Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaqueJoshua C Bis
Cardiovascular Health Research Unit and Department of Medicine, University of Washington, Seattle, Washington, USA
Nat Genet 43:940-7. 2011
..006) in the Coronary Artery Disease Genome-Wide Replication and Meta-Analysis (CARDIoGRAM) consortium. Our findings may provide new insight into pathways leading to subclinical atherosclerosis and subsequent cardiovascular events...
- Genetic variation associated with plasma von Willebrand factor levels and the risk of incident venous thrombosis
Nicholas L Smith
Department of Epidemiology, Cardiovascular Health Research Unit, University of Washington, 1730 Minor Avenue, Seattle, WA 98101, USA
Blood 117:6007-11. 2011
..Both STXBP5 and VWF findings were replicated successfully. Variation in genes associated with VWF levels in the genome-wide association study was found to be independently associated with incident VT...
- Short-term and long-term risk of incident ischemic stroke after transient ischemic attack
Evan L Thacker
Department of Epidemiology, University of Washington, Seattle, Wash, USA
Stroke 41:239-43. 2010
..We sought to estimate short-term and long-term relative risks of ischemic stroke associated with clinically diagnosed TIA...
- Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium
Nicholas L Smith
Cardiovascular Health Study Department of Epidemiology, University of Washington, Seattle, WA 98105, USA
Circ Cardiovasc Genet 3:256-66. 2010
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- Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke
Rozenn N Lemaitre
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA
Atherosclerosis 204:e58-63. 2009
..A secondary aim was to replicate the interaction of PTGS2 rs20417 (-765G to C) with aspirin use on coronary heart disease risk observed in the Atherosclerosis Risk in Communities Study (ARIC)...
- Genetic predictors of fibrin D-dimer levels in healthy adults
Nicholas L Smith
Department of Epidemiology, University of Washington, Seattle 98101, USA
Circulation 123:1864-72. 2011
..To identity genetic loci influencing D-dimer levels, we performed the first large-scale, genome-wide association search...
- Cerivastatin, genetic variants, and the risk of rhabdomyolysis
Kristin D Marciante
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA
Pharmacogenet Genomics 21:280-8. 2011
..The bimodal response, rhabdomyolysis in a small proportion of users, points to genetic factors as a potential cause. We conducted a case-control study to evaluate genetic markers for cerivastatin-associated rhabdomyolysis...
- Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium
Nicholas L Smith
Department of Epidemiology, University of Washington, Seattle, Wash 98101, USA
Circulation 121:1382-92. 2010
..Plasma levels of coagulation factors VII (FVII), VIII (FVIII), and von Willebrand factor (vWF) influence risk of hemorrhage and thrombosis. We conducted genome-wide association studies to identify new loci associated with plasma levels...
- Variation in inflammation-related genes and risk of incident nonfatal myocardial infarction or ischemic stroke
Joshua C Bis
Department of Medicine, University of Washington, Seattle, WA 981041, USA
Atherosclerosis 198:166-73. 2008
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- Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction
Nona Sotoodehnia
Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA
Nat Genet 42:1068-76. 2010
..These findings extend our current knowledge of ventricular depolarization and conduction...
- Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium
Rozenn N Lemaitre
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America
PLoS Genet 7:e1002193. 2011
..Our findings show that common variation in n-3 metabolic pathway genes and in GCKR influences plasma phospholipid levels of n-3 PUFAs in populations of European ancestry and, for FADS1, in other ancestries...
- Common genetic variation in six lipid-related and statin-related genes, statin use and risk of incident nonfatal myocardial infarction and stroke
Lucia A Hindorff
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA
Pharmacogenet Genomics 18:677-82. 2008
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- Cholesterol ester transfer protein, interleukin-8, peroxisome proliferator activator receptor alpha, and Toll-like receptor 4 genetic variations and risk of incident nonfatal myocardial infarction and ischemic stroke
Daniel A Enquobahrie
Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
Am J Cardiol 101:1683-8. 2008
..77 to 0.99). No within-gene or gene-gene interaction was associated with MI or ischemic stroke risk. In conclusion, potential SNP-disease associations identified in the present study are novel and need further investigation...
Common variation in cytochrome P450 epoxygenase genes and the risk of incident nonfatal myocardial infarction and ischemic strokeKristin D Marciante
Cardiovascular Health Research Unit, Seattle, Washington 98101, USA
Pharmacogenet Genomics 18:535-43. 2008
..We conducted a population-based, case-control study at Group Health to determine whether common genetic variation in the CYP2J2, CYP2C8, and CYP2C9 genes was associated with the risk of myocardial infarction and ischemic stroke...
- beta1- and beta2-adrenergic receptor gene variation, beta-blocker use and risk of myocardial infarction and stroke
Rozenn N Lemaitre
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA
Am J Hypertens 21:290-6. 2008
..The benefits of beta-blocker therapy may depend on underlying genetic susceptibility...
Logic regression for analysis of the association between genetic variation in the renin-angiotensin system and myocardial infarction or strokeCharles Kooperberg
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Am J Epidemiol 165:334-43. 2007
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- Association of genetic variations with nonfatal venous thrombosis in postmenopausal women
Nicholas L Smith
Department of Epidemiology, University of Washington, Seattle, WA 98101, USA
JAMA 297:489-98. 2007
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- Renin-angiotensin system haplotypes and the risk of myocardial infarction and stroke in pharmacologically treated hypertensive patients
Kristin D Marciante
Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA
Am J Epidemiol 166:19-27. 2007
..17). In this case-control study, RAS gene haplotypes were not significantly associated with increased risks of myocardial infarction or stroke...
- Angiotensinogen Met235Thr polymorphism, angiotensin-converting enzyme inhibitor therapy, and the risk of nonfatal stroke or myocardial infarction in hypertensive patients
Joshua C Bis
Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Seattle, Washington 98101, USA
Am J Hypertens 16:1011-7. 2003
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