Hendrikus H. Boersma

Summary

Affiliation: University of Groningen, University Medical Center
Location: Groningen, The Netherlands
Summary:
Hospital Pharmacist (since 2000)
-Clinical Pharmacologist (since 2003),
-Radiopharmacist (1998-2007 and from 1 sept 2009)
-Qualified Person
-Fields of interest
*Radiopharmacy
*GMP/ Quality Assurance
*scientific research on radiopharmaceutical topics
*electronic prescription.

-Member of an Institutional Ethics Review Board
-(co-) author of 32 scientific papers (Scopus). 22 of these are Pubmed indexed.
-Science Citation index score: over 500 citations, h index = 9
-Regular paper review for the Journal of Nuclear Medicine and several other scientific journals.
-Supervisor of 2 PhD-students

Specialties-Broad interest in Hospital Pharmacy
-Medication release for Clinical Trials
-Scientific research
-Radiopharmacy, specialized in cell death related radiolabeling/ imaging techniques as well as other topics in the cardiovascular/ oncology field
-GMP/ GLP audits
-Education in radiopharmacy

Grants:
Universiteit Maastricht: PhD,
Medicine & Life Sciences
2000

Publications

  1. ncbi request reprint Simulation studies and the alignment of interests
    Godefridus G van Merode
    Department of Health Organization, Policy and Economics, Maastricht University, The Netherlands F vanMerode beoz unimaas nl
    Health Care Manag Sci 5:97-102. 2002
  2. ncbi request reprint In vivo detection of cell death in the area at risk in acute myocardial infarction
    Paul W L Thimister
    Department of Nuclear Medicine, University Hospital Maastricht, Maastricht, The Netherlands
    J Nucl Med 44:391-6. 2003
  3. ncbi request reprint Past, present, and future of annexin A5: from protein discovery to clinical applications
    Hendrikus H Boersma
    Department of Nuclear Medicine, Maastricht University Hospital, Maastricht, The Netherlands
    J Nucl Med 46:2035-50. 2005
  4. ncbi request reprint Noninvasive detection of programmed cell loss with 99mTc-labeled annexin A5 in heart failure
    Bas L J H Kietselaer
    Department of Cardiology, University Hospital of Maastricht, Maastricht, The Netherlands
    J Nucl Med 48:562-7. 2007
  5. doi request reprint Molecular imaging of matrix metalloproteinase in atherosclerotic lesions: resolution with dietary modification and statin therapy
    Shinichiro Fujimoto
    University of California, Irvine School of Medicine, Irvine, California 92697, USA
    J Am Coll Cardiol 52:1847-57. 2008
  6. ncbi request reprint Growth factor/peptide receptor imaging for the development of targeted therapy in oncology
    Christophe Van de Wiele
    Department of Nuclear Medicine, De Pintelaan 185B, 9000 Ghent, Belgium
    Curr Pharm Des 14:3340-7. 2008
  7. pmc Small-animal SPECT and SPECT/CT: application in cardiovascular research
    Reza Golestani
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands
    Eur J Nucl Med Mol Imaging 37:1766-77. 2010
  8. pmc Radionuclide imaging of bone marrow disorders
    Ali Agool
    Department of Nuclear Medicine, Medical Center Twente, Hengelo, The Netherlands
    Eur J Nucl Med Mol Imaging 38:166-78. 2011
  9. pmc Early molecular imaging of interstitial changes in patients after myocardial infarction: comparison with delayed contrast-enhanced magnetic resonance imaging
    Johan Verjans
    Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands
    J Nucl Cardiol 17:1065-72. 2010
  10. doi request reprint Abdominal aortic calcification detected by dual X-ray absorptiometry: A strong predictor for cardiovascular events
    Reza Golestani
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen UMCG, University of Groningen, Groningen, The Netherlands
    Ann Med 42:539-45. 2010

