New strategies for dealing with Staphylococcus aureus colonization and the emerging methicillin-resistant Staphylococcus aureus epidemic in atopic dermatitisMark Boguniewicz
Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Health and University of Colorado School of Medicine, Denver, CO 80206, USA
Chem Immunol Allergy 96:113-9. 2012
..Novel approaches directed at S. aureus colonization and prevention of infection include compounds mimicking antimicrobial peptides, vaccines targeting unique antigens and toxin-neutralizing agents...
Recent insights into atopic dermatitis and implications for management of infectious complicationsMark Boguniewicz
Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Health and University of Colorado School of Medicine, 1400 Jackson St, Rm J310, Denver, CO 80206, USA
J Allergy Clin Immunol 125:4-13; quiz 14-5. 2010
..A multipronged approach directed at healing or protecting the skin barrier and addressing the immune dysregulation is necessary to improve the likelihood of successful outcomes...
Cytokine modulation of atopic dermatitis filaggrin skin expressionMichael D Howell
Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Allergy Clin Immunol 124:R7-R12. 2009
..CLINICAL IMPLICATIONS: The atopic immune response contributes to the skin barrier defect in AD; therefore, neutralization of IL-4 and IL-13 could improve skin barrier integrity...
- Th2 cytokines act on S100/A11 to downregulate keratinocyte differentiation
Michael D Howell
Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
J Invest Dermatol 128:2248-58. 2008
..S100/A11 and p21 gene expression was also found to be significantly lower in acute and chronic AD skin. This study demonstrates an important role for S100/A11 and p21 in regulating skin barrier integrity and the innate immune response...
- Mechanism of HBD-3 deficiency in atopic dermatitis
Michael D Howell
Division of Allergy and Immunology, Department of Pediatrics, The National Jewish Medical and Research Center, Room K926, 1400 Jackson Street, Denver, CO 80206, USA
Clin Immunol 121:332-8. 2006
..These studies suggest that neutralizing the Th2 cytokine milieu in AD skin may augment the innate immune response against bacterial and viral pathogens...
- Atopic dermatitis: a disease of altered skin barrier and immune dysregulation
Mark Boguniewicz
Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
Immunol Rev 242:233-46. 2011
....
- Cathelicidin deficiency predisposes to eczema herpeticum
Michael D Howell
Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
J Allergy Clin Immunol 117:836-41. 2006
..Eczema herpeticum (ADEH) develops in a subset of patients with atopic dermatitis (AD) because of disseminated infection with herpes simplex virus (HSV)...
- Successful strategies in atopic dermatitis management
Noreen Heer Nicol
National Jewish Health, University of Colorado School of Nursing, Denver, CO, USA
Dermatol Nurs . 2008
..Proper patient education increases the chances of successful therapy...
- Defective killing of Staphylococcus aureus in atopic dermatitis is associated with reduced mobilization of human beta-defensin-3
Kevin O Kisich
Division of Allergy Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colo 80206, USA
J Allergy Clin Immunol 122:62-8. 2008
..Individuals with atopic dermatitis (AD) have frequent colonization and infection with Staphylococcus aureus. Rapid elimination of S. aureus depends on constitutive synthesis and mobilization of human beta-defensin-3 (HBD-3)...
- The constitutive capacity of human keratinocytes to kill Staphylococcus aureus is dependent on beta-defensin 3
Kevin O Kisich
Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
J Invest Dermatol 127:2368-80. 2007
..aureus were exposed to human skin explants. Blocking peptide binding of HBD3 inhibited killing of the bacteria, indicating an essential role for beta-defensin 3 in the constitutive killing of bacteria by normal keratinocytes...
- Macrophage inflammatory protein 3alpha deficiency in atopic dermatitis skin and role in innate immune response to vaccinia virus
Byung Eui Kim
Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Allergy Clin Immunol 119:457-63. 2007
..Macrophage inflammatory protein 3alpha (MIP-3alpha) is a C-C chemokine expressed by keratinocytes that exhibits antimicrobial activity against bacteria and fungi; however, its role in antiviral innate immunity is unknown...
- The signal transducer and activator of transcription 6 gene (STAT6) increases the propensity of patients with atopic dermatitis toward disseminated viral skin infections
Michael D Howell
Department of Pediatrics, National Jewish Health, Denver, Colo 80206, USA
J Allergy Clin Immunol 128:1006-14. 2011
..Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with increased susceptibility to recurrent skin infections...
- Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus
Michael D Howell
Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
Immunity 24:341-8. 2006
..The current study demonstrates that Th2 cytokines enhance VV replication in AD skin by subverting the innate immune response against VV in a STAT-6-dependent manner...
