F Gillardon

Summary

Affiliation: Boehringer Ingelheim

Publications

  1. pmc Signal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticity
    Susanne Zach
    Boehringer Ingelheim Pharma GmbH and Co KG, CNS Research, Biberach an der Riss, Germany
    PLoS ONE 5:e13191. 2010
  2. pmc Leucine-rich repeat kinase 2 modulates retinoic acid-induced neuronal differentiation of murine embryonic stem cells
    Cathrin Schulz
    Boehringer Ingelheim Pharma GmbH and Co KG, CNS Research, Biberach an der Riss, Germany
    PLoS ONE 6:e20820. 2011
  3. ncbi ATP-competitive LRRK2 inhibitors interfere with monoclonal antibody binding to the kinase domain of LRRK2 under native conditions. A method to directly monitor the active conformation of LRRK2?
    Frank Gillardon
    CNS Research, Boehringer Ingelheim Pharma GmbH and Co KG, Biberach an der Riss, Germany
    J Neurosci Methods 214:62-8. 2013
  4. doi Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity
    F Gillardon
    Boehringer Ingelheim Pharma GmbH and Co KG, CNS Research, Birkendorfer Strasse 65, 88397 Biberach, Germany
    Neuroscience 208:41-8. 2012
  5. doi Protein array analysis of oligomerization-induced changes in alpha-synuclein protein-protein interactions points to an interference with Cdc42 effector proteins
    C Schnack
    Boehringer Ingelheim Pharma GmbH and Co KG, CNS Research, Biberach an der Riss, Germany
    Neuroscience 154:1450-7. 2008
  6. doi Interaction of elongation factor 1-alpha with leucine-rich repeat kinase 2 impairs kinase activity and microtubule bundling in vitro
    F Gillardon
    Boehringer Ingelheim Pharma GmbH and Co KG, CNS Research, Birkendorfer St 65, 88397 Biberach an der Riss, Germany
    Neuroscience 163:533-9. 2009
  7. ncbi Predominant neuritic pathology induced by viral overexpression of alpha-synuclein in cell culture
    S Zach
    Boehringer Ingelheim Pharma GmbH and Co KG, CNS Research, Birkendorferstrasse 65, 88397 Biberach an der Riss, Germany
    Cell Mol Neurobiol 27:505-15. 2007

Collaborators

Detail Information

Publications7

  1. pmc Signal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticity
    Susanne Zach
    Boehringer Ingelheim Pharma GmbH and Co KG, CNS Research, Biberach an der Riss, Germany
    PLoS ONE 5:e13191. 2010
    ..LRRK2 has been linked to the mitogen-activated protein kinase kinase kinase family and the receptor-interacting protein kinases based on sequence similarity within the kinase domain and in vitro substrate phosphorylation...
  2. pmc Leucine-rich repeat kinase 2 modulates retinoic acid-induced neuronal differentiation of murine embryonic stem cells
    Cathrin Schulz
    Boehringer Ingelheim Pharma GmbH and Co KG, CNS Research, Biberach an der Riss, Germany
    PLoS ONE 6:e20820. 2011
    ..LRRK2 is expressed in neural precursor cells suggesting a role in neurodevelopment...
  3. ncbi ATP-competitive LRRK2 inhibitors interfere with monoclonal antibody binding to the kinase domain of LRRK2 under native conditions. A method to directly monitor the active conformation of LRRK2?
    Frank Gillardon
    CNS Research, Boehringer Ingelheim Pharma GmbH and Co KG, Biberach an der Riss, Germany
    J Neurosci Methods 214:62-8. 2013
    ..Since kinase inhibitors prevent autophosphorylation and refolding of the activation segment, we hypothesize that the antibody preferentially binds to the active conformation of LRRK2 under native conditions...
  4. doi Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity
    F Gillardon
    Boehringer Ingelheim Pharma GmbH and Co KG, CNS Research, Birkendorfer Strasse 65, 88397 Biberach, Germany
    Neuroscience 208:41-8. 2012
    ..These findings indicate that enhanced neuroinflammation may contribute to neurodegeneration in Parkinson's disease patients carrying LRRK2 mutations...
  5. doi Protein array analysis of oligomerization-induced changes in alpha-synuclein protein-protein interactions points to an interference with Cdc42 effector proteins
    C Schnack
    Boehringer Ingelheim Pharma GmbH and Co KG, CNS Research, Biberach an der Riss, Germany
    Neuroscience 154:1450-7. 2008
    ..Our data indicate that components of small GTPase signal transduction pathways may be directly targeted by alpha-synuclein oligomers which potentially leads to signaling deficits and neurodegeneration...
  6. doi Interaction of elongation factor 1-alpha with leucine-rich repeat kinase 2 impairs kinase activity and microtubule bundling in vitro
    F Gillardon
    Boehringer Ingelheim Pharma GmbH and Co KG, CNS Research, Birkendorfer St 65, 88397 Biberach an der Riss, Germany
    Neuroscience 163:533-9. 2009
    ..These findings suggest that the interaction between LRRK2 and EF1A may reciprocally modulate their physiological function...
  7. ncbi Predominant neuritic pathology induced by viral overexpression of alpha-synuclein in cell culture
    S Zach
    Boehringer Ingelheim Pharma GmbH and Co KG, CNS Research, Birkendorferstrasse 65, 88397 Biberach an der Riss, Germany
    Cell Mol Neurobiol 27:505-15. 2007
    ..Our results indicate that these cell culture models may represent an early phase of PD reflecting pathologic neuritic alterations before significant neuronal cell loss occurs...