Julie Blanchard

Summary

Publications

  1. doi request reprint Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice
    Julie Blanchard
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, 10314, USA
    Acta Neuropathol 120:605-21. 2010
  2. doi request reprint Detection of age-dependent working memory deterioration in APP751SL mice
    Julie Blanchard
    Centre for Integrative and Cognitive Neuroscience, University of Bordeaux, CNRS UMR 5228, Talence, France
    Behav Brain Res 218:129-37. 2011
  3. pmc An experimental rat model of sporadic Alzheimer's disease and rescue of cognitive impairment with a neurotrophic peptide
    Silvia Bolognin
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Acta Neuropathol 123:133-51. 2012
  4. doi request reprint Rescue of synaptic failure and alleviation of learning and memory impairments in a trisomic mouse model of down syndrome
    Julie Blanchard
    Department of Neurochemistry, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    J Neuropathol Exp Neurol 70:1070-9. 2011
  5. doi request reprint Neurotrophic peptides incorporating adamantane improve learning and memory, promote neurogenesis and synaptic plasticity in mice
    Bin Li
    Department of Neurochemistry, NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    FEBS Lett 584:3359-65. 2010
  6. doi request reprint Enhancement of dentate gyrus neurogenesis, dendritic and synaptic plasticity and memory by a neurotrophic peptide
    Muhammad Omar Chohan
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314 6399, USA
    Neurobiol Aging 32:1420-34. 2011
  7. doi request reprint Beneficial effect of a CNTF tetrapeptide on adult hippocampal neurogenesis, neuronal plasticity, and spatial memory in mice
    Julie Blanchard
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    J Alzheimers Dis 21:1185-95. 2010
  8. doi request reprint Animal models of the sporadic form of Alzheimer's disease: focus on the disease and not just the lesions
    Khalid Iqbal
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA
    J Alzheimers Dis 37:469-74. 2013
  9. pmc A non-transgenic mouse model (icv-STZ mouse) of Alzheimer's disease: similarities to and differences from the transgenic model (3xTg-AD mouse)
    Yanxing Chen
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, NY 10314, USA
    Mol Neurobiol 47:711-25. 2013
  10. pmc Alzheimer's disease neurofibrillary degeneration: pivotal and multifactorial
    Khalid Iqbal
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York, NY 10314, USA
    Biochem Soc Trans 38:962-6. 2010

