Hans Bisgaard

Summary

Publications

  1. doi request reprint Interaction between asthma and lung function growth in early life
    Hans Bisgaard
    Copenhagen Prospective Studies on Asthma in Childhood Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Am J Respir Crit Care Med 185:1183-9. 2012
  2. doi request reprint Endotyping early childhood asthma by quantitative symptom assessment
    Hans Bisgaard
    Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen, Gentofte, Copenhagen, Denmark
    J Allergy Clin Immunol 127:1155-64.e2. 2011
  3. doi request reprint Prenatal determinants of neonatal lung function in high-risk newborns
    Hans Bisgaard
    Copenhagen Prospective Studies on Asthma in Childhood, Danish Pediatric Asthma Center, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Hellerup, Denmark
    J Allergy Clin Immunol 123:651-7, 657.e1-4. 2009
  4. doi request reprint Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age
    Hans Bisgaard
    Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark
    J Allergy Clin Immunol 128:646-52.e1-5. 2011
  5. pmc Association of bacteria and viruses with wheezy episodes in young children: prospective birth cohort study
    Hans Bisgaard
    The Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen, and The Danish Pediatric Asthma Centre, Copenhagen University Hospital, Gentofte, Ledreborg Alle 34, DK 2820 Gentofte, Copenhagen, Denmark
    BMJ 341:c4978. 2010
  6. doi request reprint Long-term studies of the natural history of asthma in childhood
    Hans Bisgaard
    Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Allergy Clin Immunol 126:187-97; quiz 198-9. 2010
  7. doi request reprint Risk analysis of early childhood eczema
    Hans Bisgaard
    Copenhagen Prospective Studies on Asthma in Childhood, Danish Pediatric Asthma Center, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark
    J Allergy Clin Immunol 123:1355-60.e5. 2009
  8. pmc Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure
    Hans Bisgaard
    Copenhagen Prospective Studies on Asthma in Childhood, Danish Paediatric Asthma Centre, Copenhagen, University Hospital Gentofte, Copenhagen, Denmark
    PLoS Med 5:e131. 2008
  9. ncbi request reprint Childhood asthma after bacterial colonization of the airway in neonates
    Hans Bisgaard
    Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Copenhagen
    N Engl J Med 357:1487-95. 2007
  10. ncbi request reprint Development of atopic dermatitis during the first 3 years of life: the Copenhagen prospective study on asthma in childhood cohort study in high-risk children
    Liselotte Brydensholt Halkjaer
    Danish Pediatric Asthma Centre, Department of Pediatrics, Copenhagen University Hospital, Gentofte, Denmark
    Arch Dermatol 142:561-6. 2006

Detail Information

Publications67

  1. doi request reprint Interaction between asthma and lung function growth in early life
    Hans Bisgaard
    Copenhagen Prospective Studies on Asthma in Childhood Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Am J Respir Crit Care Med 185:1183-9. 2012
    ..The causal direction between asthma and lung function deficit is unknown, but important for the focus of preventive measures and research into the origins of asthma...
  2. doi request reprint Endotyping early childhood asthma by quantitative symptom assessment
    Hans Bisgaard
    Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen, Gentofte, Copenhagen, Denmark
    J Allergy Clin Immunol 127:1155-64.e2. 2011
    ..Asthmatic symptoms in young children reflect a heterogeneous group of diseases. Symptoms remain the primary end-point in both research and clinical management, but there is a need for standardized symptom assessment...
  3. doi request reprint Prenatal determinants of neonatal lung function in high-risk newborns
    Hans Bisgaard
    Copenhagen Prospective Studies on Asthma in Childhood, Danish Pediatric Asthma Center, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Hellerup, Denmark
    J Allergy Clin Immunol 123:651-7, 657.e1-4. 2009
    ..Neonatal lung function is suspected to be associated with wheezy disorders, but little is known about risk factors for the early lung function...
  4. doi request reprint Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age
    Hans Bisgaard
    Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark
    J Allergy Clin Immunol 128:646-52.e1-5. 2011
    ..Changes in the human microbiome have been suggested as a risk factor for a number of lifestyle-related disorders, such as atopic diseases, possibly through a modifying influence on immune maturation in infancy...
