Nathalie Goudreau

Summary

Affiliation: Boehringer Ingelheim

Publications

  1. Goudreau N, Hucke O, Faucher A, Grand MaƮtre C, Lepage O, Bonneau P, et al. Discovery and structural characterization of a new inhibitor series of HIV-1 nucleocapsid function: NMR solution structure determination of a ternary complex involving a 2:1 inhibitor/NC stoichiometry. J Mol Biol. 2013;425:1982-1998 pubmed publisher
    ..In addition, analysis of the interaction details between the inhibitor molecules and NC demonstrated how this novel inhibitor series is mimicking the guanosine nucleobases found in many reported complex structures. ..
  2. Beaulieu P, De Marte J, Garneau M, Luo L, Stammers T, Telang C, et al. A prodrug strategy for the oral delivery of a poorly soluble HCV NS5B thumb pocket 1 polymerase inhibitor using self-emulsifying drug delivery systems (SEDDS). Bioorg Med Chem Lett. 2015;25:210-5 pubmed publisher
  3. Lemke C, Titolo S, Goudreau N, Faucher A, Mason S, Bonneau P. A novel inhibitor-binding site on the HIV-1 capsid N-terminal domain leads to improved crystallization via compound-mediated dimerization. Acta Crystallogr D Biol Crystallogr. 2013;69:1115-23 pubmed publisher