Marc R Birtwistle

Summary

Publications

  1. doi request reprint Mammalian protein expression noise: scaling principles and the implications for knockdown experiments
    Marc R Birtwistle
    Mount Sinai School of Medicine, Dept of Pharmacology and Systems Therapeutics, New York, NY 10029, USA
    Mol Biosyst 8:3068-76. 2012
  2. pmc Linear approaches to intramolecular Förster resonance energy transfer probe measurements for quantitative modeling
    Marc R Birtwistle
    Systems Biology Ireland, University College Dublin, Belfield, Republic of Ireland
    PLoS ONE 6:e27823. 2011
  3. pmc Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses
    Maciej Dobrzynski
    Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland
    J R Soc Interface 11:20140383. 2014
  4. pmc Evaluating strategies to normalise biological replicates of Western blot data
    Andrea DeGasperi
    Systems Biology Ireland, University College Dublin, Dublin, Republic of Ireland
    PLoS ONE 9:e87293. 2014
  5. pmc Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise
    Marc R Birtwistle
    Dept of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    BMC Syst Biol 6:109. 2012
  6. pmc Biology using engineering tools: the negative feedback amplifier
    Marc R Birtwistle
    Systems Biology Ireland, University College Dublin, Belfield, Dublin, Republic of Ireland
    Cell Cycle 10:2069-76. 2011

Collaborators

  • Walter Kolch
  • Boris N Kholodenko
  • Andrea DeGasperi
  • Maciej Dobrzynski
  • Jens Rauch
  • Alfonso Blanco Fernandez
  • Lan K Nguyen
  • Natalia Volinsky
  • Alex Cheong
  • Alexander von Kriegsheim

Detail Information

Publications6

  1. doi request reprint Mammalian protein expression noise: scaling principles and the implications for knockdown experiments
    Marc R Birtwistle
    Mount Sinai School of Medicine, Dept of Pharmacology and Systems Therapeutics, New York, NY 10029, USA
    Mol Biosyst 8:3068-76. 2012
    ..This has implications for the interpretation of knockdown experiments when the readout is a single cell measure...
  2. pmc Linear approaches to intramolecular Förster resonance energy transfer probe measurements for quantitative modeling
    Marc R Birtwistle
    Systems Biology Ireland, University College Dublin, Belfield, Republic of Ireland
    PLoS ONE 6:e27823. 2011
    ..Thus, our results suggest that either FLIM or ratiometric methods based on R(alt) are the preferred techniques for obtaining quantitative data from FRET probe experiments for mathematical modeling purposes...
  3. pmc Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses
    Maciej Dobrzynski
    Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland
    J R Soc Interface 11:20140383. 2014
    ..With help of our theoretical framework, we perform a novel calculation of the magnitude of cell-to-cell heterogeneity in the dose-response obtained experimentally. ..
  4. pmc Evaluating strategies to normalise biological replicates of Western blot data
    Andrea DeGasperi
    Systems Biology Ireland, University College Dublin, Dublin, Republic of Ireland
    PLoS ONE 9:e87293. 2014
    ..These results will aid users of Western blotting to choose a suitable normalisation strategy and also understand the implications of this normalisation for subsequent hypothesis testing. ..
  5. pmc Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise
    Marc R Birtwistle
    Dept of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    BMC Syst Biol 6:109. 2012
    ..Here, we apply deterministic and probabilistic models and biochemical measurements to study how network topologies and cell-to-cell protein abundance variations interact to shape signaling responses...
  6. pmc Biology using engineering tools: the negative feedback amplifier
    Marc R Birtwistle
    Systems Biology Ireland, University College Dublin, Belfield, Dublin, Republic of Ireland
    Cell Cycle 10:2069-76. 2011
    ..Such behavior has important implications for how to attack deregulated signaling networks containing negative feedback in diseases such as cancer...