Reduced early insulin secretion in the etiology of type 2 diabetes mellitus in Pima IndiansClifton Bogardus
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIH, Phoenix, Arizona, USA
Diabetes 51:S262-4. 2002
..However, the genetic determinants require elucidation: correlation of the acute insulin response with the age of parental diabetes onset in fathers as well as mothers indicates a mechanism independent of the diabetic uterine environment...
- The role of insulin receptor substrate-1 gene (IRS1) in type 2 diabetes in Pima Indians
Peter Kovacs
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
Diabetes 52:3005-9. 2003
....
- Metabolic effects of the Gly1057Asp polymorphism in IRS-2 and interactions with obesity
Norbert Stefan
Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N 16th Street, Room 5 41, Phoenix, AZ 85016, USA
Diabetes 52:1544-50. 2003
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Lower metabolic rate in individuals heterozygous for either a frameshift or a functional missense MC4R variantJonathan Krakoff
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, Phoenix, AZ, USA
Diabetes 57:3267-72. 2008
..Humans with functional variants in the melanocortin 4 receptor (MC4R) are obese, hyperphagic, and hyperinsulinemic but have been reported to have no difference in energy expenditure...
- A functional Tyr1306Cys variant in LARG is associated with increased insulin action in vivo
Peter Kovacs
Diabetes Molecular Genetics Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 445 North 5th Street, Phoenix, AZ 85004, USA
Diabetes 55:1497-503. 2006
..05). We propose that the Tyr1306Cys substitution in LARG, through its differential activation of RhoA, increases insulin sensitivity in nondiabetic Pima Indians...
- Variations in peptide YY and Y2 receptor genes are associated with severe obesity in Pima Indian men
Lijun Ma
Diabetes Molecular Genetics Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th St, Phoenix, AZ 85016, USA
Diabetes 54:1598-602. 2005
..001 and P = 0.002, respectively). Our data suggest that the PYY-Y2R pathway may influence body weight through a sex-specific mechanism, but this finding requires confirmation in other populations...
- Common variation in SIM1 is reproducibly associated with BMI in Pima Indians
Michael Traurig
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, NIH, Phoenix, AZ, USA
Diabetes 58:1682-9. 2009
..Haploinsufficiency of SIM1 is a cause of rare monogenic obesity. To assess the role of SIM1 in polygenic obesity, this gene was analyzed in the Pima Indian population, which has a high prevalence of obesity...
- PCLO variants are nominally associated with early-onset type 2 diabetes and insulin resistance in Pima Indians
Lijun Ma
Department of Health and HumanServices, Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and KidneyDiseases, National Institutes of Health, Phoenix, Arizona, USA
Diabetes 57:3156-60. 2008
..PCLO encodes a presynaptic cytomatrix protein that functions as a Ca(2+) sensor that may be involved in insulin secretion and/or insulin action. Therefore, PCLO was analyzed as a candidate gene for type 2 diabetes...
- Variants in hepatocyte nuclear factor 4alpha are modestly associated with type 2 diabetes in Pima Indians
Yunhua Li Muller
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, AZ 85016, USA
Diabetes 54:3035-9. 2005
..We conclude that variants in HNF4alpha do not appear to be major determinants for type 2 diabetes in Pima Indians; however, HNF4alpha may have a minor role in type 2 diabetes susceptibility within this Native American population...
- TCF7L2 is not a major susceptibility gene for type 2 diabetes in Pima Indians: analysis of 3,501 individuals
Tingwei Guo
Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, NIH, 445 North 5th St, Phoenix, AZ 85004, USA
Diabetes 56:3082-8. 2007
..S. populations. We investigated whether TCF7L2 also has a role in type 2 diabetes susceptibility in Pima Indians...
