Gerald F Bills

Summary

Publications

  1. pmc Hypoxylon pulicicidum sp. nov. (Ascomycota, Xylariales), a pantropical insecticide-producing endophyte
    Gerald F Bills
    Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Parque Tecnológico de Ciencias de la Salud, Armilla, Granada, Spain
    PLoS ONE 7:e46687. 2012
  2. doi The "FERMEX" method for metabolite-enriched fungal extracts
    Gerald F Bills
    Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Armilla, Granada, Spain
    Methods Mol Biol 944:79-96. 2012
  3. doi Kabatiella bupleuri sp. nov. (Dothideales), a pleomorphic epiphyte and endophyte of the Mediterranean plant Bupleurum gibraltarium (Apiaceae)
    Gerald F Bills
    Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Granada, Spain
    Mycologia 104:962-73. 2012
  4. ncbi Discovery of the parnafungins, antifungal metabolites that inhibit mRNA polyadenylation, from the Fusarium larvarum complex and other Hypocrealean fungi
    Gerald F Bills
    Centro de Investigación Básica, Merck, SHARP and DOHME de ESPANA S A, Josefa Valcárcel 38, Madrid, E 28027, Spain
    Mycologia 101:449-72. 2009
  5. doi Isolation and structural elucidation of cyclic tetrapeptides from Onychocola sclerotica
    Ignacio Pérez-Victoria
    Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Avenida del Conocimiento 3, Parque Tecnológico de Ciencias de la Salud, E 18100 Armilla, Granada, Spain
    J Nat Prod 75:1210-4. 2012
  6. doi Distribution of the antifungal agents sordarins across filamentous fungi
    Francisca Vicente
    Centro de Investigación Básica, Merck Sharp and Dohme de Espana, Josefa Valcarcel, 38, 28027 Madrid, Spain
    Mycol Res 113:754-70. 2009
  7. ncbi High-throughput culturing of fungi from plant litter by a dilution-to-extinction technique
    Javier Collado
    Centro de Investigación Básica, Merck Sharp and Dohme de Espana, S A, Madrid, Spain
    FEMS Microbiol Ecol 60:521-33. 2007
  8. doi Pseudomonas soli sp. nov., a novel producer of xantholysin congeners
    Javier Pascual
    Fundación MEDINA, Avenida del Conocimiento, 3 Parque Tecnológico de Ciencias de la Salud, E 18016 Granada, Spain
    Syst Appl Microbiol 37:412-6. 2014
  9. doi Cyclic colisporifungin and linear cavinafungins, antifungal lipopeptides isolated from Colispora cavincola
    Francisco Javier Ortiz-López
    Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Avenida del Conocimiento 34, Parque Tecnológico de Ciencias de la Salud, E 18016, Armilla, Granada, Spain
    J Nat Prod 78:468-75. 2015
  10. ncbi Studies on Morinia: recognition of Morinia longiappendiculata sp. nov. as a new endophytic fungus, and a new circumscription of Morinia pestalozzioides
    Javier Collado
    Centro de Investigación Básica, Merck Research Laboratories, Merck, Sharp and Dohme de España, josefa Valcárcel 38 E 28027 Madrid, Espana
    Mycologia 98:616-27. 2006

Collaborators

  • Olga Genilloud
  • Javier Collado
  • José R Tormo
  • Terry Roemer
  • Sheo B Singh
  • Marc Stadler
  • Derek Persoh
  • Fernando Reyes
  • Pilar Hernandez
  • Jennifer Nielsen Kahn
  • Francisca Vicente
  • Jesus Martin
  • Javier Pascual
  • Victor González-Menéndez
  • Ignacio Pérez-Victoria
  • Francisco Javier Ortiz-López
  • Mercedes de la Cruz
  • Gonzalo Platas
  • Marina García-López
  • Jose A Siles
  • Nuria de Pedro
  • Noureddine El Aouad
  • Marina Sanchez-Hidalgo
  • Chaowei Zhang
  • Maria Cândida Monteiro
  • Inmaculada García-Romera
  • Bastien Cautain
  • Inmaculada Sampedro
  • Paula Sánchez-Carrasco
  • Dolores Gonzalez-Pacanowska
  • Thiciana da S Sousa
  • Guiomar Pérez-Moreno
  • Luis M Ruiz-Perez
  • Gloria Crespo
  • Cristina Carmona
  • Catalina Moreno
  • Michael A Goetz
  • Prakash Masurekar
  • Josep Guarro
  • Janet M Sigmund
  • Gary S Kath
  • Fernando Pelaez
  • Guy H Harris
  • Michael Justice
  • Antonio Gonzalez del Val
  • Angela Basilio
  • Deborah L Zink