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Simulation studies and the alignment of interests
    Godefridus G van Merode
    Department of Health Organization, Policy and Economics, Maastricht University, The Netherlands F vanMerode beoz unimaas nl
    Health Care Manag Sci 5:97-102. 2002
    ..In practice actors will behave not as recommended by the simulation model. The cause of the latter is analyzed and solutions are proposed...
  2. ncbi request reprint In vivo detection of cell death in the area at risk in acute myocardial infarction
    Paul W L Thimister
    Department of Nuclear Medicine, University Hospital Maastricht, Maastricht, The Netherlands
    J Nucl Med 44:391-6. 2003
    ..An increased programmed cell death rate has been reported in the heart after myocardial infarction (MI). The aim of this study was to correctly localize annexin A5 uptake in vivo and to determine the area at risk in humans with acute MI...
  3. ncbi request reprint Past, present, and future of annexin A5: from protein discovery to clinical applications
    Hendrikus H Boersma
    Department of Nuclear Medicine, Maastricht University Hospital, Maastricht, The Netherlands
    J Nucl Med 46:2035-50. 2005
    ..In addition, experiences with radiolabeled anxA5 open novel avenues for drug targeting with anxA5 as a biologic "cruise missile."..
  4. ncbi request reprint Noninvasive detection of programmed cell loss with 99mTc-labeled annexin A5 in heart failure
    Bas L J H Kietselaer
    Department of Cardiology, University Hospital of Maastricht, Maastricht, The Netherlands
    J Nucl Med 48:562-7. 2007
    ..The present study evaluated the role of annexin A5 imaging for detection of PCD in heart failure patients...
  5. doi request reprint Molecular imaging of matrix metalloproteinase in atherosclerotic lesions: resolution with dietary modification and statin therapy
    Shinichiro Fujimoto
    University of California, Irvine School of Medicine, Irvine, California 92697, USA
    J Am Coll Cardiol 52:1847-57. 2008
    ....
  6. ncbi request reprint Growth factor/peptide receptor imaging for the development of targeted therapy in oncology
    Christophe Van de Wiele
    Department of Nuclear Medicine, De Pintelaan 185B, 9000 Ghent, Belgium
    Curr Pharm Des 14:3340-7. 2008
    ....
  7. pmc Small-animal SPECT and SPECT/CT: application in cardiovascular research
    Reza Golestani
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands
    Eur J Nucl Med Mol Imaging 37:1766-77. 2010
    ....
  8. pmc Radionuclide imaging of bone marrow disorders
    Ali Agool
    Department of Nuclear Medicine, Medical Center Twente, Hengelo, The Netherlands
    Eur J Nucl Med Mol Imaging 38:166-78. 2011
    ..In this review the imaging of different bone marrow targets with radionuclides including PET tracers in various bone marrow diseases are discussed...
  9. pmc Early molecular imaging of interstitial changes in patients after myocardial infarction: comparison with delayed contrast-enhanced magnetic resonance imaging
    Johan Verjans
    Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands
    J Nucl Cardiol 17:1065-72. 2010
    ..In experimental studies, RIP has been shown to target integrins associated with collagen-producing myofibroblasts (MFB)...
  10. doi request reprint Abdominal aortic calcification detected by dual X-ray absorptiometry: A strong predictor for cardiovascular events
    Reza Golestani
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen UMCG, University of Groningen, Groningen, The Netherlands
    Ann Med 42:539-45. 2010
    ..AAC correlates with total atherosclerosis burden. We questioned whether VFA-detected AAC could be used for cardiovascular risk assessment...
  11. pmc Myocardial perfusion reserve compared with peripheral perfusion reserve: a [13N]ammonia PET study
    A M Scholtens
    Department of Imaging, University Medical Center Utrecht, E01 132, P O Box 85500, 3508GA Utrecht, The Netherlands
    J Nucl Cardiol 18:238-46. 2011
