Klaus J Erb
Affiliation: Boehringer Ingelheim
- Novel vaccines protecting against the development of allergic disorders: a double-edged sword?Klaus J Erb
Centre for Infectious Diseases, University of Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
Curr Opin Immunol 14:633-43. 2002..However, both approaches potentially harbour negative side effects that need to be ruled out before vaccinating young children -- the best candidates for the primary prevention of allergic disorders...
- Helminth-derived products inhibit the development of allergic responses in miceClaudia M Trujillo Vargas
Center for Infectious Diseases, University of Wurzburg, Wurzburg, Germany
Am J Respir Crit Care Med 175:336-44. 2007..Supporting this view is our published finding that infection with Nippostrongylus brasiliensis decreased ovalbumin-induced Th2 responses in the lung of mice...
- Can helminths or helminth-derived products be used in humans to prevent or treat allergic diseases?Klaus J Erb
Department of Pulmonary Research, Boehringer Ingelheim Pharma GmbH and Co KG, Biberach a d Riss, 88440, Germany
Trends Immunol 30:75-82. 2009..Has the time come to treat patients who have allergic diseases or healthy humans who are at risk of developing these diseases with helminths or helminth-derived products? Here, I discuss the pros and cons of such an approach...
- Helminths, allergic disorders and IgE-mediated immune responses: where do we stand?Klaus J Erb
Department of Pulmonary Research, Boehringer Ingelheim Pharma GmbH and Co KG, Biberach Riss, Germany
Eur J Immunol 37:1170-3. 2007..This is the first report clearly showing that a low level of helminth-specific IgE, transiently produced, is able to induce mast cell degranulation in the presence of large amounts of polyclonal IgE...
- Induced Syk deletion leads to suppressed allergic responses but has no effect on neutrophil or monocyte migration in vivoEva Wex
Department of Respiratory Diseases Research, Boehringer Ingelheim Pharma GmbH and Co KG, Biberach, Germany
Eur J Immunol 41:3208-18. 2011..Therefore, the inducible Syk knockout mice presented here provide a valuable tool to further explore the role of Syk in disease-related animal models...
- TLR agonist mediated suppression of allergic responses is associated with increased innate inflammation in the airwaysMatthias J Duechs
Pulmonary Diseases Research, Boehringer Ingelheim Pharma GmbH and Co KG, H91 02 01, Birkendorferstr 65, D 88397 Biberach ad Riss, Germany
Pulm Pharmacol Ther 24:203-14. 2011....
- The absence of mrp4 has no effect on the recruitment of neutrophils and eosinophils into the lung after LPS, cigarette smoke or allergen challengeJurgen Schymeinsky
Respiratory Diseases Research, Boehringer Ingelheim Pharma GmbH and Co KG, Biberach a d Riss, Germany
PLoS ONE 8:e61193. 2013..Taken together, our data suggest that Mrp4 is not essential for the recruitment of neutrophils into the lung after LPS or CS exposure or of eosinophils after allergen exposure...
- Development and characterisation of a novel and rapid lung eosinophil influx model in the ratMelanie Werner-Klein
Department of Pulmonary Research, Boehringer Ingelheim Pharma GmbH and Co KG, H91 02 01, Birkendorferstr 65, D 88397 Biberach a d Riss, Germany
Pulm Pharmacol Ther 21:648-56. 2008..In summary, in this novel preclinical rat model therapeutics expected to inhibit the development of airway eosinophilia can rapidly be tested...
- Sublingual immunotherapy of allergic diseasesMelanie Werner-Klein
Department of Pulmonary Research, Boehringer Ingelheim Pharma GmbH and Co. KG, Biberach an der Riss, Germany
Expert Opin Drug Deliv 3:599-612. 2006....
- Induction, exacerbation and inhibition of allergic and autoimmune diseases by infectionThomas Kamradt
, , 07740 Jena, Germany
Trends Immunol 26:260-7. 2005..In this Review, we discuss which type of infections induce, exacerbate or inhibit allergic and autoimmune diseases and point at infection-induced immunological mechanisms influencing the development of autoimmunity and atopy...
- Helminth infection modulates the development of allergen-induced airway inflammationGisela Wohlleben
Center for Infectious Diseases, University of Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
Int Immunol 16:585-96. 2004..Our results support the view that helminth infections can contribute to the suppression of allergies in humans...
- Mice deficient in nuclear factor of activated T-cell transcription factor c2 mount increased Th2 responses after infection with Nippostrongylus brasiliensis and decreased Th1 responses after mycobacterial infectionKlaus J Erb
Department of Molecular Pathology, Institute of Pathology, University of Wuerzburg, D 97080 Wuerzburg, Germany
Infect Immun 71:6641-7. 2003..These findings indicate that NFATc2 is an activator of Th1 responses and a suppressor of Th2 responses in vivo...
- Inhibition of allergic disorders by infection with bacteria or the exposure to bacterial productsClaudia Trujillo
, , Germany
Int J Med Microbiol 293:123-31. 2003..This review focuses on experimental and epidemiological studies addressing the question if bacterial infections or the exposure to bacterial products can inhibit the development of allergic responses...
- Inhibition of the IL-4/IL-13 receptor system prevents allergic sensitization without affecting established allergy in a mouse model for allergic asthmaChristian Hahn
, , Josef-Schneider-Strasse 2, , Germany
J Allergy Clin Immunol 111:1361-9. 2003..This is relevant for estimating the therapeutic effects of IL-4/IL-13 inhibitors in patients with allergic asthma...
- Infection with influenza a virus leads to flu antigen-induced cutaneous anaphylaxis in miceSusanne M Grunewald
Klinik und Poliklinik für Haut und Geschlechtskrankheiten, Universitat Wurzburg, Wurzburg, Germany
J Invest Dermatol 118:645-51. 2002..Our results may also have implications for the pathogenesis of urticaria or other atopic disorders in humans...