Clifton Bogardus

Summary

Publications

  1. ncbi request reprint Reduced early insulin secretion in the etiology of type 2 diabetes mellitus in Pima Indians
    Clifton Bogardus
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIH, Phoenix, Arizona, USA
    Diabetes 51:S262-4. 2002
  2. ncbi request reprint The role of insulin receptor substrate-1 gene (IRS1) in type 2 diabetes in Pima Indians
    Peter Kovacs
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 52:3005-9. 2003
  3. ncbi request reprint Metabolic effects of the Gly1057Asp polymorphism in IRS-2 and interactions with obesity
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N 16th Street, Room 5 41, Phoenix, AZ 85016, USA
    Diabetes 52:1544-50. 2003
  4. pmc Lower metabolic rate in individuals heterozygous for either a frameshift or a functional missense MC4R variant
    Jonathan Krakoff
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, Phoenix, AZ, USA
    Diabetes 57:3267-72. 2008
  5. pmc Variations in peptide YY and Y2 receptor genes are associated with severe obesity in Pima Indian men
    Lijun Ma
    Diabetes Molecular Genetics Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th St, Phoenix, AZ 85016, USA
    Diabetes 54:1598-602. 2005
  6. pmc Common variation in SIM1 is reproducibly associated with BMI in Pima Indians
    Michael Traurig
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, NIH, Phoenix, AZ, USA
    Diabetes 58:1682-9. 2009
  7. ncbi request reprint A functional Tyr1306Cys variant in LARG is associated with increased insulin action in vivo
    Peter Kovacs
    Diabetes Molecular Genetics Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 445 North 5th Street, Phoenix, AZ 85004, USA
    Diabetes 55:1497-503. 2006
  8. ncbi request reprint TCF7L2 is not a major susceptibility gene for type 2 diabetes in Pima Indians: analysis of 3,501 individuals
    Tingwei Guo
    Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, NIH, 445 North 5th St, Phoenix, AZ 85004, USA
    Diabetes 56:3082-8. 2007
  9. pmc Variants in hepatocyte nuclear factor 4alpha are modestly associated with type 2 diabetes in Pima Indians
    Yunhua Li Muller
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, AZ 85016, USA
    Diabetes 54:3035-9. 2005
  10. ncbi request reprint Plasma adiponectin and endogenous glucose production in humans
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, Department of Health and Human Services, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes Care 26:3315-9. 2003

Detail Information

Publications75

  1. ncbi request reprint Reduced early insulin secretion in the etiology of type 2 diabetes mellitus in Pima Indians
    Clifton Bogardus
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIH, Phoenix, Arizona, USA
    Diabetes 51:S262-4. 2002
    ..However, the genetic determinants require elucidation: correlation of the acute insulin response with the age of parental diabetes onset in fathers as well as mothers indicates a mechanism independent of the diabetic uterine environment...
  2. ncbi request reprint The role of insulin receptor substrate-1 gene (IRS1) in type 2 diabetes in Pima Indians
    Peter Kovacs
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 52:3005-9. 2003
    ....
  3. ncbi request reprint Metabolic effects of the Gly1057Asp polymorphism in IRS-2 and interactions with obesity
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N 16th Street, Room 5 41, Phoenix, AZ 85016, USA
    Diabetes 52:1544-50. 2003
    ....
  4. pmc Lower metabolic rate in individuals heterozygous for either a frameshift or a functional missense MC4R variant
    Jonathan Krakoff
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, Phoenix, AZ, USA
    Diabetes 57:3267-72. 2008
    ..Humans with functional variants in the melanocortin 4 receptor (MC4R) are obese, hyperphagic, and hyperinsulinemic but have been reported to have no difference in energy expenditure...
  5. pmc Variations in peptide YY and Y2 receptor genes are associated with severe obesity in Pima Indian men
    Lijun Ma
    Diabetes Molecular Genetics Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th St, Phoenix, AZ 85016, USA
    Diabetes 54:1598-602. 2005
    ..001 and P = 0.002, respectively). Our data suggest that the PYY-Y2R pathway may influence body weight through a sex-specific mechanism, but this finding requires confirmation in other populations...
  6. pmc Common variation in SIM1 is reproducibly associated with BMI in Pima Indians
    Michael Traurig
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, NIH, Phoenix, AZ, USA
    Diabetes 58:1682-9. 2009
    ..Haploinsufficiency of SIM1 is a cause of rare monogenic obesity. To assess the role of SIM1 in polygenic obesity, this gene was analyzed in the Pima Indian population, which has a high prevalence of obesity...