  5. pmc Association of bacteria and viruses with wheezy episodes in young children: prospective birth cohort study
    Hans Bisgaard
    The Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen, and The Danish Pediatric Asthma Centre, Copenhagen University Hospital, Gentofte, Ledreborg Alle 34, DK 2820 Gentofte, Copenhagen, Denmark
    BMJ 341:c4978. 2010
    ..To study the association between wheezy symptoms in young children and the presence of bacteria in the airways...
  6. doi request reprint Long-term studies of the natural history of asthma in childhood
    Hans Bisgaard
    Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Allergy Clin Immunol 126:187-97; quiz 198-9. 2010
    ....
  7. doi request reprint Risk analysis of early childhood eczema
    Hans Bisgaard
    Copenhagen Prospective Studies on Asthma in Childhood, Danish Pediatric Asthma Center, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark
    J Allergy Clin Immunol 123:1355-60.e5. 2009
    ..The increasing prevalence of eczema suggests the role of environmental factors triggering a genetic predisposition...
  8. pmc Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure
    Hans Bisgaard
    Copenhagen Prospective Studies on Asthma in Childhood, Danish Paediatric Asthma Centre, Copenhagen, University Hospital Gentofte, Copenhagen, Denmark
    PLoS Med 5:e131. 2008
    ..Therefore, we investigated whether there is an interaction between FLG loss-of-function mutations with environmental exposures (pets and dust mites) in relation to the development of eczema...
  9. ncbi request reprint Childhood asthma after bacterial colonization of the airway in neonates
    Hans Bisgaard
    Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Copenhagen
    N Engl J Med 357:1487-95. 2007
    ..We conducted a study to investigate a possible association between bacterial colonization of the hypopharynx in asymptomatic neonates and later development of recurrent wheeze, asthma, and allergy during the first 5 years of life...
  10. ncbi request reprint Development of atopic dermatitis during the first 3 years of life: the Copenhagen prospective study on asthma in childhood cohort study in high-risk children
    Liselotte Brydensholt Halkjaer
    Danish Pediatric Asthma Centre, Department of Pediatrics, Copenhagen University Hospital, Gentofte, Denmark
    Arch Dermatol 142:561-6. 2006
    ..To describe the development of atopic dermatitis (AD) during the first 3 years of life and identify the localization of the early skin lesions that predicts the development of AD...
  11. doi request reprint Elevated exhaled nitric oxide in high-risk neonates precedes transient early but not persistent wheeze
    Bo L K Chawes
    Copenhagen Prospective Studies on Asthma in Childhood, Danish Pediatric Asthma Center, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Gentofte, Ledreborg Alle 34, 2820 Gentofte, Denmark
    Am J Respir Crit Care Med 182:138-42. 2010
    ..Elevated fractional exhaled nitric oxide (Fe(NO)) concentration has been suggested to predict early childhood wheeze and sensitization...
  12. doi request reprint Filaggrin gene variants and atopic diseases in early childhood assessed longitudinally from birth
    Klaus Bønnelykke
    Copenhagen Studies on Asthma in Childhood, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark
    Pediatr Allergy Immunol 21:954-61. 2010
    ..The association of filaggrin variants with asthma suggests skin barrier dysfunction as a novel, and potentially modifiable, mechanism driving early childhood asthma...
  13. ncbi request reprint Fraction of exhaled nitric oxide and bronchial responsiveness are associated and continuous traits in young children independent of asthma
    Ann Marie Malby Schoos
    Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen, and Copenhagen University Hospital Gentofte, Copenhagen, Denmark
    Chest 142:1562-8. 2012
    ..These traits may be continuous in the population. The objective of this study was to investigate whether FENO and bronchial responsiveness are associated in both children with and children without a history of asthma symptoms...
  14. ncbi request reprint Intermittent inhaled corticosteroids in infants with episodic wheezing
    Hans Bisgaard
    Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Copenhagen
    N Engl J Med 354:1998-2005. 2006
    ....
  15. doi request reprint Pathogenic bacteria colonizing the airways in asymptomatic neonates stimulates topical inflammatory mediator release
    Nilofar V Følsgaard
    Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital, Gentofte, Ledreborg Alle 34, Gentofte, Copenhagen, Denmark
    Am J Respir Crit Care Med 187:589-95. 2013
    ..Bacterial colonization of neonatal airways with the pathogenic bacterial species, Moraxella catarrhalis, Streptococcus pneumoniae, and Haemophilus influenzae, is associated with later development of childhood asthma...
