Klaus J Erb

Summary

Affiliation: Boehringer Ingelheim

Publications

  1. ncbi request reprint Novel vaccines protecting against the development of allergic disorders: a double-edged sword?
    Klaus J Erb
    Centre for Infectious Diseases, University of Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
    Curr Opin Immunol 14:633-43. 2002
  2. ncbi request reprint Helminth-derived products inhibit the development of allergic responses in mice
    Claudia M Trujillo-Vargas
    Center for Infectious Diseases, University of Wurzburg, Wurzburg, Germany
    Am J Respir Crit Care Med 175:336-44. 2007
  3. doi request reprint Development of a novel severe triple allergen asthma model in mice which is resistant to dexamethasone and partially resistant to TLR7 and TLR9 agonist treatment
    Matthias J Duechs
    Respiratory Diseases Research, Boehringer Ingelheim Pharma GmbH and Co KG, Biberach a d Riss, Germany
    PLoS ONE 9:e91223. 2014
  4. ncbi request reprint Can helminths or helminth-derived products be used in humans to prevent or treat allergic diseases?
    Klaus J Erb
    Department of Pulmonary Research, Boehringer Ingelheim Pharma GmbH and Co KG, Biberach a d Riss, 88440, Germany
    Trends Immunol 30:75-82. 2009
  5. ncbi request reprint Helminths, allergic disorders and IgE-mediated immune responses: where do we stand?
    Klaus J Erb
    Department of Pulmonary Research, Boehringer Ingelheim Pharma GmbH and Co KG, Biberach Riss, Germany
    Eur J Immunol 37:1170-3. 2007
  6. pmc The absence of mrp4 has no effect on the recruitment of neutrophils and eosinophils into the lung after LPS, cigarette smoke or allergen challenge
    Jurgen Schymeinsky
    Respiratory Diseases Research, Boehringer Ingelheim Pharma GmbH and Co KG, Biberach a d Riss, Germany
    PLoS ONE 8:e61193. 2013
  7. doi request reprint Induced Syk deletion leads to suppressed allergic responses but has no effect on neutrophil or monocyte migration in vivo
    Eva Wex
    Department of Respiratory Diseases Research, Boehringer Ingelheim Pharma GmbH and Co KG, Biberach, Germany
    Eur J Immunol 41:3208-18. 2011
  8. doi request reprint TLR agonist mediated suppression of allergic responses is associated with increased innate inflammation in the airways
    Matthias J Duechs
    Pulmonary Diseases Research, Boehringer Ingelheim Pharma GmbH and Co KG, H91 02 01, Birkendorferstr 65, D 88397 Biberach ad Riss, Germany
    Pulm Pharmacol Ther 24:203-14. 2011
  9. doi request reprint Development and characterisation of a novel and rapid lung eosinophil influx model in the rat
    Melanie Werner-Klein
    Department of Pulmonary Research, Boehringer Ingelheim Pharma GmbH and Co KG, H91 02 01, Birkendorferstr 65, D 88397 Biberach a d Riss, Germany
    Pulm Pharmacol Ther 21:648-56. 2008
  10. ncbi request reprint Sublingual immunotherapy of allergic diseases
    Melanie Werner-Klein
    Department of Pulmonary Research, Boehringer Ingelheim Pharma GmbH and Co KG, Biberach an der Riss, Germany
    Expert Opin Drug Deliv 3:599-612. 2006