- Plasma adiponectin and endogenous glucose production in humans
Norbert Stefan
Clinical Diabetes and Nutrition Section, Department of Health and Human Services, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
Diabetes Care 26:3315-9. 2003
..Whereas associations of plasma adiponectin with muscle insulin sensitivity in humans have been examined, this has not been done for the liver...
- Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians
Rong Rong
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
Diabetes 58:478-88. 2009
..We investigated the association of these single nucleotide polymorphisms (SNPs) and some additional tag SNPs with type 2 diabetes and related quantitative traits in Pima Indians...
- Acute insulin response is an independent predictor of type 2 diabetes mellitus in individuals with both normal fasting and 2-h plasma glucose concentrations
Joy C Bunt
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Phoenix, Arizona 85016, USA
Diabetes Metab Res Rev 23:304-10. 2007
..We wanted to establish whether insulin secretion persists as an independent predictor of T2DM in individuals with no clinical evidence of impaired glucose regulation based on FPG and 2-h plasma glucose concentrations...
- Functional variants in MBL2 are associated with type 2 diabetes and pre-diabetes traits in Pima Indians and the old order Amish
Yunhua L Muller
Diabetes Molecular Genetics Section and, Diabetes Epidemiology, the National Institute of Diabetes and Digestive andKidney Disease, The National Institutes of Health, Phoenix, Arizona, USA
Diabetes 59:2080-5. 2010
..To assess the role of MBL2 in diabetes susceptibility, this gene was analyzed in the Pima Indian population, which has a high prevalence of type 2 diabetes...
- Endogenous glucose production, insulin sensitivity, and insulin secretion in normal glucose-tolerant Pima Indians with low birth weight
Norbert Stefan
The Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA
Metabolism 53:904-11. 2004
..We conclude that interaction of multiple defects may contribute to increased susceptibility to type 2 diabetes among individuals with LBW...
- A search for variants associated with young-onset type 2 diabetes in American Indians in a 100K genotyping array
Robert L Hanson
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, 550 E Indian School Rd, Phoenix, AZ 85014, USA
Diabetes 56:3045-52. 2007
..To identify genetic variants in linkage disequilibrium with those conferring diabetes susceptibility, a genome-wide association study for young-onset diabetes was conducted in an American-Indian population...
- The 24-h carbohydrate oxidation rate in a human respiratory chamber predicts ad libitum food intake
Nicola Pannacciulli
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Phoenix, AZ, USA
Am J Clin Nutr 86:625-32. 2007
..The 24-h respiratory quotient (24-h RQ) and 24-h carbohydrate balance (24-h CHO-Bal) are predictors of weight change. Whether these relations are mediated by the effects of substrate oxidation and balance on food intake is not known...
- High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes
Barbora Vozarova
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
Diabetes 51:1889-95. 2002
..Our findings indicate that high ALT is a marker of risk for type 2 diabetes and suggest a potential role of the liver in the pathogenesis of type 2 diabetes...
- Variants in the Ca V 2.3 (alpha 1E) subunit of voltage-activated Ca2+ channels are associated with insulin resistance and type 2 diabetes in Pima Indians
Yunhua Li Muller
Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, 455 North 5th St, Phoenix, AZ 85004, USA
Diabetes 56:3089-94. 2007
..CACNA1E encodes the voltage-dependent calcium channel Ca(v)2.3 Ca(2+), and mice lacking this channel exhibit impaired glucose tolerance and insulin secretion. Therefore, CACNA1E was investigated as a positional candidate gene...
- Evaluation of A2BP1 as an obesity gene
Lijun Ma
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, Arizona, USA
Diabetes 59:2837-45. 2010
..On the basis of this association and the obese phenotype of ataxin-2 knockout mice, A2BP1 was genetically and functionally analyzed to assess its potential role in human obesity...
- A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians
Yunhua Li Muller
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease NIH, 4212 N 16th Street, Phoenix, AZ 85016, USA
Diabetes 52:895-8. 2003
..These data indicate that the Gly482Ser missense polymorphism in PGC-1 has metabolic consequences on lipid metabolism that could influence insulin secretion...