  16. doi request reprint Neonatal bronchial hyperresponsiveness precedes acute severe viral bronchiolitis in infants
    Bo L K Chawes
    Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen and Danish Pediatric Asthma Centre, Copenhagen University Hospital, Gentofte, Denmark
    J Allergy Clin Immunol 130:354-61.e3. 2012
    ..We hypothesized that such an excessive response to respiratory tract viral infection is caused by host factors reflected in pre-existing increased bronchial responsiveness...
  17. ncbi request reprint Budesonide/formoterol maintenance plus reliever therapy: a new strategy in pediatric asthma
    Hans Bisgaard
    Danish Pediatric Asthma Center, Department of Pediatrics, Copenhagen University Hospital, Gentofte, DK 2900 Copenhagen, Denmark
    Chest 130:1733-43. 2006
    ....
  18. doi request reprint Increased risk of pneumonia and bronchiolitis after bacterial colonization of the airways as neonates
    Nadja H Vissing
    1 Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen and Copenhagen University Hospital, Gentofte, Copenhagen, Denmark
    Am J Respir Crit Care Med 188:1246-52. 2013
    ..We hypothesized that alterations in the airway microbiome in early life may be associated with susceptibility to pneumonia and bronchiolitis in young children...
  19. doi request reprint Use of antibiotics during pregnancy increases the risk of asthma in early childhood
    Lone Graff Stensballe
    Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen, and the Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark
    J Pediatr 162:832-838.e3. 2013
    ..To investigate the hypothesis that mother's use of antibiotics in pregnancy could influence asthma and eczema in early life...
  20. doi request reprint Causal direction between respiratory syncytial virus bronchiolitis and asthma studied in monozygotic twins
    Porntiva Poorisrisak
    Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, L213 Ledreborg alle 34, DK 2820 Copenhagen, Denmark
    Chest 138:338-44. 2010
    ..Our aim was to determine the differential effect within monozygotic (MZ) twin pairs discordant for severe RSV bronchiolitis in infancy on the subsequent development of asthma, pulmonary function, and allergy...
  21. ncbi request reprint Acute relief of exercise-induced bronchoconstriction by inhaled formoterol in children with persistent asthma
    Mette Northman Hermansen
    Department of Pediatrics, Copenhagen University Hospital, Gentofte, Niels Andersens Vej 65, DK 2900 Hellerup, Denmark
    Chest 129:1203-9. 2006
    ..To compare the acute bronchodilatory effect of the long-acting beta2-agonist formoterol against the short-acting beta2-agonist (SABA) terbutaline during exercise-induced bronchoconstriction (EIB) in children with asthma...
  22. pmc Prevalence and Predictors of Antibiotic Administration during Pregnancy and Birth
    Jakob Stokholm
    Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen, Naestved Hospital, Naestved, Denmark Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark
    PLoS ONE 8:e82932. 2013
    ..In this study, we describe the estimated prevalence of antibiotic administration during pregnancy and birth in the COPSAC2010 pregnancy cohort, and analyze dependence on social and lifestyle-related factors...
  23. pmc Living with cat and dog increases vaginal colonization with E. coli in pregnant women
    Jakob Stokholm
    Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen, Naestved Hospital, Naestved, Denmark
    PLoS ONE 7:e46226. 2012
    ..We studied whether cats and dogs living in the household of pregnant women affect the commensal vaginal flora, and furthermore the need for oral antibiotics and rate of urinary tract infections during pregnancy...
  24. ncbi request reprint Montelukast reduces asthma exacerbations in 2- to 5-year-old children with intermittent asthma
    Hans Bisgaard
    Department of Pediatrics, Copenhagen University Hospital, DK 2920 Gentofte, Copenhagen, Denmark
    Am J Respir Crit Care Med 171:315-22. 2005
    ..027) compared with placebo. Montelukast effectively reduced asthma exacerbations in 2- to 5-year-old patients with intermittent asthma over 12 months of treatment and was generally well tolerated...
  25. doi request reprint Upper and lower airway patency are associated in young children
    Bo Lund Krogsgaard Chawes
    Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Denmark
    Chest 137:1332-7. 2010
    ..Although allergic rhinitis and asthma frequently coexist, the nature of this association is poorly understood. Therefore, we examined whether upper and lower airway patency are associated...
