Mark Boguniewicz

Summary

Publications

  1. doi request reprint New strategies for dealing with Staphylococcus aureus colonization and the emerging methicillin-resistant Staphylococcus aureus epidemic in atopic dermatitis
    Mark Boguniewicz
    Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Health and University of Colorado School of Medicine, Denver, CO 80206, USA
    Chem Immunol Allergy 96:113-9. 2012
  2. pmc Recent insights into atopic dermatitis and implications for management of infectious complications
    Mark Boguniewicz
    Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Health and University of Colorado School of Medicine, 1400 Jackson St, Rm J310, Denver, CO 80206, USA
    J Allergy Clin Immunol 125:4-13; quiz 14-5. 2010
  3. ncbi request reprint Cytokine modulation of atopic dermatitis filaggrin skin expression
    Michael D Howell
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 124:R7-R12. 2009
  4. ncbi request reprint Th2 cytokines act on S100/A11 to downregulate keratinocyte differentiation
    Michael D Howell
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Invest Dermatol 128:2248-58. 2008
  5. ncbi request reprint Mechanism of HBD-3 deficiency in atopic dermatitis
    Michael D Howell
    Division of Allergy and Immunology, Department of Pediatrics, The National Jewish Medical and Research Center, Room K926, 1400 Jackson Street, Denver, CO 80206, USA
    Clin Immunol 121:332-8. 2006
  6. pmc Atopic dermatitis: a disease of altered skin barrier and immune dysregulation
    Mark Boguniewicz
    Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    Immunol Rev 242:233-46. 2011
  7. pmc Cathelicidin deficiency predisposes to eczema herpeticum
    Michael D Howell
    Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Allergy Clin Immunol 117:836-41. 2006
  8. ncbi request reprint Successful strategies in atopic dermatitis management
    Noreen Heer Nicol
    National Jewish Health, University of Colorado School of Nursing, Denver, CO, USA
    Dermatol Nurs . 2008
  9. doi request reprint Defective killing of Staphylococcus aureus in atopic dermatitis is associated with reduced mobilization of human beta-defensin-3
    Kevin O Kisich
    Division of Allergy Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colo 80206, USA
    J Allergy Clin Immunol 122:62-8. 2008
  10. ncbi request reprint The constitutive capacity of human keratinocytes to kill Staphylococcus aureus is dependent on beta-defensin 3
    Kevin O Kisich
    Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Invest Dermatol 127:2368-80. 2007

Detail Information

Publications39

  1. doi request reprint New strategies for dealing with Staphylococcus aureus colonization and the emerging methicillin-resistant Staphylococcus aureus epidemic in atopic dermatitis
    Mark Boguniewicz
    Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Health and University of Colorado School of Medicine, Denver, CO 80206, USA
    Chem Immunol Allergy 96:113-9. 2012
    ..Novel approaches directed at S. aureus colonization and prevention of infection include compounds mimicking antimicrobial peptides, vaccines targeting unique antigens and toxin-neutralizing agents...
  2. pmc Recent insights into atopic dermatitis and implications for management of infectious complications
    Mark Boguniewicz
    Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Health and University of Colorado School of Medicine, 1400 Jackson St, Rm J310, Denver, CO 80206, USA
    J Allergy Clin Immunol 125:4-13; quiz 14-5. 2010
    ..A multipronged approach directed at healing or protecting the skin barrier and addressing the immune dysregulation is necessary to improve the likelihood of successful outcomes...
  3. ncbi request reprint Cytokine modulation of atopic dermatitis filaggrin skin expression
    Michael D Howell
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 124:R7-R12. 2009
    ..CLINICAL IMPLICATIONS: The atopic immune response contributes to the skin barrier defect in AD; therefore, neutralization of IL-4 and IL-13 could improve skin barrier integrity...
  4. ncbi request reprint Th2 cytokines act on S100/A11 to downregulate keratinocyte differentiation
    Michael D Howell
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Invest Dermatol 128:2248-58. 2008
    ..S100/A11 and p21 gene expression was also found to be significantly lower in acute and chronic AD skin. This study demonstrates an important role for S100/A11 and p21 in regulating skin barrier integrity and the innate immune response...
