Manika Pal Bhadra



  1. Patel N, Garikapati K, Ramaiah M, Polavarapu K, Bhadra U, Bhadra M. miR-15a/miR-16 induces mitochondrial dependent apoptosis in breast cancer cells by suppressing oncogene BMI1. Life Sci. 2016;164:60-70 pubmed publisher
    ..Additionally, it also inhibits migration. Our results suggest that overexpression of miR-15a and miR-16 mediates down-regulation of BMI1, and leads to mitochondrial mediated apoptosis. ..
  2. Pushpavalli S, Sarkar A, Ramaiah M, Koteswara Rao G, Bag I, Bhadra U, et al. Drosophila MOF regulates DIAP1 and induces apoptosis in a JNK dependent pathway. Apoptosis. 2016;21:269-82 pubmed publisher
    ..Based on these results we propose that apoptosis triggered by mof (RNAi) proceeds through a caspase-dependent and JNK mediated pathway. ..
  3. Sarma P, Ramaiah M, Pal D, Bhadra U, Pal Bhadra M. A novel bisindole-PBD conjugate inhibits angiogenesis by regulating STAT3 and VEGF in breast cancer cells. Life Sci. 2016;151:264-276 pubmed publisher
    ..Altogether, our data demonstrated 5b as potent small molecule with anti-angiogenic activities. ..
  4. Pal Bhadra M, Ramaiah M, Reddy T, Krishnan A, Pushpavalli S, Babu K, et al. Plant HDAC inhibitor chrysin arrest cell growth and induce p21WAF1 by altering chromatin of STAT response element in A375 cells. BMC Cancer. 2012;12:180 pubmed publisher
    ..It proposes previously unknown sequence specific chromatin modulations in the STAT responsive elements for regulating cell cycle progression negatively via the induction of the CDK inhibitor p21WAF1. ..
  5. Janaki Ramaiah M, Lavanya A, Honarpisheh M, Zarea M, Bhadra U, Bhadra M. MiR-15/16 complex targets p70S6 kinase 1 and controls cell proliferation in MDA-MB-231 breast cancer cells. Gene. 2014;552:255-64 pubmed publisher
    ..This study suggests that exogenous microRNA-15/16 can target RPS6KB1, control cell proliferation and cause apoptosis in caspase-dependent manner even in the absence of functional p53. ..
  6. Garikapati K, Patel N, Makani V, Cilamkoti P, Bhadra U, Bhadra M. Down-regulation of BORIS/CTCFL efficiently regulates cancer stemness and metastasis in MYCN amplified neuroblastoma cell line by modulating Wnt/?-catenin signaling pathway. Biochem Biophys Res Commun. 2017;484:93-99 pubmed publisher
    ..Effectively controlling BORIS/CTCFL levels can inhibit disease establishment and hence can be considered as a potent target for cancer therapy. ..
  7. Mondal T, Lavanya A, Mallick A, Dadmala T, Kumbhare R, Bhadra U, et al. Novel Triazole linked 2-phenyl benzoxazole derivatives induce apoptosis by inhibiting miR-2, miR-13 and miR-14 function in Drosophila melanogaster. Apoptosis. 2017;22:786-799 pubmed publisher
    ..These two compounds also increase the mitochondrial reactive oxygen species (ROS) level to trigger apoptotic cell death. ..
  8. Pushpavalli S, Sarkar A, Bag I, Hunt C, Ramaiah M, Pandita T, et al. Argonaute-1 functions as a mitotic regulator by controlling Cyclin B during Drosophila early embryogenesis. FASEB J. 2014;28:655-66 pubmed publisher
    ..Thus, our results have established a novel role of Ago-1 as a regulator of the cell cycle. ..
  9. Bhadra U, Gandhi S, Palaparthi R, Balyan M, Pal Bhadra M. Drosophila maleless gene counteracts X global aneuploid effects in males. FEBS J. 2016;283:3457-70 pubmed publisher
    ..Microarray data are available at the Gene Expression Omnibus (GEO) web deposit of National Centre for Biotechnology Information (NCBI) with the accession number GSE78227. ..

More Information


  1. Patel N, Garikapati K, Pandita R, Singh D, Pandita T, Bhadra U, et al. miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin. Sci Rep. 2017;7:4263 pubmed publisher
    ..This data identifies a new target for manipulating DNA damage response that could impact the development of improved therapeutics for breast cancer. ..
  2. Patel N, Garikapati K, Pandita R, Singh D, Pandita T, Bhadra U, et al. Erratum: miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin. Sci Rep. 2017;7:12932 pubmed publisher
    ..A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ..