Holger Rosenbrock

Summary

Affiliation: Boehringer Ingelheim

Publications

  1. ncbi request reprint Synaptic vesicle protein synaptoporin is differently expressed by subpopulations of mouse hippocampal neurons
    Ilyas Singec
    Department of Neuropathology, Neurocenter, University of Freiburg, Breisacher Strasse 64, D 79106 Freiburg, Germany
    J Comp Neurol 452:139-53. 2002
  2. ncbi request reprint Partial serotonergic denervation decreases progenitor cell proliferation in the adult rat hippocampus, but has no effect on rat behavior in the forced swimming test
    Holger Rosenbrock
    Department of CNS Research, Boehringer Ingelheim Pharma GmbH and Co KG, D 88397 Biberach, Germany
    Pharmacol Biochem Behav 80:549-56. 2005
  3. doi request reprint Restoring long-term potentiation impaired by amyloid-beta oligomers: comparison of an acetylcholinesterase inhibitior and selective neuronal nicotinic receptor agonists
    Katja S Kroker
    Boehringer Ingelheim Pharma GmbH and Co KG, Dept of CNS Diseases Research, Birkendorfer Strasse 65, 88397 Biberach, Germany
    Brain Res Bull 96:28-38. 2013
  4. doi request reprint Functional interaction of metabotropic glutamate receptor 5 and NMDA-receptor by a metabotropic glutamate receptor 5 positive allosteric modulator
    Holger Rosenbrock
    Boehringer Ingelheim Pharma GmbH and Co KG, Dept of CNS Diseases Research, Birkendorfer Strasse 65, 88397 Biberach, Germany
    Eur J Pharmacol 639:40-6. 2010
  5. doi request reprint Differential effect of the mGlu5 receptor positive allosteric modulator ADX-47273 on early and late hippocampal LTP
    Katja S Kroker
    Boehringer Ingelheim Pharma GmbH and Co KG, Department of CNS Diseases Research, Biberach, Germany
    Neuropharmacology 61:707-14. 2011
  6. doi request reprint Inhibition of acetylcholinesterase and phosphodiesterase-9A has differential effects on hippocampal early and late LTP
    Katja S Kroker
    Boehringer Ingelheim Pharma GmbH and Co KG, Dept of CNS Diseases Research, Birkendorfer Strasse 65, 88397 Biberach, Germany
    Neuropharmacology 62:1964-74. 2012
  7. ncbi request reprint Effect of chronic intermittent restraint stress on hippocampal expression of marker proteins for synaptic plasticity and progenitor cell proliferation in rats
    Holger Rosenbrock
    Department of CNS Research, Boehringer Ingelheim Pharma GmbH and Co KG, Birkendorfer Strasse 65, D 88397 Biberach, Germany
    Brain Res 1040:55-63. 2005
  8. doi request reprint Differential effects of subtype-specific nicotinic acetylcholine receptor agonists on early and late hippocampal LTP
    Katja S Kroker
    Boehringer Ingelheim Pharma GmbH and Co KG, Department of CNS Diseases Research, Birkendorfer Strasse 65, 88397 Biberach, Germany
    Eur J Pharmacol 671:26-32. 2011
  9. doi request reprint A multi-slice recording system for stable late phase hippocampal long-term potentiation experiments
    Katja Sabine Kroker
    Boehringer Ingelheim Pharma GmbH and Co KG, Dept of CNS Diseases Research, Birkendorfer Strasse 65, 88397 Biberach, Germany
    J Neurosci Methods 194:394-401. 2011
  10. ncbi request reprint Globular and protofibrillar aβ aggregates impair neurotransmission by different mechanisms
    Jens Moreth
    Department of CNS Diseases Research Germany, Boehringer Ingelheim Pharma GmbH and Co KG, Birkendorfer Strasse, Biberach an der Riss D 88397, Germany
    Biochemistry 52:1466-76. 2013

