Affiliation: Boehringer Ingelheim
- Comparative safety of long-acting inhaled bronchodilators: a cohort study using the UK THIN primary care databaseMichele Jara
Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT 06877 0368, USA
Drug Saf 30:1151-60. 2007..In COPD, the organ system most frequently requiring medical care, other than the respiratory system, is the cardiac system...
- Pooled clinical trial analysis of tiotropium safetySteven Kesten
Boehringer Ingelheim Pharmaceuticals, Inc, 900 Ridgebury Road, Ridgefield, CT 06877 0368, USA
Chest 130:1695-703. 2006..Marketing approval of pharmaceutical products is often based on data from several thousand subjects or fewer. Evaluation of safety is greatly enhanced by augmenting the safety database with postapproval studies...
- Estimating effects from randomized trials with discontinuations: the need for intent-to-treat design and G-estimationSander Greenland
Epidemiology and Statistics, University of California, Los Angeles, CA, USA
Clin Trials 5:5-13. 2008..Furthermore, estimates based on ITT, on-treatment, or per-protocol comparisons can seriously understate harm or benefit...
- The INSPIRE study: influence of prior use and discontinuation of inhaled corticosteroidsStephan F Lanes
Am J Respir Crit Care Med 178:543-4; author reply 544. 2008