Anupam Bishayee

Summary

Publications

  1. ncbi The role of inflammation and liver cancer
    Anupam Bishayee
    Department of Pharmaceutical Sciences, School of Pharmacy, American University of Health Sciences, 1600 East Hill Street, Signal Hill, CA, 90755, USA
    Adv Exp Med Biol 816:401-35. 2014
  2. pmc Pomegranate Bioactive Constituents Suppress Cell Proliferation and Induce Apoptosis in an Experimental Model of Hepatocellular Carcinoma: Role of Wnt/ β -Catenin Signaling Pathway
    Deepak Bhatia
    Cancer Therapeutics and Chemoprevention Group, Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH 44272, USA
    Evid Based Complement Alternat Med 2013:371813. 2013
  3. pmc Chemopreventive effect of a novel oleanane triterpenoid in a chemically induced rodent model of breast cancer
    Anupam Bishayee
    Department of Pharmaceutical Sciences, School of Pharmacy, American University of Health Sciences, Signal Hill, CA 90755, USA
    Int J Cancer 133:1054-63. 2013
  4. ncbi Dietary phytochemicals in the chemoprevention and treatment of hepatocellular carcinoma: in vivo evidence, molecular targets, and clinical relevance
    Anupam Bishayee
    Cancer Therapeutics and Chemoprevention Group, Department of Pharmaceutical Sciences, School of Pharmacy, Signal Hill, CA 90755, USA
    Curr Cancer Drug Targets 12:1191-232. 2012
  5. ncbi Angiogenesis in hepatocellular carcinoma: a potential target for chemoprevention and therapy
    Anupam Bishayee
    Cancer Therapeutics and Chemoprevention Group, Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH 44272, USA
    Curr Cancer Drug Targets 12:1095-118. 2012
  6. doi Pomegranate phytoconstituents blunt the inflammatory cascade in a chemically induced rodent model of hepatocellular carcinogenesis
    Anupam Bishayee
    Department of Pharmaceutical Sciences, School of Pharmacy, American University of Health Sciences, Signal Hill, CA 90755, USA
    J Nutr Biochem 24:178-87. 2013
  7. ncbi Resveratrol exerts differential effects in vitro and in vivo against ovarian cancer cells
    Kimberly Sloan Stakleff
    Kenneth Calhoun Research Laboratory, Akron General Medical Center, Akron, OH, USA
    Asian Pac J Cancer Prev 13:1333-40. 2012
  8. ncbi Black currant anthocyanins abrogate oxidative stress through Nrf2- mediated antioxidant mechanisms in a rat model of hepatocellular carcinoma
    Roslin J Thoppil
    Cancer Therapeutics and Chemoprevention Group, Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH 44272, USA
    Curr Cancer Drug Targets 12:1244-57. 2012
  9. doi Black currant phytoconstituents exert chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis by suppression of the inflammatory response
    Anupam Bishayee
    Department of Pharmaceutical and Administrative Sciences, School of Pharmacy, American University of Health Sciences, Signal Hill, CA 90755, USA
    Mol Carcinog 52:304-17. 2013
  10. doi Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats
    Anupam Bishayee
    Department of Pharmaceutical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, OH 44272, USA
    J Nutr Biochem 22:1035-46. 2011

Collaborators

  • Judit Hohmann
  • Vijaykumar Sutariya
  • Peter Sipos
  • Marjorie Perloff
  • Malay Chatterjee
  • Eli Harlev
  • Bharat B Aggarwal
  • Werner J Geldenhuys
  • Altaf S Darvesh
  • Roslin J Thoppil
  • Deepak Bhatia
  • Richard T Carroll
  • Ashwin Gopalan
  • Sharon C Reuben
  • Qiwen Shi
  • Animesh Mandal
  • Thomas Mbimba
  • Kimberly Sloan Stakleff
  • Tristan D Booth
  • Daniel J Luther
  • Cornelis J Van der Schyf
  • Karishma A Samtani
  • Eviatar Nevo
  • Sharon Marcanthony
  • Danielle M Petit
  • Nicholas A Novotny
  • Erzsébet Háznagy-Radnai
  • Kendra F Barnes
  • Prabha Awale
  • Tricia Sloan
  • Denise Blanco
  • Shamima Ahmed
  • Hamayak Sisakian
  • Patricia E Shamhart
  • Vahagn Ohanyan
  • J Gary Meszaros
  • Cheryl M Hodnichak
  • Ruchi Bhatia
  • Nicholas Miladore