  26. doi request reprint Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood
    Hans Bisgaard
    Copenhagen Studies on Asthma in Childhood, The Danish Paediatrics Asthma Centre, Faculty of Health Sciences, University of Copenhagen, Gentofte Hospital, Ledreborg Alle 34, DK 2900 Gentofte, Copenhagen, Denmark
    Am J Respir Crit Care Med 179:179-85. 2009
    ..An asthma predisposition locus on chromosome 17q12-q21 has recently been replicated in different ethnic groups...
  27. doi request reprint Physical activity in young children is reduced with increasing bronchial responsiveness
    Martin Brasholt
    Copenhagen Prospective Studies on Asthma in Childhood the Danish Pediatric Asthma Center, Health Sciences, University of Copenhagen and Copenhagen University Hospital, Gentofte, Copenhagen, Denmark
    J Allergy Clin Immunol 125:1007-12. 2010
    ..It can be lower in children with subclinical asthma, and therefore methods to reveal subclinical reduction in physical activity in young children are warranted...
  28. pmc Age dependent systemic exposure to inhaled salbutamol
    Klaus Bønnelykke
    Danish Pediatric Asthma Center Copenhagen University Hospital, Gentofte, Copenhagen, Denmark
    Br J Clin Pharmacol 64:241-4. 2007
    ..To determine the effect of age on systemic exposure to inhaled salbutamol in children...
  29. doi request reprint Increased risk of eczema but reduced risk of early wheezy disorder from exclusive breast-feeding in high-risk infants
    Charlotte Giwercman
    Copenhagen Prospective Study on Asthma in Childhood, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark
    J Allergy Clin Immunol 125:866-71. 2010
    ..However, disease risk, disease manifestation, lifestyle, and the choice to breast-feed are interrelated, and therefore, analyzing true causal effects presents a number of methodologic challenges...
  30. pmc Validity of information on atopic disease and other illness in young children reported by parents in a prospective birth cohort study
    Nadja Hawwa Vissing
    Copenhagen Prospective Studies on Asthma in Childhood, The Danish Pediatric Asthma Center, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Gentofte, Ledreborg Alle 34 2900 Hellerup, Copenhagen, Denmark
    BMC Med Res Methodol 12:160. 2012
    ..We aimed to ascertain the quality of information on atopic disease and other health symptoms reported by parental interview in a closely monitored birth cohort study. Possible bias from symptom severity and socioeconomics were sought...
  31. pmc Clinical presentation of atopic dermatitis by filaggrin gene mutation status during the first 7 years of life in a prospective cohort study
    Charlotte Giwercman Carson
    Copenhagen Prospective Studies on Asthma in Childhood COPSAC, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark
    PLoS ONE 7:e48678. 2012
    ..We aimed to characterize the clinical presentation and course of atopic dermatitis associated with filaggrin mutations within the first 7 years of life...
  32. doi request reprint "To wheeze or not to wheeze": That is not the question
    Nanna Skytt
    Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Allergy Clin Immunol 130:403-7.e5. 2012
    ..The diagnosis of asthma in young children is difficult and based on clinical assessment of symptoms and results of physical examination. Respiratory wheeze has traditionally been used to define asthma in young children...
  33. ncbi request reprint The Copenhagen Prospective Study on Asthma in Childhood (COPSAC): design, rationale, and baseline data from a longitudinal birth cohort study
    Hans Bisgaard
    Department of Pediatrics, Copenhagen University Hospital, Copenhagen, Denmark
    Ann Allergy Asthma Immunol 93:381-9. 2004
    ..Little is known about the genetic-environmental interaction factors driving such proliferation...
  34. doi request reprint Children with allergic and nonallergic rhinitis have a similar risk of asthma
    Bo Lund Krogsgaard Chawes
    Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen, and the Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark
    J Allergy Clin Immunol 126:567-73.e1-8. 2010
    ..Both allergic and nonallergic rhinitis have been associated with increased prevalence of asthma...
  35. doi request reprint Lung function and bronchial responsiveness after Mycoplasma pneumoniae infection in early childhood
    Birgitte B Kjaer
    Department of Paediatrics, Copenhagen University Hospital, Glostrup, Denmark
    Pediatr Pulmonol 43:567-75. 2008
    ..42. In conclusion, M. pneumoniae infection in early childhood was not associated with long-term effects on lung function and bronchial hyperresponsiveness 2 years after infection...