- Glucose allostasis
Michael Stumvoll
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
Diabetes 52:903-9. 2003
..With increasing severity and over time, the allostatic load (increase in glycemia) may have pathological consequences, such as the development of type 2 diabetes...
- Variants in the interleukin 6 receptor gene are associated with obesity in Pima Indians
Johanna K Wolford
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, Phoenix, AZ 85016, USA
Mol Genet Metab 80:338-43. 2003
..0+/-7.5]; P=0.02-0.004). Our findings suggest that genetic variants in the IL6R gene may play a role in susceptibility to obesity. Assessment of these SNPs in other populations will be useful to determine the magnitude of obesity risk...
- CHRM3 gene variation is associated with decreased acute insulin secretion and increased risk for early-onset type 2 diabetes in Pima Indians
Yan Guo
Diabetes Molecular Genetics Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 445 N 5th St, Suite 210, Phoenix, AZ 85004, USA
Diabetes 55:3625-9. 2006
..00006) and was also modestly associated with increased risk of early-onset type 2 diabetes (adjusted P = 0.02)...
- Elevated plasma nonesterified fatty acids are associated with deterioration of acute insulin response in IGT but not NGT
Norbert Stefan
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
Am J Physiol Endocrinol Metab 284:E1156-61. 2003
..However, in subjects who have progressed to a state of IGT, chronically elevated NEFA seem to have a deleterious effect on insulin-secretory capacity...
- Association analysis of Krüppel-like factor 11 variants with type 2 diabetes in Pima Indians
Lijun Ma
Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Phoenix, Arizona 85004, USA
J Clin Endocrinol Metab 93:3644-9. 2008
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- Higher fasting plasma concentrations of glucagon-like peptide 1 are associated with higher resting energy expenditure and fat oxidation rates in humans
Nicola Pannacciulli
Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
Am J Clin Nutr 84:556-60. 2006
..Glucagon-like peptide 1 (GLP-1) is a gut hormone that decreases appetite and promotes satiety. Its role in energy metabolism regulation is still poorly understood...
- The effect of insulin on net lipid oxidation predicts worsening of insulin resistance and development of type 2 diabetes mellitus
Juraj Koska
Obesity and Diabetes Clinical Research Section, NIDDK NIH DHHS, 4212 N 16th St, Rm 5 35, Phoenix, AZ 85016, USA
Am J Physiol Endocrinol Metab 293:E264-9. 2007
..04). These data indicate that the inability of insulin to suppress L(ox) may represent an early risk marker for insulin resistance and T2DM that is independent of adiposity, acute insulin secretion, and insulin action on glucose uptake...
- Increased fat accumulation in liver may link insulin resistance with subcutaneous abdominal adipocyte enlargement, visceral adiposity, and hypoadiponectinemia in obese individuals
Juraj Koska
Obesity and Diabetes Clinical Research Section, NIDDK NIH DHHS, Phoenix, AZ 85016, USA
Am J Clin Nutr 87:295-302. 2008
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- Variants in ARHGEF11, a candidate gene for the linkage to type 2 diabetes on chromosome 1q, are nominally associated with insulin resistance and type 2 diabetes in Pima Indians
Lijun Ma
Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85004, USA
Diabetes 56:1454-9. 2007
..01). These findings suggest that variation within ARHGEF11 nominally increases risk of type 2 diabetes, possibly as a result of increased insulin resistance...
- A functional variant in the peroxisome proliferator-activated receptor gamma2 promoter is associated with predictors of obesity and type 2 diabetes in Pima Indians
Yunhua Li Muller
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, Arizona 85016, USA
Diabetes 52:1864-71. 2003
....
A genome-wide association study of BMI in American IndiansAlka Malhotra
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA
Obesity (Silver Spring) 19:2102-6. 2011
..53 × 10(-6)) for the within-family tests. Further analysis is important because only a few of these regions have been previously implicated in a GWAS and genetic susceptibility may differ by ethnicity...