  7. ncbi request reprint A functional Tyr1306Cys variant in LARG is associated with increased insulin action in vivo
    Peter Kovacs
    Diabetes Molecular Genetics Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 445 North 5th Street, Phoenix, AZ 85004, USA
    Diabetes 55:1497-503. 2006
    ..05). We propose that the Tyr1306Cys substitution in LARG, through its differential activation of RhoA, increases insulin sensitivity in nondiabetic Pima Indians...
  8. ncbi request reprint TCF7L2 is not a major susceptibility gene for type 2 diabetes in Pima Indians: analysis of 3,501 individuals
    Tingwei Guo
    Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, NIH, 445 North 5th St, Phoenix, AZ 85004, USA
    Diabetes 56:3082-8. 2007
    ..S. populations. We investigated whether TCF7L2 also has a role in type 2 diabetes susceptibility in Pima Indians...
  9. pmc Variants in hepatocyte nuclear factor 4alpha are modestly associated with type 2 diabetes in Pima Indians
    Yunhua Li Muller
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, AZ 85016, USA
    Diabetes 54:3035-9. 2005
    ..We conclude that variants in HNF4alpha do not appear to be major determinants for type 2 diabetes in Pima Indians; however, HNF4alpha may have a minor role in type 2 diabetes susceptibility within this Native American population...
  10. ncbi request reprint Plasma adiponectin and endogenous glucose production in humans
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, Department of Health and Human Services, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes Care 26:3315-9. 2003
    ..Whereas associations of plasma adiponectin with muscle insulin sensitivity in humans have been examined, this has not been done for the liver...
  11. pmc PCLO variants are nominally associated with early-onset type 2 diabetes and insulin resistance in Pima Indians
    Lijun Ma
    Department of Health and HumanServices, Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and KidneyDiseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 57:3156-60. 2008
    ..PCLO encodes a presynaptic cytomatrix protein that functions as a Ca(2+) sensor that may be involved in insulin secretion and/or insulin action. Therefore, PCLO was analyzed as a candidate gene for type 2 diabetes...
  12. pmc Strong parent-of-origin effects in the association of KCNQ1 variants with type 2 diabetes in American Indians
    Robert L Hanson
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA
    Diabetes 62:2984-91. 2013
    ..In Pima Indians, the effect of maternally derived KCNQ1 variants appears to be mediated through decreased insulin secretion and is particularly strong, accounting for 4% of the variance in liability to diabetes. ..
  13. ncbi request reprint CHRM3 gene variation is associated with decreased acute insulin secretion and increased risk for early-onset type 2 diabetes in Pima Indians
    Yan Guo
    Diabetes Molecular Genetics Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 445 N 5th St, Suite 210, Phoenix, AZ 85004, USA
    Diabetes 55:3625-9. 2006
    ..00006) and was also modestly associated with increased risk of early-onset type 2 diabetes (adjusted P = 0.02)...
  14. pmc Variants in the LEPR gene are nominally associated with higher BMI and lower 24-h energy expenditure in Pima Indians
    Michael T Traurig
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health Phoenix, Phoenix, Arizona, USA
    Obesity (Silver Spring) 20:2426-30. 2012
    ..0007 adjusted for age, sex, fat mass, fat-free mass, activity, and family membership). We conclude that common noncoding variation in the LEPR gene is associated with higher BMI and lower energy expenditure in Native Americans...
  15. pmc Evidence for a role of LPGAT1 in influencing BMI and percent body fat in Native Americans
    Michael T Traurig
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, Arizona, USA
    Obesity (Silver Spring) 21:193-202. 2013
    ..Therefore LPGAT1 was analyzed as a candidate gene for obesity in Pima Indians...
  16. ncbi request reprint Endogenous glucose production, insulin sensitivity, and insulin secretion in normal glucose-tolerant Pima Indians with low birth weight
    Norbert Stefan
    The Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA
    Metabolism 53:904-11. 2004
    ..We conclude that interaction of multiple defects may contribute to increased susceptibility to type 2 diabetes among individuals with LBW...
