Eugene R Bleecker

Summary

Publications

  1. doi request reprint Once-daily fluticasone furoate is efficacious in patients with symptomatic asthma on low-dose inhaled corticosteroids
    Eugene R Bleecker
    Center for Genomics and Personalized Medicine, Wake Forest University Health Sciences Winston Salem, North Carolina, USA
    Ann Allergy Asthma Immunol 109:353-358.e4. 2012
  2. pmc ADRB2 polymorphisms and budesonide/formoterol responses in COPD
    Eugene R Bleecker
    Center for Genomics and Personalized Medicine, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Chest 142:320-8. 2012
  3. pmc Bronchodilator efficacy and safety of indacaterol 150 μg once daily in patients with COPD: an analysis of pooled data
    Eugene R Bleecker
    Center for Genomics and Personalized Medicine Research and Translational Medicine Institute, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Int J Chron Obstruct Pulmon Dis 6:431-8. 2011
  4. pmc Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers
    Alireza Sadeghnejad
    Center for Human Genomics and Department of Medicine and Pediatrics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Respir Res 10:21. 2009
  5. pmc The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthma
    Gregory A Hawkins
    Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 130:510-5.e1. 2012
  6. ncbi request reprint Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations
    Timothy D Howard
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 112:717-22. 2003
  7. pmc Sequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control study
    Gregory A Hawkins
    Center for Human Genomics, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Am J Respir Crit Care Med 174:1101-9. 2006
  8. pmc Importance of hedgehog interacting protein and other lung function genes in asthma
    Xingnan Li
    Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 127:1457-65. 2011
  9. ncbi request reprint Identification of polymorphisms in the human glucocorticoid receptor gene (NR3C1) in a multi-racial asthma case and control screening panel
    Gregory A Hawkins
    Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    DNA Seq 15:167-73. 2004
  10. pmc COPD is associated with a macrophage scavenger receptor-1 gene sequence variation
    Jill A Ohar
    Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Chest 137:1098-107. 2010

Detail Information

Publications70

  1. doi request reprint Once-daily fluticasone furoate is efficacious in patients with symptomatic asthma on low-dose inhaled corticosteroids
    Eugene R Bleecker
    Center for Genomics and Personalized Medicine, Wake Forest University Health Sciences Winston Salem, North Carolina, USA
    Ann Allergy Asthma Immunol 109:353-358.e4. 2012
    ..Fluticasone furoate (FF) is an inhaled corticosteroid (ICS) with 24-hour activity in development as a once-daily treatment for the long-term management of asthma...
  2. pmc ADRB2 polymorphisms and budesonide/formoterol responses in COPD
    Eugene R Bleecker
    Center for Genomics and Personalized Medicine, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Chest 142:320-8. 2012
    ..We aimed to investigate the effects of the ADRB2 Gly16Arg polymorphism on response to formoterol alone or in combination with the inhaled corticosteroid budesonide in patients with COPD...
  3. pmc Bronchodilator efficacy and safety of indacaterol 150 μg once daily in patients with COPD: an analysis of pooled data
    Eugene R Bleecker
    Center for Genomics and Personalized Medicine Research and Translational Medicine Institute, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Int J Chron Obstruct Pulmon Dis 6:431-8. 2011
    ..As indacaterol is the first once-daily β(2)-agonist to be developed, it is relevant to evaluate its bronchodilator efficacy, safety, and tolerability...
  4. pmc Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers
    Alireza Sadeghnejad
    Center for Human Genomics and Department of Medicine and Pediatrics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Respir Res 10:21. 2009
    ..We evaluated the association between polymorphisms in ADAM33 gene with COPD and lung function in long term tobacco smokers...
  5. pmc The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthma
    Gregory A Hawkins
    Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 130:510-5.e1. 2012
    ..The SNP rs4129267 is in linkage disequilibrium (r(2) = 1) with the IL6R coding SNP rs2228145 (Asp(358)Ala). This IL6R coding change increases IL-6 receptor (IL-6R) shedding and promotes IL-6 transsignaling...
  6. ncbi request reprint Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations
    Timothy D Howard
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 112:717-22. 2003
    ..Recently, a gene potentially involved in airway remodeling, a disintegrin and metalloprotease 33 (ADAM33), was implicated in asthma susceptibility...
