Benjamin S Bleier

Summary

Publications

  1. doi request reprint Primary human sinonasal epithelial cell culture model for topical drug delivery in patients with chronic rhinosinusitis with nasal polyposis
    Benjamin S Bleier
    Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA
    J Pharm Pharmacol 64:449-56. 2012
  2. doi request reprint Dose quantification of topical drug delivery to the paranasal sinuses by fluorescein luminosity calculation
    Benjamin S Bleier
    Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA
    Int Forum Allergy Rhinol 2:316-20. 2012
  3. doi request reprint Regional expression of epithelial MDR1/P-glycoprotein in chronic rhinosinusitis with and without nasal polyposis
    Benjamin S Bleier
    Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Int Forum Allergy Rhinol 2:122-5. 2012
  4. doi request reprint Preliminary study on the stability of beta-2 transferrin in extracorporeal cerebrospinal fluid
    Benjamin S Bleier
    Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Otolaryngol Head Neck Surg 144:101-3. 2011
  5. doi request reprint Antibiotic eluting chitosan glycerophosphate implant in the setting of acute bacterial sinusitis: a rabbit model
    Benjamin S Bleier
    Department of Otorhinolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Rhinol Allergy 24:129-32. 2010
  6. doi request reprint Novel topical therapeutics
    Benjamin S Bleier
    Division of Rhinology, Department of Otolaryngology Head and Neck Surgery, Medical University of South Carolina, 135 Rutledge Avenue, MSC 550, Charleston, SC 29425, USA
    Otolaryngol Clin North Am 43:539-49, viii-ix. 2010
  7. doi request reprint Endonasal laser tissue welding: first human experience
    Benjamin S Bleier
    Department of Otorhinolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Am J Rhinol Allergy 24:244-6. 2010
  8. doi request reprint Prevention and management of medial rectus injury
    Benjamin S Bleier
    Division of Rhinology, Department of Otolaryngology Head and Neck Surgery, Medical University of South Carolina, 135 Rutledge Avenue, MSC 550, Charleston, SC 29425, USA
    Otolaryngol Clin North Am 43:801-7. 2010
  9. doi request reprint Mucocele rate after endoscopic skull base reconstruction using vascularized pedicled flaps
    Benjamin S Bleier
    Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Rhinol Allergy 25:186-7. 2011
  10. doi request reprint Laser tissue welding in lung and tracheobronchial repair: an animal model
    Benjamin S Bleier
    Division of Rhinology, Department of Otolaryngology Head and Neck Surgery, Medical University of South Carolina, Charleston, SC 29425, USA
    Chest 138:345-9. 2010