  17. pmc Evaluation of A2BP1 as an obesity gene
    Lijun Ma
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 59:2837-45. 2010
    ..On the basis of this association and the obese phenotype of ataxin-2 knockout mice, A2BP1 was genetically and functionally analyzed to assess its potential role in human obesity...
  18. pmc Acute insulin response is an independent predictor of type 2 diabetes mellitus in individuals with both normal fasting and 2-h plasma glucose concentrations
    Joy C Bunt
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Phoenix, Arizona 85016, USA
    Diabetes Metab Res Rev 23:304-10. 2007
    ..We wanted to establish whether insulin secretion persists as an independent predictor of T2DM in individuals with no clinical evidence of impaired glucose regulation based on FPG and 2-h plasma glucose concentrations...
  19. pmc Functional variants in MBL2 are associated with type 2 diabetes and pre-diabetes traits in Pima Indians and the old order Amish
    Yunhua L Muller
    Diabetes Molecular Genetics Section and, Diabetes Epidemiology, the National Institute of Diabetes and Digestive andKidney Disease, The National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 59:2080-5. 2010
    ..To assess the role of MBL2 in diabetes susceptibility, this gene was analyzed in the Pima Indian population, which has a high prevalence of type 2 diabetes...
  20. ncbi request reprint Variants in the Ca V 2.3 (alpha 1E) subunit of voltage-activated Ca2+ channels are associated with insulin resistance and type 2 diabetes in Pima Indians
    Yunhua Li Muller
    Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, 455 North 5th St, Phoenix, AZ 85004, USA
    Diabetes 56:3089-94. 2007
    ..CACNA1E encodes the voltage-dependent calcium channel Ca(v)2.3 Ca(2+), and mice lacking this channel exhibit impaired glucose tolerance and insulin secretion. Therefore, CACNA1E was investigated as a positional candidate gene...
  21. pmc The 24-h carbohydrate oxidation rate in a human respiratory chamber predicts ad libitum food intake
    Nicola Pannacciulli
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Phoenix, AZ, USA
    Am J Clin Nutr 86:625-32. 2007
    ..The 24-h respiratory quotient (24-h RQ) and 24-h carbohydrate balance (24-h CHO-Bal) are predictors of weight change. Whether these relations are mediated by the effects of substrate oxidation and balance on food intake is not known...
  22. ncbi request reprint A search for variants associated with young-onset type 2 diabetes in American Indians in a 100K genotyping array
    Robert L Hanson
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, 550 E Indian School Rd, Phoenix, AZ 85014, USA
    Diabetes 56:3045-52. 2007
    ..To identify genetic variants in linkage disequilibrium with those conferring diabetes susceptibility, a genome-wide association study for young-onset diabetes was conducted in an American-Indian population...
  23. ncbi request reprint High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes
    Barbora Vozarova
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 51:1889-95. 2002
    ..Our findings indicate that high ALT is a marker of risk for type 2 diabetes and suggest a potential role of the liver in the pathogenesis of type 2 diabetes...
  24. pmc Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians
    Rong Rong
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 58:478-88. 2009
    ..We investigated the association of these single nucleotide polymorphisms (SNPs) and some additional tag SNPs with type 2 diabetes and related quantitative traits in Pima Indians...
  25. pmc A genome-wide association study in American Indians implicates DNER as a susceptibility locus for type 2 diabetes
    Robert L Hanson
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ
    Diabetes 63:369-76. 2014
    ..Transfection studies in murine pancreatic β-cells suggested that DNER regulates expression of notch signaling pathway genes. These studies implicate DNER as a susceptibility gene for T2DM in American Indians. ..
  26. pmc MAP2K3 is associated with body mass index in American Indians and Caucasians and may mediate hypothalamic inflammation
    Li Bian
    Diabetes Molecular Genetics Section and Diabetes Epidemiology and Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Phoenix, AZ 85004, USA
    Hum Mol Genet 22:4438-49. 2013
    ..We conclude that MAP2K3 is a reproducible obesity locus that may affect body weight via complex mechanisms involving appetite regulation and hypothalamic inflammation. ..
  27. ncbi request reprint Glucose allostasis
    Michael Stumvoll
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 52:903-9. 2003
    ..With increasing severity and over time, the allostatic load (increase in glycemia) may have pathological consequences, such as the development of type 2 diabetes...