  5. ncbi request reprint Mechanism of HBD-3 deficiency in atopic dermatitis
    Michael D Howell
    Division of Allergy and Immunology, Department of Pediatrics, The National Jewish Medical and Research Center, Room K926, 1400 Jackson Street, Denver, CO 80206, USA
    Clin Immunol 121:332-8. 2006
    ..These studies suggest that neutralizing the Th2 cytokine milieu in AD skin may augment the innate immune response against bacterial and viral pathogens...
  6. pmc Atopic dermatitis: a disease of altered skin barrier and immune dysregulation
    Mark Boguniewicz
    Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    Immunol Rev 242:233-46. 2011
    ....
  7. pmc Cathelicidin deficiency predisposes to eczema herpeticum
    Michael D Howell
    Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Allergy Clin Immunol 117:836-41. 2006
    ..Eczema herpeticum (ADEH) develops in a subset of patients with atopic dermatitis (AD) because of disseminated infection with herpes simplex virus (HSV)...
  8. ncbi request reprint Successful strategies in atopic dermatitis management
    Noreen Heer Nicol
    National Jewish Health, University of Colorado School of Nursing, Denver, CO, USA
    Dermatol Nurs . 2008
    ..Proper patient education increases the chances of successful therapy...
  9. doi request reprint Defective killing of Staphylococcus aureus in atopic dermatitis is associated with reduced mobilization of human beta-defensin-3
    Kevin O Kisich
    Division of Allergy Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colo 80206, USA
    J Allergy Clin Immunol 122:62-8. 2008
    ..Individuals with atopic dermatitis (AD) have frequent colonization and infection with Staphylococcus aureus. Rapid elimination of S. aureus depends on constitutive synthesis and mobilization of human beta-defensin-3 (HBD-3)...
  10. ncbi request reprint The constitutive capacity of human keratinocytes to kill Staphylococcus aureus is dependent on beta-defensin 3
    Kevin O Kisich
    Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Invest Dermatol 127:2368-80. 2007
    ..aureus were exposed to human skin explants. Blocking peptide binding of HBD3 inhibited killing of the bacteria, indicating an essential role for beta-defensin 3 in the constitutive killing of bacteria by normal keratinocytes...
  11. pmc Macrophage inflammatory protein 3alpha deficiency in atopic dermatitis skin and role in innate immune response to vaccinia virus
    Byung Eui Kim
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 119:457-63. 2007
    ..Macrophage inflammatory protein 3alpha (MIP-3alpha) is a C-C chemokine expressed by keratinocytes that exhibits antimicrobial activity against bacteria and fungi; however, its role in antiviral innate immunity is unknown...
  12. pmc The signal transducer and activator of transcription 6 gene (STAT6) increases the propensity of patients with atopic dermatitis toward disseminated viral skin infections
    Michael D Howell
    Department of Pediatrics, National Jewish Health, Denver, Colo 80206, USA
    J Allergy Clin Immunol 128:1006-14. 2011
    ..Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with increased susceptibility to recurrent skin infections...
  13. ncbi request reprint Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus
    Michael D Howell
    Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    Immunity 24:341-8. 2006
    ..The current study demonstrates that Th2 cytokines enhance VV replication in AD skin by subverting the innate immune response against VV in a STAT-6-dependent manner...
  14. ncbi request reprint Interleukin-10 downregulates anti-microbial peptide expression in atopic dermatitis
    Michael D Howell
    Division of Allergy and Immunology, Department of Pediatrics, The National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Invest Dermatol 125:738-45. 2005
    ..Additionally, treatment of AD skin explants with anti-IL-10 augmented the expression of both HBD-2 and LL-37. Thus, increased levels of IL-10 may contribute to the AMP deficiency in both IAD and EAD by reducing cytokines that induce AMP...
  15. pmc Cytokine modulation of atopic dermatitis filaggrin skin expression
    Michael D Howell
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 120:150-5. 2007
    ..Atopic dermatitis (AD) is a chronic inflammatory skin disease that is characterized by a defective skin barrier function. Recent studies have reported mutations of the skin barrier gene encoding filaggrin in a subset of patients with AD...
  16. pmc Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6
    Byung Eui Kim
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Clin Immunol 126:332-7. 2008
    ..This study suggests that Th2 cytokines inhibit expression of LOR and IVL through a STAT-6 dependent mechanism...
