- Single particle characterization of iron-induced pore-forming alpha-synuclein oligomersMarcus Kostka
CNS Research, Boehringer Ingelheim Pharma GmbH and Co KG, CNS Research, Birkendorferstrasse 65, 88397 Biberach, Germany
J Biol Chem 283:10992-1003. 2008..Moreover, scanning for intensely fluorescent targets allows high throughput screening for aggregation inhibitors and may provide new approaches for drug development and therapy...
- Different species of alpha-synuclein oligomers induce calcium influx and seedingKarin M Danzer
Central Nervous System Research, Boehringer Ingelheim Pharma, 88397 Biberach, Germany
J Neurosci 27:9220-32. 2007..This has important implications for the development of disease-modifying drugs for the treatment of PD and other synucleinopathies...
- PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrinHarald Steiner
Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer s and Parkinson s Disease Research, Schillerstrasse 44, Ludwig Maximilians University, 80336 Munich, Germany
J Biol Chem 277:39062-5. 2002..We conclude that PEN-2 is an integral gamma-secretase complex component and that gamma-secretase complex components are expressed in a coordinated manner...
- Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1Keiro Shirotani
Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer s and Parkinson s Disease Research, Ludwig Maximilians University, 80336 Munich, Germany
J Neurochem 89:1520-7. 2004..Moreover, binding of the latter two complex partners critically depends on the integrity of the Nct ectodomain...