Detail Information

Publications17

  1. pmc Hypoxylon pulicicidum sp. nov. (Ascomycota, Xylariales), a pantropical insecticide-producing endophyte
    Gerald F Bills
    Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Parque Tecnológico de Ciencias de la Salud, Armilla, Granada, Spain
    PLoS ONE 7:e46687. 2012
    ....
  2. doi The "FERMEX" method for metabolite-enriched fungal extracts
    Gerald F Bills
    Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Armilla, Granada, Spain
    Methods Mol Biol 944:79-96. 2012
    ..The necessary equipment, protocol, and media recipes are described along with examples of bioactive fungal metabolites produced in this system...
  3. doi Kabatiella bupleuri sp. nov. (Dothideales), a pleomorphic epiphyte and endophyte of the Mediterranean plant Bupleurum gibraltarium (Apiaceae)
    Gerald F Bills
    Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Granada, Spain
    Mycologia 104:962-73. 2012
    ..This new species is a sister species of the morphologically similar clover pathogen, K. caulivora...
  4. ncbi Discovery of the parnafungins, antifungal metabolites that inhibit mRNA polyadenylation, from the Fusarium larvarum complex and other Hypocrealean fungi
    Gerald F Bills
    Centro de Investigación Básica, Merck, SHARP and DOHME de ESPANA S A, Josefa Valcárcel 38, Madrid, E 28027, Spain
    Mycologia 101:449-72. 2009
    ..rubrum represents a species distinct from var. larvarum. Finally we report that two other species from the Hypocreales, Trichonectria rectipila and Cladobotryum pinarense, are able to produce parnafungins and their open-ring forms...
  5. doi Isolation and structural elucidation of cyclic tetrapeptides from Onychocola sclerotica
    Ignacio Pérez-Victoria
    Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Avenida del Conocimiento 3, Parque Tecnológico de Ciencias de la Salud, E 18100 Armilla, Granada, Spain
    J Nat Prod 75:1210-4. 2012
    ..2) but did not inhibit the hERG potassium channel and were not cytotoxic. These peptides are the first secondary metabolites ever reported from fungi of the order Arachnomycetales...
  6. doi Distribution of the antifungal agents sordarins across filamentous fungi
    Francisca Vicente
    Centro de Investigación Básica, Merck Sharp and Dohme de Espana, Josefa Valcarcel, 38, 28027 Madrid, Spain
    Mycol Res 113:754-70. 2009
    ..e., Sordariales, Eurotiales, and Microascales), suggesting that the production of sordarin is a trait more frequently associated to members of the Xylariales than to any other fungal order...
  7. ncbi High-throughput culturing of fungi from plant litter by a dilution-to-extinction technique
    Javier Collado
    Centro de Investigación Básica, Merck Sharp and Dohme de Espana, S A, Madrid, Spain
    FEMS Microbiol Ecol 60:521-33. 2007
    ..Intercolony interactions are reduced, permitting longer incubation times, and colony initiation and recovery improved. Effort to evaluate and recover colonies from fungal isolation plates was substantially reduced...
  8. doi Pseudomonas soli sp. nov., a novel producer of xantholysin congeners
    Javier Pascual
    Fundación MEDINA, Avenida del Conocimiento, 3 Parque Tecnológico de Ciencias de la Salud, E 18016 Granada, Spain
    Syst Appl Microbiol 37:412-6. 2014
    ....
  9. doi Cyclic colisporifungin and linear cavinafungins, antifungal lipopeptides isolated from Colispora cavincola
    Francisco Javier Ortiz-López
    Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Avenida del Conocimiento 34, Parque Tecnológico de Ciencias de la Salud, E 18016, Armilla, Granada, Spain
    J Nat Prod 78:468-75. 2015
    ..The linear peptides displayed broad-spectrum antifungal activities inhibiting growth of Candida species (MIC values 0.5-4 μg/mL) as well as A. fumigatus with a prominent inhibition of 8 μg/mL...
