Michael J Berridge

Summary

Publications

  1. ncbi request reprint Calcium signalling and psychiatric disease: bipolar disorder and schizophrenia
    Michael J Berridge
    The Babraham Institute, Babraham, Cambridge, CB22 3AT, UK
    Cell Tissue Res 357:477-92. 2014
  2. pmc Calcium regulation of neural rhythms, memory and Alzheimer's disease
    Michael J Berridge
    The Babraham Institute, Babraham, Cambridge, CB22 3AT, UK
    J Physiol 592:281-93. 2014
  3. pmc Dysregulation of neural calcium signaling in Alzheimer disease, bipolar disorder and schizophrenia
    Michael J Berridge
    The Babraham Institute, Babraham, Cambridge, UK
    Prion 7:2-13. 2013
  4. doi request reprint Calcium signalling remodelling and disease
    Michael J Berridge
    Babraham Institute, Babraham, Cambridge CB22 3AT, U K
    Biochem Soc Trans 40:297-309. 2012
  5. ncbi request reprint Inositol 1,4,5-trisphosphate supports the arrhythmogenic action of endothelin-1 on ventricular cardiac myocytes
    Andrew Proven
    Calcium Group, Laboratory of Molecular Signalling, Babraham Institute, Babraham, Cambridge, CB2 4AT, UK
    J Cell Sci 119:3363-75. 2006
  6. ncbi request reprint 2-Aminoethoxydiphenyl borate (2-APB) antagonises inositol 1,4,5-trisphosphate-induced calcium release, inhibits calcium pumps and has a use-dependent and slowly reversible action on store-operated calcium entry channels
    Claire M Peppiatt
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Cell Calcium 34:97-108. 2003
  7. ncbi request reprint The spatial pattern of atrial cardiomyocyte calcium signalling modulates contraction
    Lauren Mackenzie
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham Hall, Babraham, Cambridge, CB2 4AT, UK
    J Cell Sci 117:6327-37. 2004
  8. ncbi request reprint 2-aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of InsP3-induced Ca2+ release
    Martin D Bootman
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    FASEB J 16:1145-50. 2002
  9. doi request reprint Calcium signalling and Alzheimer's disease
    Michael J Berridge
    The Babraham Institute, Babraham, Cambridge, CB22 3AT, UK
    Neurochem Res 36:1149-56. 2011
  10. ncbi request reprint Local and global spontaneous calcium events regulate neurite outgrowth and onset of GABAergic phenotype during neural precursor differentiation
    Francesca Ciccolini
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, United Kingdom
    J Neurosci 23:103-11. 2003

