M R Bennett

Summary

Publications

  1. pmc Adenosine modulation of calcium currents in postganglionic neurones of avian cultured ciliary ganglia
    M R Bennett
    Neurobiology Research Centre, University of Sydney, Australia
    Br J Pharmacol 106:25-32. 1992
  2. pmc Quantal transmitter release at somatic motor-nerve terminals: stochastic analysis of the subunit hypothesis
    M R Bennett
    Department of Physiology, University of Sydney, New South Wales, Australia
    Biophys J 70:654-68. 1996
  3. ncbi request reprint Depression of transmitter release at synapses in the rat superior cervical ganglion: the role of transmitter depletion
    Y Q Lin
    Department of Physiology, University of Sydney, NSW, Australia
    Auton Neurosci 88:16-24. 2001
  4. doi request reprint A model of NMDA receptor control of F-actin treadmilling in synaptic spines and their growth
    Max R Bennett
    The Brain and Mind Research Institute, The University of Sydney, New South Wales 2006, Australia
    Bull Math Biol 73:2109-31. 2011
  5. ncbi request reprint Stress and trauma: BDNF control of dendritic-spine formation and regression
    M R Bennett
    The Brain and Mind Research Institute, The University of Sydney, Australia Electronic address
    Prog Neurobiol 112:80-99. 2014
  6. pmc Fiber pathway pathology, synapse loss and decline of cortical function in schizophrenia
    Max R Bennett
    The Brain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia
    PLoS ONE 8:e60518. 2013
  7. doi request reprint The discovery of a new class of synaptic transmitters in smooth muscle 50 years ago and amelioration of coronary artery thrombosis
    M R Bennett
    Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia
    Acta Physiol (Oxf) 207:236-43. 2013
  8. doi request reprint A model of neuregulin control of NMDA receptors on synaptic spines
    Max R Bennett
    The Brain and Mind Research Institute and The Centre for Mathematical Biology, The University of Sydney, Sydney, New South Wales, 2006, Australia
    Bull Math Biol 74:717-35. 2012
  9. doi request reprint The prefrontal-limbic network in depression: A core pathology of synapse regression
    M R Bennett
    Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, NSW 2050, Australia
    Prog Neurobiol 93:457-67. 2011
  10. doi request reprint Schizophrenia: susceptibility genes, dendritic-spine pathology and gray matter loss
    M R Bennett
    Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, NSW 2050, Australia
    Prog Neurobiol 95:275-300. 2011

Collaborators

Detail Information

Publications44

  1. pmc Adenosine modulation of calcium currents in postganglionic neurones of avian cultured ciliary ganglia
    M R Bennett
    Neurobiology Research Centre, University of Sydney, Australia
    Br J Pharmacol 106:25-32. 1992
    ..7. These observations of the effects of 2-chloroadenosine on the transient and sustained currents are discussed in relation to the different calcium channel types at preganglionic nerve terminals...
  2. pmc Quantal transmitter release at somatic motor-nerve terminals: stochastic analysis of the subunit hypothesis
    M R Bennett
    Department of Physiology, University of Sydney, New South Wales, Australia
    Biophys J 70:654-68. 1996
    ..This did not provide evidence for a subunit structure...
  3. ncbi request reprint Depression of transmitter release at synapses in the rat superior cervical ganglion: the role of transmitter depletion
    Y Q Lin
    Department of Physiology, University of Sydney, NSW, Australia
    Auton Neurosci 88:16-24. 2001
    ..Depletion of the docked vesicles during exocytosis then leads to depression of transmitter release during a train of impulses...
  4. doi request reprint A model of NMDA receptor control of F-actin treadmilling in synaptic spines and their growth
    Max R Bennett
    The Brain and Mind Research Institute, The University of Sydney, New South Wales 2006, Australia
    Bull Math Biol 73:2109-31. 2011
    ..Such modelling provides a quantitative description of the synaptic-spine dynamics of the filamentous to globular actin ratio that is observed experimentally...
