with a lower risk of discontinuation...
  48. ncbi request reprint [Cardiac involvement in rheumatoid arthritis]
    M Turiel
    Universita di Milano, Dipartimento di Tecnologie per la Salute, Milano, Italia
    Reumatismo 61:244-53. 2009
    ..Considering that early cardiac involvement negatively affects the prognosis, it is mandatory to identify high CV risk RA patients to better define long-term management of this population...
  49. ncbi request reprint CD69 expression on neutrophils from patients with rheumatoid arthritis
    F Atzeni
    Rheumatology Unit, Ospedale L Sacco, Milan, Italy
    Clin Exp Rheumatol 22:331-4. 2004
    ....
  50. ncbi request reprint Etiopathogenetic mechanisms of fibromyalgia syndrome
    S Stisi
    Rheumatology Unit, G Rummo Hospital, Benevento, Italy
    Reumatismo 60:25-35. 2008
    ..Understanding of pathogenetic pathways in FMS has advanced beyond observing patient responses to neurophysiologically targeted therapies and basic research...
  51. doi request reprint Treatment of rheumatoid arthritis with anti-TNF-alpha agents: a reappraisal
    Roberto Caporali
    Rheumatology Unit, University of Pavia, IRCCS Policlinico S Matteo Foundation, 27100 Pavia, Italy
    Autoimmun Rev 8:274-80. 2009
    ..As the first published registry of anti-TNFalpha-treated patients in Italy, Lombardy Rheumatology Network (LORHEN) is already making its contribution in this direction...
  52. ncbi request reprint Drug-induced lupus erythematosus
    Piercarlo Sarzi-Puttini
    Department of Rheumatology, Rheumatology Unit, L Sacco University Hospital, Via GB Grassi 74, Milan 20157, Italy
    Autoimmunity 38:507-18. 2005
    ....
  53. doi request reprint Safety and usefulness of minor salivary gland biopsy: retrospective analysis of 502 procedures performed at a single center
    Roberto Caporali
    Department of Rheumatology, University of Pavia, IRCCS San Matteo Foundation, Pavia, Italy
    Arthritis Rheum 59:714-20. 2008
    ..To analyze the safety of our biopsy technique and the effectiveness of minor salivary gland biopsy (MSGB) for the diagnosis of Sjögren's syndrome (SS) and amyloidosis...
  54. ncbi request reprint Behçet's disease and cardiovascular involvement
    F Atzeni
    Rheumatology Unit, L Sacco University Hospital, Milan, Italy
    Lupus 14:723-6. 2005
    ..This review discusses the general aspects of the pathogenic mechanisms and clinical features cardiovascular involvement in BD, and provides the data of cardiovascular involvement in a cohort of Italian BD patients...
  55. ncbi request reprint Skin manifestations in vasculitis and erythema nodosum
    F Atzeni
    Rheumatology Department, L Sacco University Hospital, Milan, Italy
    Clin Exp Rheumatol 24:S60-6. 2006
    ..The main treatment of EN is that of the underlying associated conditions, if demonstrated. Aspirin and other NSAIDs in full doses are often sufficient...
  56. ncbi request reprint [Cardiovascular risk factors in systemic lupus erythematosus and in antiphospholipid syndrome]
    P Sarzi-Puttini
    Unità Operativa di Reumatologia, Azienda Ospedaliera, Polo Universitario L Sacco, Milan, Italy
    Minerva Med 94:63-70. 2003
    ..Primary and secondary APS are both associated with a significant increase of cardiovascular risk...
  57. doi request reprint Cardiovascular involvement in systemic autoimmune diseases
    Simona Sitia
    IRCCS Orthopedic Galeazzi Institute, University of Milan, Department of Health Technologies, Cardiology Unit, Milan, Italy
    Autoimmun Rev 8:281-6. 2009
    ....
  58. doi request reprint Organ-specific autoantibodies in patients with rheumatoid arthritis treated with adalimumab: a prospective long-term follow-up
    Fabiola Atzeni
    Rheumatology Unit, L Sacco University Hospital, Milan, Italy
    Autoimmunity 41:87-91. 2008
    ..Aim of our study was to assess the prevalence and concentration of a panel of organ-specific autoantibodies in patients with RA and to evaluate their relationship with clinical manifestations and treatment efficacy...