  7. pmc Sequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control study
    Gregory A Hawkins
    Center for Human Genomics, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Am J Respir Crit Care Med 174:1101-9. 2006
    ....
  8. pmc Importance of hedgehog interacting protein and other lung function genes in asthma
    Xingnan Li
    Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 127:1457-65. 2011
    ..The importance of these genes in lung function in white and African American subjects with asthma is unknown...
  9. ncbi request reprint Identification of polymorphisms in the human glucocorticoid receptor gene (NR3C1) in a multi-racial asthma case and control screening panel
    Gregory A Hawkins
    Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    DNA Seq 15:167-73. 2004
    ..This data shows the variability of NR3C1 polymorphism frequencies between racial groups and confirms that NR3C1 non-synonymous coding polymorphisms are generally rare in mild/moderate asthmatics and unaffected controls...
  10. pmc COPD is associated with a macrophage scavenger receptor-1 gene sequence variation
    Jill A Ohar
    Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Chest 137:1098-107. 2010
    ....
  11. doi request reprint The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids
    Gregory A Hawkins
    Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 123:1376-83.e7. 2009
    ..Corticosteroids exert their anti-inflammatory action by binding and activating the intracellular glucocorticoid receptor heterocomplex...
  12. pmc Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients
    Xingnan Li
    Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 132:313-20.e15. 2013
    ..Recent meta-analyses of genome-wide association studies in general populations of European descent have identified 28 loci for lung function...
  13. ncbi request reprint Mutational analysis of PINX1 in hereditary prostate cancer
    Gregory A Hawkins
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Prostate 60:298-302. 2004
    ..The PinX1 gene is located within chromosomal region 8p22-23, a region associated with LOH and potentially linked to increased prostate cancer risk...
  14. ncbi request reprint Association between genetic polymorphisms in the prostate-specific antigen gene promoter and serum prostate-specific antigen levels
    Scott D Cramer
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Natl Cancer Inst 95:1044-53. 2003
    ..However, polymorphisms associated with variations in PSA levels have not been identified...
  15. ncbi request reprint A comprehensive evaluation of IL4 variants in ethnically diverse populations: association of total serum IgE levels and asthma in white subjects
    Monica J Basehore
    Center for Human Genomics, Section of Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 114:80-7. 2004
    ..This cytokine is important in IgE isotype switching and the regulation of allergic inflammation; however, published studies have not delineated the specific role of variation in this gene in allergic disorders...
  16. ncbi request reprint Sequence variants in the human 25-hydroxyvitamin D3 1-alpha-hydroxylase (CYP27B1) gene are not associated with prostate cancer risk
    Gregory A Hawkins
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Prostate 53:175-8. 2002
    ..25-hydroxyvitamin D(3) 1-alpha-hydroxylase, the enzyme that catalyzes the final step of vitamin D synthesis, converting 25-hydroxyvitamin D(3) to 1,25-dihydroxyvitamin D(3), is expressed in the prostate...
  17. pmc Common sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Hum Genet 72:208-12. 2003
    ..These results consistently suggest that MSR1 may play an important role in prostate carcinogenesis...
  18. ncbi request reprint Fine mapping of an IgE-controlling gene on chromosome 2q: Analysis of CTLA4 and CD28
    Timothy D Howard
    Center for Human Genomics, Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 110:743-51. 2002
    ..Two candidate genes, CTLA4 and CD28, important homeostatic regulators of T-cell activation and subsequent IgE production, map within this candidate region...
  19. pmc Effect of rare variants in ADRB2 on risk of severe exacerbations and symptom control during longacting β agonist treatment in a multiethnic asthma population: a genetic study
    Victor E Ortega
    Center for Genomics and Personalized Medicine, Wake Forest School of Medicine, Winston Salem, NC, USA
    Lancet Respir Med 2:204-13. 2014
    ..We hypothesise that rare ADRB2 variants modulate therapeutic responses to LABA therapy and contribute to rare, severe adverse events...
  20. pmc Predictors of response to tiotropium versus salmeterol in asthmatic adults
    Stephen P Peters
    Wake Forest School of Medicine, Winston Salem, NC Electronic address
    J Allergy Clin Immunol 132:1068-1074.e1. 2013
    ..Tiotropium has activity as an asthma controller. However, predictors of a positive response to tiotropium have not been described...