- Interleukin-10 downregulates anti-microbial peptide expression in atopic dermatitis
Michael D Howell
Division of Allergy and Immunology, Department of Pediatrics, The National Jewish Medical and Research Center, Denver, Colorado 80206, USA
J Invest Dermatol 125:738-45. 2005
..Additionally, treatment of AD skin explants with anti-IL-10 augmented the expression of both HBD-2 and LL-37. Thus, increased levels of IL-10 may contribute to the AMP deficiency in both IAD and EAD by reducing cytokines that induce AMP...
- Cytokine modulation of atopic dermatitis filaggrin skin expression
Michael D Howell
Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Allergy Clin Immunol 120:150-5. 2007
..Atopic dermatitis (AD) is a chronic inflammatory skin disease that is characterized by a defective skin barrier function. Recent studies have reported mutations of the skin barrier gene encoding filaggrin in a subset of patients with AD...
- Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6
Byung Eui Kim
Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
Clin Immunol 126:332-7. 2008
..This study suggests that Th2 cytokines inhibit expression of LOR and IVL through a STAT-6 dependent mechanism...
- Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes
Ichiro Nomura
Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Immunol 171:3262-9. 2003
..These observations could explain the increased susceptibility of AD skin to microorganisms, and suggest a new fundamental rule that may explain the mechanism for frequent infection in other Th2 cytokine-mediated diseases...
- Distinct patterns of gene expression in the skin lesions of atopic dermatitis and psoriasis: a gene microarray analysis
Ichiro Nomura
Department Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Allergy Clin Immunol 112:1195-202. 2003
..Such observations may contribute to a characteristic "signature" for these two skin diseases...
- 10. Atopic dermatitis
Mark Boguniewicz
Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Rm J310, Denver, CO 80206, USA
J Allergy Clin Immunol 117:S475-80. 2006
..New treatment approaches include use of topical steroids as maintenance therapy and use of topical calcineurin inhibitors for early intervention with topical steroids used as rescue therapy...
- Endogenous antimicrobial peptides and skin infections in atopic dermatitis
Peck Y Ong
Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
N Engl J Med 347:1151-60. 2002
..aureus. CONCLUSIONS: A deficiency in the expression of antimicrobial peptides may account for the susceptibility of patients with atopic dermatitis to skin infection with S. aureus...
- TNF-α downregulates filaggrin and loricrin through c-Jun N-terminal kinase: role for TNF-α antagonists to improve skin barrier
Byung Eui Kim
Department of Pediatrics, National Jewish Health, Denver, Colorado 80206, USA
J Invest Dermatol 131:1272-9. 2011
..Our current study suggests that TNF inhibits barrier protein expression, and TNF-α antagonists may contribute to clinical improvement in patients with psoriasis by improving barrier protein expression...
- Human atopic dermatitis complicated by eczema herpeticum is associated with abnormalities in IFN-γ response
Donald Y M Leung
Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
J Allergy Clin Immunol 127:965-73.e1-5. 2011
..The basis for increased susceptibility of patients with atopic dermatitis (AD) to develop disseminated viral skin infections such as eczema herpeticum (AD with a history of eczema herpeticum, ADEH(+)) is poorly understood...
- Atopic dermatitis
Mark Boguniewicz
Division of Pediatric Allergy-Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
J Allergy Clin Immunol 118:40-3. 2006
- New insights into atopic dermatitis
Donald Y M Leung
Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
J Clin Invest 113:651-7. 2004
..This review summarizes recent progress in our understanding of the pathophysiology of atopic dermatitis and the implications for new management strategies...
- A multiple-domain framework of clinical, economic, and patient-reported outcomes for evaluating benefits of intervention in atopic dermatitis
Mark Boguniewicz
National Jewish Medical and Research Center, Denver, CO, USA
J Drugs Dermatol 6:416-23. 2007
..This study is intended to help guide future research efforts on the net costs and benefits of different interventions across a diverse set of domains and in larger populations...
- Update on atopic dermatitis: insights into pathogenesis and new treatment paradigms
Mark Boguniewicz
Division of Pediatric Allergy-Immunology, National Jewish Medical and Research Center, 1400 Jackson St. Denver, CO 80206, USA
Allergy Asthma Proc 25:279-82. 2004
....