  28. ncbi request reprint Elevated plasma nonesterified fatty acids are associated with deterioration of acute insulin response in IGT but not NGT
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Am J Physiol Endocrinol Metab 284:E1156-61. 2003
    ..However, in subjects who have progressed to a state of IGT, chronically elevated NEFA seem to have a deleterious effect on insulin-secretory capacity...
  29. ncbi request reprint Variants in the interleukin 6 receptor gene are associated with obesity in Pima Indians
    Johanna K Wolford
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, Phoenix, AZ 85016, USA
    Mol Genet Metab 80:338-43. 2003
    ..0+/-7.5]; P=0.02-0.004). Our findings suggest that genetic variants in the IL6R gene may play a role in susceptibility to obesity. Assessment of these SNPs in other populations will be useful to determine the magnitude of obesity risk...
  30. ncbi request reprint A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians
    Yunhua Li Muller
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease NIH, 4212 N 16th Street, Phoenix, AZ 85016, USA
    Diabetes 52:895-8. 2003
    ..These data indicate that the Gly482Ser missense polymorphism in PGC-1 has metabolic consequences on lipid metabolism that could influence insulin secretion...
  31. ncbi request reprint Increased fat accumulation in liver may link insulin resistance with subcutaneous abdominal adipocyte enlargement, visceral adiposity, and hypoadiponectinemia in obese individuals
    Juraj Koska
    Obesity and Diabetes Clinical Research Section, NIDDK NIH DHHS, Phoenix, AZ 85016, USA
    Am J Clin Nutr 87:295-302. 2008
    ....
  32. ncbi request reprint A functional variant in the peroxisome proliferator-activated receptor gamma2 promoter is associated with predictors of obesity and type 2 diabetes in Pima Indians
    Yunhua Li Muller
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 52:1864-71. 2003
    ....
  33. ncbi request reprint The effect of insulin on net lipid oxidation predicts worsening of insulin resistance and development of type 2 diabetes mellitus
    Juraj Koska
    Obesity and Diabetes Clinical Research Section, NIDDK NIH DHHS, 4212 N 16th St, Rm 5 35, Phoenix, AZ 85016, USA
    Am J Physiol Endocrinol Metab 293:E264-9. 2007
    ..04). These data indicate that the inability of insulin to suppress L(ox) may represent an early risk marker for insulin resistance and T2DM that is independent of adiposity, acute insulin secretion, and insulin action on glucose uptake...
  34. pmc Association analysis of Krüppel-like factor 11 variants with type 2 diabetes in Pima Indians
    Lijun Ma
    Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Phoenix, Arizona 85004, USA
    J Clin Endocrinol Metab 93:3644-9. 2008
    ....
  35. ncbi request reprint Higher fasting plasma concentrations of glucagon-like peptide 1 are associated with higher resting energy expenditure and fat oxidation rates in humans
    Nicola Pannacciulli
    Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    Am J Clin Nutr 84:556-60. 2006
    ..Glucagon-like peptide 1 (GLP-1) is a gut hormone that decreases appetite and promotes satiety. Its role in energy metabolism regulation is still poorly understood...
  36. ncbi request reprint Variants in ARHGEF11, a candidate gene for the linkage to type 2 diabetes on chromosome 1q, are nominally associated with insulin resistance and type 2 diabetes in Pima Indians
    Lijun Ma
    Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85004, USA
    Diabetes 56:1454-9. 2007
    ..01). These findings suggest that variation within ARHGEF11 nominally increases risk of type 2 diabetes, possibly as a result of increased insulin resistance...
  37. doi request reprint A genome-wide association study of BMI in American Indians
    Alka Malhotra
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA
    Obesity (Silver Spring) 19:2102-6. 2011
    ..53 × 10(-6)) for the within-family tests. Further analysis is important because only a few of these regions have been previously implicated in a GWAS and genetic susceptibility may differ by ethnicity...
  38. pmc Variants in ASK1 are associated with skeletal muscle ASK1 expression, in vivo insulin resistance, and type 2 diabetes in Pima Indians
    Li Bian
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Phoenix, Arizona, USA
    Diabetes 59:1276-82. 2010
    ..Genetic variants in or near ASK1 were analyzed to assess the role of this gene in insulin action and type 2 diabetes...
  39. ncbi request reprint Differential expression of matrix metalloproteinase 3 (MMP3) in preadipocytes/stromal vascular cells from nonobese nondiabetic versus obese nondiabetic Pima Indians
    Michael T Traurig
    NIDDK, NIH, 445 North 5th St, Phoenix, AZ 85004, USA
    Diabetes 55:3160-5. 2006
    ....
