David E Blask

Summary

Publications

  1. ncbi request reprint New actions of melatonin on tumor metabolism and growth
    D E Blask
    Bassett Research Institute, Mary Imogene Bassett Hospital, Cooperstown, NY 13326 1394, USA
    Biol Signals Recept 8:49-55. 1999
  2. ncbi request reprint Melatonin inhibition of cancer growth in vivo involves suppression of tumor fatty acid metabolism via melatonin receptor-mediated signal transduction events
    D E Blask
    Laboratory of Experimental Neuroendocrinology Oncology, Bassett Research Institute, Cooperstown, New York 13326 1394, USA
    Cancer Res 59:4693-701. 1999
  3. ncbi request reprint Melatonin as a chronobiotic/anticancer agent: cellular, biochemical, and molecular mechanisms of action and their implications for circadian-based cancer therapy
    David E Blask
    Laboratory of Experimental Neuroendocrinology Oncology, Bassett Research Institute, Cooperstown, NY 13326, USA
    Curr Top Med Chem 2:113-32. 2002
  4. ncbi request reprint Human cancer xenograft perfusion in situ in rats: a new perfusion system that minimizes delivery time and maintains normal tissue physiology and responsiveness to growth-inhibitory agents
    Erin M Dauchy
    Laboratory of Chrononeuroendocrine Oncology, Bassett Research Institute, Cooperstown, NY, USA
    J Am Assoc Lab Anim Sci 45:38-44. 2006
  5. ncbi request reprint Inhibition of fatty acid transport and proliferative activity in tissue-isolated human squamous cell cancer xenografts perfused in situ with melatonin or eicosapentaenoic or conjugated linoleic acids
    Robert T Dauchy
    Bassett Research Institute, The Mary Imogene Bassett Hospital, Cooperstown, NY, USA
    Comp Med 57:377-82. 2007
  6. ncbi request reprint Dietary fish oil deactivates a growth-promoting signaling pathway in hepatoma 7288CTC in Buffalo rats
    Laura C Smith
    Bassett Research Institute, Cooperstown, NY 13326, USA
    Nutr Cancer 56:204-13. 2006
  7. ncbi request reprint Melatonin-depleted blood from premenopausal women exposed to light at night stimulates growth of human breast cancer xenografts in nude rats
    David E Blask
    Laboratory of Chrono Neuroendocrine Oncology, Bassett Research Institute, The Mary Imogene Bassett Hospital, Cooperstown, New York 13326, USA
    Cancer Res 65:11174-84. 2005
  8. ncbi request reprint Differential inhibition of fatty acid transport in tissue-isolated steroid receptor negative human breast cancer xenografts perfused in situ with isomers of conjugated linoleic acid
    Robert T Dauchy
    Bassett Research Institute, The Mary Imogene Bassett Hospital, One Atwell Road, Cooperstown, NY 13326, USA
    Cancer Lett 209:7-15. 2004
  9. ncbi request reprint Eicosapentaenoic acid suppresses cell proliferation in MCF-7 human breast cancer xenografts in nude rats via a pertussis toxin-sensitive signal transduction pathway
    Leonard A Sauer
    Bassett Research Institute, Cooperstown, NY 13326, USA
    J Nutr 135:2124-9. 2005
  10. ncbi request reprint Growth and fatty acid metabolism of human breast cancer (MCF-7) xenografts in nude rats: impact of constant light-induced nocturnal melatonin suppression
    David E Blask
    Laboratory of Chrono Neuroendocrine Oncology, Bassett Research Institute, Cooperstown, NY 13326, USA
    Breast Cancer Res Treat 79:313-20. 2003