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Calcium signalling and psychiatric disease: bipolar disorder and schizophrenia
    Michael J Berridge
    The Babraham Institute, Babraham, Cambridge, CB22 3AT, UK
    Cell Tissue Res 357:477-92. 2014
    ..In particular, dysregulation of the Ca(2+) signalling pathway has been implicated in the development of some of the major psychiatric diseases such as bipolar disorder (BPD) and schizophrenia. ..
  2. pmc Calcium regulation of neural rhythms, memory and Alzheimer's disease
    Michael J Berridge
    The Babraham Institute, Babraham, Cambridge, CB22 3AT, UK
    J Physiol 592:281-93. 2014
    ..The Aβ deregulates Ca(2+) signalling through direct effects on the neurons and indirectly by inducing inflammatory responses in the microglia and astrocytes. Some of these deleterious effects of Aβ may be alleviated by vitamin D. ..
  3. pmc Dysregulation of neural calcium signaling in Alzheimer disease, bipolar disorder and schizophrenia
    Michael J Berridge
    The Babraham Institute, Babraham, Cambridge, UK
    Prion 7:2-13. 2013
    ..Various treatments, which are known to act by reducing the activity of Ca(2+) signaling, have proved successful in alleviating the symptoms of some of these neural diseases...
  4. doi request reprint Calcium signalling remodelling and disease
    Michael J Berridge
    Babraham Institute, Babraham, Cambridge CB22 3AT, U K
    Biochem Soc Trans 40:297-309. 2012
    ..Such subtle dysregulation of Ca2+ signals have been linked to some of the major diseases in humans such as cardiac disease, schizophrenia, bipolar disorder and Alzheimer's disease...
  5. ncbi request reprint Inositol 1,4,5-trisphosphate supports the arrhythmogenic action of endothelin-1 on ventricular cardiac myocytes
    Andrew Proven
    Calcium Group, Laboratory of Molecular Signalling, Babraham Institute, Babraham, Cambridge, CB2 4AT, UK
    J Cell Sci 119:3363-75. 2006
    ..We propose that Ins(1,4,5)P3 receptors support the development of both inotropy and spontaneous pro-arrhythmic Ca2+ signals in ventricular myocytes stimulated with a Gq-coupled agonist...
  6. ncbi request reprint 2-Aminoethoxydiphenyl borate (2-APB) antagonises inositol 1,4,5-trisphosphate-induced calcium release, inhibits calcium pumps and has a use-dependent and slowly reversible action on store-operated calcium entry channels
    Claire M Peppiatt
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Cell Calcium 34:97-108. 2003
    ..Our data suggest that 2-APB has multiple cellular targets, a use-dependent action, is difficult to reverse and may affect Ca(2+) signalling in cell types where InsP(3) and SOC are not active...
  7. ncbi request reprint The spatial pattern of atrial cardiomyocyte calcium signalling modulates contraction
    Lauren Mackenzie
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham Hall, Babraham, Cambridge, CB2 4AT, UK
    J Cell Sci 117:6327-37. 2004
    ..These data indicate how calcium signals and their consequences are determined by the interplay of multiple subcellular calcium management systems...
  8. ncbi request reprint 2-aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of InsP3-induced Ca2+ release
    Martin D Bootman
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    FASEB J 16:1145-50. 2002
    ..These data indicate that although it must be used with caution, 2-APB can be useful in probing certain aspects of Ca2+ signaling...
  9. doi request reprint Calcium signalling and Alzheimer's disease
    Michael J Berridge
    The Babraham Institute, Babraham, Cambridge, CB22 3AT, UK
    Neurochem Res 36:1149-56. 2011
    ..Further dysregulation in Ca(2+) signalling will then go on to induce the neurodegeneration that characterizes the later stages of dementia...
  10. ncbi request reprint Local and global spontaneous calcium events regulate neurite outgrowth and onset of GABAergic phenotype during neural precursor differentiation
    Francesca Ciccolini
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, United Kingdom
    J Neurosci 23:103-11. 2003
    ..Thus, spontaneous Ca(2+) signals are an intrinsic property of differentiating neurosphere-derived precursors. Their frequency may specify neuronal morphology and acquisition of neurotransmitter phenotype...
  11. ncbi request reprint Calcium microdomains: organization and function
    Michael J Berridge
    Babraham Institute, Babraham, Cambridge, UK
    Cell Calcium 40:405-12. 2006
    ..Control of cardiac cell contraction and gene transcription provides another example of how the parallel processing of Ca(2+) signalling can occur through microdomains of intracellular Ca(2+)...
  12. ncbi request reprint Calcium signalling: dynamics, homeostasis and remodelling
    Michael J Berridge
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Nat Rev Mol Cell Biol 4:517-29. 2003
    ..Ca2+ has a direct role in controlling the expression patterns of its signalling systems that are constantly being remodelled in both health and disease...
  13. ncbi request reprint Calcium signalling: more messengers, more channels, more complexity
    Martin D Bootman
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, CB2 4AT, Cambridge, UK
    Curr Biol 12:R563-5. 2002
    ..Recent studies have expanded the number of channel types and messengers that lead to Ca(2+) signals within cells. Furthermore, we are beginning to understand the complex interplay between different sources of Ca(2+)...
  14. pmc The role of inositol 1,4,5-trisphosphate receptors in Ca(2+) signalling and the generation of arrhythmias in rat atrial myocytes
    Lauren Mackenzie
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    J Physiol 541:395-409. 2002
    ....
  15. ncbi request reprint Calcium hypothesis of Alzheimer's disease
    Michael J Berridge
    The Babraham Institute, Cambridge CB22 3AT, UK
    Pflugers Arch 459:441-9. 2010
    ..The alteration in Ca(2+) signaling will also contribute to the neurodegeneration that characterizes the later stages of dementia...
  16. ncbi request reprint Calcium-induced calcium release
    H Llewelyn Roderick
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge, CB2 4AT, UK
    Curr Biol 13:R425. 2003
  17. doi request reprint Inositol trisphosphate and calcium signalling mechanisms
    Michael J Berridge
    The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Biochim Biophys Acta 1793:933-40. 2009
    ....
  18. ncbi request reprint Unlocking the secrets of cell signaling
    Michael J Berridge
    The Babraham Institute, Babraham Research Campus, Babraham, Cambridge CB2 4AT, United Kingdom
    Annu Rev Physiol 67:1-21. 2005
    ....
  19. pmc Activating calcium release through inositol 1,4,5-trisphosphate receptors without inositol 1,4,5-trisphosphate
    Martin D Bootman
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge, CB2 4AT United Kingdom
    Proc Natl Acad Sci U S A 99:7320-2. 2002
  20. pmc Smooth muscle cell calcium activation mechanisms
    Michael J Berridge
    The Babraham Institute, Babraham, Cambridge CB22 4AT, UK
    J Physiol 586:5047-61. 2008
    ....
  21. ncbi request reprint Calcium signal transduction and cellular control mechanisms
    Michael J Berridge
    The Babraham Institute, The Babraham Campus, Cambridge CB2 4AT, UK
    Biochim Biophys Acta 1742:3-7. 2004
  22. ncbi request reprint The endoplasmic reticulum: a multifunctional signaling organelle
    Michael J Berridge
    Laboratory of Molecular Signaling, The Babraham Institute, Cambridge CB2 4AT, Babraham, UK
    Cell Calcium 32:235-49. 2002
    ..Conversely, the presenilins that appear to increase the Ca(2+) content of the ER lumen make cells more susceptible to apoptosis...