- Disease management of atopic dermatitis: an updated practice parameter. Joint Task Force on Practice Parameters
Donald Y M Leung
Division of Pediatric Allergy-Immunology, Department of Pediatrics, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, Colorado, USA
Ann Allergy Asthma Immunol 93:S1-21. 2004
- A multidisciplinary approach to evaluation and treatment of atopic dermatitis
Mark Boguniewicz
Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Medical and Research Center and University of Colorado School of Medicine, Denver, CO 80206, USA
Semin Cutan Med Surg 27:115-27. 2008
..A multidisciplinary approach is needed to comprehensively evaluate triggers and response to treatment, address confounding factors including sleep disruption, and educate patients and caregivers...
- Treatment options and new therapeutic approaches in atopic dermatitis
Mark Boguniewicz
Division of Pediatric Allergy-Immunology, Department of Pediatrics, National Jewish Medical and Research Center, University of Colorado School of Medicine, Denver, CO, USA
Dermatol Nurs . 2003
..The introduction of new drug therapies reinforces the importance of dermatology nursing in managing atopic dermatitis...
- Topical treatment of atopic dermatitis
Mark Boguniewicz
Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Medical and Research Center, University of Colorado School of Medicine, 1400 Jackson Street, Room J310, Denver, CO 80206, USA
Immunol Allergy Clin North Am 24:631-44, vi-vii. 2004
..Although the optimal treatment approach remains to be defined, several studies suggest the use of topical calcineurin inhibitors as early intervention therapy and topical corticosteroids as rescue therapy...
- Atopic dermatitis: beyond the itch that rashes
Mark Boguniewicz
Division of Pediatric Allergy-Immunology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, J 310, Denver, CO 80206, USA
Immunol Allergy Clin North Am 25:333-51, vii. 2005
..Although the optimal treatment approach remains to be defined, several recent studies suggest a rationale for using topical calcineurin inhibitors as early intervention and adding topical corticosteroids as rescue therapy if needed...
- Chronic urticaria in children
Mark Boguniewicz
Division of Pediatric Allergy-Immunology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Allergy Asthma Proc 26:13-7. 2005
..Second-generation antihistamines usually are preferred for chronic therapy. Leukotriene receptor antagonists may be of benefit in a subset of children with CU...
- Advances in allergic skin diseases
Donald Y M Leung
Division of Pediatric Allergy and Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Allergy Clin Immunol 111:S805-12. 2003
..The introduction of a new class of topical anti-inflammatory medications, topical calcineurin inhibitors, has significantly increased our treatment options and led to a rethinking of potential management approaches in atopic dermatitis...
- Current management of atopic dermatitis and interruption of the atopic march
Mark Boguniewicz
Division of Pediatric Allergy-Immunology, National Jewish Medical Research Center and University of Colorado School of Medicine, Denver, Colorado 80206, USA
J Allergy Clin Immunol 112:S140-50. 2003
..Studies aimed at defining optimal combination therapy and early intervention might change the treatment paradigm for atopic dermatitis...
- The autoimmune nature of chronic urticaria
Mark Boguniewicz
Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Allergy Asthma Proc 29:433-8. 2008
..New research suggests that in some patients with CU, the activation of the extrinsic coagulation pathway with thrombin generation might play an important role in their CU...
- MAS063DP is effective monotherapy for mild to moderate atopic dermatitis in infants and children: a multicenter, randomized, vehicle-controlled study
Mark Boguniewicz
Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Medical and Research Center and University of Colorado School of Medicine, Denver, CO 80206, USA
J Pediatr 152:854-9. 2008
..To examine the efficacy and safety of MAS063DP (Atopiclair) cream in the management of mild to moderate atopic dermatitis in infants and children...
- Decreased IL-15 may contribute to elevated IgE and acute inflammation in atopic dermatitis
Peck Y Ong
Division of Allergy and Immunology, Department of Pediatrics, The National Jewish Medical and Research Center, Denver, CO 80206, USA
J Immunol 168:505-10. 2002
..In addition, IL-15 was found to suppress IgE synthesis (p < 0.01) by the PBMC of AD patients. These data support the concept that reduced IL-15 expression may contribute to the pathogenesis of AD...
- Combination therapy and new directions for managing atopic dermatitis
Mark Boguniewicz
Division of Pediatric Allergy-Immunology, National Jewish Medical and Research Center, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado, USA
Allergy Asthma Proc 23:243-6. 2002
..Recently, topical calcineurin inhibitors, including tacrolimus and pimecrolimus, have been shown effective as monotherapy for this chronic relapsing disease...
- Beryllium skin patch testing to analyze T cell stimulation and granulomatous inflammation in the lung
Andrew P Fontenot
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Immunol 168:3627-34. 2002
..These studies using skin patch testing provide new insight into the dynamics of T cell influx and mobilization during granulomatous inflammation...
