Neil Benson

Summary

Publications

  1. doi request reprint Network-based discovery through mechanistic systems biology. Implications for applications--SMEs and drug discovery: where the action is
    Neil Benson
    Xenologiq Ltd, Unit 43, Canterbury Innovation Centre, University Road, Canterbury CT2 7FG, UK Electronic address
    Drug Discov Today Technol 15:41-8. 2015
  2. pmc Modeling of celiac disease immune response and the therapeutic effect of potential drugs
    Oleg O Demin
    Institute for System Biology SPb, Moscow, Russia
    BMC Syst Biol 7:56. 2013
  3. doi request reprint Reducing systems biology to practice in pharmaceutical company research; selected case studies
    N Benson
    Modelling and Simulation, Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research, Pfizer Ltd, Sandwich CT13 9NJ, UK
    Adv Exp Med Biol 736:607-15. 2012
  4. doi request reprint Cross-membrane signal transduction of receptor tyrosine kinases (RTKs): from systems biology to systems pharmacology
    Neil Benson
    Xenologiq Ltd, Unit 7, Denne Hill business park, Canterbury, Kent CT4 6HD, UK
    J Math Biol 66:719-42. 2013

Collaborators

  • Lambertus A Peletier
  • Oleg O Demin
  • Sergey V Smirnov
  • Cesar Pichardo-Almarza
  • Victor V Sokolov
  • Lourdes Cucurull-Sanchez
  • M Victoria Flores
  • Oleg V Demin

Detail Information

Publications5

  1. doi request reprint Network-based discovery through mechanistic systems biology. Implications for applications--SMEs and drug discovery: where the action is
    Neil Benson
    Xenologiq Ltd, Unit 43, Canterbury Innovation Centre, University Road, Canterbury CT2 7FG, UK Electronic address
    Drug Discov Today Technol 15:41-8. 2015
    ..Although we are on the journey to the virtual human, the length, path and rate of learning from this remain an open question. Success will be dependent on the will to invest and make the most of the insight generated along the way. ..
  2. pmc Modeling of celiac disease immune response and the therapeutic effect of potential drugs
    Oleg O Demin
    Institute for System Biology SPb, Moscow, Russia
    BMC Syst Biol 7:56. 2013
    ..The main aim of this work is to develop a mathematical model of the immune response in CD patients and to predict the efficacy of a transglutaminase-2 (TG-2) inhibitor as a potential drug for treatment of CD...
  3. doi request reprint Reducing systems biology to practice in pharmaceutical company research; selected case studies
    N Benson
    Modelling and Simulation, Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research, Pfizer Ltd, Sandwich CT13 9NJ, UK
    Adv Exp Med Biol 736:607-15. 2012
    ..Examples of applications to the identification of optimal drug targets in given pathways, selecting drug modalities and defining biomarkers are discussed, together with future directions...
  4. doi request reprint Cross-membrane signal transduction of receptor tyrosine kinases (RTKs): from systems biology to systems pharmacology
    Neil Benson
    Xenologiq Ltd, Unit 7, Denne Hill business park, Canterbury, Kent CT4 6HD, UK
    J Math Biol 66:719-42. 2013
    ..We thus present a transparent tool for studying the effects of drug intervention and ways of administration on cross-membrane signalling through these receptors...