  59. ncbi request reprint Potential target of infliximab in autoimmune and inflammatory diseases
    Fabiola Atzeni
    Rheumatology Unit, L Sacco Hospital, University of Milan, Via GB Grassi 74, 20157 Milan, Italy
    Autoimmun Rev 6:529-36. 2007
    ..A number of other more rare disorders also may be responsive to TNF blockade. We here review the current and prospective roles of infliximab in the treatment of autoimmune diseases and other conditions...
  60. ncbi request reprint Potential off-label use of infliximab in autoimmune and non-autoimmune diseases: a review
    Fabiola Atzeni
    Rheumatology Unit, L Sacco University Hospital, Via GB Grassi 74, 20157 Milan, Italy
    Autoimmun Rev 4:144-52. 2005
    ..We here review the current and prospective roles of infliximab in the treatment of autoimmune diseases and other conditions that do not currently have FDA or EMEA approval...
  61. ncbi request reprint Efficacy of tidal irrigation in Milwaukee shoulder syndrome
    Oscar Epis
    Department of Rheumatology, University of Pavia, IRCCS Policlinico S Matteo Foundation, Pavia, Italy
    J Rheumatol 34:1545-50. 2007
    ..To assess the efficacy of tidal irrigation in patients with Milwaukee shoulder syndrome (MSS)...
  62. ncbi request reprint Pain and ketoprofen: what is its role in clinical practice?
    P Sarzi-Puttini
    Rheumatology Unit, L Sacco University Hospital, Milan, Italy
    Reumatismo 62:172-88. 2010
    ....
  63. ncbi request reprint HIV/AIDS: epidemic update, new treatment strategies and impact on autoimmunity
    F Croce
    Department of Clinical Sciences L Sacco, University of Milan, Milan, Italy
    Clin Exp Rheumatol 26:S48-52. 2008
    ..Current epidemiological, therapeutic, autoimmune and rheumatic aspects of HIV-1 infection are here discussed...
  64. ncbi request reprint Localized and systemic forms of scleroderma in adults and children
    F Atzeni
    Rheumatology Unit, L Sacco University Hospital, Milan, Italy
    Clin Exp Rheumatol 24:S36-45. 2006
    ..The actual and select advantage of the early nailfold videocapillaroscopic (NVC) analysis is to distinguish between the primary RP and the secondary RP and to allow the early detection of SSc...
  65. doi request reprint Resistant cases of psoriatic arthritis: how to manage them
    Fabiola Atzeni
    Rheumatology Unit, L Sacco Hospital, Milan, Italy
    J Rheumatol Suppl 83:73-5. 2009
    ..A number of clinical trials have shown that tumor necrosis factor antagonists are generally safe and efficacious in the treatment of PsA, and can inhibit the progression of radiographic damage...
  66. doi request reprint Anti-thyroid antibodies and thyroid dysfunction in rheumatoid arthritis: prevalence and clinical value
    Fabiola Atzeni
    Rheumatology Unit, L Sacco University Hospital, Milan, Italy
    Autoimmunity 41:111-5. 2008
    ..The aim of this study was to assess thyroid function as well as the prevalence and clinical value of anti-thyroid antibodies in patients with rheumatoid arthritis (RA)...
  67. doi request reprint Recommendations for the management of mixed cryoglobulinemia syndrome in hepatitis C virus-infected patients
    Maurizio Pietrogrande
    Medicina Interna, Department of Medicine, Surgery and Dentistry, Policlinico San Marco of Zingonia, University of Milan, Italy
    Autoimmun Rev 10:444-54. 2011
    ..The objective of this review was to define a core set of recommendations for the treatment of HCV-associated mixed cryoglobulinemia syndrome (MCS) by combining current evidence from clinical trials and expert opinion...
  68. ncbi request reprint Inflammatory response and the endothelium
    P L Meroni
    Department of Internal Medicine, University of Milan, Istituto Auxologico Italiano, Milan, Italy
    Thromb Res 114:329-34. 2004
    ..As shown in antiphospholipid syndrome experimental animal models, a two-hit hypothesis is suggested...