- Variants in ASK1 are associated with skeletal muscle ASK1 expression, in vivo insulin resistance, and type 2 diabetes in Pima Indians
Li Bian
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Phoenix, Arizona, USA
Diabetes 59:1276-82. 2010
..Genetic variants in or near ASK1 were analyzed to assess the role of this gene in insulin action and type 2 diabetes...
- Differential expression of matrix metalloproteinase 3 (MMP3) in preadipocytes/stromal vascular cells from nonobese nondiabetic versus obese nondiabetic Pima Indians
Michael T Traurig
NIDDK, NIH, 445 North 5th St, Phoenix, AZ 85004, USA
Diabetes 55:3160-5. 2006
....
- Association analyses of variants in the DIO2 gene with early-onset type 2 diabetes mellitus in Pima Indians
Saraswathy Nair
Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
Thyroid 22:80-7. 2012
..Thyroid hormones regulate energy balance and may also influence glucose metabolism. Therefore, we hypothesized that variations in DIO2 could contribute to obesity or type 2 diabetes mellitus (T2DM) in Pima Indians...
- A novel missense substitution (Val1483Ile) in the fatty acid synthase gene (FAS) is associated with percentage of body fat and substrate oxidation rates in nondiabetic Pima Indians
Peter Kovacs
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
Diabetes 53:1915-9. 2004
..Our findings indicate that the Val1483Ile substitution in FAS is protective against obesity in Pima Indians, an effect possibly explained by the role of this gene in the regulation of substrate oxidation...
- Parasympathetic blockade attenuates augmented pancreatic polypeptide but not insulin secretion in Pima Indians
Barbora Vozarova de Courten
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
Diabetes 53:663-71. 2004
..However, the hyperinsulinemia of this population does not appear to be due to increased vagal input to pancreatic beta-cells...
- Genetic variation in the human winged helix/forkhead transcription factor gene FOXC2 in Pima Indians
Peter Kovacs
Department of Health and Human Services, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIH, 4212 N 16th Street, Phoenix, AZ 85016, USA
Diabetes 52:1292-5. 2003
....
- Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans
Norbert Stefan
Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
Diabetes 51:1884-8. 2002
..Prospectively, low plasma adiponectin concentration at baseline precedes a decrease in insulin sensitivity. Our data indicate that adiponectin plays an important role in regulation of insulin sensitivity in humans...
- Greater impact of melanocortin-4 receptor deficiency on rates of growth and risk of type 2 diabetes during childhood compared with adulthood in Pima Indians
Marie S Thearle
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
Diabetes 61:250-7. 2012
..The greater rates of body mass accumulation and risk of type 2 diabetes before the age of 20 years in individuals with MC4R deficiency indicate that the effects of these mutations are more apparent during the active growth of childhood...
- Variants in the LEPR gene are nominally associated with higher BMI and lower 24-h energy expenditure in Pima Indians
Michael T Traurig
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health Phoenix, Phoenix, Arizona, USA
Obesity (Silver Spring) 20:2426-30. 2012
..0007 adjusted for age, sex, fat mass, fat-free mass, activity, and family membership). We conclude that common noncoding variation in the LEPR gene is associated with higher BMI and lower energy expenditure in Native Americans...
- Molecular analysis of KCNJ10 on 1q as a candidate gene for Type 2 diabetes in Pima Indians
Vidya S Farook
Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
Diabetes 51:3342-6. 2002
..1 to 2.9. We conclude that these variants in KCNJ10 are unlikely to be the cause of linkage of type 2 diabetes with 1q in Pima Indians...
