Bioactive lipids in schizophreniaGregor E Berger
ORYGEN Youth Health and ORYGEN Research Centre, Department of Psychiatry, University of Melbourne, Australia
Int Rev Psychiatry 18:85-98. 2006
..This review investigates the role of bioactive lipids in schizophrenia and its treatment, as well as its potential use in prevention...
- Ethyl-eicosapentaenoic acid in first-episode psychosis: a randomized, placebo-controlled trial
Gregor E Berger
ORYGEN Research Centre incorporating the Early Psychosis Prevention and Intervention Centre EPPIC, University of Melbourne, Australia
J Clin Psychiatry 68:1867-75. 2007
..To investigate if ethyl-eicosapentaenoic acid (E-EPA) augmentation improves antipsychotic efficacy and tolerability in first-episode psychosis (FEP)...
Ethyl-eicosapentaenoic acid in first-episode psychosis. A 1H-MRS studyGregor E Berger
Department of Psychiatry, ORYGEN Research Centre, University of Melbourne, Parkville, Australia
Neuropsychopharmacology 33:2467-73. 2008
..Larger confirmatory studies of these postulated metabolic brain effects of E-EPA are warranted...
- Polyunsaturated fatty acids in emerging psychosis
Nilufar Mossaheb
Department of Child and Adolescent Psychiatry, Medical University Vienna, Austria
Curr Pharm Des 18:576-91. 2012
..The neuroprotective potential of n-3 LC-PUFAs for indicated prevention, i.e. delaying transition to psychosis in high-risk populations needs to be further explored...
- Dosing quetiapine in drug-naive first-episode psychosis: a controlled, double-blind, randomized, single-center study investigating efficacy, tolerability, and safety of 200 mg/day vs. 400 mg/day of quetiapine fumarate in 141 patients aged 15 to 25 years
Gregor E Berger
The Schloessli Clinic, Department of Research and Education, Schlösslistrasse 8, CH 8618 Oetwil am See, Switzerland
J Clin Psychiatry 69:1702-14. 2008
..To assess dosing, efficacy, and tolerability of quetiapine fumarate in drug-naive first-episode psychosis...
- A 1H-MRS investigation of the medial temporal lobe in antipsychotic-naïve and early-treated first episode psychosis
Stephen J Wood
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
Schizophr Res 102:163-70. 2008
..Seemingly illness-related Cr/PCr elevations were also specific to the diagnosis of schizophrenia-spectrum disorder and seem worthy of future study...
- Neuroprotective effects of ethyl-eicosapentaenoic acid in first episode psychosis: a longitudinal T2 relaxometry pilot study
Stephen J Wood
Melbourne Neuropsychiatry Centre, University of Melbourne, Australia
Psychiatry Res 182:180-2. 2010
..There was an increase in T(2) in the placebo group but not in the E-EPA group, suggesting a neuroprotective effect of E-EPA treatment. In addition, the smaller the increase in T(2), the greater the improvement in negative symptoms...
- Medial temporal lobe glutathione concentration in first episode psychosis: a 1H-MRS investigation
Stephen J Wood
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
Neurobiol Dis 33:354-7. 2009
..This study provides further evidence of significant perturbations in brain GSH in first episode psychosis, and supports a broader involvement of GSH in the pathophysiology of schizophrenia...
- The effect of atypical antipsychotics on pituitary gland volume in patients with first-episode psychosis: a longitudinal MRI study
John Paul Nicolo
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
Schizophr Res 116:49-54. 2010
..Qualifying and quantifying the effect of atypical antipsychotics on the volume of the pituitary gland will determine whether this measure is valid as a future estimate of HPA-axis activation in psychotic populations...
- Adhesio interthalamica in individuals at high-risk for developing psychosis and patients with psychotic disorders
Tsutomu Takahashi
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
Prog Neuropsychopharmacol Biol Psychiatry 32:1708-14. 2008
....
- Neuroprotective effects of low-dose lithium in individuals at ultra-high risk for psychosis. A longitudinal MRI/MRS study
Gregor E Berger
Orygen Youth Health Research Centre, Locked Bag 10, Parkville, Victoria, 3052, Australia
Curr Pharm Des 18:570-5. 2012
..To investigate if low-dose lithium may counteract the microstructural and metabolic brain changes proposed to occur in individuals at ultra-high risk (UHR) for psychosis...
