Katrin Beyer

Summary

Publications

  1. Beyer K, Domingo Sàbat M, Ariza A. Molecular pathology of Lewy body diseases. Int J Mol Sci. 2009;10:724-45 pubmed publisher
    ..The present paper attempts to give an overview of recent molecular findings related to the pathogenesis of Lewy body diseases. ..
  2. request reprint
    Beyer K, Humbert J, Ferrer A, Lao J, Latorre P, Lopez D, et al. A variable poly-T sequence modulates alpha-synuclein isoform expression and is associated with aging. J Neurosci Res. 2007;85:1538-46 pubmed
    ..In conclusion, this newly identified poly-T polymorphism is a human-specific sequence; its length influences alpha-synuclein 126 expression levels; and, finally, it seems to exert a specific influence on normal aging. ..
  3. request reprint
    Beyer K, Domingo Sàbat M, Lao J, Carrato C, Ferrer I, Ariza A. Identification and characterization of a new alpha-synuclein isoform and its role in Lewy body diseases. Neurogenetics. 2008;9:15-23 pubmed
    ..Overexpression of alpha-synuclein 98 in LBD and AD brains would indicate its specific involvement in the pathogenesis of these neurodegenerative disorders...
  4. Beyer K, Domingo Sàbat M, Humbert J, Carrato C, Ferrer I, Ariza A. Differential expression of alpha-synuclein, parkin, and synphilin-1 isoforms in Lewy body disease. Neurogenetics. 2008;9:163-72 pubmed publisher
    ..In conclusion, isoform-expression profiles in LB diseases represent additional evidence for the direct involvement of isoform-expression deregulation in the development of neurodegenerative disorders. ..
  5. Beyer K, Domingo Sàbat M, Santos C, Tolosa E, Ferrer I, Ariza A. The decrease of ?-synuclein in cortical brain areas defines a molecular subgroup of dementia with Lewy bodies. Brain. 2010;133:3724-33 pubmed publisher
    ..Furthermore, our findings provide new insights into the pathogenesis of Lewy body diseases that may be important for the understanding of molecular mechanisms involved in these complex diseases. ..
  6. Beyer K, Ispierto L, Latorre P, Tolosa E, Ariza A. Alpha- and beta-synuclein expression in Parkinson disease with and without dementia. J Neurol Sci. 2011;310:112-7 pubmed publisher
    ..Our findings provide new insights into the pathogenesis of dementia in PD, indicating that differential BS and AS expression in the caudate nucleus may represent one of the molecular mechanisms involved in these complex diseases. ..
  7. Beyer K, Muñoz Mármol A, Sanz C, Marginet Flinch R, Ferrer I, Ariza A. New brain-specific beta-synuclein isoforms show expression ratio changes in Lewy body diseases. Neurogenetics. 2012;13:61-72 pubmed publisher
    ....
  8. Beyer K, Ariza A. ?-Synuclein posttranslational modification and alternative splicing as a trigger for neurodegeneration. Mol Neurobiol. 2013;47:509-24 pubmed publisher
    ..The implications of deregulated alternative splicing are examined as well, and a hypothesis for the development of the pure form of dementia with Lewy bodies is proposed. ..

Locale

Detail Information

Publications8

  1. Beyer K, Domingo Sàbat M, Ariza A. Molecular pathology of Lewy body diseases. Int J Mol Sci. 2009;10:724-45 pubmed publisher
    ..The present paper attempts to give an overview of recent molecular findings related to the pathogenesis of Lewy body diseases. ..
  2. request reprint
    Beyer K, Humbert J, Ferrer A, Lao J, Latorre P, Lopez D, et al. A variable poly-T sequence modulates alpha-synuclein isoform expression and is associated with aging. J Neurosci Res. 2007;85:1538-46 pubmed
    ..In conclusion, this newly identified poly-T polymorphism is a human-specific sequence; its length influences alpha-synuclein 126 expression levels; and, finally, it seems to exert a specific influence on normal aging. ..
  3. request reprint
    Beyer K, Domingo Sàbat M, Lao J, Carrato C, Ferrer I, Ariza A. Identification and characterization of a new alpha-synuclein isoform and its role in Lewy body diseases. Neurogenetics. 2008;9:15-23 pubmed
    ..Overexpression of alpha-synuclein 98 in LBD and AD brains would indicate its specific involvement in the pathogenesis of these neurodegenerative disorders...
  4. Beyer K, Domingo Sàbat M, Humbert J, Carrato C, Ferrer I, Ariza A. Differential expression of alpha-synuclein, parkin, and synphilin-1 isoforms in Lewy body disease. Neurogenetics. 2008;9:163-72 pubmed publisher
    ..In conclusion, isoform-expression profiles in LB diseases represent additional evidence for the direct involvement of isoform-expression deregulation in the development of neurodegenerative disorders. ..
  5. Beyer K, Domingo Sàbat M, Santos C, Tolosa E, Ferrer I, Ariza A. The decrease of ?-synuclein in cortical brain areas defines a molecular subgroup of dementia with Lewy bodies. Brain. 2010;133:3724-33 pubmed publisher
    ..Furthermore, our findings provide new insights into the pathogenesis of Lewy body diseases that may be important for the understanding of molecular mechanisms involved in these complex diseases. ..
  6. Beyer K, Ispierto L, Latorre P, Tolosa E, Ariza A. Alpha- and beta-synuclein expression in Parkinson disease with and without dementia. J Neurol Sci. 2011;310:112-7 pubmed publisher
    ..Our findings provide new insights into the pathogenesis of dementia in PD, indicating that differential BS and AS expression in the caudate nucleus may represent one of the molecular mechanisms involved in these complex diseases. ..
  7. Beyer K, Muñoz Mármol A, Sanz C, Marginet Flinch R, Ferrer I, Ariza A. New brain-specific beta-synuclein isoforms show expression ratio changes in Lewy body diseases. Neurogenetics. 2012;13:61-72 pubmed publisher
    ....
  8. Beyer K, Ariza A. ?-Synuclein posttranslational modification and alternative splicing as a trigger for neurodegeneration. Mol Neurobiol. 2013;47:509-24 pubmed publisher
    ..The implications of deregulated alternative splicing are examined as well, and a hypothesis for the development of the pure form of dementia with Lewy bodies is proposed. ..