Jochen Urthaler

Summary

Affiliation: Boehringer Ingelheim

Publications

  1. ncbi request reprint Application of monoliths for plasmid DNA purification development and transfer to production
    Jochen Urthaler
    Boehringer Ingelheim Austria GmbH, Dr Boehringer Gasse 5 11, A 1121 Vienna, Austria
    J Chromatogr A 1065:93-106. 2005
  2. ncbi request reprint Improved downstream process for the production of plasmid DNA for gene therapy
    Jochen Urthaler
    Boehringer Ingelheim Austria GmbH, Vienna, Austria
    Acta Biochim Pol 52:703-11. 2005
  3. ncbi request reprint Automated alkaline lysis for industrial scale cGMP production of pharmaceutical grade plasmid-DNA
    Jochen Urthaler
    Boehringer Ingelheim Austria GmbH, Dr Boehringer Gasse 5 11, A 1121 Vienna, Austria
    J Biotechnol 128:132-49. 2007
  4. ncbi request reprint Mass transfer characteristics of plasmids in monoliths
    Alfred Zöchling
    Institute of Applied Microbiology, University of Natural Resources and Applied Life Sciences, Muthgasse 18, A 1190 Vienna, Austria
    J Sep Sci 27:819-27. 2004

Collaborators

Detail Information

Publications4

  1. ncbi request reprint Application of monoliths for plasmid DNA purification development and transfer to production
    Jochen Urthaler
    Boehringer Ingelheim Austria GmbH, Dr Boehringer Gasse 5 11, A 1121 Vienna, Austria
    J Chromatogr A 1065:93-106. 2005
    ..The analytical results obtained from these runs confirmed suitability for pharmaceutical applications...
  2. ncbi request reprint Improved downstream process for the production of plasmid DNA for gene therapy
    Jochen Urthaler
    Boehringer Ingelheim Austria GmbH, Vienna, Austria
    Acta Biochim Pol 52:703-11. 2005
    ..It is scaleable and free of animal-derived substances, detergents (except lysis) and organic solvents. The process delivers high-purity plasmid DNA of homogeneities up to 98% supercoiled form at a high yield in any desired final buffer...
  3. ncbi request reprint Automated alkaline lysis for industrial scale cGMP production of pharmaceutical grade plasmid-DNA
    Jochen Urthaler
    Boehringer Ingelheim Austria GmbH, Dr Boehringer Gasse 5 11, A 1121 Vienna, Austria
    J Biotechnol 128:132-49. 2007
    ..The process does not need enzymes and it is scalable and routinely used for cGMP-production of pharmaceutical grade plasmid DNA from 200 L fermentations...
  4. ncbi request reprint Mass transfer characteristics of plasmids in monoliths
    Alfred Zöchling
    Institute of Applied Microbiology, University of Natural Resources and Applied Life Sciences, Muthgasse 18, A 1190 Vienna, Austria
    J Sep Sci 27:819-27. 2004
    ..These types of monoliths are considered to be the preferred adsorbents for plasmid separation...