Detail Information

Publications33

  1. ncbi The role of inflammation and liver cancer
    Anupam Bishayee
    Department of Pharmaceutical Sciences, School of Pharmacy, American University of Health Sciences, 1600 East Hill Street, Signal Hill, CA, 90755, USA
    Adv Exp Med Biol 816:401-35. 2014
    ....
  2. pmc Pomegranate Bioactive Constituents Suppress Cell Proliferation and Induce Apoptosis in an Experimental Model of Hepatocellular Carcinoma: Role of Wnt/ β -Catenin Signaling Pathway
    Deepak Bhatia
    Cancer Therapeutics and Chemoprevention Group, Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH 44272, USA
    Evid Based Complement Alternat Med 2013:371813. 2013
    ..PE, thus, targets two interconnected molecular circuits (canonical NF- κ B and Wnt/ β -catenin pathways) to exert chemoprevention of HCC...
  3. pmc Chemopreventive effect of a novel oleanane triterpenoid in a chemically induced rodent model of breast cancer
    Anupam Bishayee
    Department of Pharmaceutical Sciences, School of Pharmacy, American University of Health Sciences, Signal Hill, CA 90755, USA
    Int J Cancer 133:1054-63. 2013
    ..AMR-Me could be developed as a chemopreventive drug to reduce the risk of human breast cancer that remains a devastating disease. ..
  4. ncbi Dietary phytochemicals in the chemoprevention and treatment of hepatocellular carcinoma: in vivo evidence, molecular targets, and clinical relevance
    Anupam Bishayee
    Cancer Therapeutics and Chemoprevention Group, Department of Pharmaceutical Sciences, School of Pharmacy, Signal Hill, CA 90755, USA
    Curr Cancer Drug Targets 12:1191-232. 2012
    ..Finally, current challenges, limitations, future directions, innovative concepts and novel hypotheses for the use of dietary phytochemicals in the chemoprevention and amelioration of human HCC are presented...
  5. ncbi Angiogenesis in hepatocellular carcinoma: a potential target for chemoprevention and therapy
    Anupam Bishayee
    Cancer Therapeutics and Chemoprevention Group, Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH 44272, USA
    Curr Cancer Drug Targets 12:1095-118. 2012
    ..Finally, the future directions as well as the benefits and potential challenges involved in the use of antiangiogenic pharmacotherapy in the treatment of HCC are also discussed...
  6. doi Pomegranate phytoconstituents blunt the inflammatory cascade in a chemically induced rodent model of hepatocellular carcinogenesis
    Anupam Bishayee
    Department of Pharmaceutical Sciences, School of Pharmacy, American University of Health Sciences, Signal Hill, CA 90755, USA
    J Nutr Biochem 24:178-87. 2013
    ....
  7. ncbi Resveratrol exerts differential effects in vitro and in vivo against ovarian cancer cells
    Kimberly Sloan Stakleff
    Kenneth Calhoun Research Laboratory, Akron General Medical Center, Akron, OH, USA
    Asian Pac J Cancer Prev 13:1333-40. 2012
    ..While resveratrol is effective in suppressing the in vitro cellular invasion of NuTu-19 ovarian cancer cells, these effects do not appear to impact on in vivo NuTu-19 ovarian cancers in rats...
  8. ncbi Black currant anthocyanins abrogate oxidative stress through Nrf2- mediated antioxidant mechanisms in a rat model of hepatocellular carcinoma
    Roslin J Thoppil
    Cancer Therapeutics and Chemoprevention Group, Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH 44272, USA
    Curr Cancer Drug Targets 12:1244-57. 2012
    ....
  9. doi Black currant phytoconstituents exert chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis by suppression of the inflammatory response
    Anupam Bishayee
    Department of Pharmaceutical and Administrative Sciences, School of Pharmacy, American University of Health Sciences, Signal Hill, CA 90755, USA
    Mol Carcinog 52:304-17. 2013
    ..These results coupled with an excellent safety profile of BCSE support the development of black currant phytochemicals for the chemoprevention of inflammation-driven hepatocellular cancer...
  10. doi Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats
    Anupam Bishayee
    Department of Pharmaceutical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, OH 44272, USA
    J Nutr Biochem 22:1035-46. 2011
    ..These results along with a safety profile of BCSE encourage the development of black currant bioactive constituents as chemopreventive agents for human liver cancer...
  11. ncbi Resveratrol suppresses oxidative stress and inflammatory response in diethylnitrosamine-initiated rat hepatocarcinogenesis
    Anupam Bishayee
    Department of Pharmaceutical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, 44272, USA
    Cancer Prev Res (Phila) 3:753-63. 2010
    ..The outcome of this study may benefit the development of resveratrol in the prevention and intervention of human HCC...
