Genomes and Genes


Mathieu J M Bertrand



  1. Dondelinger Y, Delanghe T, Priem D, Wynosky Dolfi M, Sorobetea D, Rojas Rivera D, et al. Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation. Nat Commun. 2019;10:1729 pubmed publisher
  2. Priem D, Dondelinger Y, Bertrand M. Monitoring RIPK1 Phosphorylation in the TNFR1 Signaling Complex. Methods Mol Biol. 2018;1857:171-179 pubmed publisher
    ..Here, we describe a detailed protocol to isolate complex I-associated RIPK1 from cells and provide different tools to study the phosphorylation status of RIPK1 in TNFR1 complex I. ..
  3. Estornes Y, Dondelinger Y, Weber K, Bruggeman I, Peall A, MacFarlane M, et al. N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosis. Cell Death Dis. 2018;9:494 pubmed publisher
    ..We therefore reveal a new mechanism restraining TRAIL cytotoxicity in mouse cells. ..
  4. Dondelinger Y, Jouan Lanhouet S, Divert T, Theatre E, Bertin J, Gough P, et al. NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling. Mol Cell. 2015;60:63-76 pubmed publisher
    ..We therefore report on an unexpected, NF-κB-independent role for the IKK complex in protecting cells from RIPK1-dependent death downstream of TNFR1. ..
  5. Dondelinger Y, Darding M, Bertrand M, Walczak H. Poly-ubiquitination in TNFR1-mediated necroptosis. Cell Mol Life Sci. 2016;73:2165-76 pubmed publisher
  6. Ting A, Bertrand M. More to Life than NF-κB in TNFR1 Signaling. Trends Immunol. 2016;37:535-545 pubmed publisher
    ..These revelations bring complexity to the control of TNF-induced cell death, and suggest clinical benefit of RIPK1 inhibitors in TNF-driven human inflammatory disorders. ..