Katrin Beyer

Summary

Publications

  1. ncbi request reprint The Th1/E47cs-G apolipoprotein E (APOE) promoter allele is a risk factor for Alzheimer disease of very later onset
    Katrin Beyer
    Department of Pathology, Hospital Universitari Germans Trias i Pujol, Autonomous University of Barcelona, Ctra de Canyet s n, 08916 Badalona, Barcelona, Spain
    Neurosci Lett 326:187-90. 2002
  2. pmc Molecular pathology of Lewy body diseases
    Katrin Beyer
    Department of Pathology, Hospital Universitari Germans Trias i Pujol, Autonomous University of Barcelona, Spain
    Int J Mol Sci 10:724-45. 2009
  3. doi request reprint α-Synuclein posttranslational modification and alternative splicing as a trigger for neurodegeneration
    Katrin Beyer
    Department of Pathology, Hospital Universitari Germans Trias i Pujol, Universitat Autonoma de Barcelona, 08916 Badalona, Barcelona, Spain
    Mol Neurobiol 47:509-24. 2013
  4. doi request reprint New brain-specific beta-synuclein isoforms show expression ratio changes in Lewy body diseases
    Katrin Beyer
    Servicio de Anatomia Patologica, Hospital Universitario Germans Trias i Pujol, Ctra Canyet s n, 08916, Badalona, Barcelona, Spain
    Neurogenetics 13:61-72. 2012
  5. doi request reprint Alpha- and beta-synuclein expression in Parkinson disease with and without dementia
    Katrin Beyer
    Servicio de Anatomia Patologica, Hospital Universitario Germans Trias i Pujol, Universidad Autonoma de Barcelona, Spain
    J Neurol Sci 310:112-7. 2011
  6. doi request reprint The decrease of β-synuclein in cortical brain areas defines a molecular subgroup of dementia with Lewy bodies
    Katrin Beyer
    Servicio de Anatomia Patologica, Hospital Universitario Germans Trias i Pujol, Universidad Autonoma de Barcelona, Barcelona, Spain
    Brain 133:3724-33. 2010
  7. ncbi request reprint The therapeutical potential of alpha-synuclein antiaggregatory agents for dementia with Lewy bodies
    Katrin Beyer
    Department of Pathology, Hospital Universitari Germans Trias i Pujol, Autonomous University of Barcelona, Badalona, Barcelona, Spain
    Curr Med Chem 15:2748-59. 2008
  8. doi request reprint Differential expression of alpha-synuclein, parkin, and synphilin-1 isoforms in Lewy body disease
    Katrin Beyer
    Department of Pathology, Hospital Germans Trias i Pujol, Autonomous University of Barcelona, Barcelona, Spain
    Neurogenetics 9:163-72. 2008
  9. ncbi request reprint Identification and characterization of a new alpha-synuclein isoform and its role in Lewy body diseases
    Katrin Beyer
    Department of Pathology, Hospital Universitari Germans Trias i Pujol, Autonomous University of Barcelona, Barcelona, Spain
    Neurogenetics 9:15-23. 2008
  10. ncbi request reprint A variable poly-T sequence modulates alpha-synuclein isoform expression and is associated with aging
    Katrin Beyer
    Department of Pathology, Hospital Germans Trias i Pujol, Autonomous University of Barcelona, Badalona, Spain
    J Neurosci Res 85:1538-46. 2007