Collaborators

Detail Information

Publications33

  1. doi request reprint Primary human sinonasal epithelial cell culture model for topical drug delivery in patients with chronic rhinosinusitis with nasal polyposis
    Benjamin S Bleier
    Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA
    J Pharm Pharmacol 64:449-56. 2012
    ....
  2. doi request reprint Dose quantification of topical drug delivery to the paranasal sinuses by fluorescein luminosity calculation
    Benjamin S Bleier
    Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA
    Int Forum Allergy Rhinol 2:316-20. 2012
    ..The purpose of this study is to refine this technique to provide an accurate method of determining concentration of dose delivery as well...
  3. doi request reprint Regional expression of epithelial MDR1/P-glycoprotein in chronic rhinosinusitis with and without nasal polyposis
    Benjamin S Bleier
    Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Int Forum Allergy Rhinol 2:122-5. 2012
    ..The purpose of this study is to determine the pattern and degree of epithelial P-gp expression in chronic rhinosinusitis (CRS) with nasal polyposis (CRSwNP) or CRS without nasal polyposis (CRSsNP)...
  4. doi request reprint Preliminary study on the stability of beta-2 transferrin in extracorporeal cerebrospinal fluid
    Benjamin S Bleier
    Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Otolaryngol Head Neck Surg 144:101-3. 2011
    ..The purpose of this study is to understand how age, storage temperature, and exposure to mucus affect the ability to detect beta-2 transferrin in CSF...
  5. doi request reprint Antibiotic eluting chitosan glycerophosphate implant in the setting of acute bacterial sinusitis: a rabbit model
    Benjamin S Bleier
    Department of Otorhinolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Rhinol Allergy 24:129-32. 2010
    ..The purpose of this study was to assess the potential for CGP as an antibiotic impregnated implant in a rabbit model of acute bacterial sinusitis...
  6. doi request reprint Novel topical therapeutics
    Benjamin S Bleier
    Division of Rhinology, Department of Otolaryngology Head and Neck Surgery, Medical University of South Carolina, 135 Rutledge Avenue, MSC 550, Charleston, SC 29425, USA
    Otolaryngol Clin North Am 43:539-49, viii-ix. 2010
    ..Although multiple barriers to administration and absorption exist, implantable therapeutics using new classes of drug-eluting polymers allow for prolonged, site-specific drug delivery and hold great promise in overcoming these obstacles...
  7. doi request reprint Endonasal laser tissue welding: first human experience
    Benjamin S Bleier
    Department of Otorhinolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Am J Rhinol Allergy 24:244-6. 2010
    ..The objective of this study is to assess the safety and technical feasibility of endoscopic LTW in human sinonasal mucosa...
  8. doi request reprint Prevention and management of medial rectus injury
    Benjamin S Bleier
    Division of Rhinology, Department of Otolaryngology Head and Neck Surgery, Medical University of South Carolina, 135 Rutledge Avenue, MSC 550, Charleston, SC 29425, USA
    Otolaryngol Clin North Am 43:801-7. 2010
    ..Despite optimal surgical and medical interventions, the prognosis is relatively poor and patients should be counseled that the primary goal of these interventions is to reestablish a binocular single visual field...
  9. doi request reprint Mucocele rate after endoscopic skull base reconstruction using vascularized pedicled flaps
    Benjamin S Bleier
    Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Rhinol Allergy 25:186-7. 2011
    ..The purpose of this study was to determine the rate of mucocele formation after nasoseptal flap reconstruction without mucosal stripping...
  10. doi request reprint Laser tissue welding in lung and tracheobronchial repair: an animal model
    Benjamin S Bleier
    Division of Rhinology, Department of Otolaryngology Head and Neck Surgery, Medical University of South Carolina, Charleston, SC 29425, USA
    Chest 138:345-9. 2010
    ..Laser tissue welding (LTW) is an alternative method that produces wound repairs that are significantly stronger than those of fibrin glue and may be used to repair air leaks...
  11. doi request reprint Endoscopic anatomy of the postganglionic pterygopalatine innervation of the posterolateral nasal mucosa
    Benjamin S Bleier
    Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Int Forum Allergy Rhinol 1:113-7. 2011
    ..The purpose of this study is correlate these anatomic descriptions with endoscopic findings and to define the pattern and location of the posterolateral neurovascular rami...
  12. doi request reprint Temporospatial quantification of fluorescein-labeled sinonasal irrigation delivery
    Benjamin S Bleier
    Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA
    Int Forum Allergy Rhinol 1:361-5. 2011
    ..Despite multiple distribution studies, there remains a need for a method capable quantifying not only the site and amount of agent deposition but the rate of clearance as well...
  13. doi request reprint Chitosan glycerophosphate-based semirigid dexamethasone eluting biodegradable stent
    Benjamin S Bleier
    Department of Otorhinolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Rhinol Allergy 23:76-9. 2009
    ..The purpose of this study was to optimize the chitosan formulation to produce a pliable sheet, to assess the innate longevity and inflammatory potential of the polymer, and to study the in vivo rate of dexamethasone release over time...
  14. doi request reprint Laser-welded endoscopic endoluminal repair of iatrogenic esophageal perforation: an animal model
    Benjamin S Bleier
    Department of Otorhinolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Otolaryngol Head Neck Surg 139:713-7. 2008
    ..To test the feasibility of laser tissue welding (LTW) in creating an endoscopic transluminal repair of esophageal perforation...
  15. doi request reprint Increased presence of dendritic cells and dendritic cell chemokines in the sinus mucosa of chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis
    Chris M Ayers
    Department of Otolaryngology Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, USA
    Int Forum Allergy Rhinol 1:296-302. 2011
    ..Once DC presence was established we considered possible mechanisms for DC recruitment to the sinuses...
  16. doi request reprint The bipedicled anterior septal flap: a radioanatomic and cadaveric study
    Benjamin S Bleier
    Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Laryngoscope 121:1367-71. 2011