    ..We compared perfusion flow in the myocardium with the upper limb during rest and adenosine stress [13N]ammonia PET to establish whether peripheral perfusion reserve (PPR) correlates with MPR...
  12. ncbi request reprint Stem cell tracking: reversing the silence of the lambs
    Hendrikus H Boersma
    Maastricht University Hospital Maastricht, NL 6202 Maastricht, The Netherlands
    J Nucl Med 46:200-3. 2005
  13. ncbi request reprint The ApoCorrect assay: a novel, rapid method to determine the biological functionality of radiolabeled and fluorescent Annexin A5
    Hendrikus H Boersma
    Department of Clinical Pharmacy and Toxicology, University Hospital Maastricht, P O Box 5800, NL 6202 AZ Maastricht, The Netherlands
    Anal Biochem 327:126-34. 2004
    ..The bead assay is specific, stability-indicating, repeatable, and reproducible. It allows one to determine within 25 min the biological active fraction of a 99mTc-Annexin A5 preparation. We dubbed this assay the ApoCorrect assay...
  14. pmc Oral tegafur/folinic acid chemotherapy decreases phenytoin efficacy
    N M L Veldhorst-Janssen
    Br J Cancer 90:745. 2004
  15. ncbi request reprint Transient enhanced uptake of 123I-metaiodobenzylguanidine in the contralateral adrenal region after resection of an adrenal pheochromocytoma
    H H Boersma
    N Engl J Med 342:1450-1. 2000
  16. ncbi request reprint Visualisation of cell death in vivo in patients with acute myocardial infarction
    L Hofstra
    Department of Cardiology, University Hospital Maastricht, The Netherlands
    Lancet 356:209-12. 2000
    ..We studied in-vivo cell death in the hearts of patients with an acute myocardial infarction using imaging with technetium-99m-labelled annexin-V-a protein that binds to cells undergoing apoptosis...
  17. ncbi request reprint Patient dosimetry of intravenously administered 99mTc-annexin V
    G J Kemerink
    Department of Nuclear Medicine, University Hospital Maastricht, The Netherlands
    J Nucl Med 42:382-7. 2001
    ..Because information on biodistribution and radiation burden is desired for the application of any radiopharmaceutical, a dosimetric study of 99mTc-i-AnxV was undertaken...
  18. ncbi request reprint In vivo detection of apoptosis in an intracardiac tumor
    L Hofstra
    JAMA 285:1841-2. 2001
  19. ncbi request reprint Biodistribution and dosimetry of 99mTc-BTAP-annexin-V in humans
    G J Kemerink
    Department of Nuclear Medicine, University Hospital Maastricht, The Netherlands
    Eur J Nucl Med 28:1373-8. 2001
    ..The faster appearance of activity in the intestines may preclude imaging of apoptosis in the abdomen. The effective dose is within the lower range of values reported for typical 99mTc compounds...
  20. ncbi request reprint Compensatory uptake of I-123 MIBG in the contralateral adrenal gland after removal of a pheochromocytoma
    Hendrikus H Boersma
    Department of Nuclear Medicine, University Hospital Maastricht, Maastricht, The Netherlands
    Clin Nucl Med 27:113-6. 2002
    ..They also highlight the need for careful follow-up of such patients to distinguish between physiologic and pathologic processes...
  21. ncbi request reprint Comparison between human pharmacokinetics and imaging properties of two conjugation methods for 99mTc-annexin A5
    H H Boersma
    Department of Nuclear Medicine, University Hospital Maastricht, P O Box 5800, NL 6202 AZ Maastricht, The Netherlands
    Br J Radiol 76:553-60. 2003
    ..B-AnxA5 has a faster clearance and a lower radiation dose. Imaging of apoptosis in the abdomen will be difficult with both radiopharmaceuticals, and especially with B-AnxA5 because of its faster appearance in the gut...
  22. doi request reprint In vivo imaging of apoptosis in oncology: an update
    Christel Vangestel
    Department ofGastroenterology, University Hospital Ghent, Belgium
    Mol Imaging 10:340-58. 2011
    ..In the future, rapid progress in the field of apoptosis imaging in oncology is expected...