Jörg T Kley
Affiliation: Boehringer Ingelheim
- Discovery of BI 99179, a potent and selective inhibitor of type I fatty acid synthase with central exposureJörg T Kley
Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH and Co KG, Birkendorfer Strasse 65, D 88397 Biberach, Germany
Bioorg Med Chem Lett 21:5924-7. 2011..Optimisation yielded BI 99179 which is characterised by high potency, remarkably high selectivity and significant exposure (both peripheral and central) upon oral administration in rats...