Influence of endothelin 1 receptor inhibition on functional, structural and molecular changes in the rat heart after irradiationMarjan Boerma
University of Arkansas for Medical Sciences, Department of Pharmaceutical Sciences, Little Rock, Arkansas, USA
Radiat Res 170:275-83. 2008
..Because of the known opposing effects of ETA and ETB, studies with selective antagonists may clarify the role of each receptor...
- Reduction of radiation-induced vascular nitrosative stress by the vitamin E analog γ-tocotrienol: evidence of a role for tetrahydrobiopterin
Maaike Berbee
University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Int J Radiat Oncol Biol Phys 79:884-91. 2011
..This study investigated the effects of radiation on BH4 bioavailability and of GT3 on BH4 metabolism...
- The somatostatin analog SOM230 (pasireotide) ameliorates injury of the intestinal mucosa and increases survival after total-body irradiation by inhibiting exocrine pancreatic secretion
Qiang Fu
Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Radiat Res 171:698-707. 2009
..The mechanism likely involves reduction of intraluminal pancreatic enzymes. Because of its efficacy and favorable safety profile, SOM230 is a promising countermeasure against radiation and should undergo further development...
- Influence of sublethal total-body irradiation on immune cell populations in the intestinal mucosa
Sarita Garg
Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Radiat Res 173:469-78. 2010
..We conclude that the intestinal immune system undergoes profound changes after sublethal TBI and that these changes likely contribute to postirradiation pathophysiological manifestations...
- Simvastatin ameliorates radiation enteropathy development after localized, fractionated irradiation by a protein C-independent mechanism
Junru Wang
Department of Surgery, Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA
Int J Radiat Oncol Biol Phys 68:1483-90. 2007
..We examined whether administration of simvastatin ameliorates intestinal radiation injury, and whether the effect depends on protein C activation...
- Involvement of heat shock factor 1 in statin-induced transcriptional upregulation of endothelial thrombomodulin
Qiang Fu
Department of Microbiology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Circ Res 103:369-77. 2008
..These results may have broad implications and suggest the use of heat shock protein modulators to selectively regulate pleiotropic statin effects...
- Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin
Marjan Boerma
Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA
Blood Coagul Fibrinolysis 19:709-18. 2008
..These results form the basis for further studies to assess the possible therapeutic benefit of combined treatments...
- Activation of protease activated receptor 2 by exogenous agonist exacerbates early radiation injury in rat intestine
Junru Wang
Division of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, AR, USA
Int J Radiat Oncol Biol Phys 77:1206-12. 2010
..We examined the mechanistic significance of radiation enteropathy development by assessing the effect of exogenous PAR(2) activation...
- Prevention and treatment of functional and structural radiation injury in the rat heart by pentoxifylline and alpha-tocopherol
Marjan Boerma
Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Int J Radiat Oncol Biol Phys 72:170-7. 2008
..Radiation-induced heart disease (RIHD) is a severe side effect of thoracic radiotherapy. This study examined the effects of pentoxifylline (PTX) and alpha-tocopherol on cardiac injury in a rat model of RIHD...
- Preclinical evaluation of Som230 as a radiation mitigator in a mouse model: postexposure time window and mechanisms of action
Qiang Fu
Division of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Radiat Res 175:728-35. 2011
..The mechanism likely involves preservation of intestinal barrier function due to decreased secretion of pancreatic enzymes into the bowel lumen...
- gamma-Tocotrienol ameliorates intestinal radiation injury and reduces vascular oxidative stress after total-body irradiation by an HMG-CoA reductase-dependent mechanism
Maaike Berbee
Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Radiat Res 171:596-605. 2009
..The radioprotective efficacy of GT3 against vascular injury is related to its properties as an HMG-CoA reductase inhibitor...
Influence of mast cells on structural and functional manifestations of radiation-induced heart diseaseMarjan Boerma
Department of Surgery and Pathology, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, 4301 West Markham, Slot 725, Little Rock, AR 72205, USA
Cancer Res 65:3100-7. 2005
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Impact of vascular endothelial growth factor on skin graft survival in irradiated ratsGresham T Richter
Department of Otolaryngology Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Arch Facial Plast Surg 11:110-3. 2009
..To evaluate the effect of vascular endothelial growth factor (VEGF) on full-thickness skin graft (FTSG) survival on irradiated tissue as a model of wound healing in ischemic conditions...