- Bimodal distribution of RNA expression levels in human skeletal muscle tissue
Clinton C Mason
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, 1550 E, Indian School Rd, Phoenix, AZ 85014, USA
BMC Genomics 12:98. 2011
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- Evaluation of the microsomal glutathione S-transferase 3 (MGST3) locus on 1q23 as a Type 2 diabetes susceptibility gene in Pima Indians
Farook Thameem
Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
Hum Genet 113:353-8. 2003
..We conclude that alterations of MGST3 are unlikely to contribute to T2DM or differences in insulin sensitivity in the Pima Indians...
- Melanocortin 4 receptor gene variation is associated with severe obesity in Pima Indians
Lijun Ma
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, 4212 N 16th St, Phoenix, AZ 85016, USA
Diabetes 53:2696-9. 2004
..We conclude that variations in MC4R may account for a small portion of obesity in Pima Indians, but they do not explain the overall high prevalence of obesity in this Native American population...
- Lower total fasting plasma adiponectin concentrations are associated with higher metabolic rates
Nicola Pannacciulli
Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH DHHS, 4212 North 16th Street, Phoenix, AZ 85016, USA
J Clin Endocrinol Metab 91:1600-3. 2006
..The possible role of adiponectin, a protein uniquely produced by the adipose tissue and significantly reduced in obesity and other insulin-resistant states, in the regulation of energy expenditure (EE) is still poorly understood...
- A C-reactive protein promoter polymorphism is associated with type 2 diabetes mellitus in Pima Indians
Johanna K Wolford
Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
Mol Genet Metab 78:136-44. 2003
..However, these findings suggest that variation within the CRP locus may play a role in diabetes susceptibility in Pima Indians...
- Palmitate action to inhibit glycogen synthase and stimulate protein phosphatase 2A increases with risk factors for type 2 diabetes
David M Mott
Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIH, 4212 N 16th Street, Phoenix, AZ 85016, USA
Am J Physiol Endocrinol Metab 294:E444-50. 2008
..We conclude that subjects at risk for Type 2 diabetes have intrinsic differences in palmitate regulation of at least two enzymes (PP2A and glycogen synthase), contributing to abnormal insulin regulation of glucose metabolism...
- Association of amino acid variants in the activating transcription factor 6 gene (ATF6) on 1q21-q23 with type 2 diabetes in Pima Indians
Farook Thameem
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 445 N 5th St, Suite 210, Phoenix, AZ 85004, USA
Diabetes 55:839-42. 2006
..Because these variants are not unique to the Pimas, it will be feasible to investigate their association with type 2 diabetes in other populations to better evaluate their significance for a predisposition to the disease...
- Plasma concentrations of free triiodothyronine predict weight change in euthyroid persons
Emilio Ortega
Phoenix Epidemiological Clinical and Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Phoenix, AZ 85016, USA
Am J Clin Nutr 85:440-5. 2007
..Factors that influence energy metabolism and substrate oxidation, such as thyroid hormones (THs), may be important regulators of body weight...
- Evidence for a role of LPGAT1 in influencing BMI and percent body fat in native Americans
Michael T Traurig
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, Arizona, USA
Obesity (Silver Spring) 21:193-202. 2013
..Therefore LPGAT1 was analyzed as a candidate gene for obesity in Pima Indians...
- Positional cloning of an obesity/diabetes susceptibility gene(s) on chromosome 11 in Pima Indians
Leslie Baier
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Arizona 85016, USA
Ann N Y Acad Sci 967:258-64. 2002
..A region containing a cluster of SNPs strongly associated with BMI and a second region, approximately 2 Mb telomeric, containing a cluster of SNPs associated with diabetes have been preliminarily identified...
- Effect of paternal diabetes on pre-diabetic phenotypes in adult offspring
Adela Penesova
Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Phoenix, Arizona, USA
Diabetes Care 33:1823-8. 2010
..We aimed to examine a metabolic phenotype in three different groups of offspring to see distinct paternal versus maternal effects...
