Detection of occult Scedosporium species in respiratory tract specimens from patients with cystic fibrosis by use of selective mediaC C Blyth
Centre of Infectious Diseases and Microbiology Laboratory Services, ICPMR, Westmead Hospital, Darcy Rd, Westmead, NSW 2145, Australia
J Clin Microbiol 48:314-6. 2010
..9%) patients yielded a Scedosporium sp., most frequently Scedosporium aurantiacum (17/218). Scedosporium was recovered on SceSel+, Mycosel, and SABD from 90.6%, 50.0%, and 46.9% of the specimens tested, respectively...
- Influenza outbreaks during World Youth Day 2008 mass gathering
Christopher C Blyth
Westmead Hospital, Sydney, New South Wales, Australia
Emerg Infect Dis 16:809-15. 2010
..Greater flexibility by public health authorities and hospitals is required to appropriately manage and contain these outbreaks...
Clinical associations and prevalence of Scedosporium spp. in Australian cystic fibrosis patients: identification of novel risk factors?Christopher C Blyth
Centre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead, NSW, Australia
Med Mycol 48:S37-44. 2010
..Studies are required to confirm independent risk factors for Scedosporium colonization and to determine its impact on lung disease...
- Development and validation of a multiplex PCR for detection of Scedosporium spp. in respiratory tract specimens from patients with cystic fibrosis
Azian Harun
Molecular Mycology Research Laboratory, Medical School Westmead Hospital, Westmead, NSW 2145, Australia
J Clin Microbiol 49:1508-12. 2011
..1% and 97.2%, respectively. This highly species-specific multiplex PCR assay offers a rapid and simple method of detection of the most clinically important Scedosporium species in respiratory tract specimens...
- The impact of bacterial and viral co-infection in severe influenza
Christopher C Blyth
Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research ICPMR, Westmead Hospital, Sydney, NSW, Australia
Influenza Other Respi Viruses 7:168-76. 2013
..Many questions remain concerning the burden, risk factors and impact of bacterial and viral co-infection in patients with pandemic influenza admitted to the intensive care unit (ICU)...
- Viral pneumonitis is increased in obese patients during the first wave of pandemic A(H1N1) 2009 virus
Jen Kok
Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Sydney Institute for Emerging Infections and Biosecurity, University of Sydney, Westmead Hospital, Westmead, New South Wales, Australia
PLoS ONE 8:e55631. 2013
..It is postulated that excess inflammation and cytokine production in obese patients following severe influenza infection leads to viral pneumonitis and/or acute respiratory distress syndrome...
- Fatal mycotic aneurysms due to Scedosporium and Pseudallescheria infection
Adrian Ong
Centre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead, New South Wales, Australia
J Clin Microbiol 49:2067-71. 2011
..The thoracoabdominal aorta was affected in one patient, and cerebral vessels were affected in the other. Despite voriconazole therapy and surgical resection, the patients died. Previously reported cases are reviewed...
- Pandemic (H1N1) 2009 influenza virus seroconversion rates in HIV-infected individuals
Jen Kok
Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales, Australia
J Acquir Immune Defic Syndr 56:91-4. 2011
..Neither HIV infection, nor severe immunosuppression, was a significant risk factor for pandemic influenza during the first southern hemisphere pandemic wave...
- Pneumonia and lung infections due to emerging and unusual fungal pathogens
Sharon C A Chen
Centre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead, Australia
Semin Respir Crit Care Med 32:703-16. 2011
..Surgical resection of diseased tissue and support of the host immune system are often required to optimize outcomes...
- Enhanced diagnosis of pandemic (H1N1) 2009 influenza infection using molecular and serological testing in intensive care unit patients with suspected influenza
Jenna M Iwasenko
Department of Microbiology, South Eastern Area Laboratory Services, Prince of Wales Hospital, Randwick, New South Wales, Australia
Clin Infect Dis 51:70-2. 2010
..These results indicate that up to one-third of pH1N1 cases may not have laboratory confirmation of infection unless serological testing is included for suspected cases...
- Detection of the rapid emergence of the H275Y mutation associated with oseltamivir resistance in severe pandemic influenza virus A/H1N1 09 infections
Bin Wang
Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead, NSW 2145, Australia
Antiviral Res 87:16-21. 2010
..In the light of emerging resistance, close monitoring and understanding of the nature and dynamics of resistance mutations in newly emerging strains should be a priority...
Antifungal therapy in infants and children with proven, probable or suspected invasive fungal infectionsChristopher C Blyth
Centre for Infectious Disease and Microbiology, ICPMR, Westmead Hospital, Darcy Road, Westmead, New South Wales, Australia, 2145
Cochrane Database Syst Rev 2:CD006343. 2010
..Further comparative paediatric antifungal drug trials and epidemiological and pharmacological studies are required highlighting the differences between neonates, children and adults with invasive fungal infections...
- Influenza outbreak during Sydney World Youth Day 2008: the utility of laboratory testing and case definitions on mass gathering outbreak containment
Sebastiaan J van Hal
Centre for Infectious Diseases and Microbiology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, Sydney, New South Wales, Australia
PLoS ONE 4:e6620. 2009
..However, the utility of these clinical case definitions and laboratory testing in mass gathering outbreaks remains unknown...
- Comparison of a rapid antigen test with nucleic acid testing during cocirculation of pandemic influenza A/H1N1 2009 and seasonal influenza A/H3N2
Jen Kok
Centre for Infectious Diseases and Microbiology Laboratory Services, Level 3, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales 2145, Australia
J Clin Microbiol 48:290-1. 2010
..4% versus 74.2%, P < 0.001). Nucleic acid tests should be used to detect pandemic influenza virus when rapid antigen tests are negative...
- Nontuberculous mycobacterial infection in children: a prospective national study
Christopher C Blyth
Department of Immunology and Infectious Diseases, Sydney Children s Hospital, New South Wales, Australia
Pediatr Infect Dis J 28:801-5. 2009
..The epidemiology and management of nontuberculous mycobacterial (NTM) infection in Australian children is unknown...
- Point of care testing: diagnosis outside the virology laboratory
Christopher C Blyth
Centre for Infectious Diseases and Microbiology Laboratory Services, Westmead Hospital, Sydney, NSW, Australia
Methods Mol Biol 665:415-33. 2011
..The sensitivity, specificity, and turn-around time of available POCTs are included for common conditions including respiratory viral infections (e.g. influenza, RSV) and blood-borne viral infections (e.g. HIV)...
- Not just little adults: candidemia epidemiology, molecular characterization, and antifungal susceptibility in neonatal and pediatric patients
Christopher C Blyth
Centre for Infectious Diseases and Microbiology, Westmead Hospital, Hawkesbury Road, Westmend, New South Wales 2145, Australia
Pediatrics 123:1360-8. 2009
..The purpose of this work was to identify differences in incidence, risk factors, microbiology, treatment, and clinical outcome of candidemia in neonates, children, and adults that might impact on management...
