Chad E Beyer

Summary

Publications

  1. doi request reprint Angiotensin IV elevates oxytocin levels in the rat amygdala and produces anxiolytic-like activity through subsequent oxytocin receptor activation
    Chad E Beyer
    Pfizer Global Research and Development CN8000, Princeton, NJ, 08543 8000, USA
    Psychopharmacology (Berl) 209:303-11. 2010
  2. ncbi request reprint Depression-like phenotype following chronic CB1 receptor antagonism
    Chad E Beyer
    Pfizer Global Research and Development, Princeton, NJ 08543, USA
    Neurobiol Dis 39:148-55. 2010
  3. doi request reprint Receptor and behavioral pharmacology of WAY-267464, a non-peptide oxytocin receptor agonist
    Robert H Ring
    Discovery Neuroscience, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    Neuropharmacology 58:69-77. 2010
  4. doi request reprint Acid sensing ion channel (ASIC) inhibitors exhibit anxiolytic-like activity in preclinical pharmacological models
    Jason M Dwyer
    Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ, 08543 8000, USA
    Psychopharmacology (Berl) 203:41-52. 2009
  5. doi request reprint Inhibition of uptake 2 (or extraneuronal monoamine transporter) by normetanephrine potentiates the neurochemical effects of venlafaxine
    Zia Rahman
    Wyeth Research, Discovery Neuroscience, Depression and Anxiety Disorders, CN 8000, Princeton, NJ 08543 8000, USA
    Brain Res 1203:68-78. 2008
  6. doi request reprint WS-50030 [7-{4-[3-(1H-inden-3-yl)propyl]piperazin-1-yl}-1,3-benzoxazol-2(3H)-one]: a novel dopamine D2 receptor partial agonist/serotonin reuptake inhibitor with preclinical antipsychotic-like and antidepressant-like activity
    Julie A Brennan
    Discovery Neuroscience, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    J Pharmacol Exp Ther 332:190-201. 2010
  7. doi request reprint Preclinical characterization of BRL 44408: antidepressant- and analgesic-like activity through selective alpha2A-adrenoceptor antagonism
    Jason M Dwyer
    Discovery Neuroscience, Wyeth Research, Princeton, NJ 08543 8000, USA
    Int J Neuropsychopharmacol 13:1193-205. 2010
  8. doi request reprint Pharmacology of neuropeptide S in mice: therapeutic relevance to anxiety disorders
    Sarah K Leonard
    Depression and Anxiety Disorders, Discovery Neuroscience, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    Psychopharmacology (Berl) 197:601-11. 2008
  9. ncbi request reprint Development of a liquid chromatography/tandem mass spectrometry method for the quantitation of acetylcholine and related neurotransmitters in brain microdialysis samples
    Mei Yi Zhang
    Chemical and Screening Sciences, Princeton, Wyeth Research, NJ 08543, USA
    J Pharm Biomed Anal 44:586-93. 2007
  10. doi request reprint Synthesis, potency, and in vivo evaluation of 2-piperazin-1-ylquinoline analogues as dual serotonin reuptake inhibitors and serotonin 5-HT1A receptor antagonists
    Dahui Zhou
    Chemical Sciences, Wyeth Research, CN 8000, Princeton, New Jersey 08543, USA
    J Med Chem 52:4955-9. 2009

