Gene L Bidwell

Summary

Publications

  1. ncbi request reprint Peptides for cancer therapy: a drug-development opportunity and a drug-delivery challenge
    Gene L Bidwell
    Department of Neurology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Ther Deliv 3:609-21. 2012
  2. pmc A thermally targeted c-Myc inhibitory polypeptide inhibits breast tumor growth
    Gene L Bidwell
    Department of Biochemistry, The University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Cancer Lett 319:136-43. 2012
  3. pmc Cell penetrating elastin-like polypeptides for therapeutic peptide delivery
    Gene L Bidwell
    University of Mississippi Medical Center, Department of Biochemistry, Jackson, 39216, USA
    Adv Drug Deliv Rev 62:1486-96. 2010
  4. doi request reprint Targeting a c-Myc inhibitory polypeptide to specific intracellular compartments using cell penetrating peptides
    Gene L Bidwell
    Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    J Control Release 135:2-10. 2009
  5. pmc Inhibition of ovarian cancer cell proliferation by a cell cycle inhibitory peptide fused to a thermally responsive polypeptide carrier
    Iqbal Massodi
    Department of Biochemistry, University of Mississippi Medical Center, Jackson, 39216, USA
    Int J Cancer 126:533-44. 2010
  6. ncbi request reprint Thermally targeted delivery of chemotherapeutics and anti-cancer peptides by elastin-like polypeptide
    Drazen Raucher
    University of Mississippi Medical Center, Department of Biochemistry, 2500 North State Street, Jackson, MS 39216, USA
    Expert Opin Drug Deliv 5:353-69. 2008
  7. ncbi request reprint A thermally targeted elastin-like polypeptide-doxorubicin conjugate overcomes drug resistance
    Gene L Bidwell
    Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Invest New Drugs 25:313-26. 2007
  8. ncbi request reprint Evaluation of cell penetrating peptides fused to elastin-like polypeptide for drug delivery
    Iqbal Massodi
    Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    J Control Release 108:396-408. 2005
  9. ncbi request reprint Development of elastin-like polypeptide for thermally targeted delivery of doxorubicin
    Gene L Bidwell
    The University of Mississippi Medical Center, Jackson, MS 39216, USA
    Biochem Pharmacol 73:620-31. 2007
  10. pmc Thermally targeted delivery of a c-Myc inhibitory polypeptide inhibits tumor progression and extends survival in a rat glioma model
    Gene L Bidwell
    Department of Neurology, University of Mississippi Medical Center, Jackson, Mississippi, United States of America
    PLoS ONE 8:e55104. 2013