  36. doi request reprint The causal direction in the association between respiratory syncytial virus hospitalization and asthma
    Lone Graff Stensballe
    Bandim Health Project, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    J Allergy Clin Immunol 123:131-137.e1. 2009
    ..Earlier studies have reported an increased risk of asthma after respiratory syncytial virus (RSV) hospitalization. Other studies found that asthmatic disposition and propensity to wheeze increase the risk of RSV hospitalization...
  37. ncbi request reprint Measurements of exhaled nitric oxide in healthy subjects age 4 to 17 years
    Frederik Buchvald
    The Copenhagen Studies of Asthma in Childhood Research Clinic, Copenhagen University Hospital, Gentofte, Denmark
    J Allergy Clin Immunol 115:1130-6. 2005
    ..Fractional exhaled nitric oxide (FE NO ) is used in monitoring of asthma...
  38. doi request reprint Aerosol particle size does not predict pharmacokinetic determined lung dose in children
    Klaus Bønnelykke
    Copenhagen Prospective Studies on Asthma in Childhood, Danish Pediatric Asthma Center, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark
    J Clin Pharmacol 53:517-22. 2013
    ..Measures of particles size segments were not related to lung dose in children. Until further evidence is provided it may be warranted to emphasize pharmacokinetic or pharmacodynamic assessments of drug delivery to the lung...
  39. pmc Pharmacokinetic comparison of inhaled fixed combination vs. the free combination of beclomethasone and formoterol pMDIs in asthmatic children
    Bo L K Chawes
    Copenhagen University Hospital, Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen and Danish Pediatric Asthma Center, Gentofte, Denmark
    Br J Clin Pharmacol 75:1081-8. 2013
    ..the free combination of BDP and formoterol pMDIs in asthmatic children...
  40. doi request reprint Safety and tolerability of montelukast in placebo-controlled pediatric studies and their open-label extensions
    Hans Bisgaard
    Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark
    Pediatr Pulmonol 44:568-79. 2009
    ..Because of its wide use as a pediatric controller, there is a need for a further review of the safety and tolerability of montelukast in children...
  41. ncbi request reprint Hyperventilation with cold versus dry air in 2- to 5-year-old children with asthma
    Kim G Nielsen
    Department of Pediatrics, Pulmonary Service, Copenhagen University Hospital, Rigshospitalet DK 2100, Copenhagen, Denmark
    Am J Respir Crit Care Med 171:238-41. 2005
    ..This finding suggests CACh as the preferred method of challenge...
  42. ncbi request reprint Exhaled nitric oxide predicts exercise-induced bronchoconstriction in asthmatic school children
    Frederik Buchvald
    Danish Pediatric Asthma Centre, Department of Pediatrics, Copenhagen University Hospital, DK 2900 Gentofte, Niels Andersensvej 79, 2900 Hellerup, Denmark
    Chest 128:1964-7. 2005
    ..We hypothesized that FeNO may be used for prescreening of asthmatic children to exclude those with good asthma control unlikely to have EIB, thereby reducing the need for exercise testing...
  43. pmc Altered response to A(H1N1)pnd09 vaccination in pregnant women: a single blinded randomized controlled trial
    Anne Louise Bischoff
    Copenhagen Prospective Studies on Asthma in Childhood COPSAC, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Gentofte, Denmark
    PLoS ONE 8:e56700. 2013
    ..The secondary aims were to compare influences of dose and adjuvant on the immune response...
  44. ncbi request reprint Effect of long-acting beta2 agonists on exacerbation rates of asthma in children
    Hans Bisgaard
    Copenhagen Studies on Asthma in Childhood COPSAC, Department of Pediatrics, Copenhagen University Hospital, Amtssygehuset i Gentofte, Copenhagen, Denmark
    Pediatr Pulmonol 36:391-8. 2003
    ..Studies should be designed to directly explore the implications of these observations in pediatric patients...
  45. doi request reprint Coarse and fine particles but not ultrafine particles in urban air trigger hospital admission for asthma in children
    Amne Iskandar
    Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Ledreborg Alle 34, 2820 Gentofte, Denmark
    Thorax 67:252-7. 2012
    ..There are no available studies on the particular effect of ultrafine particles (UFPs) on paediatric admissions for asthma...
  46. ncbi request reprint Prevalence of asthma-like symptoms in young children
    Hans Bisgaard
    Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark
    Pediatr Pulmonol 42:723-8. 2007
    ..To determine the prevalence, impact, and treatment of asthma-like symptoms in preschool children in USA and Europe...