  40. pmc Lower "awake and fed thermogenesis" predicts future weight gain in subjects with abdominal adiposity
    Paolo Piaggi
    Obesity and Diabetes Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona
    Diabetes 62:4043-51. 2013
    ..AFT may influence daily energy balance, is reduced in obese individuals, and predicts future weight gain in these subjects. Once central adiposity develops, a blunting of AFT may occur that then contributes to further weight gain...
  41. pmc Association analyses of variants in the DIO2 gene with early-onset type 2 diabetes mellitus in Pima Indians
    Saraswathy Nair
    Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Thyroid 22:80-7. 2012
    ..Thyroid hormones regulate energy balance and may also influence glucose metabolism. Therefore, we hypothesized that variations in DIO2 could contribute to obesity or type 2 diabetes mellitus (T2DM) in Pima Indians...
  42. ncbi request reprint Parasympathetic blockade attenuates augmented pancreatic polypeptide but not insulin secretion in Pima Indians
    Barbora Vozarova de Courten
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 53:663-71. 2004
    ..However, the hyperinsulinemia of this population does not appear to be due to increased vagal input to pancreatic beta-cells...
  43. ncbi request reprint A novel missense substitution (Val1483Ile) in the fatty acid synthase gene (FAS) is associated with percentage of body fat and substrate oxidation rates in nondiabetic Pima Indians
    Peter Kovacs
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 53:1915-9. 2004
    ..Our findings indicate that the Val1483Ile substitution in FAS is protective against obesity in Pima Indians, an effect possibly explained by the role of this gene in the regulation of substrate oxidation...
  44. ncbi request reprint Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 51:1884-8. 2002
    ..Prospectively, low plasma adiponectin concentration at baseline precedes a decrease in insulin sensitivity. Our data indicate that adiponectin plays an important role in regulation of insulin sensitivity in humans...
  45. ncbi request reprint Genetic variation in the human winged helix/forkhead transcription factor gene FOXC2 in Pima Indians
    Peter Kovacs
    Department of Health and Human Services, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIH, 4212 N 16th Street, Phoenix, AZ 85016, USA
    Diabetes 52:1292-5. 2003
    ....
  46. pmc Identification of genetic variation that determines human trehalase activity and its association with type 2 diabetes
    Yunhua L Muller
    Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, AZ 85004, USA
    Hum Genet 132:697-707. 2013
    ..Alternatively, TREH variants may be tagging a nearby T2D locus...
  47. pmc Greater impact of melanocortin-4 receptor deficiency on rates of growth and risk of type 2 diabetes during childhood compared with adulthood in Pima Indians
    Marie S Thearle
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 61:250-7. 2012
    ..The greater rates of body mass accumulation and risk of type 2 diabetes before the age of 20 years in individuals with MC4R deficiency indicate that the effects of these mutations are more apparent during the active growth of childhood...
  48. pmc Bimodal distribution of RNA expression levels in human skeletal muscle tissue
    Clinton C Mason
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, 1550 E, Indian School Rd, Phoenix, AZ 85014, USA
    BMC Genomics 12:98. 2011
    ....
  49. ncbi request reprint Molecular analysis of KCNJ10 on 1q as a candidate gene for Type 2 diabetes in Pima Indians
    Vidya S Farook
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 51:3342-6. 2002
    ..1 to 2.9. We conclude that these variants in KCNJ10 are unlikely to be the cause of linkage of type 2 diabetes with 1q in Pima Indians...
  50. pmc Common genetic variation in the glucokinase gene (GCK) is associated with type 2 diabetes and rates of carbohydrate oxidation and energy expenditure
    Yunhua L Muller
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, 445 North 5th Street, Phoenix, AZ, 85004, USA
    Diabetologia 57:1382-90. 2014
    ..Rare mutations in GCK cause MODY. We investigated whether common variation (minor allele frequency ≥0.01) in GCK is associated with metabolic traits and type 2 diabetes...
  51. pmc Whole exome sequencing identifies variation in CYB5A and RNF10 associated with adiposity and type 2 diabetes
    Ke Huang
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Arizona, USA
    Obesity (Silver Spring) 22:984-8. 2014
    ..The objective of this study was to identify coding variation that increases risk for T2D via an effect on a pre-diabetic trait...