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Peptides for cancer therapy: a drug-development opportunity and a drug-delivery challenge
    Gene L Bidwell
    Department of Neurology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Ther Deliv 3:609-21. 2012
    ..This article will discuss ways of overcoming many of these hurdles by utilizing macromolecular peptide delivery systems and tumor-targeting agents...
  2. pmc A thermally targeted c-Myc inhibitory polypeptide inhibits breast tumor growth
    Gene L Bidwell
    Department of Biochemistry, The University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Cancer Lett 319:136-43. 2012
    ..This work provides a new modality for targeted delivery of a specific oncogene inhibitory peptide, and this strategy may be expanded for delivery of other therapeutic peptides or small molecule drugs...
  3. pmc Cell penetrating elastin-like polypeptides for therapeutic peptide delivery
    Gene L Bidwell
    University of Mississippi Medical Center, Department of Biochemistry, Jackson, 39216, USA
    Adv Drug Deliv Rev 62:1486-96. 2010
    ....
  4. doi request reprint Targeting a c-Myc inhibitory polypeptide to specific intracellular compartments using cell penetrating peptides
    Gene L Bidwell
    Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    J Control Release 135:2-10. 2009
    ..This data demonstrates that ELP can be targeted to the desired cellular compartment simply by choice of the CPP used, resulting in a more potent nuclear targeted c-Myc inhibitory polypeptide which may be beneficial in cancer therapy...
  5. pmc Inhibition of ovarian cancer cell proliferation by a cell cycle inhibitory peptide fused to a thermally responsive polypeptide carrier
    Iqbal Massodi
    Department of Biochemistry, University of Mississippi Medical Center, Jackson, 39216, USA
    Int J Cancer 126:533-44. 2010
    ..These studies indicate that ELP is a promising macromolecular carrier for the delivery of cell cycle inhibitory peptides to solid tumors...
  6. ncbi request reprint Thermally targeted delivery of chemotherapeutics and anti-cancer peptides by elastin-like polypeptide
    Drazen Raucher
    University of Mississippi Medical Center, Department of Biochemistry, 2500 North State Street, Jackson, MS 39216, USA
    Expert Opin Drug Deliv 5:353-69. 2008
    ..Further examination of the in vivo biodistribution and efficacy will provide the necessary data to advance ELP technology toward the ultimate goal of human therapeutics...
  7. ncbi request reprint A thermally targeted elastin-like polypeptide-doxorubicin conjugate overcomes drug resistance
    Gene L Bidwell
    Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Invest New Drugs 25:313-26. 2007
    ..Both cytotoxicity and apoptosis were enhanced by hyperthermia in the Dox resistant cells. The results suggest that ELP-Dox conjugates may provide a means to thermally target solid tumors and to overcome drug resistance in cancer cells...
  8. ncbi request reprint Evaluation of cell penetrating peptides fused to elastin-like polypeptide for drug delivery
    Iqbal Massodi
    Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    J Control Release 108:396-408. 2005
    ..This polypeptide was shown to inhibit proliferation of SKOV-3 and HeLa cells by slowing their growth rate...
  9. ncbi request reprint Development of elastin-like polypeptide for thermally targeted delivery of doxorubicin
    Gene L Bidwell
    The University of Mississippi Medical Center, Jackson, MS 39216, USA
    Biochem Pharmacol 73:620-31. 2007
    ..The ELP delivered doxorubicin displayed a cytoplasmic distribution and induced temperature dependent caspase activation...
  10. pmc Thermally targeted delivery of a c-Myc inhibitory polypeptide inhibits tumor progression and extends survival in a rat glioma model
    Gene L Bidwell
    Department of Neurology, University of Mississippi Medical Center, Jackson, Mississippi, United States of America
    PLoS ONE 8:e55104. 2013
    ..This work demonstrates that a c-Myc inhibitory peptide can be effectively delivered to brain tumors...
  11. doi request reprint Inhibition of ovarian cancer cell metastasis by a fusion polypeptide Tat-ELP
    Iqbal Massodi
    Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Clin Exp Metastasis 26:251-60. 2009
    ..Since cell attachment is an important step in tumor cell invasion and metastasis, these results suggest a novel role of Tat-ELP as a therapeutic intervention in cancer metastasis...
  12. ncbi request reprint Enhancing the antiproliferative effect of topoisomerase II inhibitors using a polypeptide inhibitor of c-Myc
    Gene L Bidwell
    Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, United States
    Biochem Pharmacol 71:248-56. 2006
    ..In summary, our results suggest that polypeptides, which inhibit c-Myc transcriptional function, may prove to be a useful tool in combination therapy with topoisomerase II inhibiting drugs...
  13. doi request reprint Therapeutic peptides for cancer therapy. Part II - cell cycle inhibitory peptides and apoptosis-inducing peptides
    Drazen Raucher
    The University of Mississippi Medical Center, Department of Biochemistry, Jackson, 39216, USA
    Expert Opin Drug Deliv 6:1049-64. 2009
    ..Therapeutic peptides have great potential as anticancer agents owing to their ease of rational design and target specificity. However, their utility in vivo is limited by low stability and poor tumor penetration...
  14. pmc A thermally targeted peptide inhibitor of symmetrical dimethylation inhibits cancer-cell proliferation
    Gene L Bidwell
    Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Peptides 31:834-41. 2010
    ..The fusion polypeptide inhibited the interaction of SMN/SmB, inhibited proliferation, and induced apoptosis in HeLa cells...
  15. ncbi request reprint Application of thermally responsive polypeptides directed against c-Myc transcriptional function for cancer therapy
    Gene L Bidwell
    Department of Biochemistry, University of Mississippi Medical Center, Jackson, 39216, USA
    Mol Cancer Ther 4:1076-85. 2005
    ..These studies show that genetically engineered elastin-like polypeptide carriers may provide a new way to thermally target specific oncogene inhibitors to solid tumors...
  16. doi request reprint Therapeutic peptides for cancer therapy. Part I - peptide inhibitors of signal transduction cascades
    Gene L Bidwell
    The University of Mississippi Medical Center, Department of Biochemistry, Jackson, 39216, USA
    Expert Opin Drug Deliv 6:1033-47. 2009
    ..Therapeutic peptides have great potential as anticancer agents owing to their ease of rational design and target specificity. However, their utility in vivo is limited by low stability and poor tumor penetration...
  17. pmc Structural and hydrodynamic analysis of a novel drug delivery vector: ELP[V5G3A2-150]
    Daniel F Lyons
    Department of Biochemistry, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Biophys J 104:2009-21. 2013
    ..Labeling ELP[V5G3A2-150] with fluorescein lowers the TT by 3.5°C at 20 μM, whereas ELP[V5G3A2-150] dissolution in physiological media (fetal bovine serum) increases the TT by ∼2.2°C...