  47. ncbi request reprint Twelve-month safety and efficacy of inhaled fluticasone propionate in children aged 1 to 3 years with recurrent wheezing
    Hans Bisgaard
    Department of Pediatrics, Copenhagen University Hospital, Copenhagen, Denmark
    Pediatrics 113:e87-94. 2004
    ..Our aim was to compare the 12-month safety and efficacy of fluticasone propionate (FP) and sodium cromoglycate (SCG) in children aged 1 to 3 years with mild to moderate recurrent wheeze...
  48. doi request reprint Transfer of maternal IgE can be a common cause of increased IgE levels in cord blood
    Klaus Bønnelykke
    Copenhagen Prospective Studies on Asthma in Childhood, Danish Pediatric Asthma Center, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark
    J Allergy Clin Immunol 126:657-63. 2010
    ..This also suggests that total IgE in cord blood might primarily be a maternal product...
  49. ncbi request reprint Serial lung function and responsiveness in cystic fibrosis during early childhood
    Kim G Nielsen
    Department of Pediatrics, Pulmonary Service, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Am J Respir Crit Care Med 169:1209-16. 2004
    ..Reduced lung function was documented from consistently abnormal levels of sRaw and FEV1 during the study. Bronchodilator responsiveness and response to cold air challenge were normal...
  50. ncbi request reprint Sensitivity of bronchial responsiveness measurements in young infants
    Lotte Loland
    Danish Pediatric Asthma Center, Department of Pediatrics, Copenhagen University Hospital, Gentofte, Niels Andersens Vej 65, DK 2900 Hellerup, Denmark
    Chest 129:669-75. 2006
    ..The objective of this study was to compare sensitivity and repeatability of indexes of lung function in young infants during induced airway obstruction...
  51. ncbi request reprint Comparisons of the complementary effect on exhaled nitric oxide of salmeterol vs montelukast in asthmatic children taking regular inhaled budesonide
    Frederik Buchvald
    Department of Pediatrics, Rigshospitalet, National University Hospital, Copenhagen, Denmark
    Ann Allergy Asthma Immunol 91:309-13. 2003
    ..Any complementary effects would be relevant to the choice between these alternatives. Exhaled nitric oxide (FeNO) may reflect these effects...
  52. ncbi request reprint Understanding mild persistent asthma in children: the next frontier
    Hans Bisgaard
    Danish Paediatric Asthma Center, Department of Paediatrics, University Hospital of Copenhagen, DK 2900 Gentofte, Copenhagen, Denmark
    J Allergy Clin Immunol 115:708-13. 2005
    ..There is a need for further investigation into the true prevalence of mild persistent asthma in children and adolescents, and optimal treatment...
  53. ncbi request reprint Feasibility of repetitive lung function measurements by raised volume rapid thoracoabdominal compression during methacholine challenge in young infants
    Lotte Loland
    Danish Pediatric Asthma Center, Department of Pediatrics, Copenhagen University Hospital, Gentofte, Niels Andersens Vej 65, DK 2900 Hellerup, Denmark
    Chest 133:115-22. 2008
    ..The aim of the study was to evaluate the feasibility of lung function measurements by the raised volume rapid thoracoabdominal compression (RVRTC) technique during bronchial methacholine challenge in young infants...
  54. doi request reprint Sensitization does not develop in utero
    Klaus Bønnelykke
    Danish Pediatric Asthma Center, Department of Pediatrics, Copenhagen University Hospital, Copenhagen, Denmark
    J Allergy Clin Immunol 121:646-51. 2008
    ..Intrauterine sensitization has been suggested to play a role in the development of atopic disease in children, and this has led to current guidelines recommending allergen avoidance during pregnancy...
  55. ncbi request reprint Plethysmographic measurements of specific airway resistance in young children
    Hans Bisgaard
    Copenhagen University Hospital, Gentofte, DK 2900 Copenhagen, Denmark
    Chest 128:355-62. 2005
    ..sRaw measurements offers a method for clinical monitoring and research during this critical period of growth and development early in life...
  56. doi request reprint Elevated eosinophil protein X in urine from healthy neonates precedes development of atopy in the first 6 years of life
    Bo Lund Krogsgaard Chawes
    Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Am J Respir Crit Care Med 184:656-61. 2011
    ..Biomarkers predicting development of atopic disease are needed for targeted preventive measures and to study if disease pathology may be active before onset of symptoms...