  17. ncbi request reprint Distinct patterns of gene expression in the skin lesions of atopic dermatitis and psoriasis: a gene microarray analysis
    Ichiro Nomura
    Department Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 112:1195-202. 2003
    ..DNA microarray studies allow the simultaneous comparison of thousands of messenger RNAs that may identify the disease-specific pattern of tissue inflammatory responses...
  18. ncbi request reprint Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes
    Ichiro Nomura
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 171:3262-9. 2003
    ..These observations could explain the increased susceptibility of AD skin to microorganisms, and suggest a new fundamental rule that may explain the mechanism for frequent infection in other Th2 cytokine-mediated diseases...
  19. ncbi request reprint 10. Atopic dermatitis
    Mark Boguniewicz
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Rm J310, Denver, CO 80206, USA
    J Allergy Clin Immunol 117:S475-80. 2006
    ..New treatment approaches include use of topical steroids as maintenance therapy and use of topical calcineurin inhibitors for early intervention with topical steroids used as rescue therapy...
  20. ncbi request reprint Endogenous antimicrobial peptides and skin infections in atopic dermatitis
    Peck Y Ong
    Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    N Engl J Med 347:1151-60. 2002
    ..We compared the levels of expression of LL-37 and human beta-defensin 2 (HBD-2) in inflamed skin from patients with atopic dermatitis and from those with psoriasis...
  21. doi request reprint TNF-α downregulates filaggrin and loricrin through c-Jun N-terminal kinase: role for TNF-α antagonists to improve skin barrier
    Byung Eui Kim
    Department of Pediatrics, National Jewish Health, Denver, Colorado 80206, USA
    J Invest Dermatol 131:1272-9. 2011
    ..Our current study suggests that TNF inhibits barrier protein expression, and TNF-α antagonists may contribute to clinical improvement in patients with psoriasis by improving barrier protein expression...
  22. pmc Human atopic dermatitis complicated by eczema herpeticum is associated with abnormalities in IFN-γ response
    Donald Y M Leung
    Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 127:965-73.e1-5. 2011
    ..The basis for increased susceptibility of patients with atopic dermatitis (AD) to develop disseminated viral skin infections such as eczema herpeticum (AD with a history of eczema herpeticum, ADEH(+)) is poorly understood...
  23. ncbi request reprint Atopic dermatitis
    Mark Boguniewicz
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Allergy Clin Immunol 118:40-3. 2006
  24. pmc New insights into atopic dermatitis
    Donald Y M Leung
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    J Clin Invest 113:651-7. 2004
    ..This review summarizes recent progress in our understanding of the pathophysiology of atopic dermatitis and the implications for new management strategies...
  25. ncbi request reprint A multiple-domain framework of clinical, economic, and patient-reported outcomes for evaluating benefits of intervention in atopic dermatitis
    Mark Boguniewicz
    National Jewish Medical and Research Center, Denver, CO, USA
    J Drugs Dermatol 6:416-23. 2007
    ..This study is intended to help guide future research efforts on the net costs and benefits of different interventions across a diverse set of domains and in larger populations...
  26. ncbi request reprint Update on atopic dermatitis: insights into pathogenesis and new treatment paradigms
    Mark Boguniewicz
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, 1400 Jackson St Denver, CO 80206, USA
    Allergy Asthma Proc 25:279-82. 2004
    ....
  27. ncbi request reprint Disease management of atopic dermatitis: an updated practice parameter. Joint Task Force on Practice Parameters
    Donald Y M Leung
    Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, Colorado, USA
    Ann Allergy Asthma Immunol 93:S1-21. 2004
  28. doi request reprint A multidisciplinary approach to evaluation and treatment of atopic dermatitis
    Mark Boguniewicz
    Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Medical and Research Center and University of Colorado School of Medicine, Denver, CO 80206, USA
    Semin Cutan Med Surg 27:115-27. 2008
    ..A multidisciplinary approach is needed to comprehensively evaluate triggers and response to treatment, address confounding factors including sleep disruption, and educate patients and caregivers...
