Lutz Birnbaumer



  1. Trouillet A, Keller M, Weiss J, Leinders Zufall T, Birnbaumer L, Zufall F, et al. Central role of G protein Gαi2 and Gαi2+ vomeronasal neurons in balancing territorial and infant-directed aggression of male mice. Proc Natl Acad Sci U S A. 2019;116:5135-5143 pubmed publisher
  2. Devanathan V, Hagedorn I, Köhler D, Pexa K, Cherpokova D, Kraft P, et al. Platelet Gi protein Gαi2 is an essential mediator of thrombo-inflammatory organ damage in mice. Proc Natl Acad Sci U S A. 2015;112:6491-6 pubmed publisher
    ..In conclusion, our data provide definitive evidence that platelet Gα(i2) not only controls hemostatic and thrombotic responses but also is critical for the development of ischemia/reperfusion injury in vivo. ..
  3. Gao X, Cao Q, Cheng Y, Zhao D, Wang Z, Yang H, et al. Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response. Proc Natl Acad Sci U S A. 2018;115:E2960-E2969 pubmed publisher
    ..Taken together, our results reveal that chronic stress disturbs gut microbiota, triggering immune system response and facilitating DSS-induced colitis. ..
  4. Riazanski V, Gabdoulkhakova A, Boynton L, Eguchi R, Deriy L, Hogarth D, et al. TRPC6 channel translocation into phagosomal membrane augments phagosomal function. Proc Natl Acad Sci U S A. 2015;112:E6486-95 pubmed publisher
    ..These data show that enhancing vesicular insertion of the TRPC6 channel to the plasma membrane may represent a general mechanism for restoring phagosome activity in conditions, where it is lost or impaired. ..
  5. Chaudhuri P, Rosenbaum M, Sinharoy P, Damron D, Birnbaumer L, Graham L. Membrane translocation of TRPC6 channels and endothelial migration are regulated by calmodulin and PI3 kinase activation. Proc Natl Acad Sci U S A. 2016;113:2110-5 pubmed publisher
    ..These findings suggest that lysoPC induces CaM phosphorylation at Tyr(99) by a Src family kinase and that phosphorylated CaM activates PI3K to produce PIP3, which promotes TRPC6 translocation to the cell membrane. ..
  6. Choi J, Kim S, Choi C, Cha H, Oh H, Ghil S, et al. Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice. Proc Natl Acad Sci U S A. 2016;113:10974-9 pubmed publisher
  7. Saliba Y, Jebara V, Hajal J, Maroun R, Chacar S, Smayra V, et al. Transient Receptor Potential Canonical 3 and Nuclear Factor of Activated T-cells C3 Signaling Pathway Critically Regulates Myocardial Fibrosis. Antioxid Redox Signal. 2018;: pubmed publisher
    ..E. and critically regulates ventricular CF phenotype and MF. These findings strongly argue for P.E., through TRPC3 targeting, as potential and interesting therapeutics for MF management. ..
  8. Hou X, Xiao H, Zhang Y, Zeng X, Huang M, Chen X, et al. Transient receptor potential channel 6 knockdown prevents apoptosis of renal tubular epithelial cells upon oxidative stress via autophagy activation. Cell Death Dis. 2018;9:1015 pubmed publisher
  9. Birnbaumer L. From GTP and G proteins to TRPC channels: a personal account. J Mol Med (Berl). 2015;93:941-53 pubmed publisher
    ..Towards the end, I summarize roles of TRPC channels in health and disease. ..

More Information


  1. Cheng Y, Gao X, Li X, Cao Q, Zhao D, Zhou J, et al. Depression promotes prostate cancer invasion and metastasis via a sympathetic-cAMP-FAK signaling pathway. Oncogene. 2018;37:2953-2966 pubmed publisher
    ..We suggest that blocking β2AR with propranolol or inhibiting FAK activation with PF562 271 may be novel strategies for depressed patients with invasive prostate cancer. ..