  57. doi request reprint Study of montelukast for the treatment of respiratory symptoms of post-respiratory syncytial virus bronchiolitis in children
    Hans Bisgaard
    Danish Pediatric Asthma Center, Department of Pediatrics, Copenhagen University Hospital, Gentofte, DK 2900 Copenhagen, Denmark
    Am J Respir Crit Care Med 178:854-60. 2008
    ..Am J Respir Crit Care Med 2003;167:379-383) reported the efficacy of montelukast in post-respiratory syncytial virus (RSV) bronchiolitic respiratory symptoms...
  58. doi request reprint Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization
    Klaus Bønnelykke
    COPSAC COpenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen and Copenhagen University Hospital, Gentofte, Denmark
    Nat Genet 45:902-6. 2013
    ..Understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease. ..
  59. doi request reprint Objective assessment of levels and patterns of physical activity in preschool children
    Martin Brasholt
    Copenhagen Prospective Studies on Asthma in Childhood, Danish Pediatric Asthma Center, Faculty of Health Sciences, Copenhagen University Hospital Gentofte, Gentofte, Denmark
    Pediatr Res 74:333-8. 2013
    ..The aim of this study was to examine in detail levels and patterns of physical activity in preschool children and the effects of gender and BMI on this activity...
  60. pmc Alcohol intake in pregnancy increases the child's risk of atopic dermatitis. the COPSAC prospective birth cohort study of a high risk population
    Charlotte Giwercman Carson
    Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark
    PLoS ONE 7:e42710. 2012
    ..It has been proposed that alcohol consumption may be one contributing risk factor in this development...
  61. doi request reprint Neonatal cytokine profile in the airway mucosal lining fluid is skewed by maternal atopy
    Nilofar V Følsgaard
    Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Gentofte, Denmark
    Am J Respir Crit Care Med 185:275-80. 2012
    ..We hypothesized that mother's and father's atopy would have a differential imprinting on the cytokines and chemokines in the upper airway mucosal lining fluid of healthy neonates...
  62. doi request reprint Polyunsaturated fatty acid content of mother's milk is associated with childhood body composition
    Louise Pedersen
    Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen, Naestved Hospital, Copenhagen, Denmark
    Pediatr Res 72:631-6. 2012
    ..The objective of this study was to investigate the relationship between docosahexaenoic acid (DHA) content and n-6/n-3 polyunsaturated fatty acid ratio in breast milk, body composition, and timing of adiposity rebound in children...
  63. ncbi request reprint Cold air challenge and specific airway resistance in preschool children
    Kim Gjerum Nielsen
    Pediatric Pulmonary Service, Pediatric Clinic I, Juliane Marie Centre, Rigshospitalet, Copenhagen University Hospital, Denmark
    Paediatr Respir Rev 6:255-66. 2005
    ..The effects of classic anti-asthmatic therapies have also been documented with these techniques. The need for further standardisation and improvement of these methods and future perspectives are outlined...
  64. pmc Robustness of genome-wide scanning using archived dried blood spot samples as a DNA source
    Mads V Hollegaard
    Department of Clinical Biochemistry and Immunology, Statens Serum Institut, Ørestads Boulevard, Copenhagen, DK 2300, Denmark
    BMC Genet 12:58. 2011
    ..We examined the robustness of using DBS samples for whole-genome amplification following genome-wide scanning, using arrays from Illumina and Affymetrix...
  65. ncbi request reprint Maternal vaginal microflora during pregnancy and the risk of asthma hospitalization and use of antiasthma medication in early childhood
    Christine Stabell Benn
    Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen, Denmark
    J Allergy Clin Immunol 110:72-7. 2002
    ..It is therefore conceivable that the maternal vaginal microflora might influence the establishment of the infant flora and, as a consequence, the development of wheezing and allergic diseases...
  66. ncbi request reprint Long-acting beta2 agonists and paediatric asthma
    Hans Bisgaard
    Danish Paediatric Asthma Centre, Copenhagen, University Hospital, DK 2900 Gentofte, Copenhagen, Denmark
    Lancet 367:286-8. 2006
  67. ncbi request reprint Systemic activity of inhaled steroids in 1- to 3-year-old children with asthma
    Jacob Anhøj
    Pulmonary Service, Department of Paediatrics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Pediatrics 109:E40. 2002
    ..To study the systemic activity of inhaled steroids in young children...