  12. doi The health benefits of blackcurrants
    Ashwin Gopalan
    Cancer Therapeutics and Chemoprevention Group, Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, 4209 State Route 44, Rootstown, OH 44272, USA
    Food Funct 3:795-809. 2012
    ....
  13. ncbi Alteration of hepatic proinflammatory cytokines is involved in the resveratrol-mediated chemoprevention of chemically-induced hepatocarcinogenesis
    Thomas Mbimba
    Cancer Therapeutics and Chemoprevention Group, Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH 44272, USA
    Curr Pharm Biotechnol 13:229-34. 2012
    ..From the current results in conjunction with our previous findings, it can be concluded that resveratrol-mediated chemoprevention of rat liver carcinogenesis is related to alteration of proinflammatory cytokines...
  14. pmc Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms
    Anupam Bishayee
    Cancer Therapeutics and Chemoprevention Group, Department of Pharmaceutical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, OH 44272, USA
    Carcinogenesis 32:888-96. 2011
    ..The outcome of this study strongly supports the development of pomegranate-derived products in the prevention and treatment of human HCC, which remains a devastating disease...
  15. doi Chemopreventive doses of resveratrol do not produce cardiotoxicity in a rodent model of hepatocellular carcinoma
    Daniel J Luther
    Department of Integrative Medical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, OH 44272, USA
    Invest New Drugs 29:380-91. 2011
    ..Our results indicate that resveratrol-mediated chemoprevention of rat liver carcinogenesis is devoid of any adverse cardiovascular events. Resveratrol may be developed as a chemopreventive as well as therapeutic drug for human HCC...
  16. doi Curcumin and neurodegenerative diseases: a perspective
    Altaf S Darvesh
    College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH 44272, USA
    Expert Opin Investig Drugs 21:1123-40. 2012
    ..Curcumin has shown therapeutic potential for neurodegenerative diseases including Alzheimer's disease (AD) and Parkinson's disease (PD)...
  17. ncbi Anthocyanin-rich black currant extract suppresses the growth of human hepatocellular carcinoma cells
    Anupam Bishayee
    Cancer Therapeutics and Chemoprevention Group, Department of Pharmaceutical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, 4209 State Route 44, Rootstown, OH 44272, USA
    Nat Prod Commun 5:1613-8. 2010
    ..This product could be useful in the prevention and treatment of human hepatocellular carcinoma...
  18. ncbi Natural products of dietary origin as lead compounds in virtual screening and drug design
    Werner J Geldenhuys
    Department of Pharmaceutical Sciences, Northeast Ohio Medical University, 4209 State Route 44, Rootstown, OH 44272, USA
    Curr Pharm Biotechnol 13:117-24. 2012
    ..Natural dietary constituents, such as resveratrol, curcumin and caffeine as well as other compounds, are discussed to illustrate this approach...
  19. doi Antitumor activities of extracts from selected desert plants against HepG2 human hepatocellular carcinoma cells
    Roslin J Thoppil
    Cancer Therapeutics and Chemoprevention Group, Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH, USA
    Pharm Biol 51:668-74. 2013
    ..Although many desert plants have been investigated for their antitumor properties, a large number of them still remain to be explored for possible therapeutic applications in oncologic diseases...
  20. doi Chemopreventive and therapeutic potential of tea polyphenols in hepatocellular cancer
    Altaf S Darvesh
    Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, Ohio, USA
    Nutr Cancer 65:329-44. 2013
    ....
  21. doi Resveratrol in the chemoprevention and treatment of hepatocellular carcinoma
    Anupam Bishayee
    Department of Pharmaceutical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, 44272, USA
    Cancer Treat Rev 36:43-53. 2010
    ..Future directions and challenges involved in the use of resveratrol for the prevention and treatment of HCC are also discussed...
  22. doi Resveratrol and liver disease: from bench to bedside and community
    Anupam Bishayee
    Department of Pharmaceutical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, OH, USA
    Liver Int 30:1103-14. 2010
    ..The challenges involved, future directions and novel approaches such as site-specific drug delivery in the use of resveratrol for the prevention and treatment of liver disease are also discussed...
  23. ncbi Selenium in the prevention and treatment of hepatocellular carcinoma
    Altaf S Darvesh
    Cancer Therapeutics and Chemoprevention Emphasis Group, Department of Pharmaceutical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, OH 44272, USA