  10. ncbi Studies on Morinia: recognition of Morinia longiappendiculata sp. nov. as a new endophytic fungus, and a new circumscription of Morinia pestalozzioides
    Javier Collado
    Centro de Investigación Básica, Merck Research Laboratories, Merck, Sharp and Dohme de España, josefa Valcárcel 38 E 28027 Madrid, Espana
    Mycologia 98:616-27. 2006
    ..A lectotype and epitype are designated for the species. A study of bioactive metabolites revealed that M. pestalozzioides cultures produced moriniafungin, a novel sordarin analog with potent antifungal activity...
  11. doi MDN-0104, an antiplasmodial betaine lipid from Heterospora chenopodii
    Jesus Martin
    Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Avenida del Conocimiento 34, Parque Tecnológico de Ciencias de la Salud, E 18016, Granada, Spain
    J Nat Prod 77:2118-23. 2014
    ..Interestingly, the related fungus Heterospora dimorphospora was also found to produce compound 1, suggesting that species of this genus may be a promising source of monoacylglyceryltrimethylhomoserines. ..
  12. doi Manipulating filamentous fungus chemical phenotypes by growth on nutritional arrays
    José R Tormo
    Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Armilla, Granada, Spain
    Methods Mol Biol 944:59-78. 2012
    ..The necessary equipment, custom tools, and protocols to grow fungi in nutritional arrays are described along with examples of bioactive secondary metabolites discovered using this system...
  13. ncbi Conspecificity of the cerulenin and helvolic acid producing 'Cephalosporium caerulens', and the hypocrealean fungus Sarocladium oryzae
    Gerald F Bills
    Centro de Investigación Básica, Merck Sharp and Dohme de Espana, Josefa Valcárcel 38, ES 28027 Madrid, Spain
    Mycol Res 108:1291-300. 2004
    ..At least two of the isolates of S. oryzae produced titres of cerulenin and helvolic acid similar to those of KF-140. This finding demonstrates that manufacture of cerulenin need not be limited to the original strain...
  14. pmc Prescreening bacterial colonies for bioactive molecules with Janus plates, a SBS standard double-faced microbial culturing system
    Marina Sanchez-Hidalgo
    Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Parque Tecnológico de Ciencias de la Salud, Armilla, Granada, Spain
    Antonie Van Leeuwenhoek 102:361-74. 2012
    ..We also envisage the method's utility for functional prescreening colonies of clones from genomic and metagenomic libraries or improved strains originating from mutagenized cells...
  15. doi Pseudomonas granadensis sp. nov., a new bacterial species isolated from the Tejeda, Almijara and Alhama Natural Park, Granada, Spain
    Javier Pascual
    Fundación MEDINA, Avenida del Conocimiento, 3 Health Sciences Technology Park, 18016 Granada, Spain
    Int J Syst Evol Microbiol 65:625-32. 2015
    ..nov. is proposed. The type strain is F-278,770(T) ( = DSM 28040(T) = LMG 27940(T))...
  16. doi Chemical and physical modulation of antibiotic activity in emericella species
    Mercedes de la Cruz
    Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Avda del Conocimiento 3, Parque Tecnológico de Ciencias de la Salud, ES 18100 Armilla, Granada
    Chem Biodivers 9:1095-113. 2012
    ..Several species are reported for the first time to produce echinocandin B. A new echinocandin analog, echinocandin E, was identified from E. quadrilineata...
  17. doi Effects of dry olive residue transformed by Coriolopsis floccosa (Polyporaceae) on the distribution and dynamic of a culturable fungal soil community
    Jose A Siles
    Department of Soil Microbiology and Symbiotic Systems, Estacion Experimental del Zaidin, Consejo Superior de Investigaciones Cientificas CSIC, C Profesor Albareda, 1, 18008, Granada, Spain
    Microb Ecol 67:648-58. 2014
    ..However, when C. floccosa-transformed DOR was applied to the soil, changes in fungal diversity were less evident, and species composition was similar to unamended soil. ..