  69. ncbi request reprint [Complementary medicine in rheumatoid arthritis]
    P Sarzi-Puttini
    Unita di Reumatologia, Università Ospedale L Sacco, Via G B Grassi 74, 20157 Milano, Italia
    Reumatismo 57:226-31. 2005
    ....
  70. ncbi request reprint Efficacy and safety of leflunomide or methotrexate plus subcutaneous tumour necrosis factor-alpha blocking agents in rheumatoid arthritis
    M Benucci
    Rheumatology Unit, Ospedale S Giovanni di Dio, ASL 10 Florence, Italy
    Int J Immunopathol Pharmacol 24:269-76. 2011
    ..Our data showed a greater reduction of DAS28 in the MTX group and, in combination with ETN, better results after two years of therapy...
  71. doi request reprint The heart in rheumatoid arthritis
    Maurizio Turiel
    Cardiology Unit, Dipartimento di Tecnologie per la Salute, IRCCS Orthopedic Galeazzi Institute, University of Milan, Milan, Italy
    Autoimmun Rev 9:414-8. 2010
    ..As these are all associated with an unfavourable prognosis, it is essential to detect subclinical cardiac involvement in still asymptomatic RA patients in order to assure adequate long-term treatment...
  72. ncbi request reprint The role of echocardiographic techniques in connective tissue diseases
    Maurizio Turiel
    Department of Cardiology, Istituto Galeazzi, University of Milan, Via Galeazzi 4, 20161 Milano, Italy
    Autoimmun Rev 4:171-7. 2005
    ....
  73. doi request reprint Anti-TNF therapy restores the hypothalamic-pituitary-adrenal axis
    Fabiola Atzeni
    Rheumatology Unit, University Hospital L Sacco, Milan, Italy
    Ann N Y Acad Sci 1193:179-81. 2010
    ..Long-term therapy with anti-TNF agents sensitizes the pituitary gland and improves adrenal androgen secretion, thus stimulating an alternative form of anti-inflammatory action...
  74. doi request reprint Psoriatic arthritis: clinical improvement and correlation with hormone axes in etanercept-treated patients
    Fabiola Atzeni
    Rheumatology Unit, University Hospital L Sacco, Milan, Italy
    Ann N Y Acad Sci 1193:176-8. 2010
    ..However, the greater increase in serum cortisol in comparison with serum 17OHP or ASD was related to clinical improvement, which indicates that the improvement was more related to the higher cortisol levels...
  75. doi request reprint Non-invasive assessment of coronary flow reserve and ADMA levels: a case-control study of early rheumatoid arthritis patients
    Maurizio Turiel
    Department of Health Technologies, Cardiology Unit, IRCCS Orthopedic Galeazzi Institute, University of Milan, Milano, Italy
    Rheumatology (Oxford) 48:834-9. 2009
    ....
  76. ncbi request reprint Environment and systemic lupus erythematosus: an overview
    Piercarlo Sarzi-Puttini
    Rheumatology Unit, Department of Rheumatology, L Sacco University Hospital, Milan, Italy
    Autoimmunity 38:465-72. 2005
    ..A better understanding of the etiopathogenetic mechanism of SLE is required in order to clarify the multiple interactions between environmental exposures and genetic factors...
  77. ncbi request reprint Thrombotic risk factors in primary antiphospholipid syndrome: a 5-year prospective study
    Maurizio Turiel
    Department of Cardiology, Istituto Ortopedico Galeazzi, University of Milan, Via Galeazzi 4, 20161 Milan, Italy
    Stroke 36:1490-4. 2005
    ..Because thromboembolic events are frequently observed in primary antiphospholipid syndrome (PAPS), we assessed the risk factors for new thrombotic episodes...
  78. ncbi request reprint Abnormalities of cardiovascular neural control and reduced orthostatic tolerance in patients with primary fibromyalgia
    Raffaello Furlan
    Department of Internal Medicine II, Ospedale L Sacco, Universita degli Studi di Milano, Milano, Italy
    J Rheumatol 32:1787-93. 2005
    ..We tested the hypothesis that FM is characterized by sympathetic overactivity and alterations in cardiovascular autonomic response to gravitational stimulus...
