Leonardo Bolognese

..CC does not exert a protective effect in patients who undergo mechanical intervention in the first 6 hours of AMI onset...

..In the setting of non-ST-segment-elevation (NSTE) acute coronary syndromes (ACS), the pathophysiological mechanisms underlying post-percutaneous coronary intervention (PCI) cardiac troponin I (cTnI) elevation remain unclear...

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..We aimed to compare IVUS-guided PCI versus standard PCI in a large registry of patients undergoing PCI for bifurcations in the drug-eluting stent era...

..51, 95% CI 1.04 to 2.18, p = 0.03). Thus, diabetes is an independent predictor of clinical outcome even if PTCA is used as the primary reperfusion strategy...

..We hypothesized that preserved microvascular integrity in the area at risk would favorably influence left ventricular (LV) remodeling and long-term outcome after acute myocardial infarction...

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..The prevalence, course, and prognostic value of LV remodeling after primary PTCA are still to be clarified...

..Furthermore, whereas high-osmolar contrast media was shown to have direct nephrotoxicity, the role of low-osmolar and iso-osmolar agents is still debated...

..However, optimal timing of glycoprotein IIb/IIIa inhibitor administration - 'upstream' in the coronary care unit or 'downstream' when the patient goes to the catheterization laboratory - has not been established...

..At the same time, improved survival in recent decades may have contributed to an increase in the pool of people at risk for developing HF. Thus, the epidemiology and treatment of this condition has not stood still...

..The aim of this study was to evaluate the long-term clinical outcome of the efficacy and safety of sirolimus-eluting stents (SES) for in-stent restenosis (ISR) in the TRUE (Tuscany Registry of Unselected In-Stent Restenosis) database...

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..Due to the widespread use of drug-eluting stents (DES), in-DES restenosis is increasing. The aim of this study is to evaluate the clinical outcome of patients undergoing repeat percutaneous coronary intervention (PCI) for DES restenosis...

..The mechanism of the clinical benefit of abciximab at 1 month was not related to the patency of the IRA...

..We hypothesized that manual thrombus aspiration during primary PCI would favorably influence tissue-level myocardial perfusion and left ventricular (LV) functional recovery and remodeling...

..The effects of other variables associated with a longer time to reperfusion may have a stronger impact on mortality, obscuring the incremental value of time to reperfusion at multivariate analysis...

..The benefit of early PCI is similar in women and men, and any potential referral bias in the use of PCI based on gender differences should be avoided...

..95 +/- 5% (P = NS) in groups 1 and 2 respectively. CONCLUSIONS: Replacement of VDD pacemakers with the Saphir 3 model designed for a short dipole is safe and reliable when used in combination with previously implanted nondedicated leads...

..The optimal treatment strategy for elderly patients presenting with ST-elevation myocardial infarction is still controversial and few investigations have studied this high-risk population in a community setting...

..This study sought to evaluate the effectiveness and safety of the sirolimus-eluting stent in the treatment of in-stent restenosis (ISR) in consecutive unselected patients undergoing coronary intervention in a real-world scenario...

..Limited data are available about the clinical impact of the implementation of a systematic primary angioplasty infarct reperfusion program in the real world...

..The aim of this study was the evaluation of an immediate transfer for primary angioplasty (PPCI) in elderly (age > or = 75 years) patients with ST elevation acute myocardial infarction (STEMI)...

..Alternatives to ordinary CM, such as carbon dioxide or gadolinium chelates, can be used in patients at high risk of CIN undergoing peripheral diagnostic or interventional procedures, thus reducing the occurrence of CIN...

..We sought to evaluate the efficacy of abciximab as adjunctive therapy to routine infarct-related artery (IRA) stenting...

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..Conclusion: DEBs are an emerging strategy for carotid ISR, with encouraging midterm results in these patients. Further experience in larger cohorts is needed to confirm these preliminary observations...

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..The benefit of DESs in reducing cardiac mortality was obtained in the period in which clinical manifestations of restenosis usually peak...

..The aim of this study was to assess the long-term clinical outcome of percutaneous peripheral interventions in diabetic patients with critical limb ischemia (CLI) in terms of occurrence of major amputation and mortality...

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..In conclusion, patients with ULMCA stenosis and ACS treated with DESs have an increased risk of cardiac mortality and MI during the first year after the intervention compared to stable patients...

..To evaluate whether long-term antiplatelet therapy may be effective and well tolerated...

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..However, the combination of delayed healing with DES and the increasing complexity of the stent implantation raises more demanding safety concerns about the dosage and duration of dual antiplatelet therapy...

..CONCLUSIONS: Independently of the implanted lead, the replacement of VDD pacemakers with devices designed for a short dipole is feasible, safe and reliable. This possibility overcomes a presumed limitation of this pacing modality...

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..Although periprocedural drug therapy has been shown to improve the outcome of percutaneous coronary intervention (PCI), information regarding its use in daily clinical practice is limited...

..If a mechanical recanalization is likely to be performed in an emergency, it is probably desirable that the patient receives abciximab, the glycoprotein IIb/IIIa antagonist with the strongest evidence of benefit for angioplasty in AMI...

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..Except for a lower use of glycoprotein IIb/IIIa receptor antagonists for acute myocardial infarction, no discriminations were observed in elderly patients in terms of clinical indications, antiplatelet therapy and drug-eluting stent use...

..We report the case of late sirolimus-eluting stent thrombosis occurring 22 months after its elective implantation in a restenotic BMS and soon after the interruption of combined anti-platelet therapy with aspirin and Clopidogrel...

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..Similarly, whether tirofiban administered at high-bolus dose (HBD) followed by standard infusion is a valuable alternative to abciximab in the setting of ST-segment elevation myocardial infarction remains uncertain...

..To assess the best management, we randomised patients with STEMI treated by thrombolysis and abciximab at a non-interventional hospital to immediate transfer for PCI, or to standard medical therapy with transfer for rescue angioplasty...

..Similarly, the use of drug-eluting stents in this patient population is currently discouraged because of conflicting results on efficacy reported in randomized trials and safety concerns reported by registries...

..20% in the invasive arm. According to these estimates, with two-tailed alpha of 0.05, power will be 80, 85, or 90% with 252, 289, and 338 patients per group, respectively. The goal is to enroll 700 patients from 50 centers...

..The BLITZ-2 study was planned to survey the epidemiology and management strategies of NSTEACS in the Italian cardiological network...

..The Board of the Emergency Area of the National Association of Hospital Cardiologists (ANMCO) will review the document and analyze the issues of major concern...

..The tolerability of this anti-thrombotic regimen (i.e. unfractionated heparin for the duration of PCIs, preceded and followed by subcutaneous injection of nadroparin) is not yet documented...

..In such a fast-evolving field of medicine as the management of carotid stenosis, it is mandatory to stimulate a continuous and fruitful discussion among all the professionals involved in this very evolutionary field...