  5. ncbi request reprint Stress and trauma: BDNF control of dendritic-spine formation and regression
    M R Bennett
    The Brain and Mind Research Institute, The University of Sydney, Australia Electronic address
    Prog Neurobiol 112:80-99. 2014
    ..It seems then that CRF does have a role to play in determining BDNF control of dendritic spines. ..
  6. pmc Fiber pathway pathology, synapse loss and decline of cortical function in schizophrenia
    Max R Bennett
    The Brain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia
    PLoS ONE 8:e60518. 2013
    ..This work suggests that deterioration of longitudinal fasciculi in schizophrenia explains the loss of activity in the gray matter...
  7. doi request reprint The discovery of a new class of synaptic transmitters in smooth muscle 50 years ago and amelioration of coronary artery thrombosis
    M R Bennett
    Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia
    Acta Physiol (Oxf) 207:236-43. 2013
    ..The discovery of the role of P2Y(12) receptors in increasing thrombosis lead to the focused research that resulted in clopidogrel and ticagrelor...
  8. doi request reprint A model of neuregulin control of NMDA receptors on synaptic spines
    Max R Bennett
    The Brain and Mind Research Institute and The Centre for Mathematical Biology, The University of Sydney, Sydney, New South Wales, 2006, Australia
    Bull Math Biol 74:717-35. 2012
    ..This quantitative description of the Nrg/NMDAR pathway provides a model for experimental elucidation of what goes awry in animal models of schizophrenia...
  9. doi request reprint The prefrontal-limbic network in depression: A core pathology of synapse regression
    M R Bennett
    Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, NSW 2050, Australia
    Prog Neurobiol 93:457-67. 2011
    ..It is concluded that it is the loss of synapses and concomitantly that of the dendrites on which they normally impinge that accounts quantitatively for the major loss of grey matter in different components of the PLN in depression...
  10. doi request reprint Schizophrenia: susceptibility genes, dendritic-spine pathology and gray matter loss
    M R Bennett
    Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, NSW 2050, Australia
    Prog Neurobiol 95:275-300. 2011
    ..This will help reestablish neural networks in the PTN and so the loss of gray matter in the PTN...
  11. doi request reprint The prefrontal-limbic network in depression: Modulation by hypothalamus, basal ganglia and midbrain
    M R Bennett
    Brain and Mind Research Institute, University of Sydney, Camperdown, NSW 2050, Australia
    Prog Neurobiol 93:468-87. 2011
    ..Here the likely mechanisms by which these modulations are affected are described and the implications of their failure for depression associated with suicidal diathesis, late-life and psychoses discussed...
  12. pmc Probabilistic secretion of quanta and the synaptosecretosome hypothesis: evoked release at active zones of varicosities, boutons, and endplates
    M R Bennett
    Department of Physiology, Institute for Biomedical Research, University of Sydney, New South Wales, Australia
    Biophys J 73:1815-29. 1997
    ..The concept of the stochastic operation of a synaptosecretosome can accommodate most phenomena involving the release of transmitter quanta at these synapses...
  13. pmc The effect of nitric oxide on the efficacy of synaptic transmission through the chick ciliary ganglion
    T R Scott
    Department of Physiology, University of Sydney, Australia
    Br J Pharmacol 110:627-32. 1993
    ..6. These results suggest that nitric oxide modulates synaptic transmission through the ganglion by acting on an endogenous guanylate cyclase that produces cyclic GMP...
  14. pmc The probability of quantal secretion near a single calcium channel of an active zone
    M R Bennett
    The Neurobiology Laboratory, Institute for Biomedical Research, Department of Physiology, University of Sydney, New South Wales 2006, Australia
    Biophys J 78:2201-21. 2000
    ....