Collaborators

Detail Information

Publications19

  1. ncbi request reprint The Th1/E47cs-G apolipoprotein E (APOE) promoter allele is a risk factor for Alzheimer disease of very later onset
    Katrin Beyer
    Department of Pathology, Hospital Universitari Germans Trias i Pujol, Autonomous University of Barcelona, Ctra de Canyet s n, 08916 Badalona, Barcelona, Spain
    Neurosci Lett 326:187-90. 2002
    ..Significantly, patients whose age at onset of AD was 80 years or more showed an association between the Th1/E47cs-G allele and AD that was independent of the APOE4 allele...
  2. pmc Molecular pathology of Lewy body diseases
    Katrin Beyer
    Department of Pathology, Hospital Universitari Germans Trias i Pujol, Autonomous University of Barcelona, Spain
    Int J Mol Sci 10:724-45. 2009
    ..The present paper attempts to give an overview of recent molecular findings related to the pathogenesis of Lewy body diseases...
  3. doi request reprint α-Synuclein posttranslational modification and alternative splicing as a trigger for neurodegeneration
    Katrin Beyer
    Department of Pathology, Hospital Universitari Germans Trias i Pujol, Universitat Autonoma de Barcelona, 08916 Badalona, Barcelona, Spain
    Mol Neurobiol 47:509-24. 2013
    ..The implications of deregulated alternative splicing are examined as well, and a hypothesis for the development of the pure form of dementia with Lewy bodies is proposed...
  4. doi request reprint New brain-specific beta-synuclein isoforms show expression ratio changes in Lewy body diseases
    Katrin Beyer
    Servicio de Anatomia Patologica, Hospital Universitario Germans Trias i Pujol, Ctra Canyet s n, 08916, Badalona, Barcelona, Spain
    Neurogenetics 13:61-72. 2012
    ....
  5. doi request reprint Alpha- and beta-synuclein expression in Parkinson disease with and without dementia
    Katrin Beyer
    Servicio de Anatomia Patologica, Hospital Universitario Germans Trias i Pujol, Universidad Autonoma de Barcelona, Spain
    J Neurol Sci 310:112-7. 2011
    ..Our findings provide new insights into the pathogenesis of dementia in PD, indicating that differential BS and AS expression in the caudate nucleus may represent one of the molecular mechanisms involved in these complex diseases...
  6. doi request reprint The decrease of β-synuclein in cortical brain areas defines a molecular subgroup of dementia with Lewy bodies
    Katrin Beyer
    Servicio de Anatomia Patologica, Hospital Universitario Germans Trias i Pujol, Universidad Autonoma de Barcelona, Barcelona, Spain
    Brain 133:3724-33. 2010
    ..Furthermore, our findings provide new insights into the pathogenesis of Lewy body diseases that may be important for the understanding of molecular mechanisms involved in these complex diseases...
  7. ncbi request reprint The therapeutical potential of alpha-synuclein antiaggregatory agents for dementia with Lewy bodies
    Katrin Beyer
    Department of Pathology, Hospital Universitari Germans Trias i Pujol, Autonomous University of Barcelona, Badalona, Barcelona, Spain
    Curr Med Chem 15:2748-59. 2008
    ..Each chapter section includes the discussion of possible strategies for the development of drugs and therapies...
  8. doi request reprint Differential expression of alpha-synuclein, parkin, and synphilin-1 isoforms in Lewy body disease
    Katrin Beyer
    Department of Pathology, Hospital Germans Trias i Pujol, Autonomous University of Barcelona, Barcelona, Spain
    Neurogenetics 9:163-72. 2008
    ..In conclusion, isoform-expression profiles in LB diseases represent additional evidence for the direct involvement of isoform-expression deregulation in the development of neurodegenerative disorders...
  9. ncbi request reprint Identification and characterization of a new alpha-synuclein isoform and its role in Lewy body diseases
    Katrin Beyer
    Department of Pathology, Hospital Universitari Germans Trias i Pujol, Autonomous University of Barcelona, Barcelona, Spain
    Neurogenetics 9:15-23. 2008
    ..Overexpression of alpha-synuclein 98 in LBD and AD brains would indicate its specific involvement in the pathogenesis of these neurodegenerative disorders...