Collaborators

  • Lutz Wollin
  • Heinz Gerd Hoymann
  • Michael P Sanderson
  • S M Grunewald
  • Udo Herz
  • Harald Renz
  • Florian Gantner
  • Armin Braun
  • Matthias J Duechs
  • Melanie Werner-Klein
  • Gisela Wohlleben
  • Christian Hahn
  • Christopher Tomsic
  • Cornelia Tilp
  • Jurgen Schymeinsky
  • Eva Wex
  • Claudia Trujillo
  • Claudia M Trujillo-Vargas
  • Rolf Göggel
  • Thomas Kamradt
  • Yunhai Cui
  • Hannah Mayer
  • John D Schuetz
  • Thierry Bouyssou
  • Ewald Benediktus
  • Andreas Schnapp
  • Birgit E Stierstorfer
  • Andreas Westhof
  • Tobias Polte
  • Stefan Ehlers
  • Gesine Hansen
  • Frank Kalkbrenner
  • Yvonne Ritze
  • Ursula Tatsch
  • Justus Müller
  • Martin Teufel
  • Eva B Brocker
  • Walter Sebald
  • Albert Duschl

Detail Information

Publications16

  1. ncbi request reprint Novel vaccines protecting against the development of allergic disorders: a double-edged sword?
    Klaus J Erb
    Centre for Infectious Diseases, University of Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
    Curr Opin Immunol 14:633-43. 2002
    ..However, both approaches potentially harbour negative side effects that need to be ruled out before vaccinating young children -- the best candidates for the primary prevention of allergic disorders...
  2. ncbi request reprint Helminth-derived products inhibit the development of allergic responses in mice
    Claudia M Trujillo-Vargas
    Center for Infectious Diseases, University of Wurzburg, Wurzburg, Germany
    Am J Respir Crit Care Med 175:336-44. 2007
    ..Supporting this view is our published finding that infection with Nippostrongylus brasiliensis decreased ovalbumin-induced Th2 responses in the lung of mice...
  3. doi request reprint Development of a novel severe triple allergen asthma model in mice which is resistant to dexamethasone and partially resistant to TLR7 and TLR9 agonist treatment
    Matthias J Duechs
    Respiratory Diseases Research, Boehringer Ingelheim Pharma GmbH and Co KG, Biberach a d Riss, Germany
    PLoS ONE 9:e91223. 2014
    ..This model may be particular useful to test new potential therapeutics aiming at treating steroid resistant asthma in humans and investigating the underlying mechanisms responsible for steroid insensitivity. ..
  4. ncbi request reprint Can helminths or helminth-derived products be used in humans to prevent or treat allergic diseases?
    Klaus J Erb
    Department of Pulmonary Research, Boehringer Ingelheim Pharma GmbH and Co KG, Biberach a d Riss, 88440, Germany
    Trends Immunol 30:75-82. 2009
    ..Has the time come to treat patients who have allergic diseases or healthy humans who are at risk of developing these diseases with helminths or helminth-derived products? Here, I discuss the pros and cons of such an approach...
  5. ncbi request reprint Helminths, allergic disorders and IgE-mediated immune responses: where do we stand?
    Klaus J Erb
    Department of Pulmonary Research, Boehringer Ingelheim Pharma GmbH and Co KG, Biberach Riss, Germany
    Eur J Immunol 37:1170-3. 2007
    ..This is the first report clearly showing that a low level of helminth-specific IgE, transiently produced, is able to induce mast cell degranulation in the presence of large amounts of polyclonal IgE...
  6. pmc The absence of mrp4 has no effect on the recruitment of neutrophils and eosinophils into the lung after LPS, cigarette smoke or allergen challenge
    Jurgen Schymeinsky
    Respiratory Diseases Research, Boehringer Ingelheim Pharma GmbH and Co KG, Biberach a d Riss, Germany
    PLoS ONE 8:e61193. 2013
    ..Taken together, our data suggest that Mrp4 is not essential for the recruitment of neutrophils into the lung after LPS or CS exposure or of eosinophils after allergen exposure...
  7. doi request reprint Induced Syk deletion leads to suppressed allergic responses but has no effect on neutrophil or monocyte migration in vivo
    Eva Wex
    Department of Respiratory Diseases Research, Boehringer Ingelheim Pharma GmbH and Co KG, Biberach, Germany