Collaborators

Detail Information

Publications19

  1. doi request reprint Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice
    Julie Blanchard
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, 10314, USA
    Acta Neuropathol 120:605-21. 2010
    ..These findings, for the first time, demonstrate the possibility of therapeutic treatment of AD and related disorders by peripheral administration of a peptide corresponding to a biologically active region of CNTF...
  2. doi request reprint Detection of age-dependent working memory deterioration in APP751SL mice
    Julie Blanchard
    Centre for Integrative and Cognitive Neuroscience, University of Bordeaux, CNRS UMR 5228, Talence, France
    Behav Brain Res 218:129-37. 2011
    ..We also demonstrated that these working memory deficits are related to progressive Aβ accumulation in the hippocampus, but not in the other selected brain structures...
  3. pmc An experimental rat model of sporadic Alzheimer's disease and rescue of cognitive impairment with a neurotrophic peptide
    Silvia Bolognin
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Acta Neuropathol 123:133-51. 2012
    ....
  4. doi request reprint Rescue of synaptic failure and alleviation of learning and memory impairments in a trisomic mouse model of down syndrome
    Julie Blanchard
    Department of Neurochemistry, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    J Neuropathol Exp Neurol 70:1070-9. 2011
    ..These findings suggest a therapeutic potential of Peptide 6 in promoting functional neural integration into networks, thereby strengthening biologic substrates of memory processing...
  5. doi request reprint Neurotrophic peptides incorporating adamantane improve learning and memory, promote neurogenesis and synaptic plasticity in mice
    Bin Li
    Department of Neurochemistry, NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    FEBS Lett 584:3359-65. 2010
    ..P21 induced enhancement of neurogenesis and maturation of newly born neurons in the granular cell layer and subgranular zone of the dentate gyrus...
  6. doi request reprint Enhancement of dentate gyrus neurogenesis, dendritic and synaptic plasticity and memory by a neurotrophic peptide
    Muhammad Omar Chohan
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314 6399, USA
    Neurobiol Aging 32:1420-34. 2011
    ..The fact that Peptide 6 is both neurogenic and neurotrophic and that this peptide is effective when given peripherally, demonstrates its potential for prevention and treatment of learning and memory disorders...
  7. doi request reprint Beneficial effect of a CNTF tetrapeptide on adult hippocampal neurogenesis, neuronal plasticity, and spatial memory in mice
    Julie Blanchard
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    J Alzheimers Dis 21:1185-95. 2010
    ..Overall, these findings demonstrated the therapeutic potential of Peptide 6c for regeneration of the brain and improvement of cognition...
  8. doi request reprint Animal models of the sporadic form of Alzheimer's disease: focus on the disease and not just the lesions
    Khalid Iqbal
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA
    J Alzheimers Dis 37:469-74. 2013
    ....
  9. pmc A non-transgenic mouse model (icv-STZ mouse) of Alzheimer's disease: similarities to and differences from the transgenic model (3xTg-AD mouse)
    Yanxing Chen
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, NY 10314, USA
    Mol Neurobiol 47:711-25. 2013
    ....
  10. pmc Alzheimer's disease neurofibrillary degeneration: pivotal and multifactorial
    Khalid Iqbal
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York, NY 10314, USA
    Biochem Soc Trans 38:962-6. 2010
    ..Restoration of PP2A activity by inhibition of the cleavage of I(2)(PP2A)/SET offers a promising therapeutic opportunity in AD with this aetiopathogenic mechanism...
  11. pmc Intracerebroventricular streptozotocin exacerbates Alzheimer-like changes of 3xTg-AD mice
    Yanxing Chen
    Department of Neurochemistry, Inge Grundke Iqbal Research Floor, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY, 10314 6399, USA
    Mol Neurobiol 49:547-62. 2014
    ..These findings provide experimental evidence of the role of metabolic insult in AD...
  12. pmc The carboxy-terminal fragment of inhibitor-2 of protein phosphatase-2A induces Alzheimer disease pathology and cognitive impairment
    Xiaochuan Wang
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    FASEB J 24:4420-32. 2010
    ..These findings suggest a novel etiopathogenic mechanism of AD, which is initiated by the cleavage of I(2)(PP2A), producing I(2CTF), and describe a novel disease-relevant nontransgenic animal model of AD...
  13. doi request reprint Inhibition of Protein Phosphatase-2A (PP2A) by I1PP2A Leads to Hyperphosphorylation of Tau, Neurodegeneration, and Cognitive Impairment in Rats
    Xiaochuan Wang
    Department of Neurochemistry, Inge Grundke Iqbal Research Floor, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA
    J Alzheimers Dis 45:423-35. 2015
    ..These studies suggest that I1PP2A can inhibit PP2A activity, and in turn induce AD neurofibrillary degeneration and cognitive deficits in rats. ..
  14. doi request reprint Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer's disease
    Syed Faraz Kazim
    Department of Neurochemistry, Inge Grundke Iqbal Research Floor, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA Neural and Behavioral Science Graduate Program, State University of New York SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA SUNY IBR Center for Developmental Neuroscience CDN, 1050 Forest Hill Road, Staten Island, NY 10314, USA Electronic address
    Neurobiol Dis 71:110-30. 2014
    ..P021 treatment also rescued deficits in cognition, neurogenesis, and synaptic plasticity in 3xTg-AD mice. These findings demonstrate the potential of the neurotrophic peptide mimetic as a disease modifying therapy for AD. ..
  15. pmc Sera from children with autism induce autistic features which can be rescued with a CNTF small peptide mimetic in rats
    Syed Faraz Kazim
    Inge Grundke Iqbal Research Floor, Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities NYSIBR, Staten Island, New York, United States of America Neural and Behavioral Science Graduate Program, State University of New York SUNY Downstate Medical Center, Brooklyn, New York, United States of America SUNY Downstate NYSIBR Center for Developmental Neuroscience CDN, Staten Island, New York, United States of America
    PLoS ONE 10:e0118627. 2015
    ..These findings implicate the involvement of neurotrophic imbalance during early brain development in the pathophysiology of autism and a proof of principle of P6 as a potential therapeutic strategy for autism. ..
  16. doi request reprint Characterization of cognition alteration across the course of the disease in APP751SL mice with parallel estimation of cerebral Abeta deposition
    Julie Blanchard
    Centre for Integrative and Cognitive Neuroscience, University of Bordeaux, CNRS UMR 5228, Talence, France
    Behav Brain Res 201:147-57. 2009
    ..Because this mouse model displayed gradual memory deficits it gives the opportunity to investigate the temporal progression of molecular and cellular mechanisms that induce cognitive decline...
  17. pmc Therapeutic benefits of a component of coffee in a rat model of Alzheimer's disease
    Gustavo Basurto-Islas
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA
    Neurobiol Aging 35:2701-12. 2014
    ....
  18. doi request reprint Insulin sensitizers improve learning and attenuate tau hyperphosphorylation and neuroinflammation in 3xTg-AD mice
    Yang Yu
    Department of Neurochemistry, Inge Grundke Iqbal Research Floor, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY, 10314 6399, USA
    J Neural Transm 122:593-606. 2015
    ..These findings shed new light on the possible mechanisms by which these two insulin sensitizers might be useful for treating AD and support further clinical trials evaluating the efficacy of these drugs. ..
  19. pmc Alzheimer disease and amyotrophic lateral sclerosis: an etiopathogenic connection
    Xiaochuan Wang
    Department of Neurochemistry, Inge Grundke Iqbal Research Floor, New York State Institute for Basic Research, in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY, 10314 6399, USA
    Acta Neuropathol 127:243-56. 2014
    ..These findings suggest a previously undiscovered etiopathogenic relationship between sporadic forms of AD and ALS that is linked to I2(PP2A) and the potential of I2(PP2A)-based therapeutics for these diseases...