  10. ncbi request reprint A variable poly-T sequence modulates alpha-synuclein isoform expression and is associated with aging
    Katrin Beyer
    Department of Pathology, Hospital Germans Trias i Pujol, Autonomous University of Barcelona, Badalona, Spain
    J Neurosci Res 85:1538-46. 2007
    ..In conclusion, this newly identified poly-T polymorphism is a human-specific sequence; its length influences alpha-synuclein 126 expression levels; and, finally, it seems to exert a specific influence on normal aging...
  11. ncbi request reprint Low alpha-synuclein 126 mRNA levels in dementia with Lewy bodies and Alzheimer disease
    Katrin Beyer
    Department of Pathology, Hospital Universitari Germans Trias i Pujol, Autonomous University of Barcelona, Badalona, Spain
    Neuroreport 17:1327-30. 2006
    ..Alpha-synuclein 126 mRNA expression was markedly decreased in the three dementias in comparison with controls, suggesting an important role of this alpha-synuclein isoform in the normal brain...
  12. ncbi request reprint Alpha-synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers
    Katrin Beyer
    Department of Pathology, Hospital Universitari Germans Trias i Pujol, Autonomous University of Barcelona, 08916 Badalona, Barcelona, Spain
    Acta Neuropathol 112:237-51. 2006
    ..The present review attempts to summarize the data so far available on alpha-synuclein structure, posttranslational modifications, and alternative splicing as possible enhancers of aggregation...
  13. ncbi request reprint Parkin and synphilin-1 isoform expression changes in Lewy body diseases
    Jordi Humbert
    Departments of Pathology, Hospital Germans Trias i Pujol, Autonomous University of Barcelona, 08916 Badalona, Spain
    Neurobiol Dis 26:681-7. 2007
    ..These findings suggest that parkin and synphilin-1 isoform expression changes play a significant role in the pathogenesis of LB diseases...
  14. ncbi request reprint Methionine synthase polymorphism is a risk factor for Alzheimer disease
    Katrin Beyer
    Department of Pathology, Hospital Universitari Germans Trias i Pujol, Autonomous University of Barcelona, 08916 Badalona, Barcelona, Spain
    Neuroreport 14:1391-4. 2003
    ..These findings provide novel evidence implicating genetic enzymatic alterations of homocysteine metabolic pathways in the pathogenesis of AD...
  15. ncbi request reprint Cystathionine beta synthase as a risk factor for Alzheimer disease
    Katrin Beyer
    Department of Pathology, Hospital Universitari Germans Trias i Pujol, Autonomous University of Barcelona, Spain
    Curr Alzheimer Res 1:127-33. 2004
    ....
  16. ncbi request reprint Age at onset: an essential variable for the definition of genetic risk factors for sporadic Alzheimer's disease
    Katrin Beyer
    Department of Pathology, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Barcelona, Spain
    Ann N Y Acad Sci 1057:260-78. 2005
    ....
  17. ncbi request reprint Upregulation of amyloid precursor protein isoforms containing Kunitz protease inhibitor in dementia with Lewy bodies
    Katrin Beyer
    Department of Pathology, Hospital Universitari Germans Trias i Pujol, Autonomous University of Barcelona, Spain
    Brain Res Mol Brain Res 131:131-5. 2004
    ..These findings suggest a specific role of APP isoforms containing Kunitz protease inhibitor in DLB pathogenesis...
  18. ncbi request reprint Protein aggregation mechanisms in synucleinopathies: commonalities and differences
    Katrin Beyer
    Department of Pathology, Hospital Universitari Germans Trias i Pujol, Autonomous University of Barcelona, Badalona, Barcelona, Spain
    J Neuropathol Exp Neurol 66:965-74. 2007
    ..The present review summarizes our current knowledge of the commonalities and differences shown by protein aggregation mechanisms in the various synucleinopathies...
  19. doi request reprint Primary renal cell carcinoma in a transplanted kidney: genetic evidence of recipient origin
    Roger Boix
    Department of Urology, Germans Trias i Pujol University Hospital, Badalona, Spain
    Transplantation 87:1057-61. 2009
    ..So far, genetic studies to trace the origin of cancer cells have always confirmed the donor origin of these tumors...