  15. pmc Quantal and non-quantal current and potential fields around individual sympathetic varicosities on release of ATP
    M R Bennett
    The Neurobiology Laboratory, Institute for Biomedical Research, and Department of Physiology, Sydney, New South Wales 2006, Australia
    Biophys J 80:1311-28. 2001
    ..This work provides an internally consistent description of quantal potential and current fields about the varicosities of sympathetic nerve terminals and provides evidence for a non-quantal form of transmitter release...
  16. pmc The probability of quantal secretion within an array of calcium channels of an active zone
    M R Bennett
    The Neurobiology Laboratory, Institute for Biomedical Research, Department of Physiology, University of Sydney, New South Wales 2006, Australia
    Biophys J 78:2222-40. 2000
    ....
  17. doi request reprint Origins of the BOLD changes due to synaptic activity at astrocytes abutting arteriolar smooth muscle
    M R Bennett
    The Brain and Mind Research Institute, University of Sydney, NSW 2006, Australia
    J Theor Biol 252:123-30. 2008
    ....
  18. doi request reprint Glutamate potentiates lipopolysaccharide-stimulated interleukin-10 release from neonatal rat spinal cord astrocytes
    E L Werry
    Brain and Mind Research Institute and Bosch Institute, The University of Sydney, NSW 2006, Australia
    Neuroscience 207:12-24. 2012
    ..Spinal cord astrocytes may, therefore, play a larger anti-inflammatory role than first thought in situations where glutamate and a high concentration of Toll-like receptor 4 (TLR4) agonists are present...
  19. pmc Synaptic transmission at visualized sympathetic boutons: stochastic interaction between acetylcholine and its receptors
    M R Bennett
    Department of Physiology, University of Sydney, New South Wales, Australia
    Biophys J 72:1595-606. 1997
    ..The amplitude of the simulated EPSC then exhibited stochastic fluctuations similar to those of the experimental EPSC...
  20. pmc The effect of ions and second messengers on long-term potentiation of chemical transmission in avian ciliary ganglia
    T R Scott
    Department of Physiology, University of Sydney, Australia
    Br J Pharmacol 110:461-9. 1993
    ....
  21. ncbi request reprint Sympathetic neuromuscular transmission at a varicosity in a syncytium
    M R Bennett
    Department of Physiology, Institute for Biomedical Research, University of Sydney, NSW, Australia
    Microsc Res Tech 42:433-50. 1998
    ....
  22. pmc The development of topographical maps and fibre types in toad (Bufo marinus) glutaeus muscle during synapse elimination
    M R Bennett
    Neurobiology Research Centre, University of Sydney, NSW, Australia
    J Physiol 409:43-61. 1989
    ..5. The glutaeus in post-metamorphic toads (0.15 g body weight) had only a small number of tonic and slow-twitch fibres in the very dorsal layer of cells; the muscle was largely type 1.(ABSTRACT TRUNCATED AT 400 WORDS)..
  23. ncbi request reprint Sympathetic innervation of the surface of the mouse vas deferens
    N A Lavidis
    Department of Physiology, University of Sydney, N S W, Australia
    J Auton Nerv Syst 45:87-100. 1993
    ..Serial thin sections through small axon bundles and single axons, viewed with the electron microscope, confirmed the dimensions of varicosities along axons observed following DiOC2(5) staining or use of the FAGLU method...
  24. pmc Effect of nitric oxide synthase inhibition on long-term potentiation at associational-commissural and mossy fibre synapses on CA3 pyramidal neurones
    P J Nicolarakis
    Department of Physiology, University of Sydney, Australia
    Br J Pharmacol 111:521-4. 1994
    ..6 +/- 9.5% (n = 5 cells, P > 0.05). 4. These results suggest that LTP at associational-commissural synapses (fimbrial input) is significantly depressed in the presence of the NOS inhibitor L-NAME, while mossy fibre LTP is unchanged...