Detail Information

Publications27

  1. doi request reprint Angiotensin IV elevates oxytocin levels in the rat amygdala and produces anxiolytic-like activity through subsequent oxytocin receptor activation
    Chad E Beyer
    Pfizer Global Research and Development CN8000, Princeton, NJ, 08543 8000, USA
    Psychopharmacology (Berl) 209:303-11. 2010
    ....
  2. ncbi request reprint Depression-like phenotype following chronic CB1 receptor antagonism
    Chad E Beyer
    Pfizer Global Research and Development, Princeton, NJ 08543, USA
    Neurobiol Dis 39:148-55. 2010
    ..These preclinical findings mimic clinical reports and implicate possible mechanisms responsible for the unfavorable psychiatric events reported following chronic rimonabant use...
  3. doi request reprint Receptor and behavioral pharmacology of WAY-267464, a non-peptide oxytocin receptor agonist
    Robert H Ring
    Discovery Neuroscience, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    Neuropharmacology 58:69-77. 2010
    ..A selective OTR antagonist also failed to block the effects of OT on immobility in the TST. The significance of these findings for shaping the clinical development of OTR agonists is discussed...
  4. doi request reprint Acid sensing ion channel (ASIC) inhibitors exhibit anxiolytic-like activity in preclinical pharmacological models
    Jason M Dwyer
    Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, NJ, 08543 8000, USA
    Psychopharmacology (Berl) 203:41-52. 2009
    ..Of particular interest is ASIC1a, which is located in areas associated with fear and anxiety behaviors. Recent reports suggest a role for ASIC1a in preclinical models of fear conditioning and anxiety...
  5. doi request reprint Inhibition of uptake 2 (or extraneuronal monoamine transporter) by normetanephrine potentiates the neurochemical effects of venlafaxine
    Zia Rahman
    Wyeth Research, Discovery Neuroscience, Depression and Anxiety Disorders, CN 8000, Princeton, NJ 08543 8000, USA
    Brain Res 1203:68-78. 2008
    ....
  6. doi request reprint WS-50030 [7-{4-[3-(1H-inden-3-yl)propyl]piperazin-1-yl}-1,3-benzoxazol-2(3H)-one]: a novel dopamine D2 receptor partial agonist/serotonin reuptake inhibitor with preclinical antipsychotic-like and antidepressant-like activity
    Julie A Brennan
    Discovery Neuroscience, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    J Pharmacol Exp Ther 332:190-201. 2010
    ..Furthermore, WS-50030 provides a tool to further explore how combining these mechanisms might differentiate from other antipsychotics or antidepressants...
  7. doi request reprint Preclinical characterization of BRL 44408: antidepressant- and analgesic-like activity through selective alpha2A-adrenoceptor antagonism
    Jason M Dwyer
    Discovery Neuroscience, Wyeth Research, Princeton, NJ 08543 8000, USA
    Int J Neuropsychopharmacol 13:1193-205. 2010
    ..This preclinical characterization of the neurochemical and behavioural profile of BRL 44408 suggests that selective antagonism of alpha2A-adrenoceptors may represent an effective treatment strategy for mood disorders and visceral pain...
  8. doi request reprint Pharmacology of neuropeptide S in mice: therapeutic relevance to anxiety disorders
    Sarah K Leonard
    Depression and Anxiety Disorders, Discovery Neuroscience, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    Psychopharmacology (Berl) 197:601-11. 2008
    ..Neuropeptide S (NPS) and its receptor (NPSR) comprise a recently deorphaned G protein-coupled receptor system. Recent reports implicate NPS in the mediation of anxiolytic-like activity in rodents...
  9. ncbi request reprint Development of a liquid chromatography/tandem mass spectrometry method for the quantitation of acetylcholine and related neurotransmitters in brain microdialysis samples
    Mei Yi Zhang
    Chemical and Screening Sciences, Princeton, Wyeth Research, NJ 08543, USA
    J Pharm Biomed Anal 44:586-93. 2007
    ..Collectively, these biological data provided in vivo validation of this analytical method...
  10. doi request reprint Synthesis, potency, and in vivo evaluation of 2-piperazin-1-ylquinoline analogues as dual serotonin reuptake inhibitors and serotonin 5-HT1A receptor antagonists
    Dahui Zhou
    Chemical Sciences, Wyeth Research, CN 8000, Princeton, New Jersey 08543, USA
    J Med Chem 52:4955-9. 2009
    ....
  11. ncbi request reprint Differentiating antidepressants of the future: efficacy and safety
    Sharon Rosenzweig-Lipson
    Wyeth Discovery Neuroscience, Depression and Anxiety, CN 8000, Princeton, NJ 08543, USA
    Pharmacol Ther 113:134-53. 2007
    ..This review will discuss the many facets of differentiation and potential strategies for the development of novel antidepressants...
  12. ncbi request reprint Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466
    Lee E Schechter
    Discovery Neuroscience, Wyeth Research, Princeton, NJ 08543 8000, USA
    Neuropsychopharmacology 33:1323-35. 2008
    ....
  13. ncbi request reprint Anxiolytic-like activity of the non-selective galanin receptor agonist, galnon
    S Johannes R Rajarao
    Depression and Anxiety Research, Discovery Neuroscience, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    Neuropeptides 41:307-20. 2007
    ..Moreover, these data indicate rodent GALR1 receptors do not mediate galnon's in vivo activity...
  14. doi request reprint Do selective serotonin reuptake inhibitors acutely increase frontal cortex levels of serotonin?
    Chad E Beyer
    Depression and Anxiety Research, Discovery Neuroscience, Wyeth Research, Princeton, NJ 08543, USA