  21. ncbi request reprint Effect of ADRB2 polymorphisms on response to longacting beta2-agonist therapy: a pharmacogenetic analysis of two randomised studies
    Eugene R Bleecker
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Lancet 370:2118-25. 2007
    ..We, therefore, investigated whether ADRB2 polymorphisms affect response to longacting beta2-agonists in combination with inhaled corticosteroids...
  22. ncbi request reprint Sequence variants of alpha-methylacyl-CoA racemase are associated with prostate cancer risk
    Siqun L Zheng
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Cancer Res 62:6485-8. 2002
    ..78; P = 0.00006), especially in the subset of families whose probands carry the "A-A" haplotype of M9V and D175G (log of odds = 4.34; P = 0.000008). These results suggest that sequence variants in AMACR may be associated with CaP risk...
  23. pmc Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects
    Annette T Hastie
    Center for Genomics and Personalized Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 132:72-80. 2013
    ..Availability and ease of measurement are useful characteristics, but accuracy in predicting airway eosinophil and neutrophil percentages either individually or combined is not established...
  24. ncbi request reprint Evaluation of SRD5A2 sequence variants in susceptibility to hereditary and sporadic prostate cancer
    Bao Li Chang
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Prostate 56:37-44. 2003
    ..However, the role of SRD5A2 sequence variants in the susceptibility to hereditary prostate cancer (HPC) has not been evaluated to date...
  25. ncbi request reprint Polymorphic GGC repeats in the androgen receptor gene are associated with hereditary and sporadic prostate cancer risk
    Bao Li Chang
    Center for Human Genomics, Wake Forest University School of Medicine, Winton Salem, NC 27157, USA
    Hum Genet 110:122-9. 2002
    ..Further studies on this polymorphism in other independent data sets and functional analysis of the GGC repeat length on AR activity are warranted...
  26. ncbi request reprint Associations between hOGG1 sequence variants and prostate cancer susceptibility
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Cancer Res 62:2253-7. 2002
    ..These results suggest that sequence variants in this gene are associated with prostate cancer risk, presumably through defective DNA repair function of hOGG1...
  27. ncbi request reprint Common estrogen receptor polymorphism augments effects of hormone replacement therapy on E-selectin but not C-reactive protein
    David M Herrington
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
    Circulation 105:1879-82. 2002
    ..This study sought to determine if this augmentation extends to HRT regulation of E-selectin and C-reactive protein (CRP) and to explore possible mechanisms by which this polymorphism might influence estrogen action...
  28. pmc Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions
    Xingnan Li
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 125:328-335.e11. 2010
    ..Genome-wide association studies (GWASs) represent a powerful approach to investigate the association of DNA variants with disease susceptibility. To date, few GWASs for asthma have been reported...
  29. pmc IL-4 receptor polymorphisms predict reduction in asthma exacerbations during response to an anti-IL-4 receptor α antagonist
    Rebecca E Slager
    Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 130:516-22.e4. 2012
    ..We analyzed genomic DNA from participants in a 12-week placebo-controlled efficacy trial of pitrakinra (1, 3, or 10 mg twice daily), a novel IL-4/IL-13 pathway antagonist (Clinicaltrials.govNCT00801853)...
  30. doi request reprint Beta2-receptor polymorphisms in patients receiving salmeterol with or without fluticasone propionate
    Eugene R Bleecker
    Center for Human Genomics and Department of Medicine, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
    Am J Respir Crit Care Med 181:676-87. 2010
    ..Retrospective pharmacogenetic studies have questioned whether patients with asthma who are arginine homozygous at the beta(2-)adrenergic receptor (position 16) should use long-acting beta-agonists...
  31. doi request reprint Cumulative association of five genetic variants with prostate cancer
    S Lilly Zheng
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    N Engl J Med 358:910-9. 2008
    ..3--have been associated with prostate cancer. Each SNP has only a moderate association, but when SNPs are combined, the association may be stronger...