  25. pmc Adenosine modulation of potassium currents in postganglionic neurones of cultured avian ciliary ganglia
    M R Bennett
    Neurobiology Research Centre, University of Sydney, Australia
    Br J Pharmacol 104:459-65. 1991
    ..This IK(Na) was unaffected by adenosine (1O microM). 7. These results are discussed in relation to the role of adenosine in blocking Ca2 + channels and thereby modifying calcium-dependent components of K+ currents...
  26. ncbi request reprint NANC transmission at a varicosity: the individuality of single synapses
    M R Bennett
    The Neurobiology Laboratory, Department of Physiology, Institute for Biomedical Research, University of Sydney, NSW 2006, Sydney
    J Auton Nerv Syst 81:25-30. 2000
    ....
  27. pmc Autoradiography of P2x ATP receptors in the rat brain
    V J Balcar
    Department of Anatomy and Histology, University of Sydney, Australia
    Br J Pharmacol 115:302-6. 1995
    ..4. The highest density of P2x binding sites was found to be in the cerebellar cortex but the binding sites were present in all major brain regions, especially in areas known to receive strong excitatory innervation...
  28. ncbi request reprint Origins of blood volume change due to glutamatergic synaptic activity at astrocytes abutting on arteriolar smooth muscle cells
    M R Bennett
    The Neurobiology Laboratory, Department of Physiology, University of Sydney, NSW 2006, Australia
    J Theor Biol 250:172-85. 2008
    ..This model predicts a linear increase in blood flow with increasing numbers of activated astrocytes, but a non-linear increase with increasing glutamate release...
  29. pmc A quantitative model of purinergic junctional transmission of calcium waves in astrocyte networks
    M R Bennett
    The Neurobiology Laboratory, Institute for Biomedical Research, Department of Physiology, University of Sydney, New South Wales, Australia
    Biophys J 89:2235-50. 2005
    ..The properties of purinergic transmission at astrocyte junctions may determine many of the characteristics of Ca2+ propagation in networks of these cells...
  30. ncbi request reprint Statistics of transmitter release at nerve terminals
    M R Bennett
    Department of Physiology, Institute for Biomedical Research, University of Sydney, NSW, Australia
    Prog Neurobiol 60:545-606. 2000
    ..This offers the possibility in the near future of identifying the kinetic interaction of these proteins with the parameters of the stochastic process of exocytosis which confer a particular probability on individual synapses...
  31. ncbi request reprint Monoaminergic synapses and schizophrenia: 45 years of neuroleptics
    M R Bennett
    Institute for Biomedical Research and Department of Physiology, University of Sydney, NSW, Australia
    J Psychopharmacol 12:289-304. 1998
    ..This historical review ends with a consideration of the possibility that in addition to DA receptors, serotonin and perhaps other transmitter receptors are involved in the aetiology of schizophrenia...
  32. ncbi request reprint Mechanisms of calcium sequestration during facilitation at active zones of an amphibian neuromuscular junction
    M R Bennett
    The Neurobiology Laboratory, Department of Physiology, The Institute for Biomedical Research, University of Sydney, New South Wales 2006, Australia
    J Theor Biol 247:230-41. 2007
    ..Biophys. J. 86(5), 2674-2690], with the single plasmalemma pump in that model now replaced by separate pumps for the plasmalemma and endoplasmic reticulum, as well as the introduction of a mitochondrial uniporter...
  33. ncbi request reprint The concept of long term potentiation of transmission at synapses
    M R Bennett
    The Neurobiology Laboratory, Institute for Biomedical Research and The Department of Physiology, University of Sydney, NSW, Australia
    Prog Neurobiol 60:109-37. 2000
    ..There is more agreement on the important role or protein kinases in the maintenance phase of LTP. The role of LTP in memory is just now being elucidated...
  34. ncbi request reprint Vesicle-associated proteins and transmitter release from sympathetic ganglionic boutons
    D H Blair
    Neurobiology Laboratory, University of Sydney, NSW, Australia
    Neuroreport 12:607-10. 2001
    ....