- Prediction of functional outcome 18 months after a first psychotic episode: a proton magnetic resonance spectroscopy study
Stephen J Wood
Melbourne Neuropsychiatry Centre, University of Melbourne, c o National Neuroscience Facility, 161 Barry Street, Carlton, Melbourne, Victoria 3053, Australia
Arch Gen Psychiatry 63:969-76. 2006
..These studies have generally been negative, perhaps because gray and white matter volumes inaccurately assess the underlying dysfunction that might be predictive of outcome...
- Relational memory in first episode psychosis: implications for progressive hippocampal dysfunction after illness onset
Cali F Bartholomeusz
National Neuroscience Facility, Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Carlton South, Victoria, Australia
Aust N Z J Psychiatry 45:206-13. 2011
....
- Olfactory sensitivity through the course of psychosis: Relationships to olfactory identification, symptomatology and the schizophrenia odour
Warrick J Brewer
ORYGEN Research Centre, Melbourne, Victoria, Australia
Psychiatry Res 149:97-104. 2007
..This may be linked to olfactory habituation effects, abnormal chemical processing or a genetic predisposition...
- Randomized controlled trial of interventions for young people at ultra-high risk of psychosis: twelve-month outcome
Patrick D McGorry
35 Poplar Rd Locked Bag 10, Parkville, VIC 3052, Australia
J Clin Psychiatry 74:349-56. 2013
..The aim of this study was to determine which intervention was most effective at preventing transition to psychosis: cognitive therapy plus low-dose risperidone, cognitive therapy plus placebo, or supportive therapy plus placebo...
- Pilot study evaluating the effect of massage therapy on stress, anxiety and aggression in a young adult psychiatric inpatient unit
Belinda Garner
ORYGEN Research Centre, Parkville, Vic, Australia
Aust N Z J Psychiatry 42:414-22. 2008
..The aim of the present pilot study was to examine the effectiveness of a relaxation massage therapy programme in reducing stress, anxiety and aggression on a young adult psychiatric inpatient unit...
- Antibodies to infectious agents in individuals at ultra-high risk for psychosis
G Paul Amminger
ORYGEN Research Centre, Department of Psychiatry, University of Melbourne, Australia
Biol Psychiatry 61:1215-7. 2007
..While there is evidence that some cases of schizophrenia may be associated with microbial infections, the role of microbial agents has not been investigated in people with emerging psychosis...
- Pituitary volume predicts future transition to psychosis in individuals at ultra-high risk of developing psychosis
Belinda Garner
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Royal Melbourne Hospital, Melbourne, Australia
Biol Psychiatry 58:417-23. 2005
..032). CONCLUSIONS: The phase before the onset of psychosis is associated with a larger pituitary volume, suggesting activation of the HPA axis...
- Incipient neurovulnerability and neuroprotection in early psychosis
Gregor E Berger
ORYGEN Research Centre, University of Melbourne, Parkville, Victoria, Australia
Psychopharmacol Bull 37:79-101. 2003
..Neuroprotective strategies counteracting the loss or supporting the generation of progenitor cells may therefore be a potent therapeutic avenue to explore...
- Insight, symptoms and executive functions in schizophrenia
Andor E Simon
Psychiatric Outpatient Services, Specialised Programme for Early Psychosis, Bruderholz, Switzerland
Cogn Neuropsychiatry 11:437-51. 2006
..We investigated the relationship of insight with executive functions and symptoms in a group of stabilised inpatients with schizophrenia...
- Omega-3 fatty acids supplementation in children with autism: a double-blind randomized, placebo-controlled pilot study
G Paul Amminger
Department of Child and Adolescent Neuropsychiatry, Medical University of Vienna, Vienna, Austria
Biol Psychiatry 61:551-3. 2007
..There is increasing evidence that fatty acid deficiencies or imbalances may contribute to childhood neurodevelopmental disorders...
- The transition to psychosis: risk factors and brain changes
Stephen J Wood
Epidemiol Psichiatr Soc 13:137-40. 2004