  32. ncbi request reprint Evaluation of DLC1 as a prostate cancer susceptibility gene: mutation screen and association study
    Siqun L Zheng
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Mutat Res 528:45-53. 2003
    ..These results suggest that DLC1 is unlikely to play an important role in prostate cancer susceptibility...
  33. pmc Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program
    Wendy C Moore
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Am J Respir Crit Care Med 181:315-23. 2010
    ..The Severe Asthma Research Program cohort includes subjects with persistent asthma who have undergone detailed phenotypic characterization. Previous univariate methods compared features of mild, moderate, and severe asthma...
  34. pmc Safety of investigative bronchoscopy in the Severe Asthma Research Program
    Wendy C Moore
    Center for Human Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 128:328-336.e3. 2011
    ..We evaluated the safety aspects of this procedure in this cohort with specific focus on patients with severe asthma...
  35. ncbi request reprint Genome screen for asthma and bronchial hyperresponsiveness: interactions with passive smoke exposure
    Deborah A Meyers
    Center for Human Genomics, Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 115:1169-75. 2005
    ..Passive smoke exposure, characterized by parental smoking, has been shown to be a risk factor for the development of atopy and asthma...
  36. pmc Tiotropium bromide step-up therapy for adults with uncontrolled asthma
    Stephen P Peters
    Wake Forest University Health Sciences, Center for Genomics and Personalized Medicine Research, Medical Center Blvd, Winston Salem, NC 27157, USA
    N Engl J Med 363:1715-26. 2010
    ..Long-acting beta-agonist (LABA) therapy improves symptoms in patients whose asthma is poorly controlled by an inhaled glucocorticoid alone. Alternative treatments for adults with uncontrolled asthma are needed...
  37. pmc Genetics of asthma susceptibility and severity
    Rebecca E Slager
    Center for Genomics and Personalized Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Clin Chest Med 33:431-43. 2012
    ..Future genetic studies will incorporate sequencing in comprehensively phenotyped asthmatics to lead to the development of personalized therapy...
  38. doi request reprint Lung function and symptom improvement with fluticasone propionate/salmeterol and ipratropium bromide/albuterol in COPD: response by beta-agonist reversibility
    Eugene R Bleecker
    Wake Forest University Health Sciences, Winston Salem, NC, USA
    Pulm Pharmacol Ther 21:682-8. 2008
    ....
  39. pmc Do symptoms predict COPD in smokers?
    Jill A Ohar
    Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Chest 137:1345-53. 2010
    ..The US Preventive Services Task Force recommends against spirometry in the absence of symptoms. However, as much as 50% of COPD cases in the United States remain undiagnosed...
  40. pmc Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis
    Wendy C Moore
    Wake Forest School of Medicine, Center for Genomics and Personalized Medicine Research and the Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Winston Salem, NC Electronic address
    J Allergy Clin Immunol 133:1557-63.e5. 2014
    ..Subjects with concurrent increases in eosinophil (≥2%) and neutrophil (≥40%) percentages had characteristics of very severe asthma...
  41. pmc Exploring pleiotropy using principal components
    Jeannette T Bensen
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    BMC Genet 4:S53. 2003
    ....
  42. ncbi request reprint A comprehensive association study for genes in inflammation pathway provides support for their roles in prostate cancer risk in the CAPS study
    S Lilly Zheng
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Prostate 66:1556-64. 2006
    ..Considering inflammation is regulated by a complex system of gene products, we hypothesize sequence variants in many other genes of this pathway are associated with prostate cancer...
  43. ncbi request reprint IL13 promoter polymorphism 1112C/T modulates the adverse effect of tobacco smoking on lung function
    Alireza Sadeghnejad
    Center for Human Genomics and Department of Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Am J Respir Crit Care Med 176:748-52. 2007
    ..IL-13 is involved in pulmonary inflammation, remodeling, and susceptibility to chronic obstructive pulmonary disease (COPD)...
  44. pmc Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases
    Xingnan Li
    Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 130:861-8.e7. 2012
    ....
  45. ncbi request reprint Sequence analysis of HSPA1A and HSPA1B in a multi-ethnic study population
    Richard S Smith
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    DNA Seq 18:47-53. 2007
    ..Two-thirds of the polymorphisms reported in dbSNP were not identified in our screening panel. Although similar in sequence, HSPAIA and HSPAIB do not share common patterns of polymorphisms...