    Eur J Pharmacol 580:350-4. 2008
    ..The significance of this observation, along with potential explanations for the disparate neurochemical findings in the medial versus lateral cortices, will be discussed...
  15. ncbi request reprint Studying rat brain neurochemistry using nanoprobe NMR spectroscopy: a metabonomics approach
    Purnima Khandelwal
    Chemical and Screening Sciences, Discovery Analytical Chemistry and Neuroscience Discovery Research, Wyeth Research, CN 8000, Princeton, New Jersey 08543 8000, USA
    Anal Chem 76:4123-7. 2004
    ....
  16. ncbi request reprint Regulators of G-protein signaling 4: modulation of 5-HT1A-mediated neurotransmitter release in vivo
    Chad E Beyer
    Neuroscience Discovery Research, Wyeth Research, CN 8000, Princeton, NJ 08543 8000, USA
    Brain Res 1022:214-20. 2004
    ....
  17. doi request reprint The supra-additive hyperactivity caused by an amphetamine-chlordiazepoxide mixture exhibits an inverted-U dose response: negative implications for the use of a model in screening for mood stabilizers
    Michele P Kelly
    Department of Neuroscience, Discovery Research, Wyeth, Princeton, NJ 08852, USA
    Pharmacol Biochem Behav 92:649-54. 2009
    ..We argue that these data, in addition to other practical and theoretical concerns surrounding the model, limit the utility of the AMPH-CDP mixture model in drug discovery...
  18. doi request reprint ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities
    Feng Liu
    Wyeth Neuroscience Discovery Research, Princeton, New Jersey, USA
    J Pharmacol Exp Ther 327:827-39. 2008
    ..p.) in rats. Taken together, these effects are consistent with the hypothesis that allosteric potentiation of mGlu5 may provide a novel approach for development of antipsychotic and procognitive agents...
  19. ncbi request reprint Alpha 2A-adrenoceptors enhance the serotonergic effects of fluoxetine
    Chad E Beyer
    Depression and Anxiety Research, Discovery Neuroscience, Wyeth Research, Princeton, NJ 08543, USA
    Eur J Pharmacol 539:164-7. 2006
    ..c.), respectively, did not similarly alter biogenic amine levels. Collectively, these results reveal a specific role for the alpha(2A)-adrenoceptor subtype in augmenting the neurochemical effects of antidepressants...
  20. ncbi request reprint Neurochemical changes in the RVM associated with peripheral inflammatory pain stimuli
    Valerie A Smith
    Discovery Neuroscience, Wyeth Research, Princeton, NJ 08543 8000, USA
    Brain Res 1095:65-72. 2006
    ....
  21. pmc Innovative approaches for the development of antidepressant drugs: current and future strategies
    Lee E Schechter
    Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, New Jersey 08543, USA
    NeuroRx 2:590-611. 2005
    ..The present review addresses the most exciting approaches and reviews the localization, neurochemical and behavioral data that provide the supporting rationale for each of these targets or target combinations...
  22. doi request reprint Schedule-induced polydipsia: a rat model of obsessive-compulsive disorder
    Brian Platt
    Wyeth Research, Princeton, New Jersey, USA
    Curr Protoc Neurosci . 2008
    ..This protocol describes a rat SIP model of OCD and provides preclinical data for drugs that decrease polydipsia and are clinically effective in the treatment of OCD...
  23. ncbi request reprint Synthesis and biological evaluation of novel compounds within a class of 3-aminochroman derivatives with dual 5-HT1A receptor and serotonin transporter affinity
    Nicole T Hatzenbuhler
    Chemical and Screening Sciences and Discovery Neuroscience, Wyeth Research, CN 8000, Princeton, New Jersey 08543, USA
    J Med Chem 49:4785-9. 2006
    ..26a was found to be the most potent and selective compound in this series and was shown to possess neurochemical activity in vivo by producing acute and rapid increases in 5-HT in the rat frontal cortex...
  24. ncbi request reprint Measurement of neurotransmitters from extracellular fluid in brain by in vivo microdialysis and chromatography-mass spectrometry
    Mei Yi Zhang
    Chemical and Screening Sciences, Wyeth Research, Princeton, NJ 08543, USA
    J Pharm Biomed Anal 40:492-9. 2006
    ..The primary emphasis of this review will be on how these applications are used to measure levels of acetylcholine (ACh), dopamine, norepinephrine and gamma-aminobutyric acid (GABA)...
  25. ncbi request reprint Nanoprobe NMR spectroscopy and in vivo microdialysis: new analytical methods to study brain neurochemistry
    Purnima Khandelwal
    Chemical and Screening Sciences, Discovery Analytical Chemistry, Wyeth Research, CN 8000, Princeton, NJ 08543 8000, USA
    J Neurosci Methods 133:181-9. 2004
    ..To our knowledge, the present experiments are the first to describe the combination of nanoprobe NMR technology with in vivo microdialysis for the analysis of brain neurochemistry in freely-moving rats...
  26. doi request reprint Innovations in CNS drug discovery: differentiating strategies to treat depression
    Chad E Beyer
    Depression and Anxiety Research, Discovery Neuroscience, Wyeth, Princeton, NJ 08543, USA 1 732 274 4852 1 732 274 4755
    Expert Opin Drug Discov 2:1369-77. 2007
    ....
  27. ncbi request reprint Comparison of the effects of antidepressants on norepinephrine and serotonin concentrations in the rat frontal cortex: an in-vivo microdialysis study
    Chad E Beyer
    Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey 08543 8000, USA
    J Psychopharmacol 16:297-304. 2002
    ....