P Bernard

Summary

Publications

  1. ncbi Ethnopharmacology and bioinformatic combination for leads discovery: application to phospholipase A(2) inhibitors
    P Bernard
    Greenpharma S A, 1 rue de Chartres, B P 6759, 45067 Cedex 2, Orleans, France
    Phytochemistry 58:865-74. 2001
  2. pmc Modulating testosterone pathway: a new strategy to tackle male skin aging?
    Philippe Bernard
    Greenpharma SAS, Orleans, France
    Clin Interv Aging 7:351-61. 2012
  3. ncbi Application of drug repositioning strategy to TOFISOPAM
    P Bernard
    Greenpharma S A, 3 allée du Titane, 45 100 Orléans, France
    Curr Med Chem 15:3196-203. 2008
  4. ncbi Protein-based alignment in 3D QSAR of 26 indole inhibitors of human pancreatic phospholipase A2
    M Pintore
    Laboratory of Chemometrics and BioInformatics, Faculty of Sciences, , BP 6759, 45067 Cedex 2, , France
    Eur J Med Chem 36:21-30. 2001
  5. ncbi A molecular modeling and 3D QSAR study of a large series of indole inhibitors of human non-pancreatic secretory phospholipase A2
    P Bernard
    Laboratory of Chemometrics and BioInformatics, , BP 6759, 45067 Cedex 2, , France
    Eur J Med Chem 36:1-19. 2001
  6. ncbi Preliminary screening of some tropical plants for anti-tyrosinase activity
    N Baurin
    Greenpharma S A, 3 allée du Titane, 45100 Orleans, France
    J Ethnopharmacol 82:155-8. 2002
  7. ncbi Reverse pharmacognosy: another way to harness the generosity of nature
    S Blondeau
    Greenpharma SAS, 3 allée du titane 45100 Orléans, France
    Curr Pharm Des 16:1682-96. 2010

Collaborators

  • Q T Do
  • T Scior
  • S Blondeau
  • N Baurin
  • M Pintore
  • L Morin-Allory
  • E Arnoult
  • J Y Berthon

Detail Information

Publications7

  1. ncbi Ethnopharmacology and bioinformatic combination for leads discovery: application to phospholipase A(2) inhibitors
    P Bernard
    Greenpharma S A, 1 rue de Chartres, B P 6759, 45067 Cedex 2, Orleans, France
    Phytochemistry 58:865-74. 2001
    ..This suggestion was confirmed experimentally...
  2. pmc Modulating testosterone pathway: a new strategy to tackle male skin aging?
    Philippe Bernard
    Greenpharma SAS, Orleans, France
    Clin Interv Aging 7:351-61. 2012
    ..Taken together, these data indicate that honokiol modulates testosterone levels, and its structure has the potential to serve as a lead for future designs of highly selective inhibitors of 5-alpha-reductase type 1...
  3. ncbi Application of drug repositioning strategy to TOFISOPAM
    P Bernard
    Greenpharma S A, 3 allée du Titane, 45 100 Orléans, France
    Curr Med Chem 15:3196-203. 2008
    ..The identification of the biochemical mechanism of tofisopam isomers now allows to reposition this drug in new therapeutic indications where modulation of cAMP via PDE4 inhibitors are possible...
  4. ncbi Protein-based alignment in 3D QSAR of 26 indole inhibitors of human pancreatic phospholipase A2
    M Pintore
    Laboratory of Chemometrics and BioInformatics, Faculty of Sciences, , BP 6759, 45067 Cedex 2, , France
    Eur J Med Chem 36:21-30. 2001
    ....
  5. ncbi A molecular modeling and 3D QSAR study of a large series of indole inhibitors of human non-pancreatic secretory phospholipase A2
    P Bernard
    Laboratory of Chemometrics and BioInformatics, , BP 6759, 45067 Cedex 2, , France
    Eur J Med Chem 36:1-19. 2001
    ..A good correlation between predicted and experimental activity data allows to validate the 3D QSAR model. A second and global 3D QSAR including all the compounds was established, allowing the creation of the hnps-PLA2 pharmacophore...
  6. ncbi Preliminary screening of some tropical plants for anti-tyrosinase activity
    N Baurin
    Greenpharma S A, 3 allée du Titane, 45100 Orleans, France
    J Ethnopharmacol 82:155-8. 2002
    ..These 5 plants will be studied in order to isolate and identify phytochemical compounds, involved in this biological activity...
  7. ncbi Reverse pharmacognosy: another way to harness the generosity of nature
    S Blondeau
    Greenpharma SAS, 3 allée du titane 45100 Orléans, France
    Curr Pharm Des 16:1682-96. 2010
    ..by exploiting existing data from pharmacognosy. This review will focus on recent advances in computer science applied to natural substance research that consolidate the new concept of reverse pharmacognosy...