  52. ncbi request reprint Evaluation of the microsomal glutathione S-transferase 3 (MGST3) locus on 1q23 as a Type 2 diabetes susceptibility gene in Pima Indians
    Farook Thameem
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    Hum Genet 113:353-8. 2003
    ..We conclude that alterations of MGST3 are unlikely to contribute to T2DM or differences in insulin sensitivity in the Pima Indians...
  53. pmc Lower total fasting plasma adiponectin concentrations are associated with higher metabolic rates
    Nicola Pannacciulli
    Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH DHHS, 4212 North 16th Street, Phoenix, AZ 85016, USA
    J Clin Endocrinol Metab 91:1600-3. 2006
    ..The possible role of adiponectin, a protein uniquely produced by the adipose tissue and significantly reduced in obesity and other insulin-resistant states, in the regulation of energy expenditure (EE) is still poorly understood...
  54. ncbi request reprint Melanocortin 4 receptor gene variation is associated with severe obesity in Pima Indians
    Lijun Ma
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, 4212 N 16th St, Phoenix, AZ 85016, USA
    Diabetes 53:2696-9. 2004
    ..We conclude that variations in MC4R may account for a small portion of obesity in Pima Indians, but they do not explain the overall high prevalence of obesity in this Native American population...
  55. pmc Potential epigenetic dysregulation of genes associated with MODY and type 2 diabetes in humans exposed to a diabetic intrauterine environment: an analysis of genome-wide DNA methylation
    Melissa C del Rosario
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, 1550 East Indian School Road, Phoenix, AZ, 85014
    Metabolism 63:654-60. 2014
    ..The aim of this study is to investigate the potential role of DNA methylation in mediating the increased risk of developing type 2 diabetes in offspring of mothers who had diabetes during pregnancy...
  56. pmc Lower energy expenditure predicts long-term increases in weight and fat mass
    Paolo Piaggi
    Obesity and Diabetes Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    J Clin Endocrinol Metab 98:E703-7. 2013
    ..The relevance of the contribution of energy expenditure (EE) and substrate oxidation to weight change has not been fully confirmed...
  57. ncbi request reprint A C-reactive protein promoter polymorphism is associated with type 2 diabetes mellitus in Pima Indians
    Johanna K Wolford
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    Mol Genet Metab 78:136-44. 2003
    ..However, these findings suggest that variation within the CRP locus may play a role in diabetes susceptibility in Pima Indians...
  58. pmc Palmitate action to inhibit glycogen synthase and stimulate protein phosphatase 2A increases with risk factors for type 2 diabetes
    David M Mott
    Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIH, 4212 N 16th Street, Phoenix, AZ 85016, USA
    Am J Physiol Endocrinol Metab 294:E444-50. 2008
    ..We conclude that subjects at risk for Type 2 diabetes have intrinsic differences in palmitate regulation of at least two enzymes (PP2A and glycogen synthase), contributing to abnormal insulin regulation of glucose metabolism...
  59. pmc Plasma concentrations of free triiodothyronine predict weight change in euthyroid persons
    Emilio Ortega
    Phoenix Epidemiological Clinical and Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Phoenix, AZ 85016, USA
    Am J Clin Nutr 85:440-5. 2007
    ..Factors that influence energy metabolism and substrate oxidation, such as thyroid hormones (THs), may be important regulators of body weight...
  60. ncbi request reprint Association of amino acid variants in the activating transcription factor 6 gene (ATF6) on 1q21-q23 with type 2 diabetes in Pima Indians
    Farook Thameem
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 445 N 5th St, Suite 210, Phoenix, AZ 85004, USA
    Diabetes 55:839-42. 2006
    ..Because these variants are not unique to the Pimas, it will be feasible to investigate their association with type 2 diabetes in other populations to better evaluate their significance for a predisposition to the disease...
  61. pmc Assessing accuracy of genotype imputation in american indians
    Alka Malhotra
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, United States of America
    PLoS ONE 9:e102544. 2014
    ..However, some populations, such as American Indians, are not represented in HapMap. In the present study, we assessed accuracy of imputation using HapMap reference populations in a genome-wide association study in Pima Indians...
  62. ncbi request reprint Positional cloning of an obesity/diabetes susceptibility gene(s) on chromosome 11 in Pima Indians
    Leslie Baier
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Arizona 85016, USA
    Ann N Y Acad Sci 967:258-64. 2002
    ..A region containing a cluster of SNPs strongly associated with BMI and a second region, approximately 2 Mb telomeric, containing a cluster of SNPs associated with diabetes have been preliminarily identified...
