Marcus Kostka

Summary

Affiliation: Boehringer Ingelheim

Publications

  1. doi request reprint Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers
    Marcus Kostka
    CNS Research, Boehringer Ingelheim Pharma GmbH and Co KG, CNS Research, Birkendorferstrasse 65, 88397 Biberach, Germany
    J Biol Chem 283:10992-1003. 2008
  2. ncbi request reprint Different species of alpha-synuclein oligomers induce calcium influx and seeding
    Karin M Danzer
    Central Nervous System Research, Boehringer Ingelheim Pharma, 88397 Biberach, Germany
    J Neurosci 27:9220-32. 2007
  3. ncbi request reprint PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin
    Harald Steiner
    Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer s and Parkinson s Disease Research, Schillerstrasse 44, Ludwig Maximilians University, 80336 Munich, Germany
    J Biol Chem 277:39062-5. 2002
  4. ncbi request reprint Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1
    Keiro Shirotani
    Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer s and Parkinson s Disease Research, Ludwig Maximilians University, 80336 Munich, Germany
    J Neurochem 89:1520-7. 2004

Collaborators

Detail Information

Publications4

  1. doi request reprint Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers
    Marcus Kostka
    CNS Research, Boehringer Ingelheim Pharma GmbH and Co KG, CNS Research, Birkendorferstrasse 65, 88397 Biberach, Germany
    J Biol Chem 283:10992-1003. 2008
    ..Moreover, scanning for intensely fluorescent targets allows high throughput screening for aggregation inhibitors and may provide new approaches for drug development and therapy...
  2. ncbi request reprint Different species of alpha-synuclein oligomers induce calcium influx and seeding
    Karin M Danzer
    Central Nervous System Research, Boehringer Ingelheim Pharma, 88397 Biberach, Germany
    J Neurosci 27:9220-32. 2007
    ..This has important implications for the development of disease-modifying drugs for the treatment of PD and other synucleinopathies...
  3. ncbi request reprint PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin
    Harald Steiner
    Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer s and Parkinson s Disease Research, Schillerstrasse 44, Ludwig Maximilians University, 80336 Munich, Germany
    J Biol Chem 277:39062-5. 2002
    ..We conclude that PEN-2 is an integral gamma-secretase complex component and that gamma-secretase complex components are expressed in a coordinated manner...
  4. ncbi request reprint Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1
    Keiro Shirotani
    Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer s and Parkinson s Disease Research, Ludwig Maximilians University, 80336 Munich, Germany
    J Neurochem 89:1520-7. 2004
    ..Moreover, binding of the latter two complex partners critically depends on the integrity of the Nct ectodomain...