    ..The objective of this study was to define a novel bipedicled anterior septal (BAS) flap that is hypothesized to be capable of providing reproducible coverage of these difficult areas...
  17. doi request reprint Effects of an LL-37-derived antimicrobial peptide in an animal model of biofilm Pseudomonas sinusitis
    Sri Kiran Chennupati
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Rhinol Allergy 23:46-51. 2009
    ..We hypothesize that a 24 amino acid peptide derivative of LL-37 will show efficacy against biofilm-forming P. aeruginosa in an established animal model of sinusitis...
  18. doi request reprint P-glycoprotein functions as an immunomodulator in healthy human primary nasal epithelial cells
    Benjamin S Bleier
    Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Int Forum Allergy Rhinol 3:433-8. 2013
    ..The objective of this study is to therefore determine whether P-gp participates in the regulation of cytokine secretion in sinonasal epithelial cells...
  19. doi request reprint Evaluation of a polysaccharide gel for laser-assisted skull base repair
    Benjamin S Bleier
    Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Am J Rhinol Allergy 27:148-50. 2013
    ..This study was designed to define the thermal and inflammatory profile of a novel polysaccharide soldering gel, to assess the burst strength of the repair, and to determine the time required for solder resorption...
  20. ncbi request reprint Laser-assisted cerebrospinal fluid leak repair: an animal model to test feasibility
    Benjamin S Bleier
    Department of Otorhinolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19104 4206, USA
    Otolaryngol Head Neck Surg 137:810-4. 2007
    ..To test the feasibility of laser tissue welding as a method of creating an endonasal tissue bond for the purpose of cerebrospinal fluid leak repair...
  21. doi request reprint Anteriorly based pedicled flaps for skull base reconstruction
    Joshua C Meier
    Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles St, Boston MA 02114, USA
    Adv Otorhinolaryngol 74:64-70. 2013
    ....
  22. doi request reprint Cranial-base repair using endoscopic laser welding
    Benjamin S Bleier
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania School of Medicine, 1324 Pinewood Road, Villanova, Philadelphia, PA 19085, USA
    Otolaryngol Clin North Am 42:901-6, xi. 2009
    ..Laser welding is a novel technology that can be performed endoscopically and offers the potential of producing instantaneous, watertight repairs using a chromophore-doped biologic solder...
  23. doi request reprint Novel techniques and the future of skull base reconstruction
    Joshua C Meier
    Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles St, Boston, MA 02114, USA
    Adv Otorhinolaryngol 74:174-83. 2013
    ..While laser tissue welding remains an experimental technique, continued success with these novel solder formulations may catalyze the widespread adoption of this technique for skull base repair in the near future...
  24. doi request reprint Current management of juvenile nasopharyngeal angiofibroma: a tertiary center experience 1999-2007
    Benjamin S Bleier
    Department of Otorhinolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104 4206, USA
    Am J Rhinol Allergy 23:328-30. 2009
    ..The purpose of this study was to report on a series of patients presenting with JNA in an effort to further define an optimal treatment algorithm and improve outcomes...
  25. doi request reprint Septoplasty complications: avoidance and management
    Jason D Bloom
    Department of Otolaryngology Head and Neck Surgery, University of Pennsylvania, 811 Spruce Street, Philadelphia, PA 19107, USA
    Otolaryngol Clin North Am 42:463-81. 2009
    ..The septoplasty surgeon must be aware of all the possible complications that may arise so as to convey the benefits and risks of surgery effectively to prospective patients...
  26. doi request reprint In vivo laser tissue welding in the rabbit maxillary sinus
    Benjamin S Bleier
    Department of Otorhinolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104 4206, USA
    Am J Rhinol 22:625-8. 2008
    ..We performed this study to determine whether LTW can create durable tissue bonds in sinonasal mucosa that support normal wound healing and produce minimal collateral thermal injury...
  27. doi request reprint Diffuse intranasal papillomatosis and its association with human papillomavirus
    Benjamin S Bleier
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Arch Otolaryngol Head Neck Surg 134:778-80. 2008
  28. ncbi request reprint Factors predicting endoscopic exposure of Zenker's diverticulum
    Jason D Bloom
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann Otol Rhinol Laryngol 119:736-41. 2010
    ....
  29. doi request reprint P-glycoprotein is a marker of tissue eosinophilia and radiographic inflammation in chronic rhinosinusitis without nasal polyps
    Rachel E Feldman
    Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Int Forum Allergy Rhinol 3:684-7. 2013
    ..The goal of this study is to determine if P-gp expression is associated with degree of eosinophilia and severity of radiographic inflammation in patients with CRS without polyps (CRSsNP)...
  30. pmc Permeabilization of the blood-brain barrier via mucosal engrafting: implications for drug delivery to the brain
    Benjamin S Bleier
    Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e61694. 2013
    ..This proof of principle study demonstrates that mucosal engrafting represents the first permanent and stable method of bypassing the BBB thereby providing a pathway for HMW therapeutics directly into the CNS...
  31. ncbi request reprint Eccrine porocarcinoma of the nose: case report and review of world literature
    Benjamin S Bleier
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania School of Medicine, Philadelphia 19104 4206, USA
    Arch Otolaryngol Head Neck Surg 132:215-8. 2006
  32. doi request reprint Outcomes analysis in epistaxis management: development of a therapeutic algorithm
    Josef Shargorodsky
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, USA
    Otolaryngol Head Neck Surg 149:390-8. 2013
    ..This study explored the outcomes of epistaxis treatment modalities to optimize management and enable the development of a therapeutic algorithm...
  33. doi request reprint The accessory posterolateral nerve: an immunohistological analysis
    Benjamin S Bleier
    Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
    Am J Rhinol Allergy 26:271-3. 2012
    ..The goal of this study was to characterize these accessory posterolateral nerves by immunohistochemistry to determine their morphology and composition...