Regulation of endogenous glucose production in glucose transporter 4 over-expressing miceEric D Berglund
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
PLoS ONE 7:e52355. 2012
..These data emphasize that anti-diabetic therapies that target skeletal muscle, heart, and/or adipose tissue likely positively impact the liver...
Hepatic energy state is regulated by glucagon receptor signaling in miceEric D Berglund
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Clin Invest 119:2412-22. 2009
..Taken together, these data demonstrate in vivo that the hepatic energy state is sensitive to glucagon receptor activation and requires PEPCK-C, thus providing new insights into liver metabolism...
Hepatic glucagon action is essential for exercise-induced reversal of mouse fatty liverEric D Berglund
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Diabetes 60:2720-9. 2011
..However, the mechanism(s) that underlie exercise-induced reductions in fatty liver are unclear. Here we tested the hypothesis that exercise requires hepatic glucagon action to reduce fatty liver...
Glucagon and lipid interactions in the regulation of hepatic AMPK signaling and expression of PPARalpha and FGF21 transcripts in vivoEric D Berglund
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Am J Physiol Endocrinol Metab 299:E607-14. 2010
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Energy state of the liver during short-term and exhaustive exercise in C57BL/6J miceRaul C Camacho
Department of Molecular Physiology and Biolphysics and Mouse Metabolic Phenotyping Center, Vanderbilt University School of Medicine, Nashville, TN, USA
Am J Physiol Endocrinol Metab 290:E405-8. 2006
..In conclusion, AMP is sensitively regulated, consistent with it having an important role in hepatic metabolism...
Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivityEric D Berglund
Department of Molecular Physiology and Biophysics, National Institutes of Health Vanderbilt University Mouse Metabolic Phenotyping Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Endocrinology 150:4084-93. 2009
..Thus, these studies define mechanisms underlying anti-hyperglycemic actions of FGF21 and support its therapeutic potential...
Glucose metabolism in vivo in four commonly used inbred mouse strainsEric D Berglund
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Diabetes 57:1790-9. 2008
..To characterize differences in whole-body glucose metabolism between commonly used inbred mouse strains...
Emerging role of AMP-activated protein kinase in endocrine control of metabolism in the liverClinton M Hasenour
Department of Molecular Physiology and Biophysics and Mouse Metabolic Phenotyping Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA Electronic address
Mol Cell Endocrinol 366:152-62. 2013
..Few experiments have, however, firmly established a causal relationship between hormone action at the liver and AMPK signaling...