Collaborators

Detail Information

Publications20

  1. ncbi request reprint New actions of melatonin on tumor metabolism and growth
    D E Blask
    Bassett Research Institute, Mary Imogene Bassett Hospital, Cooperstown, NY 13326 1394, USA
    Biol Signals Recept 8:49-55. 1999
    ..Thus, melatonin and linoleic acid represent two important environmental signals that interact in a unique manner to regulate tumor progression and ultimately the host-cancer balance...
  2. ncbi request reprint Melatonin inhibition of cancer growth in vivo involves suppression of tumor fatty acid metabolism via melatonin receptor-mediated signal transduction events
    D E Blask
    Laboratory of Experimental Neuroendocrinology Oncology, Bassett Research Institute, Cooperstown, New York 13326 1394, USA
    Cancer Res 59:4693-701. 1999
    ..The inhibition of these signal transduction events by melatonin culminates in the suppression of LA uptake, LA metabolism to the mitogenic signaling molecule 13-HODE, and cancer growth...
  3. ncbi request reprint Melatonin as a chronobiotic/anticancer agent: cellular, biochemical, and molecular mechanisms of action and their implications for circadian-based cancer therapy
    David E Blask
    Laboratory of Experimental Neuroendocrinology Oncology, Bassett Research Institute, Cooperstown, NY 13326, USA
    Curr Top Med Chem 2:113-32. 2002
    ..It also provides the first biological explanation of melatonin-induced enhancement of the efficacy and reduced toxicity of chemo- and radiotherapy in cancer patients...
  4. ncbi request reprint Human cancer xenograft perfusion in situ in rats: a new perfusion system that minimizes delivery time and maintains normal tissue physiology and responsiveness to growth-inhibitory agents
    Erin M Dauchy
    Laboratory of Chrononeuroendocrine Oncology, Bassett Research Institute, Cooperstown, NY, USA
    J Am Assoc Lab Anim Sci 45:38-44. 2006
    ..This new system provides rapid perfusate delivery for use with both normal and neoplastic tissues while maintaining normal physiologic tissue parameters...
  5. ncbi request reprint Inhibition of fatty acid transport and proliferative activity in tissue-isolated human squamous cell cancer xenografts perfused in situ with melatonin or eicosapentaenoic or conjugated linoleic acids
    Robert T Dauchy
    Bassett Research Institute, The Mary Imogene Bassett Hospital, Cooperstown, NY, USA
    Comp Med 57:377-82. 2007
    ....
  6. ncbi request reprint Dietary fish oil deactivates a growth-promoting signaling pathway in hepatoma 7288CTC in Buffalo rats
    Laura C Smith
    Bassett Research Institute, Cooperstown, NY 13326, USA
    Nutr Cancer 56:204-13. 2006
    ..These results provide in vivo evidence that dietary fish oil suppressed a specific linoleic acid-dependent, inhibitory G protein-coupled, growth-promoting signaling pathway in rat hepatoma 7288CTC...
  7. ncbi request reprint Melatonin-depleted blood from premenopausal women exposed to light at night stimulates growth of human breast cancer xenografts in nude rats
    David E Blask
    Laboratory of Chrono Neuroendocrine Oncology, Bassett Research Institute, The Mary Imogene Bassett Hospital, Cooperstown, New York 13326, USA
    Cancer Res 65:11174-84. 2005
    ..These mechanistic studies are the first to provide a rational biological explanation for the increased breast cancer risk in female night shift workers...
  8. ncbi request reprint Differential inhibition of fatty acid transport in tissue-isolated steroid receptor negative human breast cancer xenografts perfused in situ with isomers of conjugated linoleic acid
    Robert T Dauchy
    Bassett Research Institute, The Mary Imogene Bassett Hospital, One Atwell Road, Cooperstown, NY 13326, USA
    Cancer Lett 209:7-15. 2004
    ....
  9. ncbi request reprint Eicosapentaenoic acid suppresses cell proliferation in MCF-7 human breast cancer xenografts in nude rats via a pertussis toxin-sensitive signal transduction pathway
    Leonard A Sauer
    Bassett Research Institute, Cooperstown, NY 13326, USA
    J Nutr 135:2124-9. 2005
    ..The results suggest that EPA regulates cell proliferation in MCF-7 xenografts via a novel inhibitory G protein-coupled, (n-3) FFA receptor-mediated signal transduction pathway...
  10. ncbi request reprint Growth and fatty acid metabolism of human breast cancer (MCF-7) xenografts in nude rats: impact of constant light-induced nocturnal melatonin suppression
    David E Blask