  46. ncbi request reprint Association studies of serum prostate-specific antigen levels and the genetic polymorphisms at the androgen receptor and prostate-specific antigen genes
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Cancer Epidemiol Biomarkers Prev 11:664-9. 2002
    ..A systematic approach is required to identify sequence variants in these genes and other related genes, and to test for an association between these variants and PSA levels in large samples...
  47. doi request reprint Clinical consequences of ADRbeta2 polymorphisms
    Gregory A Hawkins
    Center for Human Genomics, Section of Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Pharmacogenomics 9:349-58. 2008
    ....
  48. pmc Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes
    Annette T Hastie
    Center for Human Genomics, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 125:1028-1036.e13. 2010
    ..Patients with severe asthma have increased granulocytes in their sputum compared with patients with mild to moderate asthma...
  49. pmc Effect of β2-adrenergic receptor gene (ADRB2) 3' untranslated region polymorphisms on inhaled corticosteroid/long-acting β2-adrenergic agonist response
    Helen J Ambrose
    Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC, 27157, USA
    Respir Res 13:37. 2012
    ....
  50. ncbi request reprint Salmeterol response is not affected by beta2-adrenergic receptor genotype in subjects with persistent asthma
    Eugene R Bleecker
    Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 118:809-16. 2006
    ..However, it is not known whether similar responses occur in Arg/Arg patients receiving long-acting beta2-agonists...
  51. pmc Pharmacogenetics of the beta 2-adrenergic receptor gene
    Victor E Ortega
    Center for Human Genomics, Section of Pulmonary, Critical Care, Allergy, and Immunologic Diseases, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Immunol Allergy Clin North Am 27:665-84; vii. 2007
    ..Meanwhile, the conflicting data concerning LABAs may be caused by such factors as small sample sizes of study populations and differences in experimental design...
  52. pmc Potential impact of adding genetic markers to clinical parameters in predicting prostate biopsy outcomes in men following an initial negative biopsy: findings from the REDUCE trial
    A Karim Kader
    Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Eur Urol 62:953-61. 2012
    ..Several germline single nucleotide polymorphisms (SNPs) have been consistently associated with prostate cancer (PCa) risk...
  53. ncbi request reprint Germline sequence variants of the LZTS1 gene are associated with prostate cancer risk
    Gregory A Hawkins
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Cancer Genet Cytogenet 137:1-7. 2002
    ..Four of these SNP were statistically significant for association with prostate cancer (P < or = 0.04). These results add evidence supporting a role of LZTS1 in prostate cancer risk...
  54. pmc Major recessive gene(s) with considerable residual polygenic effect regulating adult height: confirmation of genomewide scan results for chromosomes 6, 9, and 12
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, 27157, USA
    Am J Hum Genet 71:646-50. 2002
    ..06, D6S2436), 9p1 (LOD = 2.09, D9S301), and 12q1 (LOD = 1.86, D12S375). Our results provide evidence that a combination of segregation and linkage approaches is valuable in understanding genetic determination of common complex traits...
  55. ncbi request reprint Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk
    Jianfeng Xu
    Center for Human Genomics and the Department of Public Health, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Nat Genet 32:321-5. 2002
    ..009). Among African American men, these values were 12.5% and 1.8%, respectively (P = 0.01). These results show that MSR1 may be important in susceptibility to prostate cancer in men of both African American and European descent...
  56. ncbi request reprint Estrogen-receptor polymorphisms and effects of estrogen replacement on high-density lipoprotein cholesterol in women with coronary disease
    David M Herrington
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
    N Engl J Med 346:967-74. 2002
    ....
  57. ncbi request reprint Positive results in association studies are associated with departure from Hardy-Weinberg equilibrium: hint for genotyping error?
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hum Genet 111:573-4. 2002
  58. pmc Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program
    Wendy C Moore
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 119:405-13. 2007
    ..Severe asthma causes the majority of asthma morbidity. Understanding mechanisms that contribute to the development of severe disease is important...
