- RITA--Registry of Industrial Toxicology Animal data: the application of historical control data for Leydig cell tumors in ratsThomas Nolte
Boehringer Ingelheim Pharma GmbH and Co KG, Nonclinical Drug Safety Germany, Birkendorfer Strasse 65, D 88397 Biberach Riss, Germany
Exp Toxicol Pathol 63:645-56. 2011..Furthermore, it demonstrates that the RITA database is highly beneficial for the definition of reliable historical control data for carcinogenicity studies on a scientifically solid basis...
- Standardized assessment of cell proliferation: the approach of the RITA-CEPA working groupThomas Nolte
Boehringer Ingelheim Pharma GmbH and Co KG, Dpt Non Clinical Drug Safety, 88397 Biberach Riss, Germany
Exp Toxicol Pathol 57:91-103. 2005..Membership of the CEPA group is open for all industrial organizations who develop chemical, agrochemical, or pharmaceutical products...
- Improved lipid profile through liver-specific knockdown of liver X receptor alpha in KKAy diabetic miceJoerg F Rippmann
Department of Pulmonary Diseases Research, Boehringer Ingelheim Pharma GmbH and Co KG, 88397 Biberach, Germany
J Lipid Res 50:22-31. 2009..Taken together, liver-specific knockdown of LXRalpha in vivo by shRNA reduced expression of lipogenic master genes, like SREBP1c, and improved the lipid profile of hypertriglyceridemic KKAy mice...