Milad S Bitar

Summary

Publications

  1. pmc ROS constitute a convergence nexus in the development of IGF1 resistance and impaired wound healing in a rat model of type 2 diabetes
    Milad S Bitar
    Department of Pharmacology and Toxicology, School of Medicine, PO Box 24923, Safat 13110, Kuwait
    Dis Model Mech 5:375-88. 2012
  2. doi request reprint A defect in Nrf2 signaling constitutes a mechanism for cellular stress hypersensitivity in a genetic rat model of type 2 diabetes
    Milad S Bitar
    Department of Pharmacology, Faculty of Medicine, Health Sciences Center, University of Kuwait, Safat, Kuwait
    Am J Physiol Endocrinol Metab 301:E1119-29. 2011
  3. doi request reprint Inflammation and apoptosis in aortic tissues of aged type II diabetes: amelioration with alpha-lipoic acid through phosphatidylinositol 3-kinase/Akt- dependent mechanism
    Milad S Bitar
    Department of Pharmacology and Toxicology, School of Medicine, Kuwait University, Kuwait
    Life Sci 86:844-53. 2010
  4. doi request reprint Raf kinase inhibitor protein RKIP enhances signaling by glycogen synthase kinase-3β
    Fahd Al-Mulla
    Department of Pathology, Faculty of Medicine, Health Sciences Center, Kuwait University, Safat, Kuwait, UK
    Cancer Res 71:1334-43. 2011
  5. ncbi request reprint Nitric oxide dynamics and endothelial dysfunction in type II model of genetic diabetes
    Milad S Bitar
    Department of Pharmacology, Kuwait University, School of Medicine, Kuwait
    Eur J Pharmacol 511:53-64. 2005
  6. doi request reprint RKIP: much more than Raf kinase inhibitory protein
    Fahd Al-Mulla
    Faculty of Medicine, Department of Pathology, Kuwait University Health Sciences Centre, Safat, Kuwait
    J Cell Physiol 228:1688-702. 2013
  7. doi request reprint Impaired TGF-β signaling and a defect in resolution of inflammation contribute to delayed wound healing in a female rat model of type 2 diabetes
    Fahd Al-Mulla
    Department of Pathology, University of Kuwait, Faculty of Medicine, Health Sciences Center, 13110, Kuwait
    Mol Biosyst 7:3006-20. 2011
  8. ncbi request reprint Oxidative stress--mediated alterations in glucose dynamics in a genetic animal model of type II diabetes
    Milad S Bitar
    Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, P O Box 24923, Safat, Kuwait, 13110
    Life Sci 77:2552-73. 2005
  9. pmc A new model for raf kinase inhibitory protein induced chemotherapeutic resistance
    Fahd Al-Mulla
    Department of Pathology, Health Sciences Center, Kuwait University, Faculty of Medicine, Safat, Kuwait
    PLoS ONE 7:e29532. 2012
  10. ncbi request reprint Raf kinase inhibitor protein expression in a survival analysis of colorectal cancer patients
    Fahd Al-Mulla
    Kuwait University, Faculty of Medicine, Safat, Kuwait
    J Clin Oncol 24:5672-9. 2006

