Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD miceJulie Blanchard
Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, 10314, USA
Acta Neuropathol 120:605-21. 2010
..These findings, for the first time, demonstrate the possibility of therapeutic treatment of AD and related disorders by peripheral administration of a peptide corresponding to a biologically active region of CNTF...
- Detection of age-dependent working memory deterioration in APP751SL mice
Julie Blanchard
Centre for Integrative and Cognitive Neuroscience, University of Bordeaux, CNRS UMR 5228, Talence, France
Behav Brain Res 218:129-37. 2011
..We also demonstrated that these working memory deficits are related to progressive Aβ accumulation in the hippocampus, but not in the other selected brain structures...
- An experimental rat model of sporadic Alzheimer's disease and rescue of cognitive impairment with a neurotrophic peptide
Silvia Bolognin
Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
Acta Neuropathol 123:133-51. 2012
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- Rescue of synaptic failure and alleviation of learning and memory impairments in a trisomic mouse model of down syndrome
Julie Blanchard
Department of Neurochemistry, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
J Neuropathol Exp Neurol 70:1070-9. 2011
..These findings suggest a therapeutic potential of Peptide 6 in promoting functional neural integration into networks, thereby strengthening biologic substrates of memory processing...
- Neurotrophic peptides incorporating adamantane improve learning and memory, promote neurogenesis and synaptic plasticity in mice
Bin Li
Department of Neurochemistry, NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
FEBS Lett 584:3359-65. 2010
..P21 induced enhancement of neurogenesis and maturation of newly born neurons in the granular cell layer and subgranular zone of the dentate gyrus...
- Enhancement of dentate gyrus neurogenesis, dendritic and synaptic plasticity and memory by a neurotrophic peptide
Muhammad Omar Chohan
Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314 6399, USA
Neurobiol Aging 32:1420-34. 2011
..The fact that Peptide 6 is both neurogenic and neurotrophic and that this peptide is effective when given peripherally, demonstrates its potential for prevention and treatment of learning and memory disorders...
- Beneficial effect of a CNTF tetrapeptide on adult hippocampal neurogenesis, neuronal plasticity, and spatial memory in mice
Julie Blanchard
Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
J Alzheimers Dis 21:1185-95. 2010
..Overall, these findings demonstrated the therapeutic potential of Peptide 6c for regeneration of the brain and improvement of cognition...
Alzheimer's disease neurofibrillary degeneration: pivotal and multifactorialKhalid Iqbal
Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York, NY 10314, USA
Biochem Soc Trans 38:962-6. 2010
..Restoration of PP2A activity by inhibition of the cleavage of I(2)(PP2A)/SET offers a promising therapeutic opportunity in AD with this aetiopathogenic mechanism...
- The carboxy-terminal fragment of inhibitor-2 of protein phosphatase-2A induces Alzheimer disease pathology and cognitive impairment
Xiaochuan Wang
Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
FASEB J 24:4420-32. 2010
..These findings suggest a novel etiopathogenic mechanism of AD, which is initiated by the cleavage of I(2)(PP2A), producing I(2CTF), and describe a novel disease-relevant nontransgenic animal model of AD...
- A non-transgenic mouse model (icv-STZ mouse) of Alzheimer's disease: similarities to and differences from the transgenic model (3xTg-AD mouse)
Yanxing Chen
Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, NY 10314, USA
Mol Neurobiol 47:711-25. 2013
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- Characterization of cognition alteration across the course of the disease in APP751SL mice with parallel estimation of cerebral Abeta deposition
Julie Blanchard
Centre for Integrative and Cognitive Neuroscience, University of Bordeaux, CNRS UMR 5228, Talence, France
Behav Brain Res 201:147-57. 2009
..Because this mouse model displayed gradual memory deficits it gives the opportunity to investigate the temporal progression of molecular and cellular mechanisms that induce cognitive decline...