- Local administration of interleukin-11 ameliorates intestinal radiation injury in rats
Marjan Boerma
Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Cancer Res 67:9501-6. 2007
..These data show that local administration of rhIL-11 ameliorates early intestinal radiation injury and support further development of rhIL-11 to reduce manifestations of intestinal radiation injury in the clinic...
- Selective deficiency of HIF-1alpha in myeloid cells influences secondary intention wound healing in mouse skin
Richard A Owings
Department of Pathology, University of Arkanas for Medical Sciences, Little Rock, AR, USA
In Vivo 23:879-84. 2009
..Hypoxia-inducible factor-1 (HIF-1) influences myeloid cell function. In this study we examined the role of myeloid cell HIF-1alpha on wound healing in vivo using a cell-specific knockout (KO) mouse model...
- Influence of mast cells on outcome after heterotopic cardiac transplantation in rats
Marjan Boerma
Department of Surgery, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA
Transpl Int 20:256-65. 2007
..Histopathological changes in all donor hearts were accompanied by increased immunoreactivity for ET-1. In conclusion, this study shows that mast cells play a protective role after cardiac transplantation...
- Mechanisms underlying the radioprotective properties of γ-tocotrienol: comparative gene expression profiling in tocol-treated endothelial cells
Maaike Berbee
Division of Radiation Health, University of Arkansas for Medical Sciences, 4301 West Markham, Slot 522 10, Little Rock, AR, 72205, USA
Genes Nutr 7:75-81. 2012
..These results form the basis for further studies to determine the exact importance of differentially affected GO functional clusters in endothelial radioprotection by GT3...
- Radiation damage to the gastrointestinal tract: mechanisms, diagnosis, and management
Martin Hauer-Jensen
Department of Surgery and Pathology, University of Arkansas for Medical Sciences and Surgery Service, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA
Curr Opin Support Palliat Care 1:23-9. 2007
..To summarize current knowledge about gastrointestinal radiation toxicity, with emphasis on mechanisms and clinical diagnosis and management...
- Experimental radiation-induced heart disease: past, present, and future
Marjan Boerma
Division of Radiation Health, Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Radiat Res 178:1-6. 2012
..The long-term goal of this work is to identify targets for intervention in RIHD, thereby enhancing the efficacy and safety of thoracic radiotherapy...
- Cardiac inflammation after local irradiation is influenced by the kallikrein-kinin system
Vijayalakshmi Sridharan
Division of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Cancer Res 72:4984-92. 2012
..These results suggest that the KKS plays a role in the effects of radiation on cardiac function and recruitment of inflammatory cells. The KKS may have these effects at least in part by altering Erk1/2 signaling...
- Orazipone, a locally acting immunomodulator, ameliorates intestinal radiation injury: a preclinical study in a novel rat model
Marjan Boerma
Department of Surgery, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA
Int J Radiat Oncol Biol Phys 66:552-9. 2006
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- Acute dilatory and negative inotropic effects of homocysteine are inhibited by an adenosine blocker
Richard H Kennedy
Department of Pharmaceutical Sciences and Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Arkansas, USA
Clin Exp Pharmacol Physiol 33:340-4. 2006
..However, the relatively minor antagonistic action of SPT on the inotropic effect of homocysteine suggests that additional endothelium-derived mediators underlie its effects on contractility...
- Radiation responses in skin and connective tissues: effect on wound healing and surgical outcome
Junru Wang
Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Hernia 10:502-6. 2006
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- Comparative expression profiling in primary and immortalized endothelial cells: changes in gene expression in response to hydroxy methylglutaryl-coenzyme A reductase inhibition
Marjan Boerma
Department of Surgery, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205, USA
Blood Coagul Fibrinolysis 17:173-80. 2006
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- Increased deposition of von Willebrand factor in the rat heart after local ionizing irradiation
Marjan Boerma
Department of Clinical Oncology K1 P, Leiden University Medical Center, The Netherlands
Strahlenther Onkol 180:109-16. 2004
..Increased amounts of vWf in blood plasma or tissue samples are indicative of damaged endothelium. In the present study, mRNA expression and localization of vWf were determined in irradiated rat heart tissue...