  79. ncbi request reprint Hand osteoarthritis
    Mario Fumagalli
    Rehabilitative Medicine Unit, Istituti Clinici di Perfezionamento, Milan, Italy
    Semin Arthritis Rheum 34:47-52. 2005
  80. ncbi request reprint Physical and rehabilitative approaches in osteoarthritis
    Feliciantonio Di Domenica
    Rehabilitation Department, Istituto Ortopedico G Pini, Milano, Italy
    Semin Arthritis Rheum 34:62-9. 2005
  81. ncbi request reprint Induction of CD69 activation molecule on human neutrophils by GM-CSF, IFN-gamma, and IFN-alpha
    Fabiola Atzeni
    Rheumatology Unit, Ospedale L Sacco, University of Milan, Milan, Italy
    Cell Immunol 220:20-9. 2002
    ..CD69 cross-linking on GM-CSF-primed neutrophils sinergized with LPS and increased TNF-alpha production and secretion suggesting a role for CD69-positive neutrophils in the pathogenesis and maintenance of different inflammatory diseases...
  82. ncbi request reprint [Alveolar hemorrhage in pulmonary-renal syndrome anti-SCL/70 and anti-MPO-ANCA positive]
    Caterina Defendenti
    Laboratorio di Analisi, Ospedale Fatebenefratelli, Milano, Italia
    Recenti Prog Med 100:361-4. 2009
    ..Immunosuppressive therapy was effective to treat the pulmonary condition, but chronic renal failure emerged. The clinical condition did not improve after plasmapheresis, thus chronic dialysis was required...
  83. doi request reprint Anti-polymer antibodies are correlated with pain and fatigue severity in patients with fibromyalgia syndrome
    Piercarlo Sarzi-Puttini
    Rheumatology Unit, L Sacco University Hospital, Milan, Italy
    Autoimmunity 41:74-9. 2008
    ..To investigate the prevalence of antipolymer antibody (APA) in patients with fibromyalgia (FM) and to examine its association with FM severity symptoms...
  84. ncbi request reprint Sex hormone concentrations in patients with rheumatoid arthritis are not normalized during 12 weeks of anti-tumor necrosis factor therapy
    Rainer H Straub
    Department of Internal Medicine I, Laboratory of Neuroendocrinoimmunology, University Medical Center, Regensburg, Germany
    J Rheumatol 32:1253-8. 2005
    ..Since tumor necrosis factor (TNF) alters production of these hormones, we investigated changes of these hormones during anti-TNF antibody (anti-TNF) therapy with adalimumab in longstanding RA...
  85. doi request reprint Increased cortisol relative to adrenocorticotropic hormone predicts improvement during anti-tumor necrosis factor therapy in rheumatoid arthritis
    Rainer H Straub
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
    Arthritis Rheum 58:976-84. 2008
    ..We undertook this study to investigate the predictive value of hypothalamic-pituitary-adrenal (HPA) axis hormones for clinical improvement during anti-TNF therapy...
  86. ncbi request reprint Osteoarthritis of the spine
    Piercarlo Sarzi-Puttini
    Rheumatology Unit, L Sacco University Hospital, Milan, Italy
    Semin Arthritis Rheum 34:38-43. 2005
  87. ncbi request reprint Five-year follow-up by transesophageal echocardiographic studies in primary antiphospholipid syndrome
    Maurizio Turiel
    Department of Cardiology, Istituto Ortopedico Galeazzi, Italy
    Am J Cardiol 96:574-9. 2005
    ..Anticoagulant and/or antiplatelet treatment was ineffective in terms of valvular lesion regression. New appearances of cardiac involvement are significantly related to high IgG aCL titers...
  88. ncbi request reprint Long-term prognosis and causes of death in systemic lupus erythematosus
    Andrea Doria
    Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Padova, Italy
    Am J Med 119:700-6. 2006
    ..We studied survival rate, prognostic factors, and causes of death in patients with systemic lupus erythematosus (SLE), particularly focusing on the influence of disease severity...
  89. ncbi request reprint Antigen preparation for immunological studies in systemic autoimmune diseases
    Sandra Zampieri
    Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
    Ann N Y Acad Sci 1109:193-202. 2007
    ..In this review an overview of the different biochemical methods of antigen preparation and the specific methodological applications is given, also describing potential critical aspects and benefits of the different protocols...