Detail Information

Publications17

  1. pmc ROS constitute a convergence nexus in the development of IGF1 resistance and impaired wound healing in a rat model of type 2 diabetes
    Milad S Bitar
    Department of Pharmacology and Toxicology, School of Medicine, PO Box 24923, Safat 13110, Kuwait
    Dis Model Mech 5:375-88. 2012
    ....
  2. doi request reprint A defect in Nrf2 signaling constitutes a mechanism for cellular stress hypersensitivity in a genetic rat model of type 2 diabetes
    Milad S Bitar
    Department of Pharmacology, Faculty of Medicine, Health Sciences Center, University of Kuwait, Safat, Kuwait
    Am J Physiol Endocrinol Metab 301:E1119-29. 2011
    ..Moreover, they may also offer a new perspective in the understanding and treatment of nonhealing diabetic wounds...
  3. doi request reprint Inflammation and apoptosis in aortic tissues of aged type II diabetes: amelioration with alpha-lipoic acid through phosphatidylinositol 3-kinase/Akt- dependent mechanism
    Milad S Bitar
    Department of Pharmacology and Toxicology, School of Medicine, Kuwait University, Kuwait
    Life Sci 86:844-53. 2010
    ....
  4. doi request reprint Raf kinase inhibitor protein RKIP enhances signaling by glycogen synthase kinase-3β
    Fahd Al-Mulla
    Department of Pathology, Faculty of Medicine, Health Sciences Center, Kuwait University, Safat, Kuwait, UK
    Cancer Res 71:1334-43. 2011
    ..RKIP levels in human colorectal cancer positively correlate with GSK3β expression. These findings reveal the RKIP/GSK3 axis as both a potential therapeutic target and a prognosis-based predictor of cancer progression...
  5. ncbi request reprint Nitric oxide dynamics and endothelial dysfunction in type II model of genetic diabetes
    Milad S Bitar
    Department of Pharmacology, Kuwait University, School of Medicine, Kuwait
    Eur J Pharmacol 511:53-64. 2005
    ..This phenomenon could play a potentially important role in the pathogenesis of diabetic endothelial dysfunction...
  6. doi request reprint RKIP: much more than Raf kinase inhibitory protein
    Fahd Al-Mulla
    Faculty of Medicine, Department of Pathology, Kuwait University Health Sciences Centre, Safat, Kuwait
    J Cell Physiol 228:1688-702. 2013
    ..Specific biological and functional niches are highlighted to focus future research towards an enhanced understanding of the multiple roles of RKIP in health and disease...
  7. doi request reprint Impaired TGF-β signaling and a defect in resolution of inflammation contribute to delayed wound healing in a female rat model of type 2 diabetes
    Fahd Al-Mulla
    Department of Pathology, University of Kuwait, Faculty of Medicine, Health Sciences Center, 13110, Kuwait
    Mol Biosyst 7:3006-20. 2011
    ....
  8. ncbi request reprint Oxidative stress--mediated alterations in glucose dynamics in a genetic animal model of type II diabetes
    Milad S Bitar
    Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, P O Box 24923, Safat, Kuwait, 13110
    Life Sci 77:2552-73. 2005
    ....
  9. pmc A new model for raf kinase inhibitory protein induced chemotherapeutic resistance
    Fahd Al-Mulla
    Department of Pathology, Health Sciences Center, Kuwait University, Faculty of Medicine, Safat, Kuwait
    PLoS ONE 7:e29532. 2012
    ..Our data illuminate, for the first time, the NRF2-KEAP 1 pathway as a possible target for personalized therapeutic intervention in RKIP depleted cancers...
  10. ncbi request reprint Raf kinase inhibitor protein expression in a survival analysis of colorectal cancer patients
    Fahd Al-Mulla
    Kuwait University, Faculty of Medicine, Safat, Kuwait
    J Clin Oncol 24:5672-9. 2006
    ..We examined whether RKIP expression in primary colorectal cancers (CRCs) correlates with the risk of metastasis and overall survival...
  11. doi request reprint Caveolin-1/PTRF upregulation constitutes a mechanism for mediating p53-induced cellular senescence: implications for evidence-based therapy of delayed wound healing in diabetes
    Milad S Bitar
    Department of Pharmacology and Toxicology, Kuwait University, Safat, Kuwait
    Am J Physiol Endocrinol Metab 305:E951-63. 2013
    ..Overall, our data illuminate Cav-1/PTRF-1 as a key player of a novel signaling pathway that may link a heightened state of oxidative stress to cellular senescence and impaired wound healing in diabetes. ..
  12. ncbi request reprint Very long chain fatty acids activate NADPH oxidase in human dermal fibroblasts
    Gursev S Dhaunsi
    Department of Pediatrics, Faculty of Medicine, Kuwait University, Kuwait
    Cell Biochem Funct 23:65-8. 2005
    ..This study proposes a mechanism that may be taking place in vivo during peroxisomal dysfunction and that leads to oxidative stress-mediated pathogenesis...
  13. doi request reprint RAF kinase inhibitory protein (RKIP) modulates cell cycle kinetics and motility
    Fahd Al-Mulla
    Department of Pathology, University of Kuwait, Faculty of Medicine, Health Sciences Center, 13110, Kuwait
    Mol Biosyst 7:928-41. 2011
    ....
  14. ncbi request reprint Genetic profiling of stage I and II colorectal cancer may predict metastatic relapse
    Fahd Al-Mulla
    Molecular Pathology Laboratory, Department of Pathology, Faculty of Medicine, Kuwait University, Safat, Kuwait
    Mod Pathol 19:648-58. 2006
    ..Accordingly, the molecular genetic features of primary tumours should be considered in the mainstream management of patients with this specific stage of the disease...
  15. ncbi request reprint Comparison of two probe preparation methods using long oligonucleotide microarrays
    Fahd Al-Mulla
    Kuwait University, Faculty of Medicine, Department of Pathology, Safat, Kuwait
    Biotechniques 37:827-33. 2004
    ..Overall, the microarray results generated by the poly(T) priming methodology should be viewed cautiously even when high reproducibility is evident...
  16. ncbi request reprint Antioxidants attenuate diabetes-induced activation of peroxisomal functions in the rat kidney
    Gursev S Dhaunsi
    Department of Pediatrics, Faculty of Medicine, Kuwait University, Safat, Kuwait
    J Biomed Sci 11:566-70. 2004
    ..The present study shows that the diabetes-induced effects on kidney peroxisomal functions are redox sensitive, and antioxidants might prove useful tools to alleviate nephropathy in diabetes...