    Eur J Immunol 41:3208-18. 2011
    ..Therefore, the inducible Syk knockout mice presented here provide a valuable tool to further explore the role of Syk in disease-related animal models...
  8. doi request reprint TLR agonist mediated suppression of allergic responses is associated with increased innate inflammation in the airways
    Matthias J Duechs
    Pulmonary Diseases Research, Boehringer Ingelheim Pharma GmbH and Co KG, H91 02 01, Birkendorferstr 65, D 88397 Biberach ad Riss, Germany
    Pulm Pharmacol Ther 24:203-14. 2011
    ....
  9. doi request reprint Development and characterisation of a novel and rapid lung eosinophil influx model in the rat
    Melanie Werner-Klein
    Department of Pulmonary Research, Boehringer Ingelheim Pharma GmbH and Co KG, H91 02 01, Birkendorferstr 65, D 88397 Biberach a d Riss, Germany
    Pulm Pharmacol Ther 21:648-56. 2008
    ..In summary, in this novel preclinical rat model therapeutics expected to inhibit the development of airway eosinophilia can rapidly be tested...
  10. ncbi request reprint Sublingual immunotherapy of allergic diseases
    Melanie Werner-Klein
    Department of Pulmonary Research, Boehringer Ingelheim Pharma GmbH and Co KG, Biberach an der Riss, Germany
    Expert Opin Drug Deliv 3:599-612. 2006
    ....
  11. ncbi request reprint Induction, exacerbation and inhibition of allergic and autoimmune diseases by infection
    Thomas Kamradt
    Institut fur Immunologie, Klinikum der Friedrich Schiller Universitat Jena, 07740 Jena, Germany
    Trends Immunol 26:260-7. 2005
    ..In this Review, we discuss which type of infections induce, exacerbate or inhibit allergic and autoimmune diseases and point at infection-induced immunological mechanisms influencing the development of autoimmunity and atopy...
  12. ncbi request reprint Helminth infection modulates the development of allergen-induced airway inflammation
    Gisela Wohlleben
    Center for Infectious Diseases, University of Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
    Int Immunol 16:585-96. 2004
    ..Our results support the view that helminth infections can contribute to the suppression of allergies in humans...
  13. pmc Mice deficient in nuclear factor of activated T-cell transcription factor c2 mount increased Th2 responses after infection with Nippostrongylus brasiliensis and decreased Th1 responses after mycobacterial infection
    Klaus J Erb
    Department of Molecular Pathology, Institute of Pathology, University of Wuerzburg, D 97080 Wuerzburg, Germany
    Infect Immun 71:6641-7. 2003
    ..These findings indicate that NFATc2 is an activator of Th1 responses and a suppressor of Th2 responses in vivo...
  14. ncbi request reprint Inhibition of allergic disorders by infection with bacteria or the exposure to bacterial products
    Claudia Trujillo
    Zentrum für Infektionsforschung Universität Würzburg, D 97070 Wurzburg, Germany
    Int J Med Microbiol 293:123-31. 2003
    ..This review focuses on experimental and epidemiological studies addressing the question if bacterial infections or the exposure to bacterial products can inhibit the development of allergic responses...
  15. ncbi request reprint Inhibition of the IL-4/IL-13 receptor system prevents allergic sensitization without affecting established allergy in a mouse model for allergic asthma
    Christian Hahn
    Klinik und Poliklinik für Haut und Geschlechtskrankheiten, Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    J Allergy Clin Immunol 111:1361-9. 2003
    ..IL-4 and IL-13 are considered as key regulators for the development of atopic disease...
  16. ncbi request reprint Infection with influenza a virus leads to flu antigen-induced cutaneous anaphylaxis in mice
    Susanne M Grunewald
    Klinik und Poliklinik für Haut und Geschlechtskrankheiten, Universitat Wurzburg, Wurzburg, Germany
    J Invest Dermatol 118:645-51. 2002
    ..Our results may also have implications for the pathogenesis of urticaria or other atopic disorders in humans...