  63. pmc Effect of paternal diabetes on pre-diabetic phenotypes in adult offspring
    Adela Penesova
    Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Phoenix, Arizona, USA
    Diabetes Care 33:1823-8. 2010
    ..We aimed to examine a metabolic phenotype in three different groups of offspring to see distinct paternal versus maternal effects...
  64. ncbi request reprint Polymorphisms in the oxygen-regulated protein 150 gene (ORP150) are associated with insulin resistance in Pima Indians
    Peter Kovacs
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIDDK, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 51:1618-21. 2002
    ..These data indicate that ORP150 has a role in insulin action but does not have a major role in determining susceptibility to type 2 diabetes in Pima Indians...
  65. pmc Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans
    Reiner Jumpertz
    Obesity and Diabetes Clinical Research Section, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    Am J Clin Nutr 94:58-65. 2011
    ..However, it remains uncertain as to what extent gut microbiota are an important regulator of nutrient absorption in humans...
  66. ncbi request reprint Cloning, expression and genomic structure of human LMX1A, and variant screening in Pima Indians
    Farook Thameem
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    Gene 290:217-25. 2002
    ..We did not find evidence for association of any LMX1A SNPs with T2DM and conclude that LMX1A does not contribute significantly to T2DM etiology in Pima Indians...
  67. ncbi request reprint Identification of susceptibility genes for complex metabolic diseases
    Clifton Bogardus
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Ann N Y Acad Sci 967:1-6. 2002
    ..Nonetheless, genetic strategies have emerged that, when the technologies are fully developed, should allow similar success rates as for Mendelian diseases...
  68. ncbi request reprint High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes
    Barbora Vozarova
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Diabetes 51:455-61. 2002
    ..These findings are consistent with the hypothesis that a chronic activation of the immune system may play a role in the pathogenesis of type 2 diabetes...
  69. ncbi request reprint Association of a F479L variant in the cytosolic phospholipase A2 gene (PLA2G4A) with decreased glucose turnover and oxidation rates in Pima Indians
    Johanna K Wolford
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, AZ 85016, USA
    Mol Genet Metab 79:61-6. 2003
    ..77+/-0.25 vs. 0.67+/-0.23 mg/kgEMBS/min; p=0.02). These results provide evidence supporting a role for the eicosanoid biosynthesis pathway in type 2 diabetes mellitus pathophysiology...
  70. ncbi request reprint The transcribed endosulfine alpha gene is located within a type 2 diabetes-linked region on 1q: sequence and expression analysis in Pima Indians
    Farook Thameem
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix AZ, USA
    Mol Genet Metab 81:16-21. 2004
    ..We conclude that sequence alterations in ENSA are an unlikely cause for the linkage of T2DM with 1q21-q23 in the Pima Indians...
  71. ncbi request reprint Identification of individuals with insulin resistance using routine clinical measurements
    Steven E Stern
    School of Finance and Applied Statistics, Australian National University, Canberra, Australia
    Diabetes 54:333-9. 2005
    ..1%), sensitivity (81.3%), and specificity (76.3%). Thus, insulin-resistant individuals can be identified using simple decision rules that can be tailored to specific needs...
  72. ncbi request reprint Identification of novel putative membrane proteins selectively expressed during adipose conversion of 3T3-L1 cells
    Aimin Xu
    The School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Biochem Biophys Res Commun 293:1161-7. 2002
    ....
  73. ncbi request reprint The role of glucose allostasis in type 2 diabetes
    Michael Stumvoll
    Medizinische Klinik der Universität, Otfried Muller Str 10, 72076 Tuebingen, Germany
    Rev Endocr Metab Disord 5:99-103. 2004
  74. pmc Meta-analysis of 23 type 2 diabetes linkage studies from the International Type 2 Diabetes Linkage Analysis Consortium
    Weihua Guan
    Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    Hum Hered 66:35-49. 2008
    ..The International Type 2 Diabetes Linkage Analysis Consortium was formed to localize type 2 diabetes predisposing variants based on 23 autosomal linkage scans...
  75. ncbi request reprint At work with the Pima
    Andrew Curry
    Diabetes Forecast 61:67-9. 2008