  29. ncbi request reprint Treatment options and new therapeutic approaches in atopic dermatitis
    Mark Boguniewicz
    Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Medical and Research Center, University of Colorado School of Medicine, Denver, CO, USA
    Dermatol Nurs . 2003
    ..The introduction of new drug therapies reinforces the importance of dermatology nursing in managing atopic dermatitis...
  30. ncbi request reprint Topical treatment of atopic dermatitis
    Mark Boguniewicz
    Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Medical and Research Center, University of Colorado School of Medicine, 1400 Jackson Street, Room J310, Denver, CO 80206, USA
    Immunol Allergy Clin North Am 24:631-44, vi-vii. 2004
    ..Although the optimal treatment approach remains to be defined, several studies suggest the use of topical calcineurin inhibitors as early intervention therapy and topical corticosteroids as rescue therapy...
  31. ncbi request reprint Atopic dermatitis: beyond the itch that rashes
    Mark Boguniewicz
    Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, J 310, Denver, CO 80206, USA
    Immunol Allergy Clin North Am 25:333-51, vii. 2005
    ..Although the optimal treatment approach remains to be defined, several recent studies suggest a rationale for using topical calcineurin inhibitors as early intervention and adding topical corticosteroids as rescue therapy if needed...
  32. ncbi request reprint Chronic urticaria in children
    Mark Boguniewicz
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Allergy Asthma Proc 26:13-7. 2005
    ..Second-generation antihistamines usually are preferred for chronic therapy. Leukotriene receptor antagonists may be of benefit in a subset of children with CU...
  33. ncbi request reprint Advances in allergic skin diseases
    Donald Y M Leung
    Division of Pediatric Allergy and Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 111:S805-12. 2003
    ..The introduction of a new class of topical anti-inflammatory medications, topical calcineurin inhibitors, has significantly increased our treatment options and led to a rethinking of potential management approaches in atopic dermatitis...
  34. ncbi request reprint Current management of atopic dermatitis and interruption of the atopic march
    Mark Boguniewicz
    Division of Pediatric Allergy Immunology, National Jewish Medical Research Center and University of Colorado School of Medicine, Denver, Colorado 80206, USA
    J Allergy Clin Immunol 112:S140-50. 2003
    ..Studies aimed at defining optimal combination therapy and early intervention might change the treatment paradigm for atopic dermatitis...
  35. doi request reprint The autoimmune nature of chronic urticaria
    Mark Boguniewicz
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Allergy Asthma Proc 29:433-8. 2008
    ..New research suggests that in some patients with CU, the activation of the extrinsic coagulation pathway with thrombin generation might play an important role in their CU...
  36. doi request reprint MAS063DP is effective monotherapy for mild to moderate atopic dermatitis in infants and children: a multicenter, randomized, vehicle-controlled study
    Mark Boguniewicz
    Division of Pediatric Allergy Immunology, Department of Pediatrics, National Jewish Medical and Research Center and University of Colorado School of Medicine, Denver, CO 80206, USA
    J Pediatr 152:854-9. 2008
    ..To examine the efficacy and safety of MAS063DP (Atopiclair) cream in the management of mild to moderate atopic dermatitis in infants and children...
  37. ncbi request reprint Decreased IL-15 may contribute to elevated IgE and acute inflammation in atopic dermatitis
    Peck Y Ong
    Division of Allergy and Immunology, Department of Pediatrics, The National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 168:505-10. 2002
    ..In addition, IL-15 was found to suppress IgE synthesis (p < 0.01) by the PBMC of AD patients. These data support the concept that reduced IL-15 expression may contribute to the pathogenesis of AD...
  38. ncbi request reprint Combination therapy and new directions for managing atopic dermatitis
    Mark Boguniewicz
    Division of Pediatric Allergy Immunology, National Jewish Medical and Research Center, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Allergy Asthma Proc 23:243-6. 2002
    ..Recently, topical calcineurin inhibitors, including tacrolimus and pimecrolimus, have been shown effective as monotherapy for this chronic relapsing disease...
  39. ncbi request reprint Beryllium skin patch testing to analyze T cell stimulation and granulomatous inflammation in the lung
    Andrew P Fontenot
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 168:3627-34. 2002
    ..These studies using skin patch testing provide new insight into the dynamics of T cell influx and mobilization during granulomatous inflammation...