Sarah E Bergen

Summary

Publications

  1. doi Genetic modifiers and subtypes in schizophrenia: Investigations of age at onset, severity, sex and family history
    Sarah E Bergen
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston, MA, USA Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden Electronic address
    Schizophr Res 154:48-53. 2014
  2. pmc Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder
    S E Bergen
    Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
    Mol Psychiatry 17:880-6. 2012
  3. pmc Socioeconomic status and social support following illicit drug use: causal pathways or common liability?
    Sarah E Bergen
    Department of Human Genetics, Medical College of Virginia, Virginia Commonwealth University, Box 980126, Richmond, VA 23219, USA
    Twin Res Hum Genet 11:266-74. 2008
  4. pmc Polymorphisms in SLC6A4, PAH, GABRB3, and MAOB and modification of psychotic disorder features
    Sarah E Bergen
    Virginia Commonwealth University, Department of Human and Molecular Genetics, Richmond, Virginia 23219, USA
    Schizophr Res 109:94-7. 2009
  5. pmc No association of dysbindin with symptom factors of schizophrenia in an Irish case-control sample
    Sarah E Bergen
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23219, USA
    Am J Med Genet B Neuropsychiatr Genet 153:700-5. 2010
  6. pmc Detection of susceptibility genes as modifiers due to subgroup differences in complex disease
    Sarah E Bergen
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA
    Eur J Hum Genet 18:960-4. 2010
  7. doi A polygenic burden of rare disruptive mutations in schizophrenia
    SHAUN M PURCELL
    1 Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA 2 Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA 3 Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA 4 Analytic and Translational Genetics Unit, Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA 5 Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Nature 506:185-90. 2014
  8. doi Modifiers and subtype-specific analyses in whole-genome association studies: a likelihood framework
    Phil H Lee
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Department of Psychiatry, Harvard Medical School, Boston, Mass, USA
    Hum Hered 72:10-20. 2011
  9. pmc Genome-wide association analysis identifies 13 new risk loci for schizophrenia
    Stephan Ripke
    1 Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA 2 Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA 3
    Nat Genet 45:1150-9. 2013
  10. pmc Genome-wide association studies of schizophrenia: does bigger lead to better results?
    Sarah E Bergen
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Curr Opin Psychiatry 25:76-82. 2012

Detail Information

Publications12

  1. doi Genetic modifiers and subtypes in schizophrenia: Investigations of age at onset, severity, sex and family history
    Sarah E Bergen
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Massachusetts General Hospital, Boston, MA, USA Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden Electronic address
    Schizophr Res 154:48-53. 2014
    ..continuous) implicated variation in ST18 (p=8.24×10(-7)). These results confirm recognized demographic relationships but do not support a simplified genetic architecture for schizophrenia subtypes based on these variables. ..
  2. pmc Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder
    S E Bergen
    Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
    Mol Psychiatry 17:880-6. 2012
    ..2 duplications (P=0.0035) and 22q11 deletions (P=0.03). These results reinforce prior reports of significant MHC and CNV associations in SCZ, but not BD...
  3. pmc Socioeconomic status and social support following illicit drug use: causal pathways or common liability?
    Sarah E Bergen
    Department of Human Genetics, Medical College of Virginia, Virginia Commonwealth University, Box 980126, Richmond, VA 23219, USA
    Twin Res Hum Genet 11:266-74. 2008
    ..Drug use and social discord also appear to have shared genetic factors, but increased levels of drug involvement seem to causally influence social interactions...
  4. pmc Polymorphisms in SLC6A4, PAH, GABRB3, and MAOB and modification of psychotic disorder features
    Sarah E Bergen
    Virginia Commonwealth University, Department of Human and Molecular Genetics, Richmond, Virginia 23219, USA
    Schizophr Res 109:94-7. 2009
    ..031) and QPDTPHASE (chi-square=12.54, p=.028). Also, a significant association between the GABRB3 191 bp allele and the hallucinations factor was detected using QPDTPHASE (chi-square=15.51, p=.030), but not QTDT (chi-square=2.07, p=.560)...
  5. pmc No association of dysbindin with symptom factors of schizophrenia in an Irish case-control sample
    Sarah E Bergen
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23219, USA
    Am J Med Genet B Neuropsychiatr Genet 153:700-5. 2010
    ..Several possibilities, such as differing risk haplotypes, may explain this finding...
  6. pmc Detection of susceptibility genes as modifiers due to subgroup differences in complex disease
    Sarah E Bergen
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA
    Eur J Hum Genet 18:960-4. 2010
    ..This may explain some of the inconsistent association results for many candidate gene studies of complex diseases...
  7. doi A polygenic burden of rare disruptive mutations in schizophrenia
    SHAUN M PURCELL
    1 Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA 2 Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA 3 Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA 4 Analytic and Translational Genetics Unit, Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA 5 Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Nature 506:185-90. 2014
    ..5 to 1 per cent) and moderately large effect. Taken together, these data suggest that population-based exome sequencing can discover risk alleles and complements established gene-mapping paradigms in neuropsychiatric disease. ..
  8. doi Modifiers and subtype-specific analyses in whole-genome association studies: a likelihood framework
    Phil H Lee
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Department of Psychiatry, Harvard Medical School, Boston, Mass, USA
    Hum Hered 72:10-20. 2011
    ..The primary utility of our work is the ability to distinguish between subtype-specific and modifier effects of genetic variants within a single testing framework...
  9. pmc Genome-wide association analysis identifies 13 new risk loci for schizophrenia
    Stephan Ripke
    1 Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA 2 Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA 3
    Nat Genet 45:1150-9. 2013
    ..Common genetic variation has an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this disorder. ..
  10. pmc Genome-wide association studies of schizophrenia: does bigger lead to better results?
    Sarah E Bergen
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Curr Opin Psychiatry 25:76-82. 2012
    ..This review aims to critically assess whether the results have improved as the sample size and scale of genetic association studies have grown...
  11. ncbi Age-related changes in heritability of behavioral phenotypes over adolescence and young adulthood: a meta-analysis
    Sarah E Bergen
    Virginia Institute for Psychiatric and Behavioral Genetics, Department of Human Genetics, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0126, United States of America
    Twin Res Hum Genet 10:423-33. 2007
    ..Further studies exploring heritability changes beyond young adulthood would also benefit our understanding of factors influencing heritability of behavioral traits over the lifespan...