Frederic H Vaillancourt
Affiliation: Boehringer Ingelheim
- Evaluation of phosphatidylinositol-4-kinase IIIα as a hepatitis C virus drug targetFrederic H Vaillancourt
Boehringer Ingelheim Ltd, Laval, Quebec, Canada
J Virol 86:11595-607. 2012..This essential host physiologic role raises doubt about the pursuit of PI4KIIIα inhibitors for treatment of chronic HCV infection...
- Identification of a lipid kinase as a host factor involved in hepatitis C virus RNA replicationFrederic H Vaillancourt
Boehringer Ingelheim Canada Ltd, 2100 Cunard St, Laval, QC, Canada H7S 2G5
Virology 387:5-10. 2009....
- Phosphatidylinositol 4-kinase III beta is essential for replication of human rhinovirus and its inhibition causes a lethal phenotype in vivoCatherine Spickler
Boehringer Ingelheim Canada Ltd, Laval, Quebec, Canada
Antimicrob Agents Chemother 57:3358-68. 2013..Mortality was seen in all dosing groups of mice treated with either compound, therefore suggesting that short-term inhibition of PI4KIIIβ is deleterious...