- Polymorphisms in the oxygen-regulated protein 150 gene (ORP150) are associated with insulin resistance in Pima Indians
Peter Kovacs
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK, National Institutes of Health, Phoenix, Arizona 85016, USA
Diabetes 51:1618-21. 2002
..These data indicate that ORP150 has a role in insulin action but does not have a major role in determining susceptibility to type 2 diabetes in Pima Indians...
- Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans
Reiner Jumpertz
Obesity and Diabetes Clinical Research Section, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
Am J Clin Nutr 94:58-65. 2011
..However, it remains uncertain as to what extent gut microbiota are an important regulator of nutrient absorption in humans...
- Lower energy expenditure predicts long-term increases in weight and fat mass
Paolo Piaggi
PhD, Postdoctorate Researcher, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Obesity and Diabetes Clinical Research Section, Phoenix, Arizona 85016
J Clin Endocrinol Metab 98:E703-7. 2013
..018, P = .853). Conclusions: Measures of energy expenditure and substrate oxidation are predictors of long-term weight change, indicating a small but significant role for reduced metabolic rate in weight gain...
- Cloning, expression and genomic structure of human LMX1A, and variant screening in Pima Indians
Farook Thameem
Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
Gene 290:217-25. 2002
..We did not find evidence for association of any LMX1A SNPs with T2DM and conclude that LMX1A does not contribute significantly to T2DM etiology in Pima Indians...
- High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes
Barbora Vozarova
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
Diabetes 51:455-61. 2002
..These findings are consistent with the hypothesis that a chronic activation of the immune system may play a role in the pathogenesis of type 2 diabetes...
- Identification of susceptibility genes for complex metabolic diseases
Clifton Bogardus
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
Ann N Y Acad Sci 967:1-6. 2002
..Nonetheless, genetic strategies have emerged that, when the technologies are fully developed, should allow similar success rates as for Mendelian diseases...
- The transcribed endosulfine alpha gene is located within a type 2 diabetes-linked region on 1q: sequence and expression analysis in Pima Indians
Farook Thameem
Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix AZ, USA
Mol Genet Metab 81:16-21. 2004
..We conclude that sequence alterations in ENSA are an unlikely cause for the linkage of T2DM with 1q21-q23 in the Pima Indians...
- Association of a F479L variant in the cytosolic phospholipase A2 gene (PLA2G4A) with decreased glucose turnover and oxidation rates in Pima Indians
Johanna K Wolford
Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th Street, AZ 85016, USA
Mol Genet Metab 79:61-6. 2003
..77+/-0.25 vs. 0.67+/-0.23 mg/kgEMBS/min; p=0.02). These results provide evidence supporting a role for the eicosanoid biosynthesis pathway in type 2 diabetes mellitus pathophysiology...
- Identification of novel putative membrane proteins selectively expressed during adipose conversion of 3T3-L1 cells
Aimin Xu
The School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
Biochem Biophys Res Commun 293:1161-7. 2002
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- At work with the Pima
Andrew Curry
Diabetes Forecast 61:67-9. 2008
- Meta-analysis of 23 type 2 diabetes linkage studies from the International Type 2 Diabetes Linkage Analysis Consortium
Weihua Guan
Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
Hum Hered 66:35-49. 2008
..The International Type 2 Diabetes Linkage Analysis Consortium was formed to localize type 2 diabetes predisposing variants based on 23 autosomal linkage scans...
- The role of glucose allostasis in type 2 diabetes
Michael Stumvoll
, , 72076 Tuebingen, Germany
Rev Endocr Metab Disord 5:99-103. 2004
- Identification of individuals with insulin resistance using routine clinical measurements
Steven E Stern
School of Finance and Applied Statistics, Australian National University, Canberra, Australia
Diabetes 54:333-9. 2005
..1%), sensitivity (81.3%), and specificity (76.3%). Thus, insulin-resistant individuals can be identified using simple decision rules that can be tailored to specific needs...