  35. ncbi request reprint Language and cortical function: conceptual developments
    M R Bennett
    The Neurobiology Laboratory, Department of Physiology, Institute for Biomedical Research, University of Sydney, Sydney, NSW 2006, Australia
    Prog Neurobiol 80:20-52. 2006
    ..We seek to clarify what can be substantiated concerning the workings of the brain and the exercise of linguistic skills...
  36. ncbi request reprint One hundred years of adrenaline: the discovery of autoreceptors
    M R Bennett
    Institute for Biomedical Research and The Department of Physiology, University of Sydney, Australia
    Clin Auton Res 9:145-59. 1999
    ..This paper assesses the contributions that established the idea of the adrenergic autoreceptor, 100 years after the discovery of adrenaline...
  37. pmc Nitric oxide modulation of calcium-activated potassium channels in postganglionic neurones of avian cultured ciliary ganglia
    M Cetiner
    Department of Physiology, University of Sydney, Australia
    Br J Pharmacol 110:995-1002. 1993
    ..8 ms into a depolarizing pulse, at a time that would decrease the rate of repolarization of the action potential. Ik(Ca) is also reduced at longer times (350 ms), indicating an affect on the inactivating process...
  38. ncbi request reprint The concept of transmitter receptors: 100 years on
    M R Bennett
    The Neurobiology Laboratory, Institute for Biomedical Research and Department of Physiology, University of Sydney, NSW, Australia
    Neuropharmacology 39:523-46. 2000
    ..The review concludes with the triumph of the first recordings of the electrical signs of single channel openings by Neher and Sakmann (1976) at the receptors which Langley had first described...
  39. pmc Microstructural white matter changes are correlated with the stage of psychiatric illness
    J Lagopoulos
    Clinical and Research Unit, Brain and Mind Research Institute, The University of Sydney, Camperdown, NSW, Australia
    Transl Psychiatry 3:e248. 2013
    ....
  40. doi request reprint Lipopolysaccharide-stimulated interleukin-10 release from neonatal spinal cord microglia is potentiated by glutamate
    E L Werry
    The University of Sydney, NSW, Australia
    Neuroscience 175:93-103. 2011
    ..These results show that glutamate substantially increases the release of an anti-inflammatory cytokine from neonatal spinal cord microglia activated by a high concentration of LPS...
  41. doi request reprint Resilience and reduced c-Fos expression in P2X7 receptor knockout mice exposed to repeated forced swim test
    A A Boucher
    Brain and Mind Research Institute, Faculty of Health Sciences, Department of Pharmacology, University of Sydney, Camperdown 2050 NSW, Australia
    Neuroscience 189:170-7. 2011
    ..This suggests that P2X7R antagonists may be useful therapeutics for the treatment of major depression, possibly by increasing resilience in the face of repeated stress...
  42. ncbi request reprint Synapse formation molecules in muscle and autonomic ganglia: the dual constraint hypothesis
    M R Bennett
    Neurobiology Laboratory, University of Sydney, NSW, Australia
    Prog Neurobiol 57:225-87. 1999
    ..The extent to which there is evidence for similar molecules at neuronal synapses such as those in autonomic ganglia is also considered...
  43. ncbi request reprint Forty years of amino acid transmission in the brain
    M R Bennett
    The Institute for Biomedical Research, The University of Sydney, NSW, Australia
    Neurochem Int 35:269-80. 1999
    ..The relationship is also explored between these early findings and those of the present era characterised by extensive use of techniques of molecular biology and the development of drugs against targets identified 30 to 40 years ago...
  44. ncbi request reprint Emotion and cortical-subcortical function: conceptual developments
    M R Bennett
    The Neurobiology Laboratory, Department of Physiology, Institute for Biomedical Research, University of Sydney, Sydney, NSW 2006, Australia
    Prog Neurobiol 75:29-52. 2005
    ..We attempt to clarify what can and cannot be justified as established concerning the workings of the brain and emotions...