Christoph Bock

Summary

Publications

  1. pmc Quantitative comparison of genome-wide DNA methylation mapping technologies
    Christoph Bock
    Broad Institute, Cambridge, Massachusetts, USA
    Nat Biotechnol 28:1106-14. 2010
  2. pmc DNA methylation dynamics during in vivo differentiation of blood and skin stem cells
    Christoph Bock
    Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Mol Cell 47:633-47. 2012
  3. doi Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling
    Hongcang Gu
    Broad Institute, Cambridge, Massachusetts, USA
    Nat Protoc 6:468-81. 2011
  4. pmc Genomic distribution and inter-sample variation of non-CpG methylation across human cell types
    Michael J Ziller
    Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
    PLoS Genet 7:e1002389. 2011
  5. pmc Genome-scale DNA methylation mapping of clinical samples at single-nucleotide resolution
    Hongcang Gu
    Broad Institute, Cambridge, Massachusetts, USA
    Nat Methods 7:133-6. 2010
  6. doi Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging
    Isabel Beerman
    Program in Cellular and Molecular Medicine, Division of Hematology Oncology, Boston Children s Hospital, Boston, MA 02116, USA
    Cell Stem Cell 12:413-25. 2013
  7. doi Recommendations for the design and analysis of epigenome-wide association studies
    Karin B Michels
    1 Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA 2 Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Methods 10:949-55. 2013
  8. pmc Erosion of dosage compensation impacts human iPSC disease modeling
    Shila Mekhoubad
    The Harvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
    Cell Stem Cell 10:595-609. 2012
  9. pmc High-throughput bisulfite sequencing in mammalian genomes
    Zachary D Smith
    Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
    Methods 48:226-32. 2009
  10. pmc Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines
    Christoph Bock
    Broad Institute, Cambridge, MA 02142, USA
    Cell 144:439-52. 2011

Collaborators

Detail Information

Publications12

  1. pmc Quantitative comparison of genome-wide DNA methylation mapping technologies
    Christoph Bock
    Broad Institute, Cambridge, Massachusetts, USA
    Nat Biotechnol 28:1106-14. 2010
    ..We highlight strengths and weaknesses of the four methods and give practical recommendations for the design of epigenomic case-control studies...
  2. pmc DNA methylation dynamics during in vivo differentiation of blood and skin stem cells
    Christoph Bock
    Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Mol Cell 47:633-47. 2012
    ..In summary, these results demonstrate that in vivo differentiation of adult stem cells is associated with small but informative changes in the genomic distribution of DNA methylation...
  3. doi Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling
    Hongcang Gu
    Broad Institute, Cambridge, Massachusetts, USA
    Nat Protoc 6:468-81. 2011
    ..The entire process of RRBS library construction takes ∼9 d...
  4. pmc Genomic distribution and inter-sample variation of non-CpG methylation across human cell types
    Michael J Ziller
    Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
    PLoS Genet 7:e1002389. 2011
    ..In summary these results contribute further to our understanding of cytosine methylation patterns in human cells using a large representative sample set...
  5. pmc Genome-scale DNA methylation mapping of clinical samples at single-nucleotide resolution
    Hongcang Gu
    Broad Institute, Cambridge, Massachusetts, USA
    Nat Methods 7:133-6. 2010
    ..Thirty nanograms of DNA was sufficient for genome-scale analysis and our protocol worked well on formalin-fixed, paraffin-embedded samples...
  6. doi Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging
    Isabel Beerman
    Program in Cellular and Molecular Medicine, Division of Hematology Oncology, Boston Children s Hospital, Boston, MA 02116, USA
    Cell Stem Cell 12:413-25. 2013
    ..Our results provide evidence that epigenomic alterations of the DNA methylation landscape contribute to the functional decline of HSCs during aging...
  7. doi Recommendations for the design and analysis of epigenome-wide association studies
    Karin B Michels
    1 Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA 2 Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Methods 10:949-55. 2013
    ....
  8. pmc Erosion of dosage compensation impacts human iPSC disease modeling
    Shila Mekhoubad
    The Harvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
    Cell Stem Cell 10:595-609. 2012
    ..However, our finding that most genes subject to XCI are derepressed by this erosion of XCI suggests that it should be a significant consideration when selecting hiPSC lines for modeling any disease...
  9. pmc High-throughput bisulfite sequencing in mammalian genomes
    Zachary D Smith
    Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
    Methods 48:226-32. 2009
    ..Contemporary sequencing and array-based technologies are compared against sample throughput and coverage, highlighting the variety of options available to investigate methylation on the genome-scale...
  10. pmc Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines
    Christoph Bock
    Broad Institute, Cambridge, MA 02142, USA
    Cell 144:439-52. 2011
    ..The combination of assays yields a scorecard for quick and comprehensive characterization of pluripotent cell lines...
  11. pmc RRBSMAP: a fast, accurate and user-friendly alignment tool for reduced representation bisulfite sequencing
    Yuanxin Xi
    Division of Biostatistics, Dan L Duncan Cancer Center and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Bioinformatics 28:430-2. 2012
    ..In summary, RRBSMAP removes bioinformatic hurdles and reduces the computational burden of large-scale epigenome association studies performed with RRBS...
  12. pmc Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature
    Huansheng Xu
    Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Res 22:142-54. 2012
    ....