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Synaptic vesicle protein synaptoporin is differently expressed by subpopulations of mouse hippocampal neurons
    Ilyas Singec
    Department of Neuropathology, Neurocenter, University of Freiburg, Breisacher Strasse 64, D 79106 Freiburg, Germany
    J Comp Neurol 452:139-53. 2002
    ..In conclusion, our data demonstrate that hippocampal principal cells and interneurons display a variety of synaptic vesicles that are likely to contribute to the functional characteristics of their output synapses...
  2. ncbi request reprint Partial serotonergic denervation decreases progenitor cell proliferation in the adult rat hippocampus, but has no effect on rat behavior in the forced swimming test
    Holger Rosenbrock
    Department of CNS Research, Boehringer Ingelheim Pharma GmbH and Co KG, D 88397 Biberach, Germany
    Pharmacol Biochem Behav 80:549-56. 2005
    ..These findings indicate a regulative role of 5-HT for hippocampal progenitor cell proliferation and neurogenesis, but its relation to animal models of depression remains to be elucidated...
  3. doi request reprint Restoring long-term potentiation impaired by amyloid-beta oligomers: comparison of an acetylcholinesterase inhibitior and selective neuronal nicotinic receptor agonists
    Katja S Kroker
    Boehringer Ingelheim Pharma GmbH and Co KG, Dept of CNS Diseases Research, Birkendorfer Strasse 65, 88397 Biberach, Germany
    Brain Res Bull 96:28-38. 2013
    ..As activating α7 nAChRs was found to be most efficacious in restoring Aβ42 oligomer induced LTP deficits, targeting α7 nAChRs might represent a powerful alternative approach for symptomatic treatment of AD. ..
  4. doi request reprint Functional interaction of metabotropic glutamate receptor 5 and NMDA-receptor by a metabotropic glutamate receptor 5 positive allosteric modulator
    Holger Rosenbrock
    Boehringer Ingelheim Pharma GmbH and Co KG, Dept of CNS Diseases Research, Birkendorfer Strasse 65, 88397 Biberach, Germany
    Eur J Pharmacol 639:40-6. 2010
    ....
  5. doi request reprint Differential effect of the mGlu5 receptor positive allosteric modulator ADX-47273 on early and late hippocampal LTP
    Katja S Kroker
    Boehringer Ingelheim Pharma GmbH and Co KG, Department of CNS Diseases Research, Biberach, Germany
    Neuropharmacology 61:707-14. 2011
    ....
  6. doi request reprint Inhibition of acetylcholinesterase and phosphodiesterase-9A has differential effects on hippocampal early and late LTP
    Katja S Kroker
    Boehringer Ingelheim Pharma GmbH and Co KG, Dept of CNS Diseases Research, Birkendorfer Strasse 65, 88397 Biberach, Germany
    Neuropharmacology 62:1964-74. 2012
    ..In conclusion, this study demonstrates that BAY 73-6691 exhibits a stronger effect in enhancing and prolonging LTP than donepezil suggesting that PDE9 inhibition might be more efficacious in enhancing learning and memory...
  7. ncbi request reprint Effect of chronic intermittent restraint stress on hippocampal expression of marker proteins for synaptic plasticity and progenitor cell proliferation in rats
    Holger Rosenbrock
    Department of CNS Research, Boehringer Ingelheim Pharma GmbH and Co KG, Birkendorfer Strasse 65, D 88397 Biberach, Germany
    Brain Res 1040:55-63. 2005
    ..The results might contribute to understand the relationship between stress and cellular neurobiology of depression, since chronic antidepressant treatment have been shown to increase adult neurogenesis in the rat hippocampus...
  8. doi request reprint Differential effects of subtype-specific nicotinic acetylcholine receptor agonists on early and late hippocampal LTP
    Katja S Kroker
    Boehringer Ingelheim Pharma GmbH and Co KG, Department of CNS Diseases Research, Birkendorfer Strasse 65, 88397 Biberach, Germany
    Eur J Pharmacol 671:26-32. 2011
    ..Therefore, based on these findings α7 nicotinic acetylcholine receptor (partial) agonists appear to exhibit stronger efficacy on memory improvement than α4β2 nicotinic acetylcholine receptor agonists...
  9. doi request reprint A multi-slice recording system for stable late phase hippocampal long-term potentiation experiments
    Katja Sabine Kroker
    Boehringer Ingelheim Pharma GmbH and Co KG, Dept of CNS Diseases Research, Birkendorfer Strasse 65, 88397 Biberach, Germany
    J Neurosci Methods 194:394-401. 2011
    ..Hence, this system is suitable not only to investigate molecular mechanisms underlying the late phase of LTP, but also to screen candidate compounds in the context of drug discovery...
  10. ncbi request reprint Globular and protofibrillar aβ aggregates impair neurotransmission by different mechanisms
    Jens Moreth
    Department of CNS Diseases Research Germany, Boehringer Ingelheim Pharma GmbH and Co KG, Birkendorfer Strasse, Biberach an der Riss D 88397, Germany
    Biochemistry 52:1466-76. 2013
    ..Thus, we emphasize the importance of addressing the metastability of prefacto characterized Aβ aggregates in assigning a biological effect...
  11. ncbi request reprint The selective mGlu5 receptor antagonist MTEP, similar to NMDA receptor antagonists, induces social isolation in rats
    Eliza Koros
    Department of CNS Research, Boehringer Ingelheim Pharma GmbH and Co KG, Biberach, Germany
    Neuropsychopharmacology 32:562-76. 2007
    ..These data demonstrate that social behavior deficits in rats can be caused by both the blockade of the NMDA receptor and the inhibition of mGluR5, whereas mGluR5 antagonists may not independently be able to mimic the positive symptoms...
  12. ncbi request reprint Automated classification of the behavior of rats in the forced swimming test with support vector machines
    Holger Frohlich
    Centre for Bioinformatics Tübingen, Sand 1, 72076 Tubingen, Germany
    Neural Netw 21:92-101. 2008
    ..Moreover, our technique is able to classify between tricyclic antidepressants and SSRIs. The results of this work enabled the development of an automated and highly accurate behavior classification system...
  13. ncbi request reprint Expression of brain derived neurotrophic factor, activity-regulated cytoskeleton protein mRNA, and enhancement of adult hippocampal neurogenesis in rats after sub-chronic and chronic treatment with the triple monoamine re-uptake inhibitor tesofensine
    Marianne H Larsen
    Department of Translational Neurobiology, Neurosearch A S, Pederstrupvej 93, 2750 Ballerup, Denmark
    Eur J Pharmacol 555:115-21. 2007
    ..This study shows that Tesofensine enhances hippocampal gene expression and new cell formation indicative for an antidepressant potential of this novel drug substance...