    Anticancer Agents Med Chem 10:338-45. 2010
    ..Future directions and potential challenges involved in the advance of selenium use in the prevention and treatment of liver cancer are also discussed...
  24. ncbi Curcumin and liver cancer: a review
    Altaf S Darvesh
    Cancer Therapeutics and Chemoprevention Group, Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH 44272, USA
    Curr Pharm Biotechnol 13:218-28. 2012
    ..This review also discusses potential challenges involved in the use of curcumin in HCC, such as bioavailability, pharmacokinetics, drug delivery as well as paucity of clinical studies...
  25. doi Modulation of angiogenesis by dietary phytoconstituents in the prevention and intervention of breast cancer
    Sharon C Reuben
    Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH, USA
    Mol Nutr Food Res 56:14-29. 2012
    ..In addition, the potential benefits, challenges, and future directions of research on anti-angiogenic dietary phytochemicals in the prevention and intervention of breast cancer are also addressed...
  26. doi Brain-targeted delivery of Tempol-loaded nanoparticles for neurological disorders
    Richard T Carroll
    Department of Pharmaceutical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, Ohio 44272, USA
    J Drug Target 18:665-74. 2010
    ..Our findings suggest that transferrin-conjugated NPs containing antioxidants may be useful in the treatment of neurodegenerative diseases...
  27. pmc Sequential activation of Elk-1/Egr-1/GADD45α by arsenic
    Qiwen Shi
    Department of Pharmaceutical Sciences, Northeast Ohio Medical University NEOMED, Rootstown, Ohio, USA School of Biomedical Sciences, Kent State University, Kent, Ohio, USA
    Oncotarget 5:3862-70. 2014
    ..Taken together, our data indicated that the increase of GADD45α in response to As3+ was mediated sequentially by Elk-1 and Egr-1. ..
  28. doi Resveratrol-mediated chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis: inhibition of cell proliferation and induction of apoptosis
    Anupam Bishayee
    Department of Pharmaceutical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, 4209 State Route 44, Rootstown, OH 44272, USA
    Chem Biol Interact 179:131-44. 2009
    ..Due to a favorable toxicity profile, resveratrol can potentially be developed as a chemopreventive drug against human HCC...
  29. pmc Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer
    Anupam Bishayee
    Cancer Therapeutics and Chemoprevention Group, Department of Pharmaceutical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, 4209 State Route 44, Rootstown, OH 44272, USA
    Front Biosci (Landmark Ed) 16:980-96. 2011
    ..Potential challenges and future directions involved in the advancement of these promising compounds in the prevention and therapy of human breast cancer are also identified...
  30. doi Oxidative stress and Alzheimer's disease: dietary polyphenols as potential therapeutic agents
    Altaf S Darvesh
    Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, OH 44272, USA
    Expert Rev Neurother 10:729-45. 2010
    ..Finally, innovative concepts, novel hypotheses, current challenges and future directions in the use of dietary polyphenols for the treatment of AD are discussed...
  31. ncbi Vanadium in the detection, prevention and treatment of cancer: the in vivo evidence
    Anupam Bishayee
    Department of Pharmaceutical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, 4209 State Route 44, Rootstown, OH 44272, United States
    Cancer Lett 294:1-12. 2010
    ..Supporting and challenging evidence as well as future directions of vanadium research exploring the possibility of using this dietary agent for detection, prevention and treatment of human cancers are critically discussed...
  32. doi Anticancer attributes of desert plants: a review
    Eli Harlev
    Institute of Evolution and International Graduate Center of Evolution, University of Haifa, Mount Carmel
    Anticancer Drugs 23:255-71. 2012
    ..Although many desert plants have been investigated for their antitumor properties, there are many that still remain to be explored - a challenge for the prospective cancer therapy of the future...
  33. pmc Terpenoids as potential chemopreventive and therapeutic agents in liver cancer
    Roslin J Thoppil
    Roslin J Thoppil, Anupam Bishayee, Cancer Therapeutics and Chemoprevention Group, Department of Pharmaceutical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, OH 44272, United States
    World J Hepatol 3:228-49. 2011
    ..Potential challenges and future directions involved in the advancement of these promising natural compounds in the chemoprevention and therapy of human liver cancer are also discussed...