Aviv Bergman

Summary

Publications

  1. pmc Buffering mechanisms in aging: a systems approach toward uncovering the genetic component of aging
    Aviv Bergman
    Department of Pathology, Albert Einstein College of Medicine, New York, New York, United States of America
    PLoS Comput Biol 3:e170. 2007
  2. pmc Genetic determinants of human health span and life span: progress and new opportunities
    George M Martin
    Department of Pathology, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 3:e125. 2007
  3. pmc Gene size matters
    Alexandra Mirina
    Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 7:e49093. 2012
  4. pmc Lipoprotein genotype and conserved pathway for exceptional longevity in humans
    Gil Atzmon
    Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS Biol 4:e113. 2006
  5. pmc The limits of subfunctionalization
    Thomas MacCarthy
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    BMC Evol Biol 7:213. 2007
  6. pmc Coevolution of robustness, epistasis, and recombination favors asexual reproduction
    Thomas MacCarthy
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 104:12801-6. 2007
  7. pmc The underlying molecular and network level mechanisms in the evolution of robustness in gene regulatory networks
    Mario Pujato
    Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS Comput Biol 9:e1002865. 2013
  8. pmc Site-specific molecular signatures predict aggressive disease in HNSCC
    Thomas J Belbin
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Head Neck Pathol 2:243-56. 2008
  9. ncbi request reprint Functional and evolutionary inference in gene networks: does topology matter?
    Mark L Siegal
    Department of Biology, New York University, New York, NY 10003, USA
    Genetica 129:83-103. 2007
  10. ncbi request reprint Evolutionary capacitance as a general feature of complex gene networks
    Aviv Bergman
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    Nature 424:549-52. 2003

Collaborators

Detail Information

Publications11

  1. pmc Buffering mechanisms in aging: a systems approach toward uncovering the genetic component of aging
    Aviv Bergman
    Department of Pathology, Albert Einstein College of Medicine, New York, New York, United States of America
    PLoS Comput Biol 3:e170. 2007
    ..It also provides a framework for developing strategies to prevent some age-related diseases by intervention at the appropriate level...
  2. pmc Genetic determinants of human health span and life span: progress and new opportunities
    George M Martin
    Department of Pathology, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 3:e125. 2007
    ..We can conclude that there are great opportunities for research on the genetics of human aging, particularly given the huge fund of information on human biology and pathobiology, and the rapidly developing knowledge of the human genome...
  3. pmc Gene size matters
    Alexandra Mirina
    Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 7:e49093. 2012
    ..We investigate several methods of obtaining gene level statistical significance in GWAS, and compare their effectiveness in correcting such bias. We also propose a simple algorithm based on first order statistic that corrects such bias...
  4. pmc Lipoprotein genotype and conserved pathway for exceptional longevity in humans
    Gil Atzmon
    Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS Biol 4:e113. 2006
    ..Because modulation of lipoproteins is also seen in genetically altered longevity models, it may be a common pathway influencing lifespan from nematodes to humans...
  5. pmc The limits of subfunctionalization
    Thomas MacCarthy
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    BMC Evol Biol 7:213. 2007
    ..We distinguish between subfunctionalization at the regulatory level and at the product level (e.g within temporal or spatial expression domains)...
  6. pmc Coevolution of robustness, epistasis, and recombination favors asexual reproduction
    Thomas MacCarthy
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 104:12801-6. 2007
    ....
  7. pmc The underlying molecular and network level mechanisms in the evolution of robustness in gene regulatory networks
    Mario Pujato
    Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS Comput Biol 9:e1002865. 2013
    ..Meanwhile, in highly interconnected architectures (represented by long promoters), robustness evolves almost entirely via network level changes, deleting and creating binding sites that modify the network architecture...
  8. pmc Site-specific molecular signatures predict aggressive disease in HNSCC
    Thomas J Belbin
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Head Neck Pathol 2:243-56. 2008
    ..Predictions of outcome based on gene expression profiling are therefore heavily influenced by the anatomic site of the primary tumor...
  9. ncbi request reprint Functional and evolutionary inference in gene networks: does topology matter?
    Mark L Siegal
    Department of Biology, New York University, New York, NY 10003, USA
    Genetica 129:83-103. 2007
    ..This latter pattern is generally taken as a signature of positive selection, but in our simulations its cause is often neutral coevolution of regulatory inputs to the same gene...
  10. ncbi request reprint Evolutionary capacitance as a general feature of complex gene networks
    Aviv Bergman
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    Nature 424:549-52. 2003
    ..Thus, there might exist a large class of evolutionary capacitors whose effects on phenotypic variation complement the systemic, environment-induced effects of Hsp90...
  11. pmc Waddington's canalization revisited: developmental stability and evolution
    Mark L Siegal
    Department of Biological Sciences, and Center for Computational Genetics and Biological Modeling, Stanford University, Stanford, CA 94305 5020, USA
    Proc Natl Acad Sci U S A 99:10528-32. 2002
    ..We argue that canalization may be an inevitable consequence of complex developmental-genetic processes and thus requires no explanation in terms of evolution to suppress phenotypic variation...