- Different species of alpha-synuclein oligomers induce calcium influx and seedingKarin M Danzer
Central Nervous System Research, Boehringer Ingelheim Pharma, 88397 Biberach, Germany
J Neurosci 27:9220-32. 2007..This has important implications for the development of disease-modifying drugs for the treatment of PD and other synucleinopathies...
- Functional protein kinase arrays reveal inhibition of p-21-activated kinase 4 by alpha-synuclein oligomersKarin M Danzer
Boehringer Ingelheim Pharma GmbH and Co KG, Biberach, Germany
J Neurochem 103:2401-7. 2007..Thus, PAKs may represent a target for various neurotoxic protein oligomers, and signaling deficits may contribute to the behavioral defects in chronic neurodegenerative diseases...
- Single particle characterization of iron-induced pore-forming alpha-synuclein oligomersMarcus Kostka
CNS Research, Boehringer Ingelheim Pharma GmbH and Co KG, CNS Research, Birkendorferstrasse 65, 88397 Biberach, Germany
J Biol Chem 283:10992-1003. 2008..Moreover, scanning for intensely fluorescent targets allows high throughput screening for aggregation inhibitors and may provide new approaches for drug development and therapy...