  59. ncbi request reprint Identification of coding polymorphisms in human circadian rhythm genes PER1, PER2, PER3, CLOCK, ARNTL, CRY1, CRY2 and TIMELESS in a multi-ethnic screening panel
    Gregory A Hawkins
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    DNA Seq 19:44-9. 2008
    ..In this study, the exonic regions of the circadian rhythm genes PER1, PER2, PER3, CLOCK, ARNTL, CRY1, CRY2 and TIMELESS were re-sequenced and coding changes identified in a panel of 95 individuals varying in ethnicity...
  60. pmc Asthma and gender impact accumulation of T cell subtypes
    Matthew J Loza
    Department of Internal Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Respir Res 11:103. 2010
    ..We sought to establish whether CD3+CD28-mediated and antigen-independent accumulation of type 1 and type 2 T cells differs significantly between nonasthmatic and asthmatic populations...
  61. ncbi request reprint Therapeutic responses in asthma and COPD. Corticosteroids
    Michael J Larj
    Center for Human Genomics, Division of Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1008, USA
    Chest 126:138S-149S; discussion 159S-161S. 2004
    ..Future approaches should further define phenotypes, perhaps based in part on pharmacogenetic factors that will guide anti-inflammatory therapy in asthma and COPD...
  62. ncbi request reprint Mapping susceptibility genes for allergic diseases
    Timothy D Howard
    Department of Pediatrics, Center for Human Genomics, Wake Forest University, Health Science, Winston Salem, NC 27157, USA
    Chest 123:363S-8S. 2003
    ..Understanding the basic interactions that lead to the development of allergy and asthma will lead to new therapeutic approaches that will be used to modify the development and clinical progression of these common disorders...
  63. ncbi request reprint Pharmacogenetics of asthma: where are we now?
    Michael J Larj
    Center for Medical Genomics, Wake Forest University Baptist Medical Center, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Clin Chest Med 27:109-17, vii. 2006
    ..Legal issues including patents and commercial issues concerning patient, physician, and managed care acceptance must be addressed...
  64. doi request reprint Assessing productivity loss and activity impairment in severe or difficult-to-treat asthma
    Hubert Chen
    Department of Medicine, University of California, San Francisco, CA, USA, and Genentech Inc, South San Francisco, CA, USA
    Value Health 11:231-9. 2008
    ..We sought to assess the performance characteristics of an asthma-specific adaptation of the Work Productivity and Activity Impairment Questionnaire (WPAI:Asthma) in patients with either severe or difficult-to-treat asthma...
  65. ncbi request reprint Pharmacogenetics of asthma
    Rodolfo M Pascual
    Wake Forest University Health Sciences, Center for Genomics and Personalized Medicine Research, Medical Center Boulevard, Winston Salem, NC 27157, United States
    Curr Opin Pharmacol 10:226-35. 2010
    ..Pharmacogenetic approaches hold the promise of matching individualized treatments to specific genotypes in a way that minimizes side effects while improving therapeutic outcomes...
  66. ncbi request reprint Joint effect of HSD3B1 and HSD3B2 genes is associated with hereditary and sporadic prostate cancer susceptibility
    Bao Li Chang
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Cancer Res 62:1784-9. 2002
    ..Most importantly, the subset of hereditary prostate cancer probands, whose families provided evidence for linkage at 1p13, predominantly contributed to the observed association. Additional studies are warranted to confirm these findings...
  67. ncbi request reprint Effects of beta2-agonists on airway tone and bronchial responsiveness
    Michael J Larj
    Division of Pulmonary and Critical Care Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 110:S304-12. 2002
    ....
  68. ncbi request reprint Similarities and differences in asthma and COPD. The Dutch hypothesis
    Eugene R Bleecker
    Center for Human Genomics, Wake Forest University, Medical Center Blvd, Winston Salem, NC 27157, USA
    Chest 126:93S-95S; discussion 159S-161S. 2004
  69. ncbi request reprint Asthma pharmacogenomics
    Gregory A Hawkins
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Immunol Allergy Clin North Am 25:723-42. 2005
    ..Whether pharmacogenomics becomes common practice may not depend on the availability of tests, but on factors such as affordability, ease of application, and ease of interpreting the results...
  70. pmc Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma
    Timothy D Howard
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Hum Genet 70:230-6. 2002
    ..0004). These data suggest that variations in IL4RA contribute to elevated total serum IgE levels, and interaction between IL4RA and IL13 markedly increases an individual's susceptibility to asthma...