    Laboratory of Chrono Neuroendocrine Oncology, Bassett Research Institute, Cooperstown, NY 13326, USA
    Breast Cancer Res Treat 79:313-20. 2003
    ..This is the first biological evidence for a potential link between constant light exposure and increased human breast oncogenesis involving MLT suppression and stimulation of tumor LA metabolism...
  11. ncbi request reprint Dietary factors and growth and metabolism in experimental tumors
    Leonard A Sauer
    Bassett Research Institute, Cooperstown, NY 13326, USA
    J Nutr Biochem 18:637-49. 2007
    ....
  12. ncbi request reprint Conjugated linoleic acid isomers and trans fatty acids inhibit fatty acid transport in hepatoma 7288CTC and inguinal fat pads in Buffalo rats
    Leonard A Sauer
    Bassett Research Institute, Cooperstown, NY 13326, USA
    J Nutr 134:1989-97. 2004
    ..These results support the idea that an inhibitory GPC FFAR reduces cAMP and controls FA transport by CLA isomers and trans FAs. Ligand activity is conferred by the presence of a trans double bond proximal to the carboxyl group...
  13. ncbi request reprint Melatonin uptake and growth prevention in rat hepatoma 7288CTC in response to dietary melatonin: melatonin receptor-mediated inhibition of tumor linoleic acid metabolism to the growth signaling molecule 13-hydroxyoctadecadienoic acid and the potential rol
    David E Blask
    Laboratory of Chrono Neuroendocrine Oncology, Bassett Research Institute, One Atwell Road, Cooperstown, NY 13326, USA
    Carcinogenesis 25:951-60. 2004
    ....
  14. doi request reprint Light at night activates IGF-1R/PDK1 signaling and accelerates tumor growth in human breast cancer xenografts
    Jinghai Wu
    Bassett Research Institute and Department of Internal Medicine, Bassett Healthcare Network, Cooperstown, New York, USA
    Cancer Res 71:2622-31. 2011
    ..Taken together, our findings demonstrate that LAN exposure can accelerate tumor growth in vivo, in part through continuous activation of IGF-1R/PDK1 signaling...
  15. ncbi request reprint Putting cancer to sleep at night: the neuroendocrine/circadian melatonin signal
    David E Blask
    Laboratory of Chrono Neuroendocrine Oncology, Bassett Research Institute, Cooperstown, NY 13326, USA
    Endocrine 27:179-88. 2005
    ..Dietary melatonin supplementation working in concert with the endogenous melatonin signal has the potential to be a new preventive/therapeutic strategy to optimize the host/cancer balance in favor of host survival and quality of life...
  16. ncbi request reprint Physiologic melatonin concentration, omega-3 fatty acids, and conjugated linoleic acid inhibit fatty acid transport in rodent hind limb skeletal muscle in vivo
    Robert T Dauchy
    Laboratory of Experimental Neuroendocrinolgy Oncology, Bassett Research Institute, Cooperstown, New York 13326 1394, USA
    Comp Med 53:186-90. 2003
    ..Glucose uptake and glycerol production in the hind limb were not affected. These investigations suggest a novel role for MLT, omega-3 FAs, and CLA in the regulation of FA transport and fat metabolism in skeletal muscle...
  17. ncbi request reprint Light during darkness, melatonin suppression and cancer progression
    David E Blask
    Laboratory of Experimental Neuroendocrinology Oncology, Bassett Research Institute, Cooperstown, NY 13326, USA
    Neuro Endocrinol Lett 23:52-6. 2002
    ....
  18. ncbi request reprint Light during darkness and cancer: relationships in circadian photoreception and tumor biology
    Samar A Jasser
    Department of Neurology, Light Research Program, Thomas Jefferson University, 1025 Walnut Street, Suite 507, Philadelphia, PA 19107, USA
    Cancer Causes Control 17:515-23. 2006
    ..Continued rigorous empirical inquiry into the physiology and clinical implications of these habitual, integrated aspects of life is highly warranted at this time...
  19. ncbi request reprint Re: Melatonin and breast cancer: a prospective study
    William J M Hrushesky
    J Natl Cancer Inst 96:888-9. 2004
  20. pmc Meeting report: the role of environmental lighting and circadian disruption in cancer and other diseases
    Richard G Stevens
    Department of Community Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030 6325, USA
    Environ Health Perspect 115:1357-62. 2007
    ..Third are effects of light-induced physiologic disruption on disease occurrence and prognosis